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Limiting A Liberal Education: Exploring Technology Access And Equity Through Universal Design And Critical Disability Studies, Marisa R. Carlson Dec 2025

Limiting A Liberal Education: Exploring Technology Access And Equity Through Universal Design And Critical Disability Studies, Marisa R. Carlson

Electronic Theses and Dissertations

This quantitative improvement study investigates how classroom technology policies impact equity, access, and alignment with liberal arts values at a small Catholic liberal arts college. The study arose from concerns regarding academic accommodations, where students needed to formally request access to digital tools that were widely available. The focus is on inconsistent and sometimes restrictive technology policies that create barriers for students relying on these resources.

Interpreted through the conceptual frameworks of Universal Design for Learning (UDL) and Critical Disability Studies (CDS), this study was guided by the following research questions:

  1. What expectations do students have regarding access to technology …


Not Always Welcomed, Lavaughn Wesley Dec 2025

Not Always Welcomed, Lavaughn Wesley

Electronic Theses and Dissertations

Abstract

This qualitative dissertation explores the systemic barriers faced by adjudicated and long-term suspended youth during their reentry into the public school system, focusing on a local urban community in Pennsylvania. Through the lens of Institutional Complexity Theory, this study examines how interagency disconnection, implicit bias, inequitable disciplinary practices, and inadequate support structures contribute to the marginalization of historically underserved students, particularly Black youth, students with disabilities, and those from low-income households.

The research is driven by two central questions:

(1) What are the barriers for adjudicated youth during the reentry process?

(2) How can the home school reentry process …


(Un)Intended Consequences Of Race In Medicine: The Ethics Of Race-Based Medical Practice And The Perpetuation Of Structural Racism, Allegra Merriweather Dec 2025

(Un)Intended Consequences Of Race In Medicine: The Ethics Of Race-Based Medical Practice And The Perpetuation Of Structural Racism, Allegra Merriweather

Electronic Theses and Dissertations

This dissertation proposes that race-based medicine acts as a form of structural racism that is ethically indefensible. While it may be claimed to be a neutral diagnostic tool, the medical use of race as a biological proxy only further enforces the very hierarchies it purports to remediate, reinscribing inequity from conception to death. Building off Jacques Ellul’s work on Technique, we interpret race-based medicine as a self-perpetuating system that values procedural expediency over moral accountability. In nine chapters, the analysis follows the ways this technique is manifested in genetics and assisted reproduction, where commodified racial selection preserves social hierarchies; in …


The Other Side Of The Wall: A Study On The Impact Of Paternal Incarceration On African American Children, Chance M. Wideman Dec 2025

The Other Side Of The Wall: A Study On The Impact Of Paternal Incarceration On African American Children, Chance M. Wideman

Electronic Theses and Dissertations

This qualitative dissertation explores the long-term psychological, relational, and systemic impacts of paternal incarceration on adult children. Guided by Adverse Childhood Experiences (ACE) Theory, Attachment Theory, and Family Process Theory, this study examines two research questions:

(1) What types of childhood trauma are associated with paternal incarceration?

(2) How does the childhood trauma associated with paternal incarceration impact one in adulthood?

The study draws on three in-depth narrative interviews with adults who experienced paternal incarceration in childhood. These interviews, framed as dialogic and reflexive spaces, illuminate the deep and layered consequences of incarceration across the lifespan.

