Digital Commons Network^™

Directly Polymerizable Co Releasing Molecules, Jackson Snow

Electronic Theses and Dissertations

Despite the commonly held consensus that carbon monoxide (CO) is toxic, it has been shown to be an essential signaling molecule in the human neuronal system and has been noted to have anti-inflammatory properties, act as a vasodilator, have anti-proliferative impacts on tumors, and many other beneficial effects. The current limitation to using CO as a therapeutic molecule is delivering the proper dosages using CO releasing molecules (CORMs) without exhibiting toxicity. The first chapter of this thesis will review the biological significance of CO in biological systems, the limitations of existing CORMs, and the properties of diphenylcyclopropenone (DPCP) that make …

Frequency Analysis Of Trabecular Bone Structure, Daniel Parada San Martin

Electronic Theses and Dissertations

Medical data is hard to obtain due to privacy laws making research difficult. Many databases of medical data have been compiled over the years and are available to the scientific community. These databases are not comprehensive and lack many clinical conditions. Certain type of medical conditions are rare, making them harder to obtain, or are not present at all in the aforementioned databases. Due to the sparsity or complete lack of data regarding certain conditions, research has stifled. Recent developments in machine learning and generative neural networks have made it possible to generate realistic data that can overcome the lack …

Exploring The Relational Impact Of Breast Cancer On Younger Women Partnered With Women, Kaitlin V. Ross

Electronic Theses and Dissertations

Approximately 268,600 new cases of breast cancer in women are diagnosed each year in the United States. Due to improvements in cancer detection and treatment, survivorship is higher than in the past. More than ten percent of new diagnoses are in women 45 years or younger. There are approximately one million sexual minority individuals living with cancer in the US, yet this population is understudied in cancer care. For sexual minority women with breast cancer, sociocultural factors such as lack of affirmative care influences their disease experience. Further, sexual minority women and women partnered with women may be subject to …

Examining The Impact Of Discrimination, Shame, And Acculturation On Psychological Wellbeing Of East Asian International Students, Shao-Jung Stella Ko

Electronic Theses and Dissertations

This study examined the impact of discrimination, shame, and acculturation on the psychological wellbeing of East Asian international students in the U.S. Using the Minority Stress Theory as a framework, discrimination and shame were hypothesized to have a significant negative relationship with wellbeing while acculturation was hypothesized to moderate these relationships. A sample (N = 281) of East Asian international undergraduate students completed a web-based survey with measures of perceived discrimination, interpersonal shame, acculturation, and mental health outcomes. Regression analyses containing wellbeing (outcome), acculturation (moderator), discrimination (predictor), and shame (predictor) were performed to test the hypotheses using SPSS PROCESS macro …

Bicycles And Transit: Weather Or Not: A Study On The Effect Of Weather And Air Quality On Bicycle-Transit, Bicycle, Rail Transit Counts In Denver, Christiana M. Fairfield

Electronic Theses and Dissertations

The movement of people and goods within metropolitan areas is critically important to the operational efficiency and functionality of cities. This study explores the influence of local weather conditions and the air quality index on bicycle-transit user in Denver, Colorado. Based on bicycle-transit having two key components, bicycle and transit, the effect of local weather conditions and the air quality index is also explored with bicycle use and rail-transit usage. Key findings include: (1) the most significant variable across all three modes is temperature, (2) for bicycle-transit and bicycle use, there is a steady increase in ridership as temperatures increase …

Puerto Ricans And Asthma: Looking Through The Lens Of Historical Trauma, Lisa Colón

Electronic Theses and Dissertations

This study utilized an explorative phenomenological qualitative design to begin understanding the many ways Puerto Ricans experience asthma. Further is sought to understand the asthma experience broadly and within the context of the hurricanes that devastated Puerto Rico in 2017 including the governments’ responses to that devastation. Another core goal of this study was the conceptual and empirical application of the theoretical framework of historical trauma to Puerto Ricans. I conducted 12 semi structured interviews with collaborators who expressed a range of asthma experiences. My collaborators represented a mixture of those who lived through the hurricanes in Puerto Rico and …

