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The Role Of Curcumin In Response To Bpde-Induced Dna Damage In Human Lung Epithelial Cells., Erica Nicole Rogers
The Role Of Curcumin In Response To Bpde-Induced Dna Damage In Human Lung Epithelial Cells., Erica Nicole Rogers
Electronic Theses and Dissertations
Long-term exposure to harmful carcinogens like benzo[a]pyrene (BaP) are linked to lung cancer. Benzo[a]pyrene diol epoxide (BPDE), the ultimate carcinogen produced by BaP bioactivation, is believed to play an important role in lung carcinogenesis. The tumor suppressor protein is p53 signals cell cycle arrest, DNA repair, and apoptosis in response to BPDE-induced damage. However, physiological exposure to BPDE fails to activate p53. Although the bioactive principle of turmeric spice, curcumin, shows promising effects against BPDE-induced carcinogenesis, its exact mode of action remains unclear. Therefore the aim of this dissertation was to investigate whether curcumin prevents BPDE-induced DNA damage by regulating …
An Adaptive Ensemble Learner Function Via Bagging And Rank Aggregation With Applications To High Dimensional Data., Jasmit Sureshkumar Shah
An Adaptive Ensemble Learner Function Via Bagging And Rank Aggregation With Applications To High Dimensional Data., Jasmit Sureshkumar Shah
Electronic Theses and Dissertations
An ensemble consists of a set of individual predictors whose predictions are combined. Generally, different classification and regression models tend to work well for different types of data and also, it is usually not know which algorithm will be optimal in any given application. In this thesis an ensemble regression function is presented which is adapted from Datta et al. 2010. The ensemble function is constructed by combining bagging and rank aggregation that is capable of changing its performance depending on the type of data that is being used. In the classification approach, the results can be optimized with respect …
Constructing British Identity : Tobias Smollett And His Travels Through France And Italy, Michael Anthony Skaggs 1987-
Constructing British Identity : Tobias Smollett And His Travels Through France And Italy, Michael Anthony Skaggs 1987-
Electronic Theses and Dissertations
This thesis examines Tobias Smollett's Travels through France and Italy as a product of the dynamics influencing British identity in the eighteenth century. Specifically, it compares Smollett's Travels with recent trends in the historiography of British identity and Atlantic history and defines Smollett's place in those scholarly debates. By using Tobias Smollett as an individual and Travels as reflections of Smollett's own conception of British identity, this thesis highlights some of the shortcomings of extant historiography on British identity and Atlantic history. It particularly engages issues of authority, power, religious belief, and the self/other dichotomy as they contribute to both …
Dna Polymerase Iota Promotes G2/M Checkpoint Activation And Genetic Stability After Uv-Induced Dna Damage., Lindsey Jay Stallons 1983-
Dna Polymerase Iota Promotes G2/M Checkpoint Activation And Genetic Stability After Uv-Induced Dna Damage., Lindsey Jay Stallons 1983-
Electronic Theses and Dissertations
Unrepaired DNA damage poses a serious threat to the genetic stability of a replicating cell. One mechanism of tolerating this damage is translesion DNA synthesis (TLS), in which an accessory polymerase synthesizes DNA directly across from a damaged template. TLS is carried out by polymerase ? (Pol ?), 1, K, and REV1 in the Y-family and Pol ? in the B-family. Pol ? has the well-characterized ability to perform accurate bypass of the most common UV-induced DNA lesion; loss of Pol ? results in hypermutability and severely increased risk of skin cancer. The high mutation frequency in Pol ?-deficient cells …
(An)Other Gender : A Cross-Cultural Analysis Of War-Torn France And Great Britain In Which Simone De Beauvoir And Virginia Woolf Redefine "Woman"., Anna Stamp 1979-
(An)Other Gender : A Cross-Cultural Analysis Of War-Torn France And Great Britain In Which Simone De Beauvoir And Virginia Woolf Redefine "Woman"., Anna Stamp 1979-
Electronic Theses and Dissertations
This dissertation is a cross-cultural analysis of France and Great Britain during both the First World War and World War II in which Simone de Beauvoir and Virginia Woolf redefined "woman." Utilizing New Historicism, the first chapter begins with a focus on the evolution of the two cultures from the mid-nineteenth to early twentieth century France and Great Britain and discusses the ways in which the women's movement was both perpetuated and hindered by the volatile political and cultural climates of these two countries. The second chapter discusses the traditional woman as she was viewed in both French and British …
