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Articles 13381 - 13410 of 15365
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Nitric Oxide Production: A Mechanism For Inhibition Of Chlamydia Trachomatis Replication, Bojun Chen
Nitric Oxide Production: A Mechanism For Inhibition Of Chlamydia Trachomatis Replication, Bojun Chen
Electronic Theses and Dissertations
Chlamydia trachomatis (CT) replicates in macrophages, but is inhibited by IFN-$\gamma$ or LPS. IFN-$\gamma$ and/or LPS induced nitrite production in mouse peritoneal macrophages, macrophage cell lines (RAW264.7 and J774A.1) and McCoy cells. Kinetic studies indicated that peak production occurred 48 hours post-treatment. CT infection itself was insufficient to induce nitrite production, but resulted in enhancement of nitrite production in IFN-$\gamma$-treated cells. Treatment with IFN-$\gamma$ or LPS resulted in significant inhibition of CT replication in these cells. Strong correlation between nitrite production and inhibition of CT replication was observed in RAW264.7 and J774A.1 cells (correlation coefficients: $-$0.93 and $-$0.94, p $<$ 0.001). N$\sp{\rm g}$- monomethyl-L-arginine (L-NMMA) specifically inhibited nitrite production and partially reversed inhibition of CT replication in macrophage cell lines. NOS mRNA was measured in RAW264.7 cells by Northern blot and Dot blot hybridization. Strong correlation between NOS mRNA expression and inhibition of CT replication (correlation coefficient: $-$0.97, p $<$ 0.05) was observed. Anti-TNF-$\alpha$ antibody completely neutralized the biological activity of TNF-$\alpha$ secreted by LPS-treated RAW264.7 cells, yet the antibody neither reduced nitrite production nor restored CT replication. Combination of the antibody and L-NMMA significantly enhanced restoration of CT replication. In peritoneal macrophages, inhibition of CT replication induced by IFN-$\gamma$ was partially restored by L-NMMA or anti-TNF-$\alpha$ antibody. In McCoy cells, inhibition of CT replication induced by IFN-$\gamma$ and LPS was not significantly restored by L-NMMA. Great restoration of CT replication by 1 mM L-NMMA was observed in LPS-treated J774A.1 cells (31%), but not in IFN-$\gamma$-treated cells (5%). Our data indicate that (1) NO production is one of the mechanisms for inhibition of CT replication in IFN-$\gamma$-activated peritoneal macrophages and RAW264.7 cells; (2) NO plays a significant role in CT inhibition in LPS-treated macrophage cell lines, but not peritoneal macrophages; (3) TNF-$\alpha$ may be associated with inhibition, but the mechanism(s) may not involve NO production; (4) NO production may not be the mechanism for CT inhibition in McCoy cells treated with IFN-$\gamma$ and LPS.
Enhanced Renal Sympathetic And Cardiovascular Responses To Substance P In Hypertension, Gregory W. Lindsay
Enhanced Renal Sympathetic And Cardiovascular Responses To Substance P In Hypertension, Gregory W. Lindsay
Electronic Theses and Dissertations
Blood pressure, heart rate, and renal sympathetic nerve responses were measured in 9-13 week old male spontaneously hypertensive rats (SHR) and compared to those in age and sex-matched Wistar-Kyoto (WKY) rats following intravenous injection of the neuropeptide substance P (SP), the nicotinic stimulant 1,1-dimethyl-4-phenylpiperazinium (DMPP), and the adrenoceptor stimulant norepinephrine (NE). Charles River Sprague-Dawley (CD) rats were used in some studies to develop methodologies. Measurements were made in control rats and also following sinoaortic denervation, pithing, ganglion blockade, or adrenoceptor blockade. Responses were evaluated in order to determine if ganglion stimulation by SP was enhanced in SHR compared to WKY …
Capital Maintenance Funding Of Two-Year Colleges In The Tennessee Board Of Regents System And Selected Funding Models, Charles A. Hurley
