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Poly (Adp-Ribose) Polymerase-1 (Parp1) Expression In The Frontal Cortex And Hippocampus In Major Depressive Disorder (Mdd) And Suicide, Ramona Faith Fulkerson

Electronic Theses and Dissertations

Major Depressive Disorder (MDD) is a prevalent psychiatric disorder that has a complex pathophysiology. In this study we evaluate the expression of PARP1 and the downstream alarmin protein high mobility group box 1 (HMGB1) in two brain areas that have demonstrated pathology in MDD. MDD donors were compared to controls. MDD subgroups that died by suicide were also compared to those that did not die by suicide. Immunoblotting to determine PARP1 and HMGB1 protein expression was performed in white and grey matter from the frontal cortex and the hippocampus. In BA10 white and grey matter, PARP1 protein expression was significantly …

Co-Rumination, Psychological Inflexibility, And Internalizing Symptoms In Adolescence, John Parigger

Electronic Theses and Dissertations

Two risk factors for anxiety and depression in adolescence were examined: co-rumination, which occurs when friends excessively talk about problems; and psychological inflexibility, which occurs when one avoids negative feelings and fails to act on values. I hypothesized that psychological inflexibility would exacerbate the effect of co-rumination on adolescent anxiety and depression. Participants were 167 adolescents (Mage = 14.60 years, SD = 1.3; 65.7% cisgender males) who completed standard measures as part of an online survey. Results indicated no moderation effect, but there were main effects of co-rumination and psychological inflexibility on depression symptoms. Co-rumination may relate to …

Informed Consent Document Delivery: Effects On Appalachian Caregivers' Comprehension, Trust In Researchers, And Willingness To Participate, Tess A. Simpson

Electronic Theses and Dissertations

The purpose of the present study was to investigate whether altering an informed consent document (ICD), in ways that either promote or inhibit accessibility, would affect potential participants’ willingness to participate in a child development laboratory-based study. Specifically, I was interested in assessing the willingness to participate of historically underrepresented groups, especially Appalachian caregiver-child dyads. I altered three parameters of a previously approved and employed ICD to explore whether these parameters impacted Appalachian caregivers’ comprehension of the study, willingness to participate, and trust in the researchers. The manipulated parameters included reading level, utilization of illustrative pictures, and inclusion of text-to-speech …

Use Of Computational Methods To Determine The Relative Thermodynamic Stability Of Myricetin, Quercetin And 4-Methylesculetin For Use As Spin Traps, Cole Walker

Electronic Theses and Dissertations

The research conducted focused on the oxidative intermediates of antioxidants known as Myricetin, Quercetin, and 4-Methylesutin by calculating the reaction mechanism. During this research, computational quantum chemistry on selected parts for the 3 antioxidants previously mentioned were performed to find the most stable intermediate to act as a spin trap. The hypothesis is that the intermediates found can act as spin traps which will allow longer preservation of a free radical to be identified using Electron Paramagnetic Resonance (EPR) spectroscopy. This may be because the buildup of excess free radicals in a system leads them to cause damage down to …

Effect Of Chemical Enhancers On Transdermal Delivery Of Amiloride For Management Of Resistant Hypertension, Oluwatosin Tabitha Leshaodo

Electronic Theses and Dissertations

Amiloride, a diuretic used for managing resistant hypertension, is hindered by low oral bioavailability and Gastrointestinal side effects, impacting patient compliance. This study investigates transdermal delivery as an alternative to reduce pill burden and improve adherence. Using dermatomed porcine ear skin, the research examined the passive transdermal delivery of amiloride and the effect of various chemical enhancers, including oleic acid, oleyl alcohol, tocopheryl polyethylene glycol succinate, and N-methyl-2-pyrrolidone, individually or in combination. A validated High-Performance Liquid Chromatography method, adhering to Internal Council for Harmonized guidelines (ICH), was employed for quantitative analysis. In vitro permeation studies, conducted using porcine skin and …

