Digital Commons Network^™

Development Of Rationally Designed Live Attenuated Vaccines For Lassa Fever And Venezuelan Equine Encephalitis., Dylan Macgregor Johnson

Electronic Theses and Dissertations

Lassa Virus (LASV) and Venezuelan Equine Encephalitis Virus (VEEV) are two single stranded RNA viruses belonging to the Arenavirus and Alphavirus families, respectively. Both are emerging pathogens without approved vaccines or treatments. VEEV is an important biothreat pathogen because it has been weaponized and is extremely infectious as an aerosol. VEEV causes biphasic febrile illness that can progress to a viral encephalitis with low mortality, but high morbidity. LASV causes a viral hemorrhagic fever, Lassa Fever (LF), which is endemic in West Africa, and responsible for between 100-500k annual infections with a 1-2% overall mortality rate. ML29 and VEEV TC-83 …

Role Of Plant Volatile Organic Compounds (Vocs) In Seed Priming And Plant-Herbivore Interactions., Abhinav Kumar Maurya

Electronic Theses and Dissertations

This dissertation explores and expands the existing knowledge on the role of plant volatiles in facilitating seed priming and providing direct defense against herbivore. Although the roles of plant volatiles in priming a plant’s defenses and providing direct defense against pests is well known, information regarding their effects on seed and the fitness of future plants and direct toxicity to herbivores is understudied. This dissertation does a thorough examination of these two understudied aspects of plant volatiles and provides novel insight into the role of plant volatiles in seed priming and direct defense (Chapter I). Seeds in the soil can …

Black Middle-Class Neighborhoods In Louisville Through Multiple Lenses., Jamar M. Wheeler

Electronic Theses and Dissertations

This dissertation is an articles-based, mixed methods study that analyzes Black middle-class neighborhood attainment in Louisville. Racialized social structure theory is the theoretical framework that is employed to make sense of the adverse positionality of Black middle-class neighborhoods. Racialized social structure theory posits that individuals are placed in racial categories that are hierarchically arranged, which, at the neighborhood level, translates to White and Black householders advancing their material interests in competing ways. These competing interests are asymmetrical in terms of power relations, which means that the neighborhood choices of the Black middle-class are constrained by the routinized ways that the …

American Nocturne., Zahid Saeed

Electronic Theses and Dissertations

American Nocturne is a photographic meditation on the nature of America. There is a long tradition of American photographers looking around their localities to look for this feeling. Using the aesthetics of straight photography, I have worked with a largeformat view camera to search for America. The prism through which I view America is a mixture of both a veneration, an abiding fascination, and at the same time a deep ambivalence towards an overbuilding, overproducing, and over wasting culture. My hope with American Nocturne is to present my view of America, with its contradictions and its beauty. For me the …

Geographic Imaginaries Of Urban Spatial Segregation: A Case Study Of The West End Neighborhoods In Louisville, Kentucky., Amber Dock

Electronic Theses and Dissertations

The objective of this thesis is to translate the framework of geographic imaginaries into an urban context in order to capture a narrative of how residents conceptualize and experience segregation. This framework is rooted in an investigation of local discourses as they exist within a specific social, political, and historical context. Institutionalized segregation and structural racism are the foundations on which the American urban context studied here was built upon. This study employs multiple methods, including contextualizing the study area, analyzing discursive content, and visualizing the results. The results of these analyses included empirically connecting concentrations of protected classes to …

Preventable Hospitalization Among Type 2 Diabetes Patients In Kentucky Before And After Medicaid Expansion 2010-2017., Turky Jamil Arbaein

Electronic Theses and Dissertations

Objectives: 1) Analyze county level variation in T2DM-PH rates in Kentucky before ACA (2010-2013) and after the ACA (2014-2017). 2) Analyze the relationship between county level socioeconomic factors (income per capita, percentage of uninsured people, percent of urban population, primary care and general preventive offices, population aged 65 and above, median age, household income, percentage in poverty, and unemployment rate ) and county level T2DM-PH rates before (2010-2013) and after (2014-2017) ACA implementation in Kentucky. Method: This research was conducted in two phases: Phase one of this study estimated the county-level PH variation among T2DM patients across eight years (2010-2017), …