Where Virtual Well-Being Becomes Reality, Colleen M. Reilly

Electronic Theses and Dissertations

Strategies to mitigate the spread of COVID-19, specifically quarantine and social distancing protocols, have exposed a troubling paradox: mandated isolation meant to save lives has inadvertently contributed to a decline in America’s well-being. Prolonged isolation due to more remote work and decentralized workplaces has been associated with widespread loneliness and diminished physical and mental health, with effects compounded by limited face-to-face access to social support systems. While remote communication technologies (e.g., video chat) can connect individuals with colleagues and social networks, remote technologies might have limited effectiveness in business and social contexts. This study uses Roger’s Diffusion of Innovation Theory …

Emotion Dysregulation And Intimate Partner Aggression During Pregnancy: Leveraging Both Partners’ Experiences With Dyadic Data, Victoria M. Atzl

Electronic Theses and Dissertations

Intimate partner aggression (IPA) during pregnancy is a significant public health problem that has negative consequences for maternal and fetal health. This study examined emotion dysregulation as a potential predictor of IPA during pregnancy from a dyadic perspective. Participants were 113 couples expecting a baby and included 113 mothers (MOBs; Mage = 27.50 years, SDage = 5.53, rangeage = 19-40; 38.1% White, 24.8% Latinx, 15.9% African American, 14.2% biracial/multiracial, 3.5% Asian American/Pacific Islander, 2.7% Native American and .8% other) and 113 fathers (FOBs; Mage = 29.83 years, SDage = 7.61, rangeage = 18-55; 38.1% White, 22.1% African American, 20.4% Latinx, …

Trans And Genderqueer Military Service Member-Veterans: An Acculturation Phenomenology Of Civilian Reintegration, Joseph A. Galluzzo

Electronic Theses and Dissertations

As United States military policy continues to evolve and affirm the accession and retention of trans and genderqueer (TGQ) service members, more TGQ people will join and ultimately separate from military service. Reintegration is a term that represents the experience of beginning to separate from the military and transitioning into civilian life, and those who encounter it are referred to as military service member-veterans (MSMVs). Though empirical knowledge of reintegration for MSMVs overall continues to improve, cultural relevance has only recently been considered, and no research has investigated the reintegration experiences of TGQ MSMVs specifically. The primary purpose of this …

Geovisualization And Open-Source Web Mapping Of Big Origin-Destination Data, A Test Case, Joseph Hiebert

Electronic Theses and Dissertations

Migration plays a key role in determining the health and success of cities, counties, and countries. It also plays a key role in determining the health and wellbeing of the individuals and families that undergo a migration event. This has led many scholars to map and study global migration patterns to understand how and why people move. While migration data are powerful, the origin-destination (O-D), tabular format of the data can be hard to interpret. To make O-D data more powerful, geographers can lean on computer cartography and new geovisualization techniques to help decision makers make sense of large, complex …

Mis-Specification Of Functional Forms In Growth Mixture Modeling: A Monte Carlo Simulation, Richa Ghevarghese

Electronic Theses and Dissertations

Growth mixture modeling (GMM) is a methodological tool used to represent heterogeneity in longitudinal datasets through the identification of unobserved subgroups following qualitatively and quantitatively distinct trajectories in a population. These growth trajectories or functional forms are informed by the underlying developmental theory, are distinct to each subgroup, and form the core assumptions of the model. Therefore, the accuracy of the assumed functional forms of growth strongly influences substantive research and theories of growth. While there is evidence of mis-specified functional forms of growth in GMM literature, the weight of this violation has been largely overlooked. Current solutions to circumvent …

Measurements Of Atmospheric Radicals, Heather L. Runberg

Electronic Theses and Dissertations

Atmospheric particulate matter (PM) is a global health concern. PM_2.5 is formed primarily through combustion processes such as automobile use and industrial activity. Natural sources of PM_2.5 result from events like volcanos and wildfires. Upon inhalation, PM_2.5 is small enough to travel deep into the lungs where it can form reactive oxygen species (ROS), such as hydroxyl radical (OH), causing oxidative damage to pulmonary tissues. PM_2.5 has been linked to cardiopulmonary diseases such as asthma, chronic obstructive pulmonary disease (COPD), and high blood pressure.