Capital Maintenance Funding Of Two-Year Colleges In The Tennessee Board Of Regents System And Selected Funding Models, Charles A. Hurley
Electronic Theses and Dissertations
The purpose of this study was to determine the differences between selected state capital maintenance models and the model used in Tennessee. Research questions addressed the differences between the other selected models and the Tennessee model; the quantitative results of the models using data collected from the 14 Tennessee public two-year colleges, and the policy issue differences of the selected models. Research involved gathering information for each specific selected model including common factors used to calculate capital maintenance needs. Comparisons were made of the major components of each model. Actual data from the 14 Tennessee public two-year colleges was incorporated …
Called To Serve : American Nurses Go To War, 1914-1918., Katherine Burger Johnson
Called To Serve : American Nurses Go To War, 1914-1918., Katherine Burger Johnson
Electronic Theses and Dissertations
World War I resulted in the deaths of over 8,500,000 military personnel and in addition, millions of civilians. There were not enough doctors to provide the necessary medical care for the masses of seriously sick and wounded, and other than in Great Britain, there was little in the way of an organized nursing profession in Europe. Over ten thousand American women served overseas as nurses and nurses' aides from 1914 to 1918, caring for soldiers and civilians of diverse nationalities and proving to be a mainstay in the medical treatment provided for victims of "The Great War." Little has been …
Behind The Barbed Wire: German Prisoners Of War In Mississippi, 1943-1946, Edward L. Maier Iii
Behind The Barbed Wire: German Prisoners Of War In Mississippi, 1943-1946, Edward L. Maier Iii
Electronic Theses and Dissertations
No Abstract
An Assessment Of Role Ambiguity, Role Conflict, Role Frustration, And Job Satisfaction Of Presidents At Selected Private Four-Year Colleges In The Southeastern United States, Gary W. Juhan
Electronic Theses and Dissertations
Current literature has suggested that the role of the college president has perhaps become too ambiguous, complex and demanding for an individual to perform for an extended period of time. The purpose of the study was to assess the relationship between perceived role ambiguity, role conflict, role frustration and job satisfaction of selected private college presidents in the Southeastern United States. The method of the study was correlational in design. Using a thirty-seven item questionnaire developed by the author, data were collected from 141 college presidents of institutions within the Southern Association of Colleges and Schools. The institutions were private …
Mechanisms Of T Cell-Mediated Macrophage Activation: Role Of Antigen Specific And Antigen Nonspecific Cognate Interactions, Xiang Tao
Electronic Theses and Dissertations
Macrophages play an important role in host antimicrobial immunity and in non-septic inflammatory reactions. Most studies on macrophage activation have focused on the roles of the T cell-produced cytokine, interferon-$\gamma$ (IFN$\gamma)$ and bacterial product, lipopolysaccharide (LPS). T cell-macrophage interaction is a critical step in initiating both specific and nonspecific immune responses to antigenic stimulation. The current study examines the role of cognate T cell-macrophage interaction in activation of macrophage effector functions and induction of macrophage early activation gene expression. Viable resting T$\sb{\rm H}$2 clone cells can activate IFN$\gamma$-primed macrophages to produce reactive nitrogen intermediates (RNI) or express cytostatic activity. The …
Problems Facing Television Stations In Markets 30-50, Marvin F. Williams Iii
Problems Facing Television Stations In Markets 30-50, Marvin F. Williams Iii
Electronic Theses and Dissertations
No abstract provided.
