Digital Commons Network^™

Akt Disruption Leads To Non-Canonical Apical Constriction In Drosophila Embryos, Vincent Brown

Electronic Theses and Dissertations

The Akt/mTOR pathway (Akt pathway) has largely been examined in terms of its role as the primary nutrient sensing pathway due to its ability to recognize nutrient availability within a cell, particularly amino acids and glucose. Among its nutrient sensing characteristics, this pathway also contributes to a large variety of other cell functions such as cell growth, proliferation, protein synthesis, and cell survival via anti-apoptotic signaling. Although many aspects of this pathway have been carefully studied, the extent to which it regulates embryonic development remains unclear. Here, I examine Akt function in the early Drosophila embryo and demonstrate that Akt …

Influences On Small Business Leaders’ Decisions About Supportive Policies And Practices For Employees Who Have Experienced Intimate Partner Abuse, Marilyn Lucille Brock

Electronic Theses and Dissertations

Intimate partner abuse affects millions of individuals from all segments of society, and existing literature demonstrates that it has extensive impacts on American companies through loss of workplace productivity, reduced workplace safety, and employee turnover. While several supportive policies and practices have been suggested for implementation in business environments, many business leaders do not perceive the utilization of such measures as having business value. Thus, this study addresses the question, What influences business leaders’ decisions about whether and to what degree to adopt policies and practices for responding to employees’ experiences of intimate partner abuse? This dissertation is a qualitative …

The Effect Of Financial Disclosure Medium And Ceo Gender On Perceptions Of Overconfidence And Credibility, Sheryl Moriarty

Electronic Theses and Dissertations

I experimentally examine how investors react to an unexpected negative earnings announcement delivered using video versus audio by an overconfident female CEO versus an overconfident male CEO. The results show that the CEO's gender does not matter in terms of the delivery medium. I predict and did not find that CEO overconfidence is lower for a financial disclosure delivered by video as opposed to audio only. Further, the hypothesis that the perception of female CEO overconfidence is higher versus male CEO overconfidence was not supported. Overall, the participants in the study did not find either the male or the female …

On Salvation And Genre: Fast Sermons In Seventeenth-Century New England, Daniel Patrick Mcgee

Electronic Theses and Dissertations

The fast sermon is an important and overlooked genre in the literary history of colonial New England, one which complicates theories about American puritanism underwritten by the imprecise narrative construct of the jeremiad. This thesis will argue that preachers used fast sermons to shape their communities, respond to major events, and provide competing interpretations of Congregationalist doctrine throughout the seventeenth century. Borrowing from the methodologies of new formalist criticism and Louis Althusser’s theory of material ideology, it will examine common themes, motifs, and rhetorical demands in John Wheelwright’s 1637 Fast Sermon, Thomas Shepard’s 1645 Wine for Gospel Wantons, …

Investigating Servant Leadership Measurement: A Mixed-Methods Study Integrating Content Analysis And Meta-Analysis, Kai Torsten Schramm

Electronic Theses and Dissertations

This study aimed to understand the similarities and differences among servant leadership measures and the variations in their effect sizes on job performance and job satisfaction. This paper explores how the items in servant leadership measures portrayed the servant leadership construct and how these relate to the outcomes. The researcher used an exploratory sequential mixed methods design. Which involved a qualitative content analysis of the measurement items and a meta-analysis of outcomes, considering the findings from the content analysis. Six key categories determined the three main themes: selfless generosity, inspiring influence, adaptive humility, integrity, empowering, and harmonious engagement. The three …

Settler Colonialism And Refusal Through Indigenous Eyes, Charlie Amáyá Scott

Electronic Theses and Dissertations

The educational system within the united states has benefited and continues to benefit from the structures and systems of settler colonialism. Yet, despite such colonizing goals of displacement, removal, and genocide, Indigenous Peoples are still here. This critical Indigenous qualitative research study sought to understand descriptions and interpretations of settler colonialism from the perspectives of Indigenous undergraduate students and how they have, refused settler colonialism while navigating their undergraduate journeys. Indigenous ways of knowing and ways of being were centered and cited in a manner that made this dissertation more than just a research study; it became a home where …