Roles Of 5ht1a Receptor In Cns Neurogenesis And Adam21 In Spinal Cord Injury., Sheila Ann Arnold 1981-
Roles Of 5ht1a Receptor In Cns Neurogenesis And Adam21 In Spinal Cord Injury., Sheila Ann Arnold 1981-
Electronic Theses and Dissertations
These studies set out to identify strategies to rescue and repair the adult nervous system. First, we investigated the role of ciliary neurotrophic factor (CNTF) in 5HT1A receptor-induced neurogenesis in the rodent brain. Systemic treatment with an agonist, 8-OH-DPAT, increased neurogenesis only in rats and not mice, and only in one of the two neurogenic regions. This increase was not mediated by CNTF. These data suggest that translation of 5HT1A-based studies to human cell replacement therapies should be reconsidered. Secondly, the role of the plasticity-associated metalloprotease ADAM21 after spinal cord injury was investigated by comparing ADAM21-deficient mice to their wildtype …
Development And Evaluation Of Polymeric Implants Of Curcumin For Enhanced Chemopreventive Activity., Shyam Sunder Bansal
Development And Evaluation Of Polymeric Implants Of Curcumin For Enhanced Chemopreventive Activity., Shyam Sunder Bansal
Electronic Theses and Dissertations
Curcumin, a plant derived compound has shown significant potency against various chronic diseases like cancer in cell culture and animal studies. However, the introduction of this compound into clinical setting is limited by its poor oral bioavailability and thereby requires high doses for efficacy. We hypothesized that localized/systemic delivery of curcumin by polymeric implants can improve its efficacy by bypassing the oral route and by restricting majority of the drug at the tumor site. Therefore, we developed a polymeric implantable drug delivery system using poly (E-caprolactone) as the polymer and optimized it with respect to polymer molecular weight, drug load …
Identifying Predictors Of Social Functioning In College Students : A Meta-Analysis., Jennifer Blair Beard
Identifying Predictors Of Social Functioning In College Students : A Meta-Analysis., Jennifer Blair Beard
Electronic Theses and Dissertations
This meta-analysis draws studies from the literature on college student persistence, need theories, and positive psychology in investigating the strongest predictors of social functioning in college students in the United States and Canada. The predictor categories included background characteristics, measures of personality, mental health symptomology, coping style, and academic predictors. The results indicated that an individual's level of extraversion (a personality predictor), level of institutional commitment (an academic predictor), and levels of anxiety and depression (mental health predictors) are the strongest predictors of social functioning in college. The moderator analyses revealed that these effects are even stronger in public institutions …
The Relationship Between Staff Nurse Perception Of Nurse Manager Leadership Behavior And Staff Nurse Job Satisfaction In A Hospital Applying For Magnet Recognition Status., Lorraine B. Bormann
The Relationship Between Staff Nurse Perception Of Nurse Manager Leadership Behavior And Staff Nurse Job Satisfaction In A Hospital Applying For Magnet Recognition Status., Lorraine B. Bormann
Electronic Theses and Dissertations
Hospitals are challenged to understand factors related to staff nurse retention in the context of the nursing shortage slowdown (Huselid, 1995; Mancino, 2008; Mancino, 2009). Leadership is a major factor in organizational success (Gandossy & Guarnieri, 2008; Gettler, 2003; Wooten & Crane, 2003) and nurse managers are the direct link between the executive nurse leaders and the registered nurses (RN) in the staff position (Taunton, Boyle, Woods, Hansen, & Bott, 1997). Studies show that nurse manager leader behaviors influence staff nurse job satisfaction (Blegen, 1993; Irvine & Evans, 1995; Lashinger & Finegan, 2005). A primary role of the nurse leader …
The Barriers And Enabling Factors To Public Health Advocacy Skills In Kentucky Local Health Departments., Joan Buchar
The Barriers And Enabling Factors To Public Health Advocacy Skills In Kentucky Local Health Departments., Joan Buchar
Electronic Theses and Dissertations
Background: One of the core functions of public health is to develop policies that support community and individual health. There are many historic examples in which public health practitioners have advocated successfully for policies that ultimately protected and improved populations' health. Prior research suggests that local health departments are not fully engaged in health policy advocacy, thereby missing opportunities to more effectively solve public health problems. Objective: To identify the barriers and enabling factors to advocacy in Kentucky local health departments. Methods: Kentucky health policymakers and advocates were interviewed to determine which advocacy skills were effective and appropriate for use …