Five central findings emerged: …


Behavior Analytic Food Reinforcement Use And Guidelines In Interventions For Children With Autism, Christopher Rogers Dec 2025

Behavior Analytic Food Reinforcement Use And Guidelines In Interventions For Children With Autism, Christopher Rogers

Electronic Theses and Dissertations

Reinforcers create opportunities to increase behaviors in applied behavioral analysis, with healthy and unhealthy foods offering high reinforcing value. The use of food raises ethical and health concerns, so researchers and behavior analysts often avoid food reinforcement altogether. Kronfli et al. (2024) indicate healthy food alternatives bring about similar rates of responding as snack foods, potentially reducing ethical and health concerns. This research presents the question: To what degree are food reinforcers used in behavioral interventions for children with autism spectrum disorder? This review analyzes behavioral research articles containing the words “food,” “edible,” “autism,” and “children” in the context of …


Integrating The Five As Framework To Enhance Person-Centered Care For Adults Living With Obesity, Alexandra Charles Dec 2025

Integrating The Five As Framework To Enhance Person-Centered Care For Adults Living With Obesity, Alexandra Charles

Electronic Theses and Dissertations

Obesity has adverse effects on physical health, emotional well-being, and mental functioning. To effectively address this highly prevalent and multifaceted condition, the use of a structured, evidence-informed framework is essential to support providers in delivering consistent, person-centered care for individuals living with obesity. The Five As is a powerful yet not commonly implemented framework in many primary care practices. The Five As framework (Ask, Assess, Advise, Agree, Assist) offers a structured model to guide clinicians in delivering consistent, supportive, and transformative care for individuals with obesity.

The goal of the project was to implement a timely and cost-effective protocol/tool that …


Sue Gunter And The Battle For Equity In Women’S Athletics At Sfa, Derek S. Allen Dec 2025

Sue Gunter And The Battle For Equity In Women’S Athletics At Sfa, Derek S. Allen

Electronic Theses and Dissertations

From the 1950’s through the 2000’s, women’s college basketball would move from a category of inappropriate activity to selling out large arenas and being broadcast to millions of viewers on national TV. Such a result came largely from federally mandated stipulation contained within Title IX, accelerated a fight for equity and acceptance, and advanced the cause for women’s athletics more than any other initiative. However, that alone would have failed to grow the popularity of a sport such as women’s basketball if it did not produce a quality product for fans. Beyond the need for resources comparable to men’s athletics, …


Profiles Of Adults With Attention-Deficit/Hyperactivity Disorder (Adhd) Using The Personality Assessment Inventory (Pai), Tailyn L. Gillette Dec 2025

Profiles Of Adults With Attention-Deficit/Hyperactivity Disorder (Adhd) Using The Personality Assessment Inventory (Pai), Tailyn L. Gillette

Electronic Theses and Dissertations

Attention-Deficit/Hyperactivity Disorder (ADHD) is often diagnosed in childhood. However, the disorder can be more complex to diagnose in adulthood as several comorbid disorders may also impact attention. Many symptoms, often prevalent in childhood, taper off in adulthood, adding to the difficulty of differential diagnosis. Clinicians must decipher symptoms of ADHD from comorbid disorders during diagnostic procedures, which can be tedious. As the requests for adult ADHD diagnoses grow, the need for more efficient diagnostic procedures seems to be ever-present. The current research utilized an exploratory two-step cluster analysis to explore subgroups that resulted from archival data of adults with ADHD. …


Robust Anomaly Detection Under Data Imbalance, Noise, And Label Scarcity, Zahra Salekshahrezaee Dec 2025

Robust Anomaly Detection Under Data Imbalance, Noise, And Label Scarcity, Zahra Salekshahrezaee

Electronic Theses and Dissertations

In today’s data-driven landscape, large volumes of data are generated continuously, often containing imperfections such as noise, missing data, or unreliable labeling. These real-world datasets are typically high-dimensional, sparsely labeled, and imbalanced, creating substantial challenges for both supervised and unsupervised learning. These challenges are especially prevalent in the task of anomaly detection, where instances belonging to the class of interest are rare and underrepresented compared to normal instances. This dissertation proposes and evaluates robust frameworks for anomaly detection that address these data challenges and improve model performance and robustness using real-world datasets, including credit card transactions and cognitive assessments. Supervised …


Improving Patient Outcomes Through Implementation Of The Kdoqi Guidelines For Tunneled Dialysis Catheter Placement, Gabriela Echagaray Dec 2025

