Digital Commons Network^™

Estimating Cumulative Incidence Rate On Interval Censored Data In An Illness-Death Model., Chen Qian

Electronic Theses and Dissertations

Phase IV clinical trials are designed to monitor long-term side effects caused overtime by the medical treatment. For instance, in advanced primary cancer treatment, childhood cancer survivors are often at risk of developing undesired events, such as cardiotoxicity, during their adulthood. Such problems could be due to their cancer or the treatment they received for their cancer such as radiation or intensive chemotherapy. Cardiotoxicity can be diagnosed with electrophysiology with measurements of fraction shortening, afterload, etc. Often the primary focus of a study could be on estimating the cumulative incidence of a particular outcome of interest such as cardiotoxicity. However, …

Observational Studies In Group Testing And Potential Applications., Alexander Christopher Noll

Electronic Theses and Dissertations

The use of group testing to identify individuals with targeted outcomes in a population can greatly improve the efficiency, speed, and cost effectiveness of testing a population for an outcome, or at least for identifying the prevalence of an outcome in a population. The implementation of causal inference techniques can provide the basis for an observational study that would allow an investigator to gather estimates for treatment effectiveness if group testing was conducted on the population in a certain way. This thesis examines a simulation of the above outlined principles in order to demonstrate a potential application for determining treatment …

Parents' Perceptions Of Leisure Constraints And Facilitators In Elite Youth Soccer: A Phenomenological Approach., Chelsea C. Police

Electronic Theses and Dissertations

The purpose of this study was to examine perceived constraints and facilitators among parents and guardians as key stakeholders in elite youth soccer clubs. Specifically, this study identified constraints and facilitators affecting continued participation, negotiation strategies employed to help overcome constraints, demonstrated the role of parents and guardians play in organizational success, and illustrated their stakeholder salience. The present study utilized leisure constraint and stakeholder theories as the theoretical foundation. Leisure constraint theory outlined the three categories of constraints (and facilitators), which are intrapersonal, interpersonal, and structural. Stakeholder theory described how constituent groups affect organizational success by examining their specific …

Acting On What We Hear: The Impact Of A Listening Methodology In A Community Literacy Program., Megen Farrow Boyett

Electronic Theses and Dissertations

Calls for better listening, especially to racially and linguistically marginalized populations, are popular and necessary in community literacy studies. However, while scholarship has clarified the need for attending to a range of voices across the life of a community program and demonstrated clear results of good listening, it has not sufficiently outlined a methodology for listening, especially as it applies to community-engaged action. Even less scholarship has focused on attending to current listening practices, so that scholars and community partners hoping to practice active listening interpret participants’ input through a soundtrack of other, unnoticed, “voices,” and have no way of …

Presence Of Severe Acute Respiratory Syndrome Coronavirus 2 In Urban Streams Receiving Sewer Overflow, Louisville, Kentucky, Usa., Cullen Hunter

Electronic Theses and Dissertations

Pathogens may enter surface waters as they are shed in human feces and potentially delivered to surface waters via sewer overflows, particularly in the eastern United States. This study examined of the presence of fecal indicators in two forks of Beargrass Creek in Louisville, Kentucky. Surface water grab samples (N=30), sediment samples, water quality, and a paired wastewater surveillance study were analyzed. SARS-CoV-2 was detected in a single stream sample despite ubiquitous presence of the virus within the area in wastewater and consistent evidence of a human fecal indicator. These findings demonstrate the need for more green and gray infrastructure …

The High School Choral Classroom As A Platform For Cross-Cultural Education: A Content Evaluation Of The 2020 Tnmea Satb All-State Repertoire., Michael Ian Colavita

Electronic Theses and Dissertations

In the United States, there is a push toward culturally responsive music education in response to a rapidly changing student demographic. However, teaching music from unfamiliar traditions presents a unique set of challenges for the music educator. The 2020 Tennessee SATB All-State repertoire provides one example of music selected with the goal of teaching a wide array of cultural traditions. This thesis analyzes these seven pieces from a musical and pedagogical perspective to demonstrate this collection’s utility for culturally responsive music education. Evaluation of the pieces demonstrated that while most of these works come from distinct cultural traditions, few present …