Prevention And Treatment Of Lung Cancer By Green Tea Polyphenols., Pengxiao Cao
Prevention And Treatment Of Lung Cancer By Green Tea Polyphenols., Pengxiao Cao
Electronic Theses and Dissertations
Green tea polyphenols (GTPs) are gaining increasing attention because of their potential anti-tumor effects. However, poor oral bioavailability limits their efficacy in vivo. In this dissertation, two hypotheses were tested: 1) GTPs administered systemically by a sustained release system will circumvent the problem of limited bioavailability and lower the effective dose compared to the traditional oral route, and 2) adjuvant treatment of GTPs with a standard chemotherapeutic agent (e.g. cisplatin) will enhance efficacy of the therapeutic agent. In our lab, a polymeric implant delivery system was developed, in which GTPs were uniformly embedded within a polycaprolactone matrix to provide sustained …
Patient Perspective Post-Orthognathic Surgery., Jessica Tunstill Crews
Patient Perspective Post-Orthognathic Surgery., Jessica Tunstill Crews
Electronic Theses and Dissertations
The aim of the study is to determine factors contributing to satisfaction with orthognathic surgery. It was hypothesized that specific factors contribute to the patient's perception of success. 37 patients who had orthodontic/orthognathic surgery treatment at U of L participated in a survey study. 91 different analyses were tabulated. The analyses were divided into three categories. Analyses with: two categorical, two numerical, and one numerical and one categorical variable. None of the analyses with two categorical variables had significance. For the analyses with one categorical and one numerical variable, one had statistical significance. For the two numerical variables, eleven factors …
Comparison Of Two Orthodontic Indirect Bonding Methods., Gary D. Dixon
Comparison Of Two Orthodontic Indirect Bonding Methods., Gary D. Dixon
Electronic Theses and Dissertations
Purpose: The initial and long term bond failure rates of two orthodontic indirect bonding methods were compared. Materials and Methods: A review of 191 bondings provided a data base of bond failures for two indirect bonding methods. One method used a light cured adhesive system and clear vacuum formed transfer trays. A second method used a chemical cure adhesive system and putty transfer trays. The initial bond failure rates were compared using Fisher's Exact Test. The long term bond failure rates were compared using actuarial life tables and a Mantel-Haenzel comparison. Results: In initial bond failure the light cured method …
Methods And Software For Nonparametric Estimation In Multistate Models., Amanda Nicole Ferguson
Methods And Software For Nonparametric Estimation In Multistate Models., Amanda Nicole Ferguson
Electronic Theses and Dissertations
Multistate models are a type of multi-variate survival data which provide a framework for describing a complex system where individuals transition through a series of distinct states. This research focuses on nonparametric inference for general multistate models with directed tree topology. In this dissertation, we developed an R package, msSurv, which calculates the marginal stage occupation probabilities and stage entry and exit time distributions for a general, possibly non-Markov, multistage system under left-truncation and right censoring. Dependent censoring is handled via modeling the censoring hazard through observable covariates. Pointwise confidence intervals for the above mentioned quantities are obtained and returned …
Simulation Modeling And Analysis Of A Multi-Resource Medical Clinic., Bo Sun
Simulation Modeling And Analysis Of A Multi-Resource Medical Clinic., Bo Sun
Electronic Theses and Dissertations
Healthy for Life is a relatively new University of Louisville medical clinic which attempts to stem the epidemic of childhood obesity. This program offers a range of face-to-face services for overweight children. The main problem addressed by this research is the no show rate (nearly 50%) of the clinic. There are two goals of this thesis. One is to increase the staff utilization; the other is to decrease the waiting time. In this thesis, we study two potential methods to solve this problem. One involves using multiple resources for every visit; the other involves overbooking the patients. Two simulation models …
The Effect Of Tissue Damage And Inflammation On Gene Expression In Sensory Neurons., Sean Anthony Trusty 1984-
The Effect Of Tissue Damage And Inflammation On Gene Expression In Sensory Neurons., Sean Anthony Trusty 1984-
Electronic Theses and Dissertations