Improving Patient Outcomes Through Implementation Of The Kdoqi Guidelines For Tunneled Dialysis Catheter Placement, Gabriela Echagaray

Electronic Theses and Dissertations

This quality improvement (QI) project aimed to enhance adherence to the Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines for placement of tunneled dialysis catheters (TDCs) in intensive care unit (ICU) patients. The project addressed inconsistent application of best practices related to TDC placement, improved documentation, improved communication using TigerConnect, a reduction in inappropriate catheter placements, and maintenance of a zero hospital-acquired tunneled dialysis catheter-related bloodstream infection (CRBSI) rate. Notably, some patients continued to be admitted with pre-existing community-acquired tunneled catheter-related infections, underscoring the effectiveness of the hospital’s internal infection prevention strategies while highlighting the need for enhanced collaboration with outpatient …


Increasing Colon Cancer Screening Completion Rates Utilizing Patient Navigation In Primary Care: A Quality Improvement Project, Anya C. Pennycooke Dec 2025

Increasing Colon Cancer Screening Completion Rates Utilizing Patient Navigation In Primary Care: A Quality Improvement Project, Anya C. Pennycooke

Electronic Theses and Dissertations

Colorectal cancer is the second leading cause of cancer-related deaths in the United States. It is highly preventable through routine screening and early detection, yet national data indicate that one in three eligible adults remains unscreened. The purpose of this Quality Improvement (QI) project was to increase colon cancer screening completion rates by implementing a patient navigation program. Kristen Swanson’s Theory of Caring guided the intervention by promoting patient-centered communication. W. Edwards Deming’s Plan-Do-Study-Act (PDSA) model provided the framework for this approach. Patients aged 45-75 years due for colon cancer screening were identified using the electronic health record (EHR) in …


The Prospects And Challenges Of The 15-Minute City In South Florida, Mary Asumang Abankwa Dec 2025

The Prospects And Challenges Of The 15-Minute City In South Florida, Mary Asumang Abankwa

Electronic Theses and Dissertations

The 15-Minute City model has emerged as a contemporary approach that aims to enhance accessibility, reduce reliance on automobiles, and improve the quality of life. Cities like Melbourne, Barcelona, and Paris have advanced in the applicability of this model. This study evaluates the prospects and challenges of the 15MC in South Florida. This research employs a mixed-methods research design, which includes reviewing the comprehensive plans of ten South Florida Cities and spatial analysis using Geographic Information Systems (GIS). In addition to the comprehensive plan and policy review, Service Area Analysis was used to measure the 5, 10, 15, and 20-minute …


Deep Learning For Underwater Manatee Counting And Tracking, Theodor Owchariw Dec 2025

Deep Learning For Underwater Manatee Counting And Tracking, Theodor Owchariw

Electronic Theses and Dissertations

The Florida manatee (Trichechus manatus latirostris), a threatened marine mammal often found in coastal waters, require accurate monitoring to inform conservation strategies. However, traditional counting methods are hindered by observer bias and surface distortions. Recent advances in artificial intelligence (AI) address these challenges using captured aerial footage of manatees, demonstrating the potential of artificial intelligence for automating manatee counting. Still, various challenges arise hindering accurate counts.

Building on these studies, this work advances artificial intelligence with underwater footage, instance segmentation, data augmentation, and pseudo-labeling to automate manatee counting in data-scarce environments. Three experiments were conducted using 10%, 60%, and 90% …


Explainable A.I. For Analysis And Interpretation Of Heterogeneous Crime Data., Sadaf Ahmed Dec 2025

Explainable A.I. For Analysis And Interpretation Of Heterogeneous Crime Data., Sadaf Ahmed

