Digital Commons Network^™

Urinary Excretion Of (1-3)-Beta-D-Glucans., Debra K. Head

Electronic Theses and Dissertations

(1→3)-β-D-Glucans are carbohydrate polymers that are present in the cell wall of various fungi and bacteria; they are pathogen associated molecular patterns that circulate during infection and modulate immunity. Our laboratory has previously established the pharmacokinetics of intravenously and orally administered glucans; the present studies investigated the renal excretion of (1→3)-β-D-glucans following intravenous and oral administration. Three fluorescently-labeled glucans were administered to adult male rats in the presence or absence of toxic challenge. Urine specimens were collected and analyzed by fluorescence spectroscopy, size-exclusion chromatography and GPC/MALLS. 71 ± 3% of fluorescence remained in the >5K MWCO fraction; this fraction showed …

An Examination Of The Relationship Between Perceived Parental Attachment And Coping Styles., Leslie C. Wilson

Electronic Theses and Dissertations

Of all relational bonds, perhaps the strongest and most complex is the one between parent and child. The dynamics of this relationship potentially hold the key to understanding the future psychological adjustment of the child. The current study was conducted to assess the relationship between perceived parental attachment and coping styles. Undergraduate psychology students (n=300) were administered a survey to examine perceived parental attachment, coping style, and gender. In conflict with previous studies, results indicated that neither respondents' gender nor level of perceived parental attachment was significantly related to participants' reported coping style. Increased knowledge and understanding of parental attachment …

Herpes Simplex Virus Glycoprotein D/Host Cell Surface Interaction Stimulates Chlamydia Trachomatis Persistence Via A Novel Pathway., Jennifer Vanover

Electronic Theses and Dissertations

When presented with certain unfavorable environmental conditions, C. trachomatis reticulate bodies (RBs) enter into a viable, yet noncultivable state called persistence. Two hallmarks of persistent chlamydiae are swollen, aberrantly shaped RBs, as viewed by transmission electron microscopy and a decrease in infectious progeny. Several models of chlamydial persistence have been described, including interferon-γ (IFN-γ), IFN-α, IFN-β, and tumor necrosis factor-α-exposure and nutrient deprivation. Previously, we established an in vitro co-infection model of two of the most common sexually transmitted pathogens in the United States, C. trachomatis and Herpes Simplex Virus-2 (HSV). Data from this tissue culture model indicate that: i) …

Characterization Of Murine Cardiac Cholinergic Innervation And Its Remodeling In Type 1 Diabetes., Abigail Marie Mabe

Electronic Theses and Dissertations

Murine models have become increasingly popular to study various aspects of cardiovascular diseases due to their ease of genetic manipulation. Unfortunately, there has been little effort put into describing the distribution of autonomic nerves in the mouse heart, making it difficult to compare current findings from clinical and experimental models related to cardiovascular diseases. Furthermore, determination of the requirements for the development of this system and its maintenance in adult mice remains largely unexplored. This study represents the first detailed mapping of cholinergic neuroanatomy of the mouse heart based on immunohistochemical staining using true cholinergic markers. We found cholinergic innervation …

Geochemical Impacts From Permanganate Oxidation Based On Field Scale Assessments., Kelly Ann Moore

Electronic Theses and Dissertations

In situ chemical oxidation (ISCO) using permanganate is a technology for treatment of organic hazardous wastes. This research is a review of 30 permanganate (MnO₄^-) ISCO sites to determine whether there are long term impacts on groundwater quality due to the introduction of the oxidant into the subsurface. A second objective is to determine if manganese concentration can be predicted by trends in specific pre and postoxidation monitored parameters (i.e., pH and oxidation reduction potential (ORP)). The final objective is to identify the effects of site and design conditions on groundwater conditions postoxidation. Results indicate that (1) …

Police Stress: An Examination Of The Effects Of Stress And Coping Strategies., Derrick Kenwright