White Moves First: Unearthing White Privilege In The Modern Board Game., Darrell A. Johnson

Electronic Theses and Dissertations

This dissertation focuses on the design choices in the modern board game and argues that game designs emerge from and constitute dominant ideologies that endorse and secure white male superiority. This dissertation utilizes Michel Foucault’s archaeological method to “unearth” ideologies that cultural artifacts both emerge from and constitute. The project considers three central questions: 1) How does the locus of production and consumption impact the dominant ideology underlying game design? 2) How do design choices secure and constitute an ideology of white male dominance? 3) What impact does the normalization of white dominance have upon the broader community? This dissertation …

Portrait Of Modern Pluralism: A Practitioner's Perspective On Interest Group Politics And Theory., Mary Ellen Wiederwohl

Electronic Theses and Dissertations

This thesis presents a practitioner’s view on interest groups and interest group theory based primarily on Mancur Olson’s conclusions that small, organized minority interests have an advantage over the large, disorganized majority interests in the policymaking process; it tests the “why” behind this theory through an examination of a variety of factors, including the influence of money, the power of communications tools deployed by these interests, and the lobbyists’ role. It includes an introduction plus four chapters, including literature review, research methods, participant observations and in-depth interviews, and conclusion. The research methods included primarily participant observation based on a two-decade …

Analyzing The Effects Of Of Seasonal Land Cover And Precipitation On The Sediment Delivery Ratio Of An Agriculture Dominated Watershed., Jonah Liebman

Electronic Theses and Dissertations

Soil erosion is of escalating importance as increasing population and climate change have put increasing pressures on agricultural food production. Vegetation and precipitation are two factors that control the amount of soil erosion extant within a region. Sediment delivery ratios (SDRs) assess the ratio of soil eroded from a watershed system that is permanently removed from the system through stream sediment discharge. Using 1) river discharge and sediment concentration data and 2) the Revised Universal Soil Loss Equation (RUSLE), this thesis analyzes fluctuations in monthly SDRs for an average hydroclimatological crop-harvest season for the Senachwine Creek watershed, IL. Through calculating …

Food Insecuity In Historically Disenfranchised Parts Of Jefferson County, Ky., Kaitlyn Smith

Electronic Theses and Dissertations

The objective of this study is to investigate the availability of fresh and nutritious foods in Louisville’s West End communities. This study operates under the assumption that residents in Jefferson County have unequal access to food. This study also addresses the question of how residents and local non-profits feel about strategies that build community through food. This study is significant because across Louisville, more than 120,000 people are living with food insecurity, meaning they don't have reliable access to healthy, affordable food (Dare to Care 2019). Multiple reports that have been commissioned by local non-profits and metro departments in the …

Students’ Perceptions Of Campus Sexual Assault Resources: An Appalachian Perspective, Rychelle Moses

Electronic Theses and Dissertations

Research relating to campus sexual assault has traditionally focused on its prevalence and factors that serve to influence risk of victimization. Less attention has been directed toward the presence and effectiveness of campus sexual assault resources. In addition, few studies have explored the role that culture and other geographical factors may play in this process. The current study seeks to address this limitation in two unique ways: (1) determining whether an Appalachian upbringing influences knowledge of and willingness to utilize campus sexual assault resources and (2) exploring its impact on adherence to common rape myths. Survey data are gathered from …

Supplemental Instruction In First-Year Chemistry Courses: Efficacy And Gender Balance, Deidre R. Johnson

Electronic Theses and Dissertations

Increasing student success and retention rates are top goals for many higher education institutions. Supplemental Instruction (SI) is a widely used academic support program designed to increase students’ academic performance and provide students the learning skills they need to persist to graduation. Unfortunately, a lack of time, personnel, and resources often prevent in-depth, meaningful analysis on the effectiveness of SI programs. This study examined the relationship of attending SI sessions for first-year chemistry courses to student grade outcomes and retention rates for attendees. The gender of SI leaders and SI participants was also assessed to determine if leader and participant …

Association Of Perfluorinated Chemicals With Endocrino-Carcinogenetic, Obesogenic And Metabolic Health And With Markers Of Chronic Inflammation And Oxidative Stress, Ogbebor Enaholo Omoike

Electronic Theses and Dissertations

First, this study examined the association of perfluorinated chemicals with 1) cardio-metabolic health outcomes and 2) the association of phthalates with cardiometabolic health outcomes, and 3) cardio-metabolic health outcomes while assessing the possibility of additive interactions between perfluorinated chemicals (PFCs) and phthalates. Second, association with markers of chronic inflammation and oxidative stress were explored. Finally, this study examined the association of these chemicals with estrogenic cancers- Breast cancer, prostate cancer, uterine cancer and ovarian cancer.