Changes In Blood Lactate And High Intensity Exercise Endurance During A Strength - Endurance Accumulation Training Using Accentuated Eccentric Loading, Nicholas Goode

Electronic Theses and Dissertations

The purpose of this study was to investigate the effects of accentuated eccentric load (AEL) resistance training and changes in work capacity, high-intensity exercise endurance (HIEE) and lactate metabolism. Seventeen recreationally trained subjects (11 males and 6 females) (mean ± SD: age = 23.2 ± 4.2 yrs, BM = 81.3 ± 22.2 kg, height = 172.1 ± 10 cm, male relative back squat (BS) [MD1] strength (1RM*BM^-1) = 1.64 ± 0.32 kg*kg^-1, female relative BS strength = 1.39 ± 0.32 kg*kg^-1) participated in the study. Subjects completed a week of familiarization to participate in …

A Uniformly Most Powerful Test For The Mean Of A Beta Distribution, Richard Ntiamoah Kyei

Electronic Theses and Dissertations

The beta distribution is used in numerous real-world applications, including areas such as manufacturing (quality control) and analyzing patient outcomes in health care. It also plays a key role in statistical theory, including multivariate analysis of variance (MANOVA) and Bayesian statistics. It is a flexible distribution that can account for many different characteristics of real data. To our surprise, there has been very little work or discussion on performing statistical hypothesis testing for the mean when it is reasonable to assume that the population is beta distributed. Many analysts conduct traditional analyses using a t-test or nonparametric approach, try transformations, …

A Qualitative Narrative Study About Mental Well-Being And Coping Strategies In Generation-Z Undergraduate Student Leaders, Lacey Folsom

Electronic Theses and Dissertations

This study was a qualitative narrative on the advantages experienced by Generation Z students who participated in leadership roles within university-sponsored student organizations. This study incorporated generational, coping, and transactional theories to help the researcher establish a potential link between the mental well-being of students and their participation in cocurricular university-sponsored groups. The primary goal of this study was to gain a deeper understanding of how students perceived the influence of their participation in student organizations on their ability to handle mental well-being issues. It sought to explore whether factors such as time commitment, skill development, or an increased sense …

Simulation Study On Confidence Interval Estimation For Standard Deviation With Non-Normal Distributions, Theophilus Oppong Kyeremeh

Electronic Theses and Dissertations

This study explores innovative approaches to constructing confidence intervals for the population standard deviation, σ, in non-normal data scenarios. While the sample standard deviation, s, is widely used, its reliability is compromised when dealing with skewed or heavy-tailed distributions and exhibits sensitivity to outliers. Our research addresses these limitations by investigating alternative estimation methods that offer greater robustness and accuracy.

An Examination Of The Lived Experiences Of Black Women In Senior Leadership Roles At Cccu Member Institutions, Tuccoa Polk

Electronic Theses and Dissertations

This narrative inquiry qualitative research study explored the lived experiences of Black women in senior leadership roles at Council for Christian Colleges & Universities (CCCU) member institutions. Using Black feminist thought as the theoretical framework, this research study centered on the voices of 10 current or recently retired Black female senior-level leaders at CCCU campuses. The research study focused on one central research question and three subquestions that examined the challenges and barriers experienced by the participants, the role of mentorship in their leadership journey, and the impact of the participants’ Christian faith in their career trajectory to senior leadership …

Diversity Management And Organizational Resilience Among Midsized Cccu Institutions In Christian Higher Education, Kristopher M. Sutton

Electronic Theses and Dissertations

This exploratory qualitative cross-case analysis was developed to investigate how diversity management strategies were implemented and whether they coexist with organizational resilience capabilities at three U.S. private, midsized Christian-affiliated institutions of higher education associated with the Council for Christian Colleges & Universities. The researcher collected data from a senior-level chief diversity officer at each institution to determine how their diversity strategy was managed and whether a mature diversity program was concurrently present with organizational resilience capabilities. Data were collected using two primary instruments: the Diversity Management Competencies Questionnaire and semistructured interviews focused on organizational resilience. The collected data were supplemented …