Electronic Theses and Dissertations

How police officers deal with stress greatly affects how they carry out their daily lives and how they treat family and friends. In this study 2 police departments were issued surveys to see how the police officers experienced stress. Questions on the survey asked the officers about the sources of stress, sources of support, and which methods they used to alleviate the stress. The surveys were given to the respective departments over a period of 2 months, and 132 surveys were returned. The statistical analysis performed showed danger was a factor when examining stress. Administration support was found to be …

Cytotoxic Effects Of Ruthenium Compounds On Human Cancer Cell Lines., Katie Beth Brown

Electronic Theses and Dissertations

Chemotherapy is the most common cancer treatment. Traditionally, platinum-based drugs are used in chemotherapy. More recently, researchers have focused on ruthenium based compounds as a substitute for the platinum compounds. Ruthenium-based compounds appear to be less toxic to healthy cells than traditional platinum-based compounds. In this study, 7 ruthenium-based compounds were tested on HT-29 (colon) and MCF-7 (breast) human cancer cell lines with the specific aim of determining whether or not any of the ruthenium-based compounds exhibited cytotoxic properties. In addition, levels of vascular endothelial growth factor (VEGF) production were tested in supernate from the cancer cells treated with various …

Elucidating The Role Of The Α7 Nicotinic Receptor In The Etiology Of Schizophrenia., Michelle Johnson Chandley

Electronic Theses and Dissertations

The α7 subunit of the nicotinic receptor, a ligand gated ion channel with an affinity for nicotine, has long been implicated in the pathophysiology of schizophrenia due to the extremely high rate of smoking within the patient population. However, the exact role of the receptor has never fully been determined. In the following studies, various functions the receptor may assume in disease state are evaluated. There is a strong relationship between the immune system and schizophrenia, with the α7 subunit possibly serving as the link between the two. One of the following studies looks at the possibility of the receptor …

Characterization Of The Genes Involved In Biosynthesis And Transport Of Schizokinen, A Siderophore Produced By Rhizobium Leguminosarum Iari 917., David Jack Hammond

Electronic Theses and Dissertations

Iron is the 4th most abundant metal on the earth's crust and is required by most organisms as a cofactor for many enzymes; however, at physiological pH and aerobic conditions iron forms insoluble ferric oxyhydroxide polymers. Siderophores are low molecular weight compounds that scavenge ferric ions, bind with high affinity, and transport it into the cell via multicomponent transport systems. Rhizobia are soil dwelling organisms that form symbiotic relationships with host plants and fix atmospheric nitrogen, while the bacteria receive nutrients. R. leguminosarum IARI 917 produces a siderophore characterized as 'schizokinen'. In the present study, we have characterized the binding …

Iron Acquisition In Rhodococcus Erythropolis Strain Igts8: Characterization Of A Mutant Strain That Over Produces Siderophore., Melanie Anne Pratt

Electronic Theses and Dissertations

Iron is an essential nutrient for most bacteria because enzymes like nitrate reductase and cytochromes use it as a cofactor. However, in most aerobic, neutral pH environments, iron is essentially insoluble and not easily available for bacteria to use. Many bacteria respond to this problem by releasing small organic compounds called siderophores that bind and effectively solubilize iron so that it can be transported into the cell for growth. The focus of this study was to learn more about the iron acquisition and especially the transport of iron by the soil bacterium Rhodococcus erythropolis. To fulfill this aim, mutant …

A Study Of Community College Students Who Participated In A Dual-Enrollment Program Prior To High School Graduation., April Boling Sell

Electronic Theses and Dissertations

The purpose of this study was to examine the effects of dual-enrollment participation on students' postsecondary achievement as measured by various factors. The researcher explored an approach to learning that allows students to navigate the invisible barriers between high school and college. The population consisted of 901 students in a community college in northeast Tennessee during the fall of 2007 following high school graduation the previous academic year. Data gathered from dual-enrollment participants were compared to data of peers of comparable ability level who chose not to participate in the program.