PM_2.5 is small enough to remain aloft and travel many hundreds …

The Intersection Of Traumatic Brain Injury And Homelessness, Stephanie A. Chassman

Electronic Theses and Dissertations

The rates of TBI are significantly higher among individuals experiencing homelessness compared to the general population. Up to half of individuals experiencing homelessness may have a TBI. Accurate prevalence rates of TBI among individuals experiencing homelessness are difficult to obtain due to different methods of sampling participants and differing definitions of TBI; therefore, estimates may be underrepresented. Despite past research that has examined the relationship between TBI and homelessness, there are specific gaps in knowledge such as correlates and risk factors of TBI among individuals experiencing homelessness. This three-manuscript dissertation attempts to address these gaps in knowledge.

The first manuscript …

Developing, Refining, And Testing The Intersectional Model Of Service Use: A Transgender And Nonbinary-Specific Model Of Healthcare Access, Jarrod Call

Electronic Theses and Dissertations

Transgender and nonbinary (TNB) people are more likely to experience negative health outcomes than cisgender (i.e., not TNB) people, but less likely to access healthcare services due to the systemic forces of transphobia and cisgenderism. Despite this, there are few theoretical models of healthcare access specifically designed for TNB people. This three-paper dissertation addresses this gap by developing, refining, and testing the Intersectional Model of Service Use (IMSU), a population-specific framework for researching TNB healthcare access. Manuscript one describes how the initial IMSU was developed from an integrative review of currently available TNB healthcare access literature. This initial IMSU was …

Critical Experiences Of Being Humbled In Psychotherapy Training: An Interpretative Phenomenological Analysis, Mackenzie White Jessen

Electronic Theses and Dissertations

Therapists’ cultural humility has shown promise for being a “trait like” quality that improves psychotherapy treatment for marginalized populations (Hook et al., 2016, Owen et al., 2016). However, researchers have emphasized that it is important to establish whether cultural humility can be fostered or developed through training (Davis et al., 2016). The purpose of this study was to understand the phenomenon of trainees being humbled in session during graduate school training and its potential relationship to trainee development. This is the first study to specifically examine the experience of being humbled by clients in session or that explores the potential …

Structural And Hemodynamic Analysis Of Transcatheter Aortic Valves, Dong Qiu

Electronic Theses and Dissertations

The transcatheter aortic valve replacement (TAVR) procedure has become a well-established procedure for high, intermediate-risk, and low-risk patients. However, there is limited clinical data on the TAV's long-term durability, unlike SAV devices. Computational simulations can be an alternative way to evaluate the TAV devices. This dissertation aims to conduct structural and hemodynamic analyses on the TAV devices under different conditions using computational simulation approaches.

Initially, the impact of the bicuspid aortic valve on the TAV devices was evaluated. The result indicated that the CoreValve-like supra-annular self-expandable device was likely to have increased stress and strain on the leaflet when it …

“This Rigid Curricular Way”: Evaluating Expectations In Collegiate Music Education, Sophie Ailsa Lewis

Electronic Theses and Dissertations

Conversations surrounding curricular reform are abound in music education today. Much of the literature on this topic explores how professors can adapt their teaching practices to the presumed needs of students in the classroom, but student voices are infrequently centered in these discussions.

This thesis examines the study of music in the collegiate setting from the student perspective. Using a survey which I designed and interviews that I conducted, I examine the disconnect between student values and those of the institutions they attend. I then put these student perspectives in conversation with existing literature.

I discovered that student experiences revolve …

Outdoor Early Intervention Services: Current Practices And Future Directions, Tiffany Lee

Electronic Theses and Dissertations

Outdoor play is a crucial in supporting child development, resiliency, social skills, creative thinking, adaptability, family growth, and family engagement. Unfortunately, children are spending less time outside because of technology, parent fears, and other factors. Parents who have a child with a disability have even more challenges when it comes to playing outside. Thus, children with disabilities are spending even less time in outdoor environments. Early Intervention (EI) is a program that is designed for infants and toddlers between the ages of zero to three that have developmental delays and/or disabilities. EI uses a family-center approach in natural environments to …