A Radical Ethnography Of Asian American Mental Health, Sofia Huang

Electronic Theses and Dissertations

Anti-Asian racism and violence in the U.S. both historically and currently impacts the Asian American community, leading to widespread fear and negative mental health consequences for Asian Americans. This has been widely discussed in the media due to the rise in anti-Asian rhetoric and attacks during the COVID-19 pandemic. However, psychological literature does not typically address the effects of the history and politics of Asian America on Asian American mental health. In particular, psychological literature does not engage with radical political perspectives which situate Asian American mental health within the broader context of structural oppression and processes of racialization. This …

Designing An Educational Robotics Curriculum To Teach Mathematical Concepts While Fostering A Growth Mindset: A Self-Study, Lauren Harter

Electronic Theses and Dissertations

This study explores the development and implementation of a five-day curriculum designed to enhance students' understanding of algebraic concepts through the integration of educational robotics and growth mindset principles. The study is structured around three research questions that investigate influences on decision-making in curriculum design, the alignment of teaching intents with practices, and the impact of self-study on integrating algebra, robotics, and growth mindset principles. Findings reveal themes focused on the importance of research and collaboration, using the Understanding by Design (UbD) framework, intentional curriculum creation, starting somewhere, personal growth and self-reflection, and experiencing and embodying constructivism in action. The …

Examining The Effectiveness Of The Parent Implemented Functional Communication Training Through The Use Of Zoom In Children With Developmental Disabilities At Home Setting In Ksa, Abdulrhman Ashgar

Electronic Theses and Dissertations

Studies showed that children with Developmental Disabilities (DD) have communication and social difficulties; consequently, they are more likely to display disruptive behaviors. During daily interactions, disruptive behaviors can pose difficulties for individuals such as siblings, peers, parents, and educators. In KSA, parental involvement in school-related activities is overall insufficient. Also, parents were dissatisfied with their children's progress in academic and life skills. Those factors evoked the importance of having parents implement evidence-based practice to increase their competence, knowledge, and independence. Furthermore, teaching children meaningful communication ways through FCT may benefit school readiness and the development of social relationships and overall …

Making And Breaking Bonds: Studying Intrinsic Chemistry In The Gas-Phase, Luke Metzler

Electronic Theses and Dissertations

The nature of chemical interactions can be difficult to ascertain in the condensed phase; chemistry can be observed, but with the plethora of variables such as solvation, mixes of counter-ions, and complex equilibria, the true intrinsic chemical properties of a given chemical species may be obfuscated. By conducting research in the gas-phase, many of these variables can be reduced, if not eliminated entirely, which can allow for the careful observation of the true physical phenomena driving chemical reactivity.

The research presented herein focuses on the use of ion-trapping (specifically in a linear ion trap) as a method for unveiling the …

Injectable Formulations For Localized Delivery Of Immunomodulators, Ketki Velankar

Electronic Theses and Dissertations

Dysregulation of immune homeostasis is fundamental to the development of autoimmune disorders. Fibroblastic reticular cells (FRCs) within lymph nodes play crucial roles in forming a microenvironment conducive to immune cell interactions and regulating autoreactive T cells driving autoimmune diseases. Studies have shown the potential of FRCs as a form of personalized cell therapy to correct dysregulated immune responses. Successful translational efforts, however, require the cells to be formulated as injectable suspensions while retaining their native architecture, which is essential for their regulatory functions. The main challenge resides in retaining the native reticular organization of FRCs lost in conventional monolayer cultures …

Being And Sacrifice: An Essay On Hegelian Logic, Mitch Thiessen

Electronic Theses and Dissertations

A study of Hegelian logic in relation to postmodern thought, this essay investigates the limits and contemporary significance of Hegel’s concept of knowledge, both on its own terms and from the perspective of three of its most polemical critics: Søren Kierkegaard, Friedrich Nietzsche, and Georges Bataille. Of especial consequence in this study are the themes of individuality, desire, history, and death, insofar as Hegel’s critics judge him to have inadequately come to terms with—and to have even suppressed—the truth or fact of these realities, all of which are potentially fatal for his theory of the subject.

The Ethical Duty Of Care For Suicide Ideation, Tah Ngijoi Yogo

Electronic Theses and Dissertations

With suicide being a leading global cause of death, there is a need to explore the ethical complexities surrounding suicide and preventive measures. This dissertation questions the morality of suicide by examining the historical and philosophical dimensions across cultures and religions. The text argues for an approach that acknowledges rational suicide while developing the ethics of paternalistic measures for suicide prevention of vulnerable populations.