The major findings of the study included the following: …

Neuropsychiatric Features Of Parkinsonian Tauopathies And Alpha-Synucleinopathies., Megan Rayne Thompson 1985-

Electronic Theses and Dissertations

The goal of this thesis is to determine if neuropsychiatric features can differentiate parkinsonian patients with: tauopathies from those with alpha-synucleinopathies and explore caregiver distress. Three hundred and four patients (62 with tauopathies and 242 with alpha-synucleinopathies) diagnosed according to published diagnostic criteria were evaluated using the Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), and Unified Parkinson's Disease Rating Scale (UPDRS). To control for between-group differences a subsample of 235 patients were analyzed. Patients with tauopathies had significantly higher NPI total scores, more apathy, less hallucinations, lower MMSE scores and higher UPDRS scores than those with alpha-synucleinopathies. Hallucinations and delusions …

A Comparison Of Faculty And Administrator Perceptions Of The Merger Of Kentucky's Community Colleges And Vocational/Technical Institutes., Jason Douglas Warren

Electronic Theses and Dissertations

One of the most nationally-recognized, two-year legislative reform initiatives in the U.S. began in Kentucky with the passage of the Kentucky Postsecondary Education Improvement Act of 1997 (HB1). This exploratory, cross-sectional, correlational study was administered at the 10-year anniversary of the HB1-legislated formation of the Kentucky Community and Technical College System (KCTCS), which originally combined 13 community colleges formerly governed by the University of Kentucky and 25 vocational/technical institutes previously governed by the Kentucky Cabinet for Workforce Development. This dissertation examined faculty and administrator perceptions of the merger of Kentucky's community colleges and vocational/technical institutes that resulted from HB1. Two …

Energy Efficient Geographic Routing For Wireless Sensor Networks., Gang Zhao

Electronic Theses and Dissertations

A wireless sensor network consists of a large number of low-power nodes equipped with wireless radio. For two nodes not in mutual transmission range, message exchanges need to be relayed through a series of intermediate nodes, which is a process known as multi-hop routing. The design of efficient routing protocols for dynamic network topologies is a crucial for scalable sensor networks. Geographic routing is a recently developed technique that uses locally available position information of nodes to make packet forwarding decisions. This dissertation develops a framework for energy efficient geographic routing. This framework includes a path pruning strategy by exploiting …

Altered Developmental Programming Of The Mouse Mammary Gland In Female Offspring Following Perinatal Dietary Exposures : A Systems-Biology Perspective., Caleb Deen Bastian

Electronic Theses and Dissertations

Mishaps in prenatal development can influence mammary gland development and, ultimately, affect susceptibility to factors that cause breast cancer. This research was based on the underlying hypothesis that maternal dietary composition during pregnancy can alter developmental (fetal) programming of the mammary gland. We used a computational systems-biology approach and Bayesian-based stochastic search variable selection algorithm (SSVS) to identify differentially expressed genes and biological themes and pathways. Postnatal growth trajectories and gene expression in the mammary gland at 10-weeks of age in female mice were investigated following different maternal diet exposures during prenatal-lactational-early-juvenile development. This correlated a decrease in expression of …

Modeling The Relationship Between Air Quality And Intelligent Transportation System (Its) With Artificial Neural Networks., Dinesh Kumar Gupta 1965-

Electronic Theses and Dissertations

Environmental or air quality impacts of Intelligent Transportation Systems (ITS) are very difficult to measure. Some researchers have attempted to quantify the effects of individual ITS application on emissions; yet, the effects of ITS as a whole on ambient air quality have not been investigated. The objective of this research was to model the relationship between ITS and ambient air quality. The multiple Artificial Neural Networks (ANN) training with the data yielded a model for predicting the air quality. In addition, the ANN made the measurement of the effect of ITS on air quality possible. Data pertaining to sixty US …

High School Boys' Basketball And The Social Structure Of Suburban, Rural, And Urban High School Communities : A Comparative Case Study., Jason K. Miller

Electronic Theses and Dissertations

This study examined the relationship between high school boys' basketball and the social structure of a suburban, rural, and urban high school in the lower Midwest. These schools surround a metropolitan area of approximately one million people. The researcher used interviews, observations, and mining of documents to collect data. The study answered four research questions. The first question addressed the social structure of the three schools. Each school contained a group associated with sport participation called "jock" or "athlete." The second research question examined how boys' basketball participation affected social group membership and the associated positive and negative aspects. At …

