Digital Commons Network^™

Unsupervised Dimension Reduction Techniques For Lung Diagnosis Using Radiomics, Janet Kireta

Electronic Theses and Dissertations

Over the years, cancer has increasingly become a global health problem [12]. For successful treatment, early detection and diagnosis is critical. Radiomics is the use of CT, PET, MRI or Ultrasound imaging as input data, extracting features from image-based data, and then using machine learning for quantitative analysis and disease prediction [23, 14, 19, 1]. Feature reduction is critical as most quantitative features can have unnecessary redundant characteristics. The objective of this research is to use machine learning techniques in reducing the number of dimensions, thereby rendering the data manageable. Radiomics steps include Imaging, segmentation, feature extraction, and analysis. For …

Powerful And Powerless: Reconfiguring The Agency And Supremacy Of Women In Selected Festivals In The Yoruba Town Of Isaga Orile, 1900-1958, Olusegun Olatunji

Electronic Theses and Dissertations

This thesis discusses how the gender dynamics and religious festivals of the Yoruba people in Isaga Orile were not affected by colonialism. The study draws on various accounts, particularly from the Church Missionary Society’s journals, to attest to colonialism's restructuring of male political hegemony. Focusing on two major festivals, Gelede and Oro, the study argues that men's inclusion in Gelede reinforces female supremacy, while the Oro society shows men's hegemony and restrains women from its activities. The study found that gender dominants in these festivals played complementary roles by mirroring female and male roles within the Isaga Orile political system. …

Perceptions Of Primary Caregivers About Managing Their Child’S Transition To Kindergarten: A Mixed-Methods Study, Kristy Lynn Castanon

Electronic Theses and Dissertations

The study aimed to explore the perceptions of primary caregivers as they manage their child’s transition to kindergarten. The study used a mixed-methods explanatory sequential design consisting of two phases. In phase 1, 64 primary caregivers of children transitioning to kindergarten completed the Kindergarten Caregiver Perceptions survey. Phase 1 participants were recruited from K-Camp, a program designed to support families and children during the transition. Descriptive statistics were analyzed to identify the concerns of caregivers, investigate their desired information and support, examine their involvement in transition activities, and understand caregivers’ perceived level of self-efficacy in managing their child’s transition to …

Inhibiting Survival Of Salmonella During Desiccation Through The Use Of Naturally Occurring Signals, Joseph Headrick

Electronic Theses and Dissertations

A rising problem in agriculture is the increase of antibiotic-resistant Salmonella cases associated with chicken eggs, which transmit infection to humans. To counter this, new approaches to combat Salmonella in chickens and desiccated on eggshells are vital in the prevention of human foodborne illness. Disrupting signaling pathways with naturally occurring compounds provides a potential novel avenue for prevention of Salmonella infections, as this would disrupt sensing of these environments and inhibit subsequent optimal gene expression. Starting with signals identified in previous studies, salicylic acid was found to inhibit Salmonella desiccation survival on both eggshells and plastic. To expand upon this, …

Selecting Classroom Grading Practices: A Qualitative Study Exploring Teacher Experiences, Tallye Gass

Electronic Theses and Dissertations

The purpose of this qualitative research was to understand the experience of selecting grading practices for a high school math or English classroom. There is no existing research related to understanding this phenomenon. This phenomenological study included three participants who were purposefully selected based on specific criteria: They must teach math or English in grades 9, 10, 11, or 12 and have at least three years of teaching experience. The participants were interviewed using videoconferencing software, and the interviews were recorded and transcribed. Open and axial coding was used to analyze the data. The theoretical framework applied for the interpretation …

Spin Trapping Behavior Of Some Selected Melatonin Derivatives For Hydroxyl Radicals: A Computational Study, Aaron Caesar

Electronic Theses and Dissertations

Melatonin (N-acetyl-5-methoxytryptamin, MLT) is a naturally occurring antioxidant which has shown some potential for use as a spin trap. Spin traps react with short lived hydroxyl radicals (HO·) to produce more stable products called spin adducts which may be characterized by electron paramagnetic resonance spectroscopy. However, the relative stability of hydroxyl spin adducts of melatonin derivatives (MLTD) compared to 2-hydroxymelatonin (HO-MLT) has not been examined computationally. Computational studies have been done on four selected MLTD; methylmelatonin (Me-MLT), chloromelatonin (Cl-MLT), cyanomelatonin (CN-MLT), and nitromelatonin (NO₂-MLT). Geometry of the structures were optimized at the HF/6-31G(d), cc-pVXZ, (X=D and T) and …