Considering the ethics of autonomy, the dissertation discusses the practice of nudging in healthcare to highlight the role of paternalism in supporting informed consent. The text proposes an enhanced autonomy model that balances trust, influence, and …

Steroid Sulfatase In Rodent Tissues And A Cell Line: Characterization, Regulation And Inhibition, Barathi Balasubramonian

Electronic Theses and Dissertations

Inactive sulfated steroids are present in plasma at higher concentrations than unsulfated ones. Steroid sulfatase (STS) is the enzyme that removes the sulfate group from sulfated steroid hormones in local tissues, making them active. High levels of STS are linked to breast and prostate cancers, and low levels of STS cause behavioral disorders and X-linked ichthyosis. STS is present in most tissues, yet its physiological role is uncertain. We sought to characterize STS activity in several rodent model systems in order to learn more about its function. Three different sets of experiments were conducted. First, we examined STS in mouse …

Form And Matter In Kant's Theoretical Philosophy, Aaron Higgins-Brake

Electronic Theses and Dissertations

This dissertation examines the use of the terms “form” and “matter” in Kant’s theoretical philosophy from his earliest publications up to the Critique of Pure Reason (1781). I argue that these two concepts have received unfortunately little attention in the development of Kant’s thought and in his mature writings. I begin in Chapter One by examining his increasing use of them in his pre-critical writings culminating in the Inaugural Dissertation (1770), where he first develops his theory of space as a form of intuition. Then in Chapters Two to Five, I examine his account of them in his accounts of …

The Educational Experiences Of Children And Adolescents With An Ryr1-Related Disease, Jeremy Armann

Electronic Theses and Dissertations

This paper investigates the educational experiences of children and adolescents diagnosed with RYR1-related diseases, a spectrum of congenital myopathies affecting muscle function. Despite these conditions typically sparing cognitive abilities, they profoundly impact physical capabilities, presenting challenges in school environments such as participation in physical activities and social interactions. The study utilizes data collected through the RYR1-Related Disease Educational Impact and Satisfaction Survey (RDEISS) and the Behavioral and Emotional Screening System (BESS) from 49 parents of 51 children aged 3-18 years. Findings reveal prevalent classroom difficulties including handwriting issues and written expression difficulties, with 78% of children receiving special education services, …

Understanding The Supervision Of Counselors In A Grief Process Who Have Experienced A Client’S Death By Suicide., Sean Abaray

Electronic Theses and Dissertations

This qualitative phenomenological study explored the grief experiences of counselors in supervision who have experienced a client's death by suicide. Given that this phenomenological study aimed to explore a new phenomenon of study, the researcher utilized van Manen’s lived existentials as a process for data analysis. The first chapter of the dissertation introduces the problem and includes the research question. The question is: “How do counselors who have experienced a client's death by suicide experience supervision as they work to deal with the loss?" Following this chapter, the researcher reviews relevant literature selections. During the methodology chapter, the researcher describes …

Place And Placelessness: An Ecocritical Approach Towards The Mountain Imagery In Country Music, Siyuan Ma

Electronic Theses and Dissertations

Drawing upon cultural geographer Yi-Fu Tuan’s frame of place and placelessness, this ecocritical project explores how the mountain landscapes serve to construct regional, national, cultural, spiritual, religious, even racialized identities in various human societies. Using the U.S. country music as a primary example, I argue that what country music fundamentally draws from the imagery of the Appalachian Mountains is not the Anglo-Saxon ballad music or pastoral lifestyle of/from the mountains, but the powerful sense of place and placelessness (arguably only) the mountainous scenes are capable to provoke. This exploration serves to illuminate the commonalties between humanities of different cultures and …

The Impact Of Kangaroo Care (Kc) On Parent Stress, Infant Neurobehavioral Regulation, And Parent-Infant Attachment In Very And Extremely Preterm Infants, Justine Vecchiarelli