Viscoelastic Properties Of Pediatric Blood, Neema Nair 1983-

Electronic Theses and Dissertations

The performance of pediatric circulatory support devices depends on the properties of pediatric blood. This study reports the measurement of the viscoelastic properties of pediatric blood at 37°C [body temperature]. The results were compared with adult viscoelastic properties at the same temperature and also to pediatric viscoelastic properties analyzed at 22°C [room temperature]. The measurements were made using a viscoelasticity analyzer Vilastic-3 on the blood at the hematocrit at which it was drawn. Each test produced results for viscoelastic parameters versus shear rate [stretch test] at a frequency of 2 Hz. Samples were obtained with informed consent from 11 pediatric …

Design, Analysis, And Development Of Cost Effective Canine Wheelchairs., Edward Bros Fowler

Electronic Theses and Dissertations

Hind limb paralysis may occur in dogs for a variety of neurological or musculoskeletal reasons. For dogs with limited mobility their lack of ability to ambulate can have a great impact on their physical and mental health. Canine wheelchairs can provide these dogs with a mobility option. The purpose of this project was to design a cost effective, adjustable, and lightweight canine wheelchair for dogs with hind limb paralysis. To account for the diverse range of canine breed sizes, wheelchairs were categorized into three separate designs (small, medium, and large size wheelchairs). A quality function deployment (QFD) matrix was created …

Rear Impact Crashworthiness Of A Manual Wc19 Wheelchair Occupied By A 50th Percentile Atd., Zdravko Salipur

Electronic Theses and Dissertations

For persons with disabilities, access to transportation is necessary for integration into society. The Americans with Disabilities Act (ADA) has been instrumental in assuring transportation access to individuals with disabilities for purposes of employment, education, and recreation. A substantial number of wheelchair users may not be able to transfer from their wheelchair to a motor vehicle seat during transportation. It is necessary to afford these wheelchair users the same level of safety as occupants seated in motor vehicle seats. The purpose of this study was to investigate the response of a manual wheelchair used as a motor vehicle seat, while …

Advancing The Knowledge Of Local Health Care Policy Through The Growth Machine Thesis., David P. Houvenagle 1965-

Electronic Theses and Dissertations

A disciplined-configurative case study design was carried out to explore whether a growth machine exists and shapes local healthcare policy in Louisville. A historical analysis first explored whether a growth machine existed in Louisville in the past and shaped healthcare policy. Second, a network analysis was used to identify the recent contours of the Louisville growth machine. Third, qualitative interviews were conducted with central individuals as indicated by the social network analysis to assess the degree to which local healthcare policy is shaped and driven by the growth machine. The results show that Louisville has consistently had a growth machine …

A Study Of The Rita Geier Case: Efforts To Desegregate Three State Universities In Tennessee From 1990-2006., Sonja Renee Jackson-Mccoy

Electronic Theses and Dissertations

This study focuses on a 2-phase assessment of the desegregation of selected public postsecondary institutions under the Tennessee Board of Regents (TBR) [Tennessee State University and University of Memphis] and the University of Tennessee systems [University of Tennessee-Knoxville]. The 1st phase involved obtaining and analyzing the annual reports, court cases, legal journals, articles, and books concerning the 1968 Sanders v. Ellington case (better known as Geier v. Alexander); the 1984 Geier Stipulation of Settlement that mandated a desegregation plan; and the implementation of the 2001 Geier Consent Decree. The study also examines enrollment of black students in selected historically white …

Celebration Drinking And The Self-Fulfilling Prophecy Of Alcohol Misperceptions : Implications For The University Of Mississippi, Catherine Dane Woodyard

Electronic Theses and Dissertations

No abstract provided.