Particulate Matter Exposure And Community-Acquired Pneumonia Mortality Among Hospitalized Adults With Pneumococcal Pneumonia: Incidence Study (Happi) Participants., Jack Anthony Pfeiffer

Electronic Theses and Dissertations

The role of air pollution as an agent of elevated morbidity and mortality has come under increasingly intense scrutiny in recent years. As the body of literature grows, so too does our understanding of how extensive the harm of such pollutants can be. Particulate matter (PM) particularly harmful due to its small size, ability to travel great distance while airborne, and capacity to infiltrate numerous bodily systems, often to the detriment of those exposed. Besides being associated with increased mortality risk in more heavily exposed populations, PM exposure has also been associated with complications in the respiratory, cardiovascular, and nervous …

A Spatial Analysis Of Supply-Demand Of Public Transportation In Jefferson County, Kentucky., Nastaran Abdoli

Electronic Theses and Dissertations

Public transportation is important as it serves individuals, especially the transit-dependent population, by providing a basic mobility service to these people and all others who rely on public transportation. This research utilized estimating public transportation demand and supply to analyze the spatial patterns of public transportation in Jefferson County, Kentucky. The study focuses on the transit-dependent population, and it considers indicators of age, poverty status, vehicle ownership, and foreign-born population with less than five years residency in the United States. This study conducted a public transit supply-demand analysis to identify areas with imbalanced supply and demand in Jefferson County at …

Harmful Algal Blooms In The Ohio River: Spatial And Temporal Differences., Bevin Hardy

Electronic Theses and Dissertations

The frequency of harmful algal blooms (HABs) has been increasing across the globe, especially in river ecosystems. Although more common in lakes, more HABs have been reported in rivers in the past decade, particularly in the Ohio River. In 2019, a HAB stretched 200 to 300 miles throughout the Ohio River from September to October. Samples were collected for the duration of the 2019 bloom (August-October) in the McAlpine Pool in Louisville, KY to compare microcystis toxin (microcystin) concentrations on a temporal and spatial scale. Different habitats (bay, creek, river) were sampled throughout the bloom, and two additional sampling days, …

Anxiety And Self-Efficacy Related To Learning Neuroanatomy In An Integrated Medical Curriculum., Jessica S. Bergden

Electronic Theses and Dissertations

Medical student anxiety towards learning neuroanatomy — neurophobia, a key obstacle in medical education, is influencing medical student success and potentially swaying medical students away from neurology careers. This is particularly concerning with condensed neuroanatomy instructional hours from curriculum integration and the concurrent shortage of neurologists, combined with the rising prevalence of neurological disease, and medical students choosing neurological specialties at lower rates. Neuroanatomy education is one factor described in the literature as contributing toneurophobia, yet specific ways in which neuroanatomy education could be improved have not yet been explained. In this present work, we demonstrate four specific domains, namely …

Optimization With Interval Data: New Problems, Algorithms, And Applications., Mohsen Mohammadi Dehcheshmeh

Electronic Theses and Dissertations

The parameters of real-world optimization problems are often uncertain due to the failure of exact estimation of data entries. Throughout the years, several approaches have been developed to cope with uncertainty in the input parameters of optimization problems, such as robust optimization, stochastic optimization, fuzzy programming, parametric programming, and interval optimization. Each of these approaches tackles the uncertainty in the input data with different assumptions on the source of uncertainty and imposes different requirements on the returned solutions. In this dissertation, the approach we take is that of interval optimization, and more specifically, interval linear programming. The two main problems …

The Lived Experience Of Women With Head & Neck Cancer And The Impact On Close Relationships., Georgia Anderson

Electronic Theses and Dissertations

Background: Head and neck cancer (HNC) is emotionally and physically burdensome to people who are diagnosed with this disease. In the United States, nearly 30% of people diagnosed with HNC are women. Studies about depression and anxiety in this population have been conducted for decades; however, there are no studies that specifically examine the psychosocial implications of this disease from the perspective of women. Method: Women diagnosed with HNC were recruited from two academic medical centers in the Ohio-Kentucky-Indiana tri-state area to explore the lived experience of women with HNC and how this disease impacts their close relationships. Semi-structured interviews …

Determination Of The Biological Functions Of Undefined Domains Of Veev Nsp2., Andrew Michael Skidmore