Electronic Theses and Dissertations

This study examines the high-risk population of infants born atinfants, developmental delays in infants, and parent-infant relationship disruption. Kangaroo care (KC) has shown promise as an intervention to buffer these adverse effects, however, KC engagement in NICUs is obstructed by lack of clear guidelines. Furthermore, limited research exists on KC including infants born atoutcomes, infant behavioral/developmental outcomes, and parent-infant relationship outcomes conjointly. The aim of this study was, therefore, to examine the impact of kangaroo care engagement on precursors of adverse outcomes including parent stress, infant neurobehavioral organization, and parent-infant bonding with the intent of informing clinical practice. Data was …

Made In The Divine Image: The Interface Of Boki Concepts And Pontifical Biblical Commission's Reading Of Genesis 1-2, Luther Raymond

Electronic Theses and Dissertations

Certain images facilitate tailoring our perception of ourselves and the rest of creation in positively practical ways, but others lead us astray and disfigure our relationships. Christians acknowledge that humans are made in the divine image, yet we allow the domineering presence of destructive frames and perceptions to counter our being divine image-bearers. This dissertation explores the intersection of the Boki Beri-be/Keredede motif and the language of the presentation of Genesis 1-2 in the 2019 Pontifical Biblical Commission Document What Is Man? calling for a recognition that humans are the embodiment of the divine presence in creation with a calling …

Effect Of A Systematic Mindfulness Intervention On Student Internalizing, Externalizing, And Adaptive Behaviors, Akshita Nayyar

Electronic Theses and Dissertations

According to Bouchrika (2020), on a scale of 10, American teens rated their stress rate at an average of 5.8, whereas the average stress rate for adults is 3.8. Children with more school problems tend to have more negative and fewer emotions at school and at bedtime (Bai & Repetti, 2017). The most common stressors reported by school-aged children include excessive homework, unrealistic expectations from parents and coaches, peer pressure, standardized testing, and after-school activities (Ryan-Wenger et al., 2005). Schools can address these concerns by providing mental health services within their school settings by collaborating with community agencies within their …

Uptake Of Extracellular Vesicles Into Brain Endothelial Cells And Development Of Motor Neuron-Derived Extracellular Vesicles For Amyotrophic Lateral Sclerosis, Jhanvi Rajan Jhaveri

Electronic Theses and Dissertations

Extracellular vehicles (EVs) are an emerging class of drug carriers and are primarily reported to be internalized into recipient cells via a combination of endocytic routes such as clathrin-mediated, caveolae-mediated and macropinocytosis pathways. In part one of this thesis, (1) we investigated potential effects of homotypic vs. heterotypic interactions by studying the cellular uptake of homologous EVs (EV donor cells and recipient cells of the same type) vs. heterologous EVs (EV donor cells and recipient cells of different types) and (2) determined the route of EV internalization into low pinocytic/hard-to-deliver cell models such as brain endothelial cells ( …

Delivery Of Mitochondria-Containing Engineered Extracellular Vesicles To The Blood-Brain Barrier For Ischemic Stroke Therapy, Kandarp Dave

Electronic Theses and Dissertations

Ischemic stroke is the second leading cause of death worldwide, and the lack of effective treatment options is an unmet clinical need for stroke survivors. Ischemic stroke-induced oxygen-glucose deprivation (OGD) in the affected brain tissue leads to mitochondrial dysfunction and adenosine triphosphate (ATP) depletion in the brain endothelial cells (BECs) lining the blood-brain barrier (BBB). ATP deprivation in the BECs dysregulates actin cytoskeleton dynamics, resulting in BBB breakdown. Restoration of blood flow (i.e., reperfusion) upon the first-line stroke treatment further leads to BBB breakdown and widens the paracellular spaces between BECs. …

Macromolecular Crowding Effects On Enzymes That Display Non-Hyperbolic Kinetics, Kelsey A. Aldrich

Electronic Theses and Dissertations

Macromolecules occupy up to 30% of a cell's volume, yet the in vitro study of biological processes is almost exclusively performed in dilute solutions that fail to approximate the crowded interior of a cell. A growing body of literature has identified that macromolecular crowding has significant effects on a number of biochemical processes, including enzymatic activity. However, changes in kinetic parameters with increased macromolecule concentrations have only been determined for enzymes that follow hyperbolic Michaelis-Menten kinetics, despite the fact that over 25% of enzymes deviate from this model. Here, we perform the first characterization of macromolecular crowding effects on …

Rhetorical Tapestries Of Water Injustice: The Framing Of (In)Access And (In)Justice In The Struggle For Water Security In The United States, Carla R. Richards

Electronic Theses and Dissertations

This dissertation argues that access to clean water is a fundamental human right and a cornerstone of environmental justice. It critiques existing communication and rhetorical scholarship for overlooking the environmental dimensions of water access and justice. This gap hinders progress toward equity for marginalized communities disproportionately burdened by water insecurity.