An Analysis Of Reported Paid And Unpaid Time Off For Administrative Employees At Selected Public Universities In Tennessee, Ginger J. Rutherford
An Analysis Of Reported Paid And Unpaid Time Off For Administrative Employees At Selected Public Universities In Tennessee, Ginger J. Rutherford
Electronic Theses and Dissertations
Lack of research on the use of the leave fringe benefit (paid and unpaid time off) as it related to administrators in higher education was the problem of this study. The main purpose of this study was to increase the body of knowledge by analyzing the differences among paid and unpaid time off and selected demographic data for administrators at four selected public universities in Tennessee (Austin Peay State University, East Tennessee State University, Middle Tennessee State University, and Tennessee Technological University). This descriptive study was conducted to provide a historical data base on the use of paid and unpaid …
Human Lung Mast Cell Tryptase Isozymes: Separation And Examination Of Structural And Functional Differences, Susan S. Little
Human Lung Mast Cell Tryptase Isozymes: Separation And Examination Of Structural And Functional Differences, Susan S. Little
Electronic Theses and Dissertations
Tryptases are trypsin-like enzymes found in mast cell granules. Although in vivo substrates have not been positively identified, tryptases cleave a limited number of potential physiological substrates in vitro, including high molecular weight kininogen (HMWK) and vasoactive intestinal peptide (VIP). Purified human lung mast cell tryptase (HLT) apparently exists as a tetramer with an M$\sb{\rm r}$ of 135-144 kDa by gel filtration, whereas SDS-PAGE yielded two bands of M$\sb{\rm r}$ 29 Kda and 33 Kda. Tryptases are resistant to inhibition by most natural trypsin inhibitors and display some affinity for heparin. The existence of tryptase isozymes has been implied from …
Probing Protein-Protein Interactions Among Proteins Of A Nonaggregated Fatty Acid Synthetase From Euglena Gracilis Variety Bacillaris, Sande G. Williams
Probing Protein-Protein Interactions Among Proteins Of A Nonaggregated Fatty Acid Synthetase From Euglena Gracilis Variety Bacillaris, Sande G. Williams
Electronic Theses and Dissertations
Enoyl-acyl carrier protein (ACP) reductase from chloroplast nonaggregated fatty acid synthetase (FAS) of Euglena gracilis variety bacillaris was purified to a single band on a denaturing polyacrylamide gel. The enzyme was partially characterized with respect to substrate specificity, reduced nucleotide requirement, and the effect of ACP and Ca$\sp{++}$ on enzyme activity. Antibodies against the purified protein were raised in hens and isolated from eggs. ACP was purified from Euglena in yields of about 1mg/100g (wet weight) of cells. Antibodies were raised against the purified protein. ACP antibodies inhibited the Euglena chloroplast FAS using Euglena or E. coli ACP as a …
The Circumplex Model: A Method Of Discovering Church Typologies, Eric Lynnon Cupp
The Circumplex Model: A Method Of Discovering Church Typologies, Eric Lynnon Cupp
Electronic Theses and Dissertations
This thesis examines the amount of cohesion and the level of adaptability present among members of the Eastern Hills Church of Christ. Given this information, the members of the congregation were asked a single question to gauge their level of satisfaction with the church. The Eastern Hills Church of Christ is a diverse group, comprised from two churches in Athens, Texas, plus many people who have moved in from metropolitan areas. The objective of this project is to empirically test the factors of cohesion and adaptability and to use that information to find the typology of the congregation. The typological …
The Effects Of Power Clean Training On Anaerobic Performance, Kenneth L. Nichols
The Effects Of Power Clean Training On Anaerobic Performance, Kenneth L. Nichols
Electronic Theses and Dissertations
No abstract provided.
Reburning Of Nitric Oxide Involving Char / By Subramanian Kannikeswaran, Kannikeswaran Subramanian
Reburning Of Nitric Oxide Involving Char / By Subramanian Kannikeswaran, Kannikeswaran Subramanian
Electronic Theses and Dissertations
No abstract provided.
Removal Of Pollutants From Leachate Using Clay Liners / By Kuntumalla Sangameswaruni Phanindra, Kuntumalla Phanindra Sangameswaruni
Removal Of Pollutants From Leachate Using Clay Liners / By Kuntumalla Sangameswaruni Phanindra, Kuntumalla Phanindra Sangameswaruni
Electronic Theses and Dissertations
No abstract provided.
The Feminine In Frankenstein : Victor's Maternity And Subsequent Symptoms Of Postpartum Depression / By James H. Nutter, James Harold Nutter
The Feminine In Frankenstein : Victor's Maternity And Subsequent Symptoms Of Postpartum Depression / By James H. Nutter, James Harold Nutter
Electronic Theses and Dissertations
No abstract provided.