Using data from the National Health and Nutrition Examination Survey (NHANES), logistic regression models were used to investigate the relationship between PFCs and the cardio-metabolic …

Changes In Land Use Land Cover (Lulc), Surface Water Quality And Modelling Surface Discharge In Beaver Creek Watershed, Northeast Tennessee And Southwest Virginia, Tosin James

Electronic Theses and Dissertations

Beaver Creek is an impaired streams that is not supporting its designated use for recreation due to Escherichia coli (E.coli), and sediment. To address this problem, this thesis was divided into two studies.

The first study explored changes in Land Use Land Cover (LULC), and its impact on surface water quality. Changes in E.coli load between 1997-2001 and 2014-2018 were analyzed. Also, Landsat data of 2001, and 2018 were examined in Terrset 18.31. Mann-Whitney test only showed a significant reduction in E.coli for one site. Negative correlation was established between E.coli load, and Developed LULC, Forest LULC, and …

The Impact Of State-Level Laws On Syringe Service Program Access And Risk Environment Of People Who Inject Drugs (Pwid), Samuel Pettyjohn

Electronic Theses and Dissertations

Background: Understanding concentrated areas with high rates of opioid use disorder (OUD) allows for improved placement of Narcan access points through syringe services programs (SSPs). People Who Inject Drugs (PWID) have lower risk of contracting infectious diseases the closer they are to SSPs. Tennessee law prohibits SSPs within 2000ft of a school or park, impacting the placement of SSPs in non-urban areas. Testing factors related to SSP siting placement within a system dynamic model can better determine the relationship between PWID risk environment and SSP access and utility.

Methods: We identified areas of greatest need for harm reduction interventions within …

Archaeological, Geophysical, And Geospatial Analysis At David Crockett Birthplace State Park, In Upper East Tennessee, Reagan Cornett

Electronic Theses and Dissertations

A geophysical survey was conducted at David Crockett Birthplace State Park (40GN205, 40GN12) using ground-penetrating radar (GPR) and magnetometry. The data indicated multiple levels of occupation that were investigated by Phase II and Phase III archaeological excavations. New cultural components were discovered, including the remnants of a Protohistoric Native American structure containing European glass trade beads and Middle Woodland artifacts that suggest trade with Hopewell groups from Ohio. A circular Archaic hearth was uncovered at one meter below surface and similar deep anomalies were seen in the GPR data at this level. A semi-automated object-based image analysis (OBIA) was implemented …

Health And Academic Achievement In College And University Students, Amber Beane

Electronic Theses and Dissertations

The purpose of this non-experimental quantitative correlational study was to investigate the relationship between academic achievement and health in a national sample of college students using quantitative data analysis. Specifically, the researcher analyzed the relationship between three health-promoting behaviors (physical activity, strength training, and fruit and vegetable consumption), three negative health behaviors (cigarette, e-cigarette, and opioid use) and obesity with GPA.

Cross-sectional data on student health collected from the American College Health Association’s National College Health Assessment II (ACHA-NCHA-II) and completed by 426,650 college students from 650 U.S. colleges during the semesters between 2015 and 2019 formed the foundation for …

Holler, Ashley Gregg

Electronic Theses and Dissertations

The artist discusses her Master of Fine Arts thesis exhibition Holler, held at Tipton Gallery March 2^ndto March 13^th, 2020. The exhibition features an installation of works on fiber, paper, and found objects tied to her upbringing in Southern Appalachia. A variety of collected materials including bedsheets, chalkboards, and barbwire are taken out of their traditional contexts and brought into a new vantage point through the artist’s alterations.