Parental View On Hpv Vaccination, Rebecca Elaine Rhodes

Electronic Theses and Dissertations

The human papillomavirus (HPV) is a sexually transmitted infection widely seen in the United States. Millions of Americans are affected by it each year, especially those in their late teens and early 20s. Although most infections will resolve on their own, 1 in 10 will lead to health problems such as cancer. The HPV vaccine can prevent over 90% of associated precancers and cancers. However, uptake of the HPV vaccine and its completion among adolescents are significantly lower than other recommended adolescent immunizations, falling short of the Healthy People 2030 goal of 80% coverage. Understanding parental attitudes, beliefs, and perceptions …

Trust, Transparency, And Transport: The Impact Of Privacy Protection On The Acceptance Of Last-Mile Drone Delivery, Jurgen Heinz Famula

Electronic Theses and Dissertations

A common set of problems commercial delivery companies face is finding ways to increase the efficiency and reliability of the “last mile” of a package’s journey, all while reducing operating costs. This need for efficiency has driven many companies to explore using unmanned aerial vehicles (UAVs), or drones, to get packages to their final destination. Although UAVs have great potential to help increase efficiency in commercial package delivery, this comes at a potential cost to the privacy of people who intersect the flight paths of these unmanned vehicles. This thesis explores the effect of a mobile phone application for commercial …

Bridging Design And Perception: Novel Tools And Technologies For Creating Effective Human-Robot Interactions, Benjamin Dossett

Electronic Theses and Dissertations

This thesis explores human perception of robots through the use of novel tools and technologies. First, the impact of Augmented Reality (AR) data presentation on human perception of robots is investigated. A study conducted with the AR human-robot teaming system found that robot performance significantly influenced participants’ perceptions, overshadowing the impact of matching or mismatching robot confidence feedback. Second, the DU Want to Build-A-Bot platform is presented, which enables participatory robot design and opens the door for novel research of how robot design affects human perception. The Build-A-Bot platform enables the collection of diverse robot designs, facilitating machine learning analysis …

Cannabis Exposure During Pregnancy And Neural Mechanisms Of Parenting: Assessing Neural Responses To Infant Cues And Parenting Outcomes, Shannon Powers

Electronic Theses and Dissertations

As legalization of cannabis and cannabinoids spreads in the United States, access and use of cannabis during the prenatal period has increased. There is limited knowledge on the effects of prenatal cannabis use on the parental brain. One way to identify potential effects of cannabis on parenting is through studying parenting brain functions and behavior. Cannabis use disorder (CUD) has been shown to be associated with lower positive parenting and lower sensitivity to infants, but it is unclear by what mechanisms. The following two studies address this gap in knowledge by examining the association between cannabis use during the prenatal …

Honoring Indigenous Worldview: Cultural (Un)Responsiveness In Gifted Education, Vicki Boley

Electronic Theses and Dissertations

Many working understandings of giftedness exist within dominating Western frameworks, gatekeeping gifted education from students who do not “fit” inside such frameworks (Owens et al., 2018; Rinn et al., 2020; Sternberg et al., 2021). As a result, K- 12 Native American, Alaska Native, and Native Hawaiian students are underrepresented in gifted education programs (Sternberg et al., 2021) and overrepresented in special education programs (NCLD, 2023). When considering Indigenous students in particular, Western orientations surrounding giftedness perpetuate assimilation, dominance, and continued colonization (Battiste, 2013; Dunbar-Ortiz, 2014; Gentry & Gray, 2021a). Leveraging Positionality and The Pedagogy of Listening as conceptual frameworks, this …