This study examined the effects of tissue damage and inflammation on the expression in sensory neurons of P2X3, a gene that has a role in nociception and sensing bladder distension, which is regulated by nerve injury. Tissue damage induces expression of ATF3, an indicator of injury, in sensory neurons. Animals were exposed to different types of tissue damage including single and repeated skin incision, bladder incision and a spinal cord injury with bladder inflammation. P2X3 was regulated differentially between conditions of single and repeated skin incision. One condition that involves repeated tissue damage and alteration of bladder function is spinal …
Contribution Of The Rv1985c Transcriptional Regulator To Mycobacterium Tuberculosis Intracellular Adaptation., Nicholas B. Wantland 1984-
Contribution Of The Rv1985c Transcriptional Regulator To Mycobacterium Tuberculosis Intracellular Adaptation., Nicholas B. Wantland 1984-
Electronic Theses and Dissertations
Mycobacterium tuberculosis causes the often-fatal infectious disease Tuberculosis, and infects approximately one third of the world's population. Gaining a better understanding of how these bacteria regulate gene expression for intracellular survival will likely aid in developing ways to reduce disease. Studies of bacterial RNA expression in experimentally infected primary human macrophages indicated open reading frame Rv1985c, encoding a putative transcriptional regulator, may contribute to intracellular survival. Comparison of a strain constitutively expressing Rv1985c and the isogenic wildtype parent by array hybridization identified genes potentially regulated by Rv1985c. These included a group encoding factors likely relevant to cell wall remodeling, particularly …
Assisted Living Facilities In Louisville Kentucky : A Case Study To Examine Aging In Place., James Luther Wilson
Assisted Living Facilities In Louisville Kentucky : A Case Study To Examine Aging In Place., James Luther Wilson
Electronic Theses and Dissertations
As the older adult population in the United States continues its accelerated growth, there is a growing concern about the long-term care options for these elders. While nursing homes are no longer desirable and costly for federal and state governments, viable alternatives are being sought to meet this need. The development and rapid expansion of the numbers of assisted living communities have grown as older adults, family caregivers and government bureaucrats are looking for lower cost options. How beneficial are assisted living communities for the older adults that live in them? Most older adults seek to avoid multiple moves to …
Teacher-Student Relationships During Adolescence : The Role Of Parental Involvement, Behavioral Characteristics, Gender, And Income., Amanda Jeane Wyrick
Teacher-Student Relationships During Adolescence : The Role Of Parental Involvement, Behavioral Characteristics, Gender, And Income., Amanda Jeane Wyrick
Electronic Theses and Dissertations
This dissertation provides an examination of contributing factors to high quality teacher-student relationships during adolescence. High quality teacher-student relationships have been linked to better academic, emotional, and social functioning for students in elementary, middle, and high school. While the importance of teacher-student relationships is well documented, less is known about contributors to the relationship, especially during adolescence. Previous research has identified that in younger populations a student's gender, income, behavioral characteristics, and parental involvement can influence the nature of the teacher-student relationship. This dissertation provides an important extension of contributing factors into the adolescent age group, where teacher-student relationships offer …
Evaluation Of Methods For Analyzing Gene-Gene Interaction Data For Survival Outcomes., Jie Zhang
Evaluation Of Methods For Analyzing Gene-Gene Interaction Data For Survival Outcomes., Jie Zhang
Electronic Theses and Dissertations
In recent years, a number of computational and statistical problems for identifying SNP-SNP interactions in high dimensional survival data have been studied, and several data mining approaches have been proposed. However, the relative performance of these methods to detect SNP-SNP interactions has not been thoroughly investigated. In this study, we directly compared the performance of the four techniques to detect gene-gene interactions in a recently conducted study of genetic polymorphisms associated with breast cancer survival and recurrence. Four methods were evaluated for their ability to detect SNP-SNP interactions: Survival Multifactor Dimensionality Reduction, Cox regression with LJ (Lasso) and LJ-L2 (Elastic …