A Labor Of Love: Extensive Exploitation Of Contract Music Workers, Malia Odekirk

Electronic Theses and Dissertations

Workers across the United States are reckoning with unfair labor conditions by unionizing and speaking out. Systemic undervaluing of many workers has created a climate of fear, hidden agendas, and pervasive labor misconduct. The pageantry/marching arts are no exception. As a cultural insider, I conducted interviews, had many informal conversations, and ran a large survey that uncovered how the marching arts exploit instructors extensively despite their experience, education, and efforts. A systematic proclivity toward late payments, abused contracts, egregiously low compensation, and free labor begs the question: how can programs continually mistreat instructors this way? I explore this question through …

Tech-Savvy School Principals Leveraging Crisis Leadership To Support Teaching And Learning In Their Schools Through Covid-19 Pandemic, Mohsen Alzahrani

Electronic Theses and Dissertations

The purpose of this exploratory case study was to learn about the effective practices that recognized tech-savvy principals enacted to support teaching and learning in their schools during the first academic year of the COVID-19 crisis. The study involved semi structured interviews with five recognized tech-savvy school principals. It also involved analyzing supporting materials and documents.

The findings of this study indicated that tech-savvy principals were not stuck in the structural rut that most principals found themselves in during the COVID-19 crisis. Four main themes emerged from the data. The first theme addressed how recognized tech-savvy principals demonstrated decisive decision …

Evaluating The Impact Of Individual And Couple Relationship Education On Postpartum Depression, Maggie O’Reilly Treter

Electronic Theses and Dissertations

This dissertation evaluated the impact of relationship education on postpartum depression using data from two randomized controlled trials of relationship education for individuals and couples who were pregnant or recently had a baby. Paper 1 focused on a well-established relationship education program for low-income couples in Oklahoma City, Family Expectations. Key findings from Paper 1 demonstrated that being randomized to Family Expectations was associated with lower odds of experiencing depression in the first 12 months after having a baby among both mothers and fathers, though this effect was only marginally significant, and that the program had the strongest impact among …

Restorative Justice & A Dean Of Students: An Auto-Criticism Of The Role Of Care In School Discipline In A Poverty Impacted Public High School, Alicia D. Vasquez

Electronic Theses and Dissertations

This qualitative study is an auto-criticism, an approach that allows researchers to study themselves. This emergent methodology is derived from educational criticism and connoisseurship, which fits under the broader category of arts-based research. School discipline is a programmatic component of any secondary school’s educational framework and directly effects student engagement and academic achievement. An analysis of the dean role in relation to school discipline is central to this study. The main research question is what are the lived experiences of a dean who incorporates restorative justice practices in a poverty impacted public high school?

The author spent two years as …

Environmental Gradients Impact Key Leaf Traits In Riparian Trees, Amanda Malone

Electronic Theses and Dissertations

Specific leaf area (SLA) reflects a plant’s carbon investment per area and relates to generalized leaf economics spectrum growth strategies (LES). To fill gaps of knowledge about intraspecific SLA variation and why it is often inconsistent with the LES, we studied the response of two riparian tree species along the urban-rural gradient in Northeastern Colorado: an invasive, nitrogen-fixer with broad tolerances and a nitrogen-limited and shade-intolerant native. Despite these differences, the two species responded similarly, apart from the response to the urban-rural gradient, in which lower nitrogen in rural areas was associated with a more conservative strategy in the native …

Inviting The Perspectives Of Refugee Mental Health Interpreters: A Critical Narrative Analysis, Emme Y. Paik

Electronic Theses and Dissertations

The research literature lacks examination into several areas concerning mental health interpretation for refugee clients. This includes the management of interpreters’ vicarious trauma and retraumatization, interpreter’s perspectives on the appropriateness of hiring refugees as mental health interpreters, how interpreters define their trauma as well as their clients’ trauma, and support that interpreters seek for their traumatic responses from their work. The literature is also missing an analysis of how oppressive power differentials are repeated in workplace institutions, specifically for refugee mental health interpreters. Thus, this study aimed to invite the perspectives of refugee mental health interpreters on several issues pertaining …

Well-Being Development: Parents’ Perceptions Of Gifted Adolescents, Barbara Moncure Washington

Electronic Theses and Dissertations

The purpose of this study was to examine parents’ perceptions of well-being development in their gifted adolescents. This was a qualitative study that used Narrative Inquiry as a research approach. Cloninger’s (1993) Psychobiological Model of Temperament and Character the (TCI) and Clandinin and Connelley’s (2000) Three-Dimensional Narrative Inquiry Space were utilized to address the research questions: What are parents’ perceptions of temperament in their gifted adolescent? What are parents’ perceptions of character in their gifted adolescent? What are the parents’ perceptions of well-being development? Dabrowski’s Theory of Positive Disintegration (TPD) provided an analysis lens for the study.