Gregg re-contextualizes materials, language, and signifiers as a process of decoding formative experiences in domestic and academic spaces. Themes examined in the work include rote learning, tradition, …

Rural-Urban Variations In Meals On Wheels Programs, Lea C. Florence

Electronic Theses and Dissertations

Older adults are living longer than ever before. By 2060, the U.S. population aged 65 or older is projected to reach 98 million. As adults age, the prevalence of chronic diseases and disabilities increases. The need for Meals on Wheels (MOW) services is growing alongside the aging population. Yet, little is known about the geographic variation of services. Little is documented about the organizational capacity of MOW organizations in terms of geography. The current policies supporting home-and community-based services, including MOW, may be insufficient to support all older adults in all types of communities. An analysis of the More Than …

A Tale Of Two Species: Black-Tailed And White-Tailed Prairie Dog Biogeography From The Last Interglacial To 2070, April Dawn Bledsoe

Electronic Theses and Dissertations

Ecological niche models (ENMs) were created for White-tailed and Black-tailed prairie dogs and projected into the Last Interglacial (LI), the Last Glacial Maximum (LGM), and mid-Holocene (mid-H) to discern possible past suitable habitat for both species. Additionally, ENMs were projected into the future year 2070 representative concentration pathways (RCPs) 2.6 and 8.5 to discern how climate change may affect future habitat suitability. Kernel density estimations, minimum convex polygons, and median distribution centers of White-tailed and Black-tailed occurrence records were examined between time-periods to discern the effects of anthropogenic westward expansion on both species’ distributions. Current ENMs were constructed from commonly …

Applications Of Digital Remote Sensing To Quantify Glacier Change In Glacier And Mount Rainier National Parks, Brianna Clark

Electronic Theses and Dissertations

Digital remote sensing and geographic information systems were employed in performing area and volume calculations on glacial landscapes. Characteristics of glaciers from two geographic regions, the Intermountain Region (between the Rocky Mountain and Cascade Ranges) and the Pacific Northwest, were estimated for the years 1985, 2000, and 2015. Glacier National Park was studied for the Intermountain Region whereas Mount Rainier National Park was representative of the glaciers in the Pacific Northwest. Within the thirty year period of the study, the glaciers in Glacier National Park decreased in area by 27.5 percent while those on Mount Rainier only decreased by 5.7 …

A Comparative Evaluation On The Impact Of Financial Coaching In Increasing Financial Capability For Low-Income Individuals In An Employment Program, Desiree Sanabria Guadamuz

Electronic Theses and Dissertations

People living under the poverty line are more likely to practice negative financial behaviors and have low financial capability than those living at a higher socioeconomic level, this hinders low income individuals from properly navigating the complex financial market. Recent research has found that financial coaching bundled with employment trainings, income support, and financial trainings/workshops will increase financial capability. However, additional studies on the impact of financial coaching in increasing financial capability are needed. The following research aimed to contribute to the existing literature on the impact of financial coaching in the context of an integrated service model by analyzing …

Strategies Exemplary Social Studies Teachers’ Implement When Facilitating Discussions About Race, Candice Nicole Jasmer

Electronic Theses and Dissertations

Teachers experience difficulty in introducing some sensitive and controversial issues in the classroom environment. The purpose of this qualitative instrumental case study was to identify strategies that exemplary secondary social studies teachers implement when facilitating classroom discussions about sensitive and controversial issues, specifically, racial issues framed within Singleton and Linton’s 4 agreements of courageous conversations: stay engaged, speak your truth, experience discomfort, and accept and expect nonclosure. This study utilized qualitative data collection. Semi-structured, online one-to-one internet-based interviews were used to document the lived experiences of exemplary secondary social studies teachers and the strategies they use when facilitating discussions about …

Urban Informality, Environmental Xenophobia, And Infrastructures Of Citizenship: The Political Lives Of Nicaraguan Migrants In The Informal Settlement Of La Carpio, Costa Rica, Nikolai Alexander Alvarado

Electronic Theses and Dissertations

This dissertation examines urban politics, environmental justice, and infrastructure from the vantage point of South-South migration. It focuses on the work of Nicaraguan migrants living in the informal settlement of La Carpio in San José, Costa Rica, as they negotiate rights in the form of urban services. Nicaraguans in La Carpio have organized politically since 1993 to self-install, demand, and negotiate services such as potable water and electricity. In the process, they successfully compel local authorities to allocate these services and grant them an implicit recognition of their right to remain and live a decent life, regardless of their status. …