Echoes Of Indigenous Southern Culture : The Oral And Material Culture Of The Mississippi Band Of Choctaws In East Central Mississippi / By Gina Michelle Weaver, Gina Michelle Weaver
Echoes Of Indigenous Southern Culture : The Oral And Material Culture Of The Mississippi Band Of Choctaws In East Central Mississippi / By Gina Michelle Weaver, Gina Michelle Weaver
Electronic Theses and Dissertations
No abstract provided.
Comparison Of Phytoplankton Primary Production In A Flood Control Reservoir Versus A Navigational Reservoir, Therese Lynne East
Comparison Of Phytoplankton Primary Production In A Flood Control Reservoir Versus A Navigational Reservoir, Therese Lynne East
Electronic Theses and Dissertations
No abstract provided.
Detective Aspects In Wilkie Collins's Fiction, Beth Ann Mccollum
Detective Aspects In Wilkie Collins's Fiction, Beth Ann Mccollum
Electronic Theses and Dissertations
No abstract provided.
A Comparison Of State Dependent Learning Effects Among Cigarette Smoking, Nicotine, And Smoke Odor, Richard Steen Chandler
A Comparison Of State Dependent Learning Effects Among Cigarette Smoking, Nicotine, And Smoke Odor, Richard Steen Chandler
Electronic Theses and Dissertations
No abstract provided.
A Study Of Fund Raising As A Part Of Public Relations : Four Case Studies Of Private Elementary And Secondary Schools In Houston, Texas, Katy Sanderson Creath
A Study Of Fund Raising As A Part Of Public Relations : Four Case Studies Of Private Elementary And Secondary Schools In Houston, Texas, Katy Sanderson Creath
Electronic Theses and Dissertations
No abstract provided.
Deception In The Coverage Of Headlines As Seen In The National Enquirer, The Star, And The Weekly World News, Myrtle Vonsel Alexander
Deception In The Coverage Of Headlines As Seen In The National Enquirer, The Star, And The Weekly World News, Myrtle Vonsel Alexander
Electronic Theses and Dissertations
No abstract provided.
The Naming Of Rape Victims In The Press : The Opinions Of Editors And Reporters, Chris Demaske
The Naming Of Rape Victims In The Press : The Opinions Of Editors And Reporters, Chris Demaske
Electronic Theses and Dissertations
No abstract provided.
Mississippi's Segregation Academy Movement, 1954-1970, Michelle Elizabeth Callaway
Mississippi's Segregation Academy Movement, 1954-1970, Michelle Elizabeth Callaway
Electronic Theses and Dissertations
No abstract provided.
Lessons From The Wolf, Nancy Calcutt
Lessons From The Wolf, Nancy Calcutt
Electronic Theses and Dissertations
No abstract provided.
Case Management For The Mentally Ill : An Identification Of Predictors Of Consumer Outcome / By Dianne L. Sadd, Dianne L. Sadd
Case Management For The Mentally Ill : An Identification Of Predictors Of Consumer Outcome / By Dianne L. Sadd, Dianne L. Sadd
Electronic Theses and Dissertations
No abstract provided.
St. Francis Xavier Academy And The Sisters Of Mercy In Vicksburg, Mississippi, Laura Elizabeth Boughton
St. Francis Xavier Academy And The Sisters Of Mercy In Vicksburg, Mississippi, Laura Elizabeth Boughton
Electronic Theses and Dissertations
No abstract provided.
Analyzing The Correlates Of Depression In Different Neurologically Impaired And Normal Populations, Mark Steven Aloia
Analyzing The Correlates Of Depression In Different Neurologically Impaired And Normal Populations, Mark Steven Aloia
Electronic Theses and Dissertations
No abstract provided.
Dismissed And Forgotten, James Mackey Harrison
Dismissed And Forgotten, James Mackey Harrison
Electronic Theses and Dissertations
No abstract provided.
Responses Of Myriophyllum Spicatum Linneaus To A Controlled Release Formulation Of Fluridone, A Carotenoid Synthesis Inhibitor / By Rachel Burres Wright, Rachel Burres Wright
Responses Of Myriophyllum Spicatum Linneaus To A Controlled Release Formulation Of Fluridone, A Carotenoid Synthesis Inhibitor / By Rachel Burres Wright, Rachel Burres Wright
Electronic Theses and Dissertations
No abstract provided.