Enhancing Stem Education For East Tennessee In A Post-Covid World, Jennifer L. Lauer

Electronic Theses and Dissertations

I have identified a need for an analysis of the middle and high school STEM education curricula in the East Tennessee Region which does not effectively integrate technology into their current instruction, which results in low student engagement, motivation, and achievement in the instruction and learning of algebra and geometry. I propose a program to identify specific applications and methods to be integrated into these programs which will improve the abilities of teachers to positively impact their students' understanding and mastery of algebra and geometry. Using emerging and novel STEM subject instruction, teaching, and engagement methods, and focusing on the …

Bibliotherapy: A Literary And Linguistic Analysis Of Literature, Matthew Curry

Electronic Theses and Dissertations

Bibliotherapy—the process of utilizing literature for its therapeutic properties—has been around for centuries; however, it wasn’t until a surge of research in the 1920s that the process became recognized as an adequate method of therapy. With the rising mental health crisis looming over the United States, the time to develop, establish, and advocate for a bibliotherapeutic curriculum in K-12 public education is now. Using literary works such as Gary Paulsen’s Hatchet, Helena Fox’s How it Feels to Float, and Laurie Halse Anderson’s Speak, this thesis establishes the literary, therapeutic, and pedagogical reasoning for the implementation of such …

Mankind Is Machine: A Monstrous Posthuman Reading Of Philip K. Dick’S Selected Works, Gabriel Davis

Electronic Theses and Dissertations

The works of Philip K. Dick act as an ideal template for readers to explore what it means to be human in a technologically dominated world. Dick’s emphasis on the usage of androids and artificial intelligence as literary monsters allows for a posthuman reading of the traditional literary monster, notably in how their uncanny nature and behavior helps reveal the synthetic tendencies of humanity. In Do Androids Dream of Electric Sheep?, “Imposter,” and “I Hope I Shall Arrive Soon,” each narrative incorporates artificial intelligence and androids acting as others to reveal the machine-like qualities of Dick’s human characters. This …

Comparative Characteristics Of Integrin Αdβ2 Binding To Native Fibrinogen And Fibrinogen Modified By Dha Oxidation During Inflammation, Ajibola Ilesanmi

Electronic Theses and Dissertations

2-ω-carboxyethylpyrrole (CEP) is a product of docosahexaenoic acid (DHA) oxidation, which forms covalent adducts with different proteins. CEP-modified proteins can interact with macrophage receptor, integrin αDβ2. This study aims to compare αDβ2 binding to its physiological ligand, fibrinogen, and CEP-modified fibrinogen, which is formed during inflammation. We hypothesize that modification of fibrinogen changes its ligand-binding properties to integrin αDβ2 which can affect macrophage migration and retention. Recombinant αD I-domain and αDβ2-transfected HEK293 cells were used for the experiments. Using biolayer interferometry, we found that the affinity of αD I-domain binding to fibrinogen-CEP was higher than fibrinogen and inhibited by the …

Dyadic And Ecological Associations With Intimate Partner Violence (Ipv): Using Hierarchical Linear Modeling To Differentiate Ipv From Community Crime, Rachel Carpenter

Electronic Theses and Dissertations

Research on intimate partner violence (IPV) and intimate partner sexual violence (IPSV) has largely focused on individual and dyadic-level risk factors, but recently studies have explored how the surrounding environment is associated with IPV/IPSV. Studies that have explored community-level variables typically only use IPV/IPSV samples and do not first compare indicators of IPV/IPSV to those of general crime in those same communities. To address these gaps, this study was conducted in two parts. Data were retrieved from the Tennessee Bureau of Investigation Reporting System, County Health Rankings and Roadmaps System, the US Census Bureau, and other sources. Study 1 first …

Parents' Perception Of Speech-Language Pathologists In Secondary Transition, Madelyn Hunt

Electronic Theses and Dissertations

Speech-Language Pathologists provide services to youth with Down syndrome. The purpose of this study was to (a) determine if parents are aware that speech-language pathologists can provide services to prepare their children for secondary transition; (b) identify the parents’ perceptions of the services provided by speech-language pathologists; and (c) determine if in the parents’ opinion, the speech-language pathologist provided a vital role in preparing their child for transition. Using nonprobability snowball sampling, this cross-sectional mixed-method survey study included 85 parents of youth (ages 14-22) with Down syndrome across the United States. Parents rated their experiences and described their beliefs and …

Speech-Language Pathologists’ Perceptions Of The Severity Of Speech Sound Disorder, Alexis Moser

Electronic Theses and Dissertations

Objective: The purpose of this study was to determine speech-language pathologists’ (SLPs’) perceptions regarding the concept of severity of speech sound disorder (SSD).