Electronic Theses and Dissertations

This dissertation examines the problem of fragmented data in the context of crime and cybercrime analysis. While both domains generate substantial public data, these sources vary widely in format, structure, and coverage, making it difficult to perform consistent inference or develop reliable predictive models. To address these limitations, this work proposes a layered integration framework grounded in ontology-driven modeling and data fusion. The approach is applied to two distinct but related case studies, each focused on constructing a coherent representation of criminal activity from heterogeneous sources. The first case study explores the integration of drug and human trafficking data from …


Molecular Dynamics Simulations Of Biologically Relevant Interfaces: From Tear Film Lipid Layers To Rna Adsorption On Silica Surfaces., Mahbuba Khanom Dec 2025

Molecular Dynamics Simulations Of Biologically Relevant Interfaces: From Tear Film Lipid Layers To Rna Adsorption On Silica Surfaces., Mahbuba Khanom

Electronic Theses and Dissertations

Molecular dynamics (MD) simulation is an important tool in biochemical sciences for studying complex molecular processes and interfacial interactions at the molecular level. Biological interfaces play key roles in processes such as ocular lubrication and biomolecular adsorption. This dissertation studies interfacial phenomena involving two distinct yet conceptually related systems: the tear film lipid layer (TFLL) at the air–water interface at the surface of the human eye, and RNA adsorption on silica surfaces. These studies provide insight into how interfacial composition, structure, and environmental conditions affect larger-scale behavior. Atomistic MD simulations were used to model the TFLL. The TFLL is essential …


“The Moment You Are Disabled; You Are Cut Off From Society.” Assessing The Experiences Of Disabled Ghanaians And The Rights Enshrined In The United Nations Convention On The Rights Of Persons With Disabilities (Crpd)., Solomon Sackey Amoatey Dec 2025

“The Moment You Are Disabled; You Are Cut Off From Society.” Assessing The Experiences Of Disabled Ghanaians And The Rights Enshrined In The United Nations Convention On The Rights Of Persons With Disabilities (Crpd)., Solomon Sackey Amoatey

Electronic Theses and Dissertations

As Ghana continues to pursue inclusion and equality for disabled citizens, considerable tension remains between international human rights frameworks and local social, legal, and cultural practices. Guided by social constructionism and Critical Disability Theory (CDT), this qualitative, chapter-based study examined how disability is constructed through law, policy, and culture in Ghana. It also explored how these constructions influence the interpretation and implementation of disability rights. To achieve this, the study employed semi-structured interviews and document analysis to examine how law, policy, and cultural beliefs intersect to influence the implementation of the CRPD and lived experience of disabled Ghanaians.

Findings show …


Experiences Of Research Administrators With Faculty Researchers In Sponsored Project Compliance., Adrienne M. Lindsay Dec 2025

Experiences Of Research Administrators With Faculty Researchers In Sponsored Project Compliance., Adrienne M. Lindsay

Electronic Theses and Dissertations

The purpose of this study was to examine how central office research administrators perceive and describe their professional interactions with faculty researchers, and how those relationships may impact compliance with sponsored project requirements in United States higher education institutions. Cohen et al.’s (1972) organized anarchy theory and Schein’s (2010) organizational culture theory provided a foundational context for understanding research systems within higher education institutions and the social environment in which research administrators navigate potentially contentious roles, both facilitating research and stewarding compliance for the institution and the sponsor. Findings emerged around specific challenges faced by research administrators, which included role …


A Persistent Homology Framework For Scrna-Seq: Assessing Clustering Robustness And Quantifying Preprocessing And Integration Effects On Topological Features., Jonah Daneshmand Dec 2025

A Persistent Homology Framework For Scrna-Seq: Assessing Clustering Robustness And Quantifying Preprocessing And Integration Effects On Topological Features., Jonah Daneshmand

Electronic Theses and Dissertations

As single-cell RNA sequencing (scRNA-seq) data expands, robust methods for integrating diverse datasets are critical. This dissertation applies Persistent Homology (PH), a technique from Topological Data Analysis (TDA), to a collection of scRNA-seq datasets spanning eight tissue types to quantify how data integration affects topological features and biological interpretability. We assessed global topological structure using Betti curves, Euler characteristics, and persistence landscapes across raw, normalized, and integrated data representations. Our analysis revealed a performance inversion: while conventional methods excelled on unintegrated data, high-granularity topological methods, particularly those sensitive to global data structure, became superior after integration. This suggests a synergy …