Electronic Theses and Dissertations

Alphaviruses are positive sense, single strand, RNA viruses. These viruses occur on every populated continent. Alphaviruses are divided into two clades, the New-World and Old-World viruses. The New-World viruses include Eastern (EEEV), Western (WEEV), and Venezuelan equine encephalitis viruses (VEEV), and cause neuroinvasive disease. The Old-World viruses include Chikungunya (CHIKV) and Ross River viruses (RRV), and typically cause multijoint arthralgia. There are currently no approved antiviral therapeutics or vaccines for any alphavirus, making them a high priority for antiviral drug design and discovery. A benzamidine inhibitor (ML336) of VEEV was characterized, and determined to inhibit replication of VEEV RNA during …

Chronic Codeswitching: A Phenomenological Study Examining Multiracial Student Sense Of Belonging In A Predominantly White Institution., Nicholas Lamar Wright

Electronic Theses and Dissertations

Constantly feeling a lack of acceptance and getting the comment “You are too Black” or “You are too White” is a challenging, common occurrence for multiracial students, but especially those in predominantly White institutions. This is just one of the barriers that stand between multiracial students and forming a sense of belonging at a predominantly White institution. The majority of research examining sense of belonging focuses on either Black or White students, but neglect multiracial students and their experiences. This dissertation examines sense of belonging for multiracial (Black/White) students in a predominantly White institution, by interviewing 11 multiracial students at …

Incidental Exposure, Political Activity And Perceived Trust., Brianna Berry

Electronic Theses and Dissertations

The current study examines the concept of incidental versus traditional exposure to information through the context of a police brutality incident. Incidental exposure on social media is when a person is exposed to information or imagery without prior warning. It is hypothesized that 1) individuals who are incidentally exposed to a graphic police brutality event will be more likely to participate in politics and 2) will have lower perceived trust in the government. This randomized study utilizes two treatments (incidental exposure and traditional exposure) and a control group. Analysis of the data shows that support for H₁ is only …

Genetic And Functional Analysis Of Rat Mammary Cancer Susceptibility., Emily L Duderstadt

Electronic Theses and Dissertations

Breast cancer genetic susceptibility is modulated by high to low penetrance risk alleles. Population frequencies of high and moderate penetrant predisposing mutations are rare and responsible for a small percentage of population cases. Most genetic variation in breast cancer susceptibility is low penetrance common variants where causal genes and risk-associated mechanisms are largely unknown. Comparative genetics uses animal models to isolate and mechanistically evaluate genetic susceptibility to human disease. Rat strains have different susceptibility phenotypes to chemical-induced carcinogenesis. Selective breeding and genetic linkage analysis using a 7,12-dimethylbenz(a)anthracene (DMBA) rat mammary carcinogenesis model have identified Mammary carcinoma susceptibilityquantitative trait loci …

The Effects Of Great Leaps Reading On The Reading Fluency Of Elementary Students With Reading And Behavioral Deficits., Gwendolyn Shultz Ashley

Electronic Theses and Dissertations

This dissertation is an examination of one reading fluency intervention presented in digital form. It begins as an overview of the academic challenges faced by students classified as emotional behavioral disorder in our P-12 schools, due to challenges accessing the curriculum. Children that also have reading fluency deficits have an even more difficult time accessing grade level curriculum. Several theories of education are presented, with a focus on instructivist theory. Instructivist theory focuses on such methodology as Applied Behavior Analysis, which includes Discreet Trial Training and direct instruction.Repeated reading is included. All of these are components of Great Leaps for …

A Qualitative Look At Secondary Trauma Through The Lived Experiences Of Elementary Teachers., Terri L Davenport

Electronic Theses and Dissertations

This research study examined the lived experiences of elementary educators working with traumatized students. Secondary trauma among other professions such as social workers and first responders is well-documented (Bride et al., 2007). Research on the impact it has on educators is still limited (Hill, 2011). This dissertation provides evidence that educators are directly impacted by the work that they do to support and educate their students. A phenomenological approach is used to explore the troubling personal challenges educators face while working with traumatized students. The study examines elementary teachers’ experiences using the Secondary Traumatic Stress (STS) lens as a theoretical …