Using Simulation Techniques To Improve The Client Flow Of The Kentucky Cabinet For Health And Family Services., Russell Edward Harpring
Using Simulation Techniques To Improve The Client Flow Of The Kentucky Cabinet For Health And Family Services., Russell Edward Harpring
Electronic Theses and Dissertations
The client flow of the Kentucky Cabinet for Health and Family Services is a complex process that deals with a high volume of clients on any given beginning half of the month. A simulation model of an average busy day in the system was built using the Arena Simulation package. Methods for creating a simulation using Arena are included in this work. Statistics were generated from a number of different sources to create an accurate representation of the model. The simulation model shows long wait times for clients coming into the system to receive benefits. Working with a state budget …
A Water Distribution And Treatment Simulation For Testing Cyber Security Enhancements For Water Sector Scada Systems., Justin Robert Adams
A Water Distribution And Treatment Simulation For Testing Cyber Security Enhancements For Water Sector Scada Systems., Justin Robert Adams
Electronic Theses and Dissertations
Supervisory control and data acquisition (SCADA) systems are used by many critical infrastructures including electric power production and distribution, water and waste water treatment, rail transportation, and gas and oil distribution. Originally isolated proprietary systems, SCADA systems are increasingly connected to enterprise networks and the Internet and today use commercial hardware and software. As a result SCADA systems now face serious cyber-security threats. The need for testing and evaluation of developed cyber-security solutions presents a challenge since evaluation on actual systems is usually not possible and building complete physical testbeds is costly. This thesis presents the design and development of …
Feasibility Of Subcutaneous Ecg Leads For Synchronized Timing Of A Counterpulsation Device., Sean P. Warren
Feasibility Of Subcutaneous Ecg Leads For Synchronized Timing Of A Counterpulsation Device., Sean P. Warren
Electronic Theses and Dissertations
Background: Emerging circulatory support devices that operate in counterpulsation to the native heart require synchronized timing of device ejection and filling on a beat-to-beat basis with the native heart using a patient's ECG. Surface leads are commonly used for short-term patient monitoring but not appropriate for long-term use, and epicardial and non-thoracotomy leads increase the complexity of the device implant/explant procedures. Subcutaneous leads have been shown to be less susceptible to artifacts than surface leads, require less invasive surgery, and have recently been used successfully with a long-term subcutaneous implantable cardioverter-defibrillator. The objective of this study was to develop subcutaneous …
Rpm And Flow Modulation For A Continuous Flow Left Ventricular Assist Device To Increase Vascular Pulsatility : A Computer Simulation, Mock Circulation, And In-Vivo Animal Study., Mickey S. Ising
Electronic Theses and Dissertations
Purpose: Continuous flow (CF) left ventricular assist devices (LVAD) support diminishes vascular pressure pulsatility. Despite its recent clinical success and reliability, CF LVAD support has been associated with adverse events including gastrointestinal bleeding, aortic valve insufficiency, and hemorrhagic strokes. To overcome these limitations, we have developed flow/RPM modulation algorithms to provide vascular pulsatility using a CF LVAD. Methods: The effects of timing and synchronizing the CF LVAD flow/RPM modulation to the native ventricle, modulation amplitude, and modulation widths were studied on the native ventricle and vasculature using computer simulation, mock loop, and animal model studies. A total of over 100 …
Employee Health And Fitness Programs Within Educational Settings: An Examination Of Job Satisfaction And Intent To Stay, Jennifer Lea Malouff
Employee Health And Fitness Programs Within Educational Settings: An Examination Of Job Satisfaction And Intent To Stay, Jennifer Lea Malouff
Electronic Theses and Dissertations
Teachers are at the frontline of education and student learning; districts and schools are investigating innovated, yet cost-effective, ways to positively address organizational variables such as job satisfaction and immediate intent to stay. The implementation of employee health and fitness program could be a relatively simple way to not only address these issues but also positively impact the health and overall well-being of all employees. Even with the supporting research regarding employee health and fitness programs, gaps and contradictions still exist; future research is necessary in order to draw conclusions regarding program value and justification. The present study therefore sought …