The framework for …

The Pathophysiological Mechanisms Of Alzheimer's Disease; Investigating Therapeutic Interventions For Disease Onset, Alexandra A. Sandberg

Electronic Theses and Dissertations

Alzheimer’s Disease is a multifarious disease that progressively affects more people as both the proportion of older adults in the population and life expectancy increase in both the United States and worldwide. This devastating disease is a result of rampant neuronal loss in the memory centers of the brain that robs the independence of those who are diagnosed and places a heavy burden on those who care for them. Traditionally speaking, research has focused on the hallmark pathology of amyloid plaques, targeting them to try and prevent disease onset. However, countless failures in clinical trials aimed at this said pathology …

Dynamics And Turnover Of Lipid And Protein Domains In Cells And Supported Bilayers, Alan Weisgerber

Electronic Theses and Dissertations

Protein and lipid clustering is an important mechanism for cell processes such as exo- and endo-cytosis and creating functional signaling complexes. It has been seen that both lipids and proteins are involved with the formation of cluster domains on cell membranes, yet little is known about the interplay between the two. In this work I began with visualizing lipid sorting to artificially induced curvature in supported lipid bilayers, with lipid tails affecting the sorting differently to curvature. These results demonstrate that lipids sort to curvature on curved, supported lipid bilayers. The sorting depends on the number of lipids in the …

Antioxidant Biomarkers And Nutraceutical Therapeutics In Neurodegeneration And Neurotrauma, Lilia A. Koza

Electronic Theses and Dissertations

Mild traumatic brain injury (mTBI), yielding a Glascow Coma Scale of 13-15, is the most commonly occurring severity of TBI. Pathology from mTBI consists of blood brain barrier disruption, neuroinflammation, oxidative stress, excitotoxicity, mitochondrial dysfunction, protein aggregation, axonal degeneration, and resulting neuronal death. These processes deplete the body’s endogenous antioxidant system. We report a retrospective analysis of antioxidant blood biomarkers in patients with a history of mTBI from a local sports medicine clinic, Resilience Code. We found persistent sex-specific antioxidant depletions in mTBI patients associated with worsened symptomology.

Certain populations, such as athletes, are at high risk for repetitive mTBI …

Morphological Variation And Community Science In Orthoptera, Amy Byerly

Electronic Theses and Dissertations

Patterns of morphological divergence across species’ ranges provide insight into local adaptation and speciation. Here, we compare phenotypic divergence among 4,221 crickets from 337 populations of two related species of field cricket, Gryllus firmus and G. pennsylvanicus and their hybrids. We find that these species differ across their geographic range in key morphological traits, such as body size and ovipositor length, and we directly compare phenotype with genotype for a subset of crickets demonstrating nuclear genetic introgression, phenotypic intermediacy of hybrids, and essentially unidirectional mitochondrial introgression. We discuss how these morphological traits relate to life history differences between the species. …

Organellar Zn2+ Homeostasis And The Role Of Trpml Channels In Neuronal Lysosome Physiology And Axonal Transport, Taylor Franklin Minckley

Electronic Theses and Dissertations

Zinc (Zn²⁺) is crucial for proper cellular function, and as such it is important to measure and track Zn²⁺ dynamics in living cells. Fluorescent sensors have been used to estimate Zn²⁺ content of subcellular compartments, but little is known about endolysosomal Zn2+ homeostasis. Similarly, although numerous sensors have been reported, it is unclear whether and how Zn²⁺ can be released from intracellular compartments into the cytosol due to a lack of probes that can detect physiological dynamics of cytosolic Zn²⁺. My dissertation started with comparing and characterizing different Zn²⁺ sensors including the …