Controlling Selectivity In Electrocatalytic Co2 Reduction With An External Magnetic Field., Nawaraj Karki Dec 2025

Controlling Selectivity In Electrocatalytic Co2 Reduction With An External Magnetic Field., Nawaraj Karki

Electronic Theses and Dissertations

My dissertation describes how to alter the speciation and concentration of molecules at the electrode-electrolyte interface, and how those alterations affect reactivity and selectivity. This dissertation presents two distinct approaches to control the mass transport of neutral molecules such as carbon dioxide (CO2) at the electrode-electrolyte interface by using an external magnetic field. The first finding demonstrates that magnetic fields indirectly affect the mass transport of target analytes such as CO2 molecules by selectively interacting with charged species, such as hydroxide ions (OH-). Such interaction induces magnetohydrodynamic (MHD) effects, which generate localized hydrodynamic flow and …


Risk And Protective Factors For Suicidal Thoughts And Behaviors For Black Adolescent Males With Exposure To Adverse Experiences Post-Covid 19 Pandemic: Findings From The 2023 National Youth Risk Behavior Survey., Amanda Minogue Dec 2025

Risk And Protective Factors For Suicidal Thoughts And Behaviors For Black Adolescent Males With Exposure To Adverse Experiences Post-Covid 19 Pandemic: Findings From The 2023 National Youth Risk Behavior Survey., Amanda Minogue

Electronic Theses and Dissertations

Suicide is the second leading cause of death among adolescents aged 10-24 in the United States. In 2022, 784 Black adolescent males died by suicide. Recent studies have found that traditionally common associations of risk factors of suicidal thoughts and behaviors are not experienced by Black adolescents, challenging how to determine and detect risk. This dissertation reviewed the variables in the national Youth Risk Behavior Survey that closely align with risk and protective factors of suicidal thoughts and behaviors, and the interaction between these and adverse experiences in Black adolescent males. Results of this study found that among the 9 …


The Role Of Fast-Food Consumption, Residential Fast-Food Exposures, And Urinary Essential Trace Heavy Metals In Colorectal Cancer (Crc) Outcomes., Jeevan Adhikari Dec 2025

The Role Of Fast-Food Consumption, Residential Fast-Food Exposures, And Urinary Essential Trace Heavy Metals In Colorectal Cancer (Crc) Outcomes., Jeevan Adhikari

Electronic Theses and Dissertations

Background: Colorectal cancer (CRC) is a public health concern. Within the United States (US), fast-food consumption and environmental exposure to heavy metals have increased. The impact of fast-food consumption frequency from fast-food restaurants, residential fast-food exposures, and urinary essential trace heavy metals in relation to CRC outcomes have not yet been rigorously evaluated in the US. Methods: Within the LEAPS-CRC study, we used geographic information systems (GIS) and logistic regression to study the association of fast-food consumption, residential proximity to a fast-food outlet, and urinary essential trace metals with CRC incidence. Additionally, within Kentucky Cancer Registry (KCR) CRC cases, the …


Characterizing Hexavalent Chromium Neurotoxicity Across Laboratory Models., Samuel Thomas Vielee Dec 2025

Characterizing Hexavalent Chromium Neurotoxicity Across Laboratory Models., Samuel Thomas Vielee