Methods: An online survey of 40 questions was created using REDCap® and disseminated to currently practicing SLPs across the United States. A total of 296 responses were completed, and data were analyzed using descriptive statistics and coding according to grounded theory.

Results: The top five factors SLPs consider when determining SSD severity are types of errors, intelligibility, perceptual judgment, normative data, and percentile rankings. Most SLPs were unfamiliar with the International Classification of Functioning, Disability and Health …

Approaching Trans Healthcare Competency: The Implementation Of Trans Health Education For Medical Providers In Appalachia, Rebecca Altschuler

Electronic Theses and Dissertations

Barriers to competent and safe healthcare disproportionately impact people who are marginalized because of their race, ethnicity, gender, or socioeconomic status. It is well documented that transgender patients in particular experience barriers to both accessing care and receiving high quality, non-discriminatory care (Hatzenbuehler & Pachankis, 2016; James et al., 2016; Rahman et al., 2019; Safer et al., 2016). This lack of access to culturally competent healthcare services contributes to health disparities that disproportionately impact the trans community. Literature on barriers to competent care for trans patients indicates that providers experience discomfort related to their ability to provide competent care (Safer …

Preference For Abstinence-Based Recovery And Public Stigma Toward Substance Use Disorders, Diamond Meadows

Electronic Theses and Dissertations

The present study drew from the publicly available Amerispeak survey (n = 6,515) and examined public stigma towards different substances, the relationship between preferences for abstinence-based recovery and stigma toward each substance, and whether perceived dangerousness of substances moderates the relationship between preferences for abstinence-based recovery and public stigma. The results indicate that the general public has greater stigmatizing attitudes towards methamphetamine use disorder than cocaine use disorder, opioid use disorder, and alcohol use disorder. Furthermore, a preference for abstinence-based recovery was associated with greater stigmatizing attitudes toward all SUDs. The perceived dangerousness of a substance did not moderate the …

Cyclic-Di-Gmp Regulates Salmonella Typhimurium Infection Of Epithelial Cells And Macrophages, Abdulafiz Musa

Electronic Theses and Dissertations

Regulation of the bacterial second messenger cyclic-di-GMP in Salmonella Typhimurium allows it to delicately alter phenotypes to optimize invasion and survive intracellularly in epithelial cells and macrophages to become virulent and cause infection. Cyclic-di-GMP concentration is regulated by the presence of external stimuli, sensory diguanylate cyclases (DGCs) and phosphodiesterases (PDEs), and cyclic-di-GMP binding effectors. Previous studies established that maintenance of low cyclic-di-GMP concentrations is required for survival in macrophages, and that deletion of 3 active PDEs reduces this survival. Here I showed that these 3 PDEs also influenced the infection of epithelial cells. Further studies re-established the decreased survival in …

The Hysterical Woman: An Analysis Of Trauma In Gothic Women’S Literature And Modern Horror Film, Molly Holdway

Electronic Theses and Dissertations

This thesis explores trauma related to hysteria through themes of confinement, isolation, and motherhood in the works “The Yellow Wallpaper” (1892) by Charlotte Perkins-Gilman, The Haunting of Hill House (1959) by Shirley Jackson, and The Babadook (2014) directed by Jennifer Kent. Hysteria is explored first as a diagnosis and then as a weaponized term meant to keep women facing isolation and grief in a continuous state of oppression. The gothic and gothic horror genres display these themes through the dark nature of the human mind, which is vital in understanding the stories of the female characters discussed and the …

Non-Destructive Imaging Of Phytosulfokine Trafficking In Plants Using Fiber-Optic Fluorescence Microscopy, Bernard Abakah

Electronic Theses and Dissertations

Plants secrete peptide ligands and use receptor signaling to respond to stress and control development. Understanding these phenomena is key to improving plant health and productivity for food, fiber, and energy applications. Phytosulfokine (PSK), a sulfated peptide hormone, regulates plant cell division, growth, and stress tolerance via specific phytosulfokine receptors (PSKRs). This study uses fiber-optic fluorescence microscopy to elucidate trafficking of PSK in live plants. The microscope features two-color optics and an objective lens connected to a 1-m coherent imaging fiber mounted on either a conventional upright microscope body or 5-axis positioning system (X–Y–Z plus pitch and yaw). PSK and …