Educational Achievement, Engagement, And Persistence In Choctaw Nation: A Study Of The Success Through Academic Recognition Program, Suzanne Delap

Electronic Theses and Dissertations

The Choctaw Nation of Oklahoma has developed a unique initiative to support academic achievement within their tribal territory. The Success Through Academic Recognition (STAR) program is an example of an Indigenously-developed approach to supporting students from grades 2-12, with the hope of promoting achievement, persistence, and engagement. To study the STAR program, a mixed-methods approach was employed to first analyze quantitative demographic and performance data collected from a cohort of high school students from 2014 to 2018. Next, phenomenological interviews were conducted within the same cohort, to describe the lived experiences of STAR students within the Choctaw community. The database …

Subalpine Forest Tree Seedling Response To Drought, Alex Goke

Electronic Theses and Dissertations

Knowledge of tree species’ ability to tolerate drought is necessary to anticipate future forest dynamics with climate change, especially at the seedling stage given their role in shaping forest structure. We used precipitation reduction shelters to mimic drought for subalpine conifer seedlings (A. lasiocarpa and P. engelmannii) in the Rocky Mountains and compared survivorship and morphological and physiological responses to assess relative degrees of drought tolerance. We detected no significant investment in morphological tolerance traits (e.g. root biomass, leaf:stem area ratio) but substantial reductions in net photosynthesis. While shading partially ameliorated drought effects when precipitation reduction was moderate, …

Spatial And Temporal Controls On Streamflow Variability In The San Juan Mountains, Colorado, Christopher Lewis Hancock

Electronic Theses and Dissertations

This project characterizes and examines changes to the annual hydroclimatic cycle throughout alpine regions of Colorado with a focus on trends in snowpack and snowmelt hydrology. Datasets analyzed for this research include 79 SNOTEL sites throughout Colorado (24 in the San Juan Mountains) which provide climate metrics for Water Years 1988-2018. Impacts on streamflow are evaluated in the San Juan Region through a network of 11 USGS stream gauges. Correlation matrices and linear regression methods examine the relative controls on the magnitude and timing of discharge, and trend detection using the regional Kendall test quantifies the rate of change within …

U.S. Democratization In Post-Cold War Russia: A Critique, Franklin T. Hughes

Electronic Theses and Dissertations

States are path dependent entities that deviate solely in the face of catastrophic failures in the pursuit of axiomatic ends by conventional means. The inertia of bureaucratic institutions, a foreign policy consensus within a self-reproducing elite of experts, the self-interest of political elites and a sense of “national self” or identity lead states to understand themselves in light of a history and a relative level of status on the world stage. Since the end World War II, the U.S. has a certain path that places the spread of democracy and laissez-faire capitalism extremely important if not vital foreign policy goals. …

The Experiences Of Ncaa Student-Athletes With An Eating Disorder Or Disordered Eating, Rachel E. Taylor

Electronic Theses and Dissertations

The purpose of this study was to explore the experiences of student-athletes who had an eating disorder or disordered eating (ED/DE) while competing for the National Collegiate Athletic Association (NCAA). Integrating criticism and connoisseurship and critical evocative portraiture, four post-collegiate women who participated in cross country and track, who were either clinically diagnosed with an ED/DE or who self-diagnosed, participated in two interviews to describe their experiences with and the impact of ED/DE on their athletic pursuits, academic pursuits, as well as their relationships with coaches, teammates, and family. The analysis of these interviews showed the complexity of this topic. …

Retaining Gifted Individuals For The Sustainability Of Rural Communities, Jessie B. Matthews

Electronic Theses and Dissertations

Retaining Gifted Individuals for the Sustainability of Rural Communities examined the supports and barriers to young gifted adults’ choices regarding living in rural communities. The narrative methodology revealed the perceptions of remote rural community members through single, face-to-face interviews to understand the challenges and opportunities young gifted individuals encounter. Through community member interviews, participants echoed sentiments indicating supports, barriers, and the power of place play a significant role in gifted individuals’ desire to remain in their local community. The findings suggested through celebrating place, engagement in the local community, and encouragement to solve local problems, gifted individuals will engage in …