Electronic Theses and Dissertations

Hexavalent chromium [Cr(VI)] is a ubiquitous environmental pollutant and potent toxicant. Exposure to Cr(VI) in drinking water is primarily associated with cancers, inflammation, and hepatotoxicity; however, recent studies have identified Cr(VI) as a neurotoxicant in rodent and cell culture models. The literature suggest chromium accumulates in the brain, induces widespread neurodegeneration, and alters rodent behaviors. Despite these data, we lack a detailed and consistent assessments of Cr(VI) neurotoxicity across models, and interactions between aging and Cr(VI) neurotoxicity are not reported in the literature. In this dissertation, we characterize Cr(VI) neurotoxicity across 3 laboratory models: Sprague-Dawley rats, Caenorhabditis elegans, and …


Exposure To Pm2.5 And Aging., Daniel Chris Gomes Dec 2025

Exposure To Pm2.5 And Aging., Daniel Chris Gomes

Electronic Theses and Dissertations

Inhalation of fine airborne particulate matter (PM2.5) is an environmental risk factor for numerous health disorders, including cardiovascular diseases (CVD). While several studies have shown that PM2.5 exposure can induce oxidative stress, DNA damage, and inflammation, the underlying mechanisms that translate these effects into systemic pathology remain poorly understood. Some recent studies have shown that PM2.5 exposure can lead to telomere shortening in leukocytes, but the generality of this outcome and contribution to endothelial dysfunction has not yet been fully explored. We hypothesized that PM2.5inhalation accelerates cellular aging and senescence in both circulating peripheral …


Residential Segregation And Breast Cancer In Louisville: Impact Of Race And Contextual Factors On Advanced-Stage Diagnosis, Delayed Treatment, And Disease-Specific Mortality., Toheeb Ajani Mustapha Dec 2025

Residential Segregation And Breast Cancer In Louisville: Impact Of Race And Contextual Factors On Advanced-Stage Diagnosis, Delayed Treatment, And Disease-Specific Mortality., Toheeb Ajani Mustapha

Electronic Theses and Dissertations

Female breast cancer (BC) remains the most commonly diagnosed non-skin cancer and the second leading cause of cancer death among U.S. women. Despite advances in detection and treatment, substantial inequities in BC outcomes persist, driven in part by structural forces such as residential segregation. This dissertation examined the relationship between residential segregation, BC outcomes, and key contextual factors in Louisville, Kentucky. Using data from the Kentucky Cancer Registry, American Community Survey, CDC’s Population-Level Analyses and Community Estimates, and the National Neighborhood Data Archive, the study tested two hypotheses: (1) higher Black/low-income segregation is associated with elevated risks of adverse BC …


Increasing Histidyl Dipeptides In Skeletal Muscle Preserves Muscle Mass And Function In Heart Failure., Mamata Hiraman Chaudhari Dec 2025

Increasing Histidyl Dipeptides In Skeletal Muscle Preserves Muscle Mass And Function In Heart Failure., Mamata Hiraman Chaudhari

Electronic Theses and Dissertations

Introduction: Heart failure is a systemic disease associated with multiple comorbidities, such as skeletal muscle wasting and cardiopulmonary disease. Muscle wasting in heart failure patients is a severe comorbidity associated with decreased exercise capacity and poor quality of life. Previous reports show that oxidative stress is increased in the skeletal muscle of heart failure patients, which can directly lead to muscle wasting. However, antioxidant intervention in these patients was unable to improve cardiac function and consequently had no effect on muscle wasting. Although oxidative stress is the primary driver of skeletal muscle atrophy, no attempt has been made to examine …


A Multilevel Analysis To Evaluate Variability In Sdoh Clusters Within Rurality And Its Effects On Cancer-Specific And All-Cause Mortality In The Us., Stephie Ann Abraham Dec 2025

A Multilevel Analysis To Evaluate Variability In Sdoh Clusters Within Rurality And Its Effects On Cancer-Specific And All-Cause Mortality In The Us., Stephie Ann Abraham