“It’S Alive!” The Birth And Afterlife Of The Gothic Genre, Tanner Linkous

Electronic Theses and Dissertations

This thesis explores the development of the Gothic novel in England throughout the eighteenth and nineteenth centuries. This thesis establishes the Gothic as a literary mode of middle-class terror by analyzing Gothic novels within the historical context of the Industrial and Democratic revolutions. This requires an in-depth understanding of politics throughout both centuries and this thesis engages with several sources such as Maggie Kilgour’s The Rise of the Gothic Novel which adds important context to my claims. Additionally, I use several contemporary sources such as Godwin’s Caleb Williams, the writings of Edmund Burke, and On the Pleasure Derived from Objects …

Exploring Sexual And Reproductive Health Care In Central Appalachia Through The Experiences Of Transgender And Gender Non-Binary People, Chase Harless

Electronic Theses and Dissertations

Background: Transgender or nonbinary (TNB) individuals in the United States experience higher rates of sexual and reproductive health disparities when compared to their cisgender counterparts, along with lower access to care. TNB people in the south experience higher rates of disparities. Societal, interpersonal, and individual barriers contribute to these disparities in the TNB population. However, there is a paucity of research examining the sexual and reproductive health experiences of TNB people living in Central Appalachia.

Methods: An interpretive phenomenological analysis (IPA) research design was used to collect and analyze semi-structured interviews with TNB individuals living in central Appalachia regarding their …

A Comparison Of The Expressive Language Characteristics In Schizophrenia And Wernicke’S Aphasia, Taylor Thomas

Electronic Theses and Dissertations

Mental illness and language disorders are rarely linked together as a way of making a comparison. In this study, a comprehensive scoping review was initiated to discuss the differential diagnostic characteristics of expressive language in Schizophrenia and Wernicke’s Aphasia (WA). This study will examine the domains of language where there are overlaps between the characteristics of expressive language. Semantics, pragmatics, and discourse will be further examined while comparing what aspects of expressive language are key in each domain. Schizophrenia being classified as a mental illness and WA being classified as an acquired language disorder, there are fundamental properties of language …

Assessing A Pandemic: Spatiotemporal Analysis Of Covid-19 In Tennessee School-Age Children, Omobolaji Olawuyi

Electronic Theses and Dissertations

This study is a spatiotemporal analysis of the COVID-19 pandemic in school-age children (5-18 years) in Tennessee, from 2020-03-19 to 2022-02-12. Trend Analysis, Emerging Hot Spot Analysis, and a time series revealed three significant waves in both age groups. Therefore, Change Point Detection at the county level was completed using six defined change points to identify the wax and wane of the three COVID-19 waves. Hierarchical Cluster Analysis grouped counties with similar change points into six clusters. No spatial pattern was observed in distribution of the six clusters, however, when each change point was evaluated separately, spatial autocorrelation was present, …

A Multiple Regression Analysis Of Factors Influencing 2-Year College Enrollment During The Covid-19 Pandemic, Lauren Margaret Davis

Electronic Theses and Dissertations

The COVID-19 pandemic negatively impacted enrollment, a continuation of the decline ongoing since 2010. Two-year colleges are highly dependent on tuition revenue. Consequently, the pandemic exacerbated the postsecondary economic crisis, as 2-year institutions faced financial hardship amidst enrollment uncertainties. In response to the pandemic, policymakers and 2-year college leaders adapted their enrollment management efforts. However, the impact of these actions on enrollment was unknown. Using resource dependence theory, the present study aimed to understand how COVID-19 influenced 2-year colleges' acquisition of their most sustainable resource, enrollment. Separate multiple linear regression analyses explored the influence of four enrollment management efforts (shift …

Impostor Phenomenon, College-Going Knowledge, And Staff Expectations: Ramifications On First Time In College Students Enrollment, Julia A. Vickery

Electronic Theses and Dissertations

A lack of technically trained, skilled, and educated workforce has become a critical issue in Texas. Furthermore, an educated workforce improves communities and individuals with economic, health, and personal benefits. Community colleges not only provide open-access admissions and low-cost tuition but are specifically aligned with educating the technical and industrial skilled workforce. Although a post-high school education has never been more accessible or necessary for obtaining high-earning jobs, post-high school college enrollment is declining, and conventional reform strategies do not appear to be effecting change. Graduating high school students aspire to attend postsecondary training by applying and being accepted but …