Shifting Sands., Rachid Tagoulla

Electronic Theses and Dissertations

Shifting Sands is a re-exploration of the presentation of North Africans in colonial postcards, an examination of identity, and a critique of the modern Western museum. Since the inception of photography, colonizers used this medium- especially in the form of postcards- to categorize and exoticize Eastern peoples in order to more easily subjugate them. Shifting Sands is a series of reconstructed colonial postcards which challenges colonial-era stereotypes of North African peoples. The colonial gaze, represented by the camera lens, is subverted through a lensless image-making process in which sand is used to remove the subject from the colonial gaze and …

Ga-Based Iii-V Semiconductor Photoanodes For Solar Fuels And Novel Techniques To Investigate Their Photocorrosion., Sahar Pishgar

Electronic Theses and Dissertations

Solar energy is one of the most abundant renewable energy sources. However, the diurnal variation of the sun as well as seasonal and weather effects, limits the widespread global implementation of solar energy. Thus, Cost-effective energy storage is critical to overcome the intermittent nature of solar energy available on the earth. Photoelectrolysis of water to oxygen and hydrogen fuel is a promising large-scale solution to store intermittent solar energy in a dense and portable form. Photoelectrochemical (PEC) water-splitting, or artificial photosynthesis, research strives to develop a semiconductor photoelectrode with both high efficiency and long-term stability. Semiconductors of the III–V class …

Isomotive Dielectrophoresis For Enhanced Analyses Of Cell Subpopulations., Mohamed Zakarya Rashed

Electronic Theses and Dissertations

As the relentless dream of creating a true lab-on-a-chip device is closer to realization than ever before, which will be enabled through efficient and reliable sample characterization systems. Dielectrophoresis (DEP) is a term used to describe the motion of dielectric particles/ cells, by means of a non-uniform electric field (AC or DC). Cells of different dielectric properties (i.e., size, interior properties, and membrane properties) will act differently under the influence of dielectrophoretic force. Therefore, DEP can be used as a powerful, robust, and flexible tool for cellular manipulation, separation, characterization, and patterning. However, most recent DEP applications focus on …

Distribution And Ecological Effects Of Azteca Chartifex/Trigona In The Barro Colorado Nature Monument., Rachel Leann Wells

Electronic Theses and Dissertations

This dissertation explores the behavior and ecology of a conspicuous and behaviorally dominant ant species in the tropical rainforest of Panama. Competition with aggressive species is an important factor that shapes local community structure. Eavesdropping on the chemical communication systems of such behaviorally dominant species can help heterospecific species to avoid negative interactions. I review the chemical communication system and known ecological effects of the Neotropical canopy ant, Azteca chartifex/trigona (Chapter 1). There are over 40 known compounds produced by Azteca workers, yet how these compounds impact heterospecific species is unclear in many circumstances. I assessed if heterospecific …

In Bloom: Nurturing The Liberation Process Of Performer And Character As Rose In August Wilson's Fences., Paula O. Lockhart

Electronic Theses and Dissertations

Rose Maxson is the 43-year-old matriarch of the Maxson household in August Wilson’s Pulitzer Prize-winning play, Fences. She is a character with an inviolable spirit. The unwavering force she possesses rattles the pages as she relives past loves, loss, experiences heartbreak. Imagine, how I, a then 24-year old devoid of the immense life experience that Rose encompasses found my way into her. The answer is through nurture. To nurture is a process of feeding, protecting, or rearing someone or something. It is a journey with or without a destination. Rose is in a constant state of nurturing her family, …

Assessing The Role Of Chronic Arsenite Exposure In Disrupting The Egfr Signaling Axis., Christine Kim

Electronic Theses and Dissertations

Chronic arsenic exposure is a risk factor for the development of pulmonary diseases, including lung cancer, but the exact mechanism is not yet fully understood. Many previous studies have relied on acute arsenic exposure (i.e. 1-10 uM arsenic for 24 hours) to study arsenic toxicological effects. However, acute exposure does not reflect the levels or duration of arsenic associated with environmental exposure, or drinking of contaminated well water. This dissertation differentiates the effects of acute versus chronic arsenic exposures on the EGFR signaling axis and suggests possible mechanisms for chronic arsenic-induced pulmonary diseases. The EGFR is a receptor tyrosine kinase …

Comparing Instructional Techniques On Memory Retention, Retrieval, Application And Self-Efficacy Of Grading Criteria Used For Student Self-Assessment., Michael James Metz