Electronic Theses and Dissertations

Social determinants of health (SDOH) factors have consistently been shown to impact all-cause and cancer-specific mortality. Area-level SDOH factors that coexist to form “high-risk” clusters are more prevalent in rural than urban areas. However, heterogeneity within rural and urban areas may contribute to variations in SDOH factors that could influence higher mortality rates and is not considered in other studies. The primary objective of this study was to utilize ecological and individual-level data to determine if the composition of SDOH clusters within counties in the rural-urban continuum contributes to differences in all-cause (AC) and cancer-specific mortality rates of lung and …


Perceived Organizational Support Of High-Performance Support Staff Members In Professional Soccer Organizations., Erica B. Thompson Dec 2025

Perceived Organizational Support Of High-Performance Support Staff Members In Professional Soccer Organizations., Erica B. Thompson

Electronic Theses and Dissertations

The purpose of this study was to explore perceived organizational support among high-performance support staff (HPSS) within professional soccer organizations. Specifically, this study examined how HPSS define organizational support, identified factors that shape their perceptions, explored organizational challenges they experience, and analyzed how those challenges intersect with their perceptions of support. Organizational Support Theory (OST) and its central construct, Perceived Organizational Support (POS), served as the theoretical framework guiding this study. OST assumes employees form global beliefs about the extent to which their organization values their contributions and cares about their well-being. To address the study’s purpose, a basic interpretive …


Orientation Or Disorientation? A Critical Content Analysis Of Refugee Cultural Orientation Curriculum., Amanda Jean Lacey Dec 2025

Orientation Or Disorientation? A Critical Content Analysis Of Refugee Cultural Orientation Curriculum., Amanda Jean Lacey

Electronic Theses and Dissertations

Cultural Orientation (CO) is a free, legally mandated, multi-session program intended to provide refugee newcomers ages 18-65 with the knowledge, skills, and attitudes needed to integrate and achieve self-sufficiency in the United States. Despite occurring at a critical time in the resettlement process, there has been almost zero scholarship analyzing the content or efficacy of domestic CO curriculum. This dissertation addresses that gap by performing a Critical Content Analysis (CCA) on The Road Ahead (TRA), the de facto official CO curriculum promoted through the Cultural Orientation Resource Exchange (CORE). Framed by a postcolonial perspective and informed by the …


Direct And Satellite-Based Quantification Of Greenhouse Gas Fluxes In Small Ponds., Mark Christopher Tierney Dec 2025

Direct And Satellite-Based Quantification Of Greenhouse Gas Fluxes In Small Ponds., Mark Christopher Tierney

Electronic Theses and Dissertations

As evidenced by their historic losses due to anthropogenic activities, wetlands are undervalued ecosystems that provide numerous ecosystem services, from recreational opportunities to carbon (C) storage. However, these wetlands are also the largest natural source of atmospheric methane (CH4). Additionally, small water bodies (< 10,000 m2) are disproportionately large emitters relative to larger lakes and reservoirs. As construction and restoration efforts proceed, it is crucial to identify wetlands that need restoration and to understand the factors driving both greenhouse gas (GHG) fluxes and the C balance of these systems. This dissertation investigates the drivers of greenhouse gas fluxes …


A Ralgef Inhibitor Suppresses Lung Cancer Stem Cell Development And Tumorigenesis., Raphael Ngozichi Suarez Jigo Dec 2025

A Ralgef Inhibitor Suppresses Lung Cancer Stem Cell Development And Tumorigenesis., Raphael Ngozichi Suarez Jigo

Electronic Theses and Dissertations

The RALGEF family of proteins are direct downstream effectors of the RAS oncoprotein. RALGEFs act as guanine nucleotide exchange factors (GEFs) for downstream RAL proteins, thus tying RAS to the regulation of RAL. Genetic studies have demonstrated RAL proteins to be key drivers of RAS-driven transformation and metastasis. Furthermore, this pathway has been implicated in chemoresistance, exocyst-mediated transport, and the modulation of cancer stem cells. Previous work in our lab reported the activity of a novel pan-RALGEF inhibitor (C4-180) against RAS-driven pancreatic cancer models. Here we show the agent to be active against in vitro and in vivo models of …