Using The Theory Of Reasoned Action And Planned Behavior To Create A Point-Of-Use Water Treatment Behavior-Change Campaign Within The Safe Water System, Kelly Fenson-Hood
Using The Theory Of Reasoned Action And Planned Behavior To Create A Point-Of-Use Water Treatment Behavior-Change Campaign Within The Safe Water System, Kelly Fenson-Hood
Electronic Theses and Dissertations
During the summer of 2010, formative field research was collected in Kibera, Africa’s largest urban informal settlement, located in Nairobi, Kenya. Research explored how a Western-developed behavior-change theoretical model could be applied in a developing country. Data was collected through focus groups, a case study and direct observations. Recommendations were made for an intervention to reduce the incidence of childhood diarrhea. A campaign was proposed that promoted consistent and sustainable use of the Safe Water System, that is, point-of-use drinking water treatment and safe drinking water storage. Results revealed that it was indeed feasible to apply the Western model, Theory …
Executive Function Development And Early Mathematics: Examination Of Dual Language Learners, Hattie A. Harvey
Executive Function Development And Early Mathematics: Examination Of Dual Language Learners, Hattie A. Harvey
Electronic Theses and Dissertations
This study examined the convergent validity between a third-party rating scale of executive function (EF) and a task-performance measurement of EF; examined the effects of age, gender, and dual language experience on preschool children‘s EF skills (inhibition, working memory (WM), and shifting) and on early mathematical skills; and investigated the contributions of inhibition, WM, and shifting to early mathematical skills. Ninety-two children attending Head Start were assessed. Correlation analyses revealed a number of relationships between the EF rating scale and the EF taskperformance measure. A multivariate analysis of variance revealed a main effect of age on all EF measures and …
Nuclear Dependence: The Russian Federation's Future Reliance On Nuclear Weapons For National Security, Adam J. Lukszo
Nuclear Dependence: The Russian Federation's Future Reliance On Nuclear Weapons For National Security, Adam J. Lukszo
Electronic Theses and Dissertations
The Russian Federation‘s reliance on nuclear weapons for national security will steadily increase over time. Based on current evidence and historical data, the Russian state will be unable to recruit, arm, train, equip, reform, and fund their conventional forces well enough to match up with capabilities of what it views to be its potential adversaries. Russia‘s historic experience with invasion and vulnerable geographic position reinforce the need for a powerful weapon with which to maintain the current regime and ensure its territorial integrity. Declining demographics and persistent social illnesses will reduce the number of eligible male candidates able to serve …
Teacher Perceptions Of Leadership In High Poverty Schools, Devin C. Dillon
Teacher Perceptions Of Leadership In High Poverty Schools, Devin C. Dillon
Electronic Theses and Dissertations
The purpose of this study was to determine the priorities of school principals in high poverty schools that have the potential to make the greatest impact on student achievement. The study utilized secondary data analysis of a survey given to all Colorado educators to measure perceptions of school conditions, including leadership, along with school student achievement data. The TELL (Teaching, Empowering, Learning and Leading) Colorado survey was administered online to educators. The survey constructs were analyzed using Leithwood and Riehl’s framework for effective leadership actions. These actions include: setting direction, developing people, redesigning the organization and managing the instructional program. …
Development Of Wearable Sensors For Body Joint Angle Measurement, Saba Bakhshi Khayani
Development Of Wearable Sensors For Body Joint Angle Measurement, Saba Bakhshi Khayani
Electronic Theses and Dissertations
This thesis presents the development of three different methods for body joint angle measurement using wearable sensors. Continuous monitoring of patients' movements and activities has recently become one of the active research areas in the field of body sensor network and telehealth monitoring. For many medical and rehabilitation applications, a continuous monitor of the patients' daily activities at home without visiting the hospital is desirable. This type of monitoring is beneficial for the therapists and physicians as it does not require patients' physical presence. Traditionally, measuring the range of motion (ROM) is performed in hospitals by utilizing standard tools such …