Electronic Theses and Dissertations

Purpose/Objectives: Study examined the effects of active engagement (ENG) and spaced retrieval practice (SRP) on the self-assessment (SA) competencies among D1 dental students. Methods: D1 dental students (N = 120) were randomly assigned to one of four treatment conditions (n=30) in this experimental 2X2 research study: no ENG/ no SRP (control); no ENG/ SRP; ENG/no SRP; ENG/ SRP. Outcomes included content mastery (30 item multiple-choice exam) and application knowledge (simulated dentoform assessment) of the course grading rubric for SA. Results: Results indicated a statistically significant main effect for ENG and SRP on both outcome variables. Specifically, ENG …

Black Men Wanted: An Instrumental Case Study Exploring The Situational Factors Related To The Retention Of African American Male High School Teachers., Christopher Kevin Flores

Electronic Theses and Dissertations

As the nation’s high school student population becomes increasingly diverse, the declining number of minority teachers, particularly African American male teachers is becoming an area of concern. This instrumental case study of African American male high school teachers in the Fayette County Public School system in Lexington, Kentucky sought to identify the motivations for teaching, the barriers prior to and during teaching, as well as the roles these individuals are asked to fulfill in their schools. Using purposeful sampling, 10 individuals participated in semi-structured interviews aimed at providing insight to the three research questions related to motivations, barriers, and roles. …

Simulation Of Fracture Strength Improvements Of A Human Proximal Femur Using Finite Element Analysis., Waleed Ebraheem Alim

Electronic Theses and Dissertations

The most common hip fracture in the elderly occurs as a result of a fall to the side with impact over the greater trochanter resulting in a fracture of the proximal femur. The fracture usually involves the femoral neck or the intertrochanteric region. It has recently been determined that the fracture crack of a hip fracture typically initiates on the superior-lateral cortex of the femoral neck and then propagates across the femoral neck, resulting in a complete fracture. The strength of the superior-lateral cortex of the femoral neck is likely determined by the combined properties of the generally thin cortex …

The Importance Of Noncapped Viral Genomic Rna To Alphaviral Infection And Pathogenesis., Autumn Lapointe

Electronic Theses and Dissertations

Alphaviruses are mosquito-borne arboviruses that have a positive sense, single-stranded RNA genome, which are capable of causing severe disease and thus pose a significant burden to public health. During alphaviral replication, significant quantities of viral genomic RNAs that lack the canonical alphaviral 5’ cap structure are produced and packaged into viral particles, despite the fact that these noncapped genomes cannot be translated and are essentially noninfectious. The production and packaging of the noncapped genomes has been found to be true for infections across multiple vertebrate and invertebrate cell lines and alphavirus species, although the proportion of ncgRNA produced differs. Despite …

Role Of Kvβ2 Subunits In Regulation Of Resistance Arterial Tone., Sean M Raph

Electronic Theses and Dissertations

Voltage-gated potassium (Kv) channels control vascular resistance and facilitate the augmentation of myocardial blood flow in response to increases in cardiac workload (i.e., metabolic hyperemia). Native sarcolemmal Kv1 channels in arterial myocytes associate with a heteromeric auxiliary complex consisting of intracellular Kvβ1 and Kvβ2 proteins. The Kvβ proteins differentially regulate the function of heterologously expressed Kv channels, as well as native Kv1 channels in excitable cells of the cardiovascular and nervous systems. The physiological importance of vascular Kvβ proteins in mediating vasodilation remains unknown. In this study, I tested the hypothesis that Kvβ proteins functionally regulate vascular tone in response …

Teacher Perception Concerning The Role Of Elementary Principals In School Culture And Climate, Robyn Murray

Electronic Theses and Dissertations

A phenomenological research study was conducted to examine teacher perceptions of elementary principals’ behaviors affecting school culture and climate. The researcher gathered data from participant interviews. Participants were selected using purposeful sampling of teachers identified by their principals as meeting study criteria. The schools in which teachers were selected were also chosen using purposeful sampling based on superintendents’ perceptions of positive principal influence on school culture and climate.

Data analysis provided insight to the researcher into the phenomenon being explored in this study. Teachers were asked to participate in an individual interview with the researcher and provide answers to open …