Resisting And Transforming: Pastoral Theology And Care Of Korean Military Wives, Bocheol Chang

Electronic Theses and Dissertations

Korean military wives have been symbolized as "dirty," "nothing," and "evil" by Koreans, Korean Americans, and their American families. They also experience same level of oppression and discrimination within Korean American congregations. In Korea, the women suffered poverty, sexual violence, and Confucian gender discrimination. They have also experienced racial and sexual oppression, intercultural familial conflicts and violence, and identity crisis in America. All of those experiences are caused the sense of not belonging of Korean military wives.

The sense of not belonging and desperation can be explained well by Andrew Sung Park's theology of han. The theology of han …

Role Of Perceived Partner Responsiveness On Mexican American Males' Pain Severity And Depressive Symptomatology, Carolyn M. Freedman

Electronic Theses and Dissertations

This study examined the role of cultural indicators in moderating the influence of perceived partner responses and relationship satisfaction on pain severity and depressive symptomatology among a sample of 62 married and cohabiting Mexican American men, the majority of whom were first generation Mexican Americans, with chronic back and/or neck pain. The cultural indicators were not found to act as moderators in the analyses that involved pain severity and depressive symptomatology as outcome variables. Nevertheless, this study's findings are an important initial step in understanding the relationship dynamics among an understudied population with chronic pain and raise many important questions …

A Study Of Colorado's Tabor Law And Its Influence On Public Finance During The 2001 Recession, Zak Brewer

Electronic Theses and Dissertations

Colorado's constitutional Taxpayer Bill of Rights (TABOR) is a product of the citizen initiative process, a mechanism of direct democracy that allows citizens to circumvent legislatures and enact laws themselves. A prominent argument against this process is that such a mode of lawmaking can generate conflicts within state constitutions and bring about unintended consequences. This paper considers the Colorado state budget difficulties that arose during the 2001 recession, the relationship of TABOR and those difficulties, and finds that TABOR resulted in unintended consequences that were unforeseen by voters who approved the measure. Examples of these unanticipated, unintended consequences include: significant …

A Global Education Transition: Computer Simulation Of Alternative Paths To Universal Basic Education, Mohammod T. Irfan

Electronic Theses and Dissertations

As an acknowledgment of the critical role of education in realizing other development targets, the Millennium Development Goals (MDG) of the United Nations include education in a framework of development targets. The MDG targets for education include achieving universal primary education and gender parities in all levels of education by 2015.

Recent global campaigns have added to the momentum of the rapid progress of educational expansion, which began in roughly the 1960s. Countries with universal or near universal participation and completion in elementary education have started to look beyond primary, towards free and compulsory basic education- education up to lower …

Classroom Organizational Structures As Related To Student Achievement In Upper Elementary Grades In Northeast Tennessee Public Schools., Darrell Wayne Moore

Electronic Theses and Dissertations

No abstract provided.

Etsu Gearup: The Design And Development Of An Alternative Energy Greenhouse., Garth Ross Ghearing

Electronic Theses and Dissertations

East Tennessee State has partnered with David Crockett High School through the Federal Gaining Early Awareness and Readiness for Undergraduate Programs. This year's project is an alternative energy greenhouse, which incorporates solar panels and a wind turbine. The focus is on familiarizing students with control systems including programmable logic controllers and power management. There is also an emphasis on the importance of green engineering.

The high school's students have been involved in the design and development of every aspect of the system. The development of the system is ongoing and will be further integrated into classes in the fall semester. …

Reliability Generalization Of The Alcohol Use Disorders Identification Test., Chandni Patel

Electronic Theses and Dissertations

The Alcohol Use Disorder Identification Test (AUDIT) is a brief screening instrument for assessing alcohol use problems among adults. This instrument is widely used and continued evaluation of its psychometric performance is needed. Reliability and validity are the primary psychometric characteristics of interest when evaluating psychological instruments. The focus of the present study is on reliability, which reflects the consistency or repeatability of the scores produced by a given instrument. Using meta-analytic methods, results showed that approximately 65% of previously published studies using the AUDIT did not appropriately report reliability estimates. Among the remaining studies, weighted reliability estimate centered on …