This project proposes a communication approach that prioritizes culturally relevant strategies to empower these communities in advocating for their environmental rights and health needs. By bridging the communication and environmental justice fields, this project equips communities with the tools to demand fair solutions. It ultimately calls for a transformative shift …

Narrative Forms Of Violence: Fascism, Nazism, And The Holocaust In 20th-Century British Fiction, David Young

Electronic Theses and Dissertations

Narrative Forms of Violence: Fascism, Nazism, and The Holocaust in 20^th-Century British Fiction examines how British authors explore fascist and Nazi violence through narrative. The texts in this project challenge the popular perception of Nazis and fascists and help to enrich the understanding of these character types in artistic representations of fascism and the Holocaust. I seek to reveal how each author in the three central texts examined presents fascist violence’s march toward the mainstream and the ways ordinary people deal with political violence. Each author critically depicts growing fascist regimes in World War II-era Europe and contemplates …

Lateral Others In The Trauma Narrative: The Place Of The Sibling In Accounts Of Abuse And Neglect, Michelle Browne

Electronic Theses and Dissertations

The present study aimed to investigate the place of the sibling in narratives of developmental trauma as well as the sibling relationship’s impact on the formation of sense of self. Another area of interest was the impact of congruence versus incongruence in the narrative between siblings. In other words, this study sought to illuminate the impact when the sibling is understood to have reached different conclusions about shared experiences of abuse and neglect.

This study is grounded in the literature on siblings from psychoanalytic, attachment, and family systems perspectives. A series of narrative interviews were conducted with participants who identified …

Self-Efficacy Towards Teaching, Critical Thinking Dispositions, And Supervision Of Teaching Among Ces Doctoral Students, Brenda Everett

Electronic Theses and Dissertations

According to the 2024 CACREP Standards (2023), “ethical behavior, diversity, equity, inclusion, and critical thinking” are essential for counselor preparation. Thus, doctoral students must be equipped to teach and incorporate “culturally sustaining content and strategies across the eight foundational curriculum areas” into counselor training upon graduation (Section 3, p.12). Given the increase in counselor education programs (Field et al., 2020) and the need for self-efficacious counselor educators (Association for Counselor Education and Supervision [ACES] Teaching Initiative Taskforce, 2016) in these programs to teach the next generation of counselors-in-training, there is a continuous need in the literature for research on self-efficacy …

Chinese Tallow Long-Term Impact On Stand Dynamics In A Bottomland Hardwood Forest Following Vegetation Management, Nicklaus R. Langlois

Electronic Theses and Dissertations

Chinese tallow (Triadica sebifera (L.) Small) is an invasive tree known to have negative impacts on bottomland hardwood forests. Chinese tallow is proficient in reproducing and surviving in bottomland hardwood forests because it is more flood and shade tolerant than most native trees. The long-term effectiveness of Chinese tallow control is an important topic to research as only a few long-term studies of Chinese tallow control have been conducted. A 10-year re-measurement of 22 paired plots installed in 2012 on the Pineywoods Mitigation Bank near Diboll, Texas following herbicide treatments examined Chinese tallow and native tree stand structure. Each …

Rna Secondary Structures: Structure-Function Studies In Viral And Neurodegenerative Diseases, Caylee Cunningham

Electronic Theses and Dissertations

The studies within this dissertation highlight the importance of RNA structure and function, highlighting potential mechanisms in the pathogenesis of the SARS-CoV-2 virus and hallmarks of ALS. Specifically, the s2m, a 41-nt structure found within the hyper variable region of the 3’ UTR of the SARS-CoV-2 virus, was investigated as this element has no definitive role in viruses but its high conservation in several viral families warrants investigation. We used various biophysical techniques to determine if a palindromic sequence in the terminal loop could participate in dimerization activities, which may have implications in recombination and the longevity of the virus. …