The Medicine Of Memes: An Exploration Of Humor Styles, Memes, And Dark Humor, Theodor Napp

Electronic Theses and Dissertations

The usage of humor as a coping strategy is one that has been well-studied in the realm of psychology (Abel, 2002). However, research into the usage of dark humor as a coping mechanism, as well as dark humor expressed in memes, is not nearly as well-studied. This study (N = 50) replicated previous findings on humor and personality and expanded the research on self-directed humor and dark humor by comparing it to humor styles outlined by Martin et al. (2003) and Tsukawaki and Imura (2020). Replication results were mixed, with some findings supporting previous research between the Big Five personality …

The Lived Experience Of Good Therapy For Latino Clients, Rebecca Trujillo

Electronic Theses and Dissertations

The Latino population is one of the fastest growing minority populations in the United States. While there is vastness and diversity in the countries that represent Latino heritages, Latino people hold similar values that influence their lives including familismo, respeto, personalismo, and many others (Ayón & Aisenberg, 2010; Bean et. al., 2001; Bermúdez et al., 2010; Calzada et al., 2010; Elias-Juarez & Knudson-Martin, 2016). Previous researchers identified stigma regarding mental health issues in Latino communities and the role of values like familismo in contributing to the stigma of accessing mental health support outside of Latinos’ families (McGoldrick et al., 2005). …

Impact Of Personalized Interactive Storytelling On Suspension Of Disbelief In Clinical Simulation, Audra Renee-Smith Xenakis

Electronic Theses and Dissertations

The literature review found suspension of disbelief (SOD) in clinical simulation heavily weighted on educators alone within high-fidelity environments. The project examined a co-created narrative background story applied to a simulated patient’s clinical profile to determine achieving an improved connectedness toward the simulated patient leading to enhanced SOD and enhanced levels of learning and reaction. The studied population was third-semester associate degree nursing students over 18 years of age with prior clinical simulation experience who were not repeating the semester. The research methodology used a quantitative experimental design with cluster sampling, randomization, and post-Likert-scored questionnaires. The intervention group co-created personalized …

Healthcare Workers’ Perceptions, Practices, And Knowledge Of Trauma-Informed Care In The Hospital Setting, Emily Gayle Tippens

Electronic Theses and Dissertations

Psychological trauma has become a pervasive term throughout the mental health field but has been slow to gain momentum in the healthcare field. Hospitals have always been a place where people with mental health concerns or psychosis seek help, but hospitals have historically not implemented a trauma-informed care (TIC) approach. As the mental health crisis continues to become more detrimental, trauma-informed care skills will become more valuable. This study measured the knowledge, opinions, perceptions healthcare professionals in West Texas have regarding trauma-informed care. This study hypothesized that healthcare workers in West Texas would benefit from TIC training. This study hypothesized …

Forming And Maintaining Intimate Friendships As A Twentysomething, Molly S. Burke

Electronic Theses and Dissertations

Emerging adulthood is a life stage of great change, and often instability in relationships and attachment (Demir et al., 2015; Lane et al., 2017; Shulman & Connolly, 2013). Intimate friendships can be a moderating factor and assistance in gaining stability and increasing life satisfaction (Demir, 2021; Demir et al., 2015; Sanchez et al., 2020). This study used grounded theory methodology (Creswell & Poth, 2018) to develop a model of the process which Twentysomethings undergo while forming and maintaining intimate, or best, friendships. Through interviews with best friend pairs, this study found three main phases of the best friend process: forming …

An Evaluation Of A Supportive Mentoring Program For Teenagers At-Risk Of Homelessness: Effects On Academic Performance And Psychosocial Functioning In A Pilot Study, Jordan Jones

Electronic Theses and Dissertations

This study investigates the impact of homelessness on adolescents’ psychosocial functioning and academic performance and explores the efficacy of mentoring programs as a potential intervention. This study aims to examine the potential of mentoring programs to improve the overall well-being of adolescents at risk of homelessness. Homelessness is often linked with negative outcomes in areas such as mental health, social functioning, and academic achievement. Therefore, this study seeks to understand whether mentoring programs can help mitigate these negative effects and promote positive outcomes in these areas. Quantitative assessments, utilizing pre-test and post-test measures, were employed to collect data from a …