Minimum Wage: Theoretical And Empirical Debates, Ghofran Alrebh

Electronic Theses and Dissertations

This thesis aims to explore the evolution of research methodologies in the minimum wage debate, focusing on the contrasting perspectives of the neoclassical and institutional models. By examining the changes in research methodologies employed by economists from these two schools, this study seeks to shed the light on the shifting paradigms and the impact of these changes on our understanding of minimum wage policies and their implications. This highlights the limitations of relying on one economic school of thought in understanding socio-economic phenomena complexations and policy decisions. As well as it creates the necessity to critical evaluation of the method …

Reconciling Moral Dissonance: A Framework For Re-Integrating Moral Orientation With Life Agency During Warfighters’ Struggles With Military Moral Injury, Jeffrey L. Zust

Electronic Theses and Dissertations

This dissertation uses case studies to critically examine the Three Mirror Model (TMM) as a framework for understanding the formation and healing of Military Moral Injury (MMI). I adapt the work of Stephen Brookfield and Neal Krause to evaluate using the TMM as a methodology for dealing with the complex issues of MMI within a military deployment cycle (training, warfighting, and healing) (Brookfield 2012, 2017; Krause 2022). Specifically, I use theorists, researchers, healers, and warfighters as key stakeholders to identify and critically examine the intersections of disciplines and the subsets of models where warfighters’ moral orientations and moral agency form …

Capturing Latent Abilities And Latent Capacities Of Professional Golfers Using Nonlinear Mixed Effects Growth Modeling, Mac Wetherbee

Electronic Theses and Dissertations

This study demonstrates an effective and innovative approach to measuring the latent athletic abilities and capacities of professional golfers. I used nonlinear mixed effects growth modeling (e.g., Dynamic Measurement Modeling) to measure professional golfers’ ability levels and capacities for improvement. I accomplished this using a two-stage modeling approach. First, a crossed linear mixed effects model estimated each player’s ability level in each year. In the second stage, I used the results from the first stage to estimate several candidate nonlinear growth trajectories for players’ abilities over time. The quadratic growth trajectory was the best-fitting of these trajectories and was used …

Picturesque Portraiture: The Composition Of Reality In Hawthorne, Melville, And James, Angela Michael Gattuso Densmore

Electronic Theses and Dissertations

Throughout the nineteenth century, American artists were tangled in debates regarding the representation of reality. The Hudson River School of picturesque landscape painters tackled this dilemma with a compromise formula which used the real objects of nature to create ideal scenes. This dissertation applies the same picturesque formula to select examples of literary portraiture, studied under the concept of “picturesque portraiture.” Whereas the Hudson River compromise resulted in an ideal perception of reality, however, the picturesque portraits composed by nineteenth-century authors Nathaniel Hawthorne, Herman Melville, and Henry James attempt to invoke a non-idealized “actual” reality of the portrait subject’s person …

Bridging The Geometric And Quantum Information Of Structured Light, Andrew Alexander Voitiv

Electronic Theses and Dissertations

In this Dissertation, we review the several advances we have developed for preparing and measuring the geometric and quantum information of structured light. The geometric phase acts as a memory of transformations undertaken by physical processes; quantum entanglement underpins quantum information science which explores the theoretical and technological applications of nonclassical correlations. Beginning with classical light, we demonstrate novel experiments and measurements of geometric phase that are enabled by spatially structuring laser beams. We then extend those concepts to complement the richer possibilities within quantum optics. Our work covers new abilities in tailoring and measuring the phase content of spatially-structured …

Sources Of Sexual And Romantic Education: Associations With Sexual Minority Men’S Sexual Experiences And Romantic Relationship Quality, Charlie Huntington

Electronic Theses and Dissertations

Individuals with sexual minority identities experience a variety of poorer mental and physical health outcomes, including those related to sexual and romantic quality, relative to heterosexual individuals (Beaulieu et al., 2017; CDC, 2021). These poorer romantic, sexual, and psychological outcomes may be attributable in part to lacking access to affirmative and relevant modeling of sexual minority experiences, such as through sex education (Gillespie et al., 2022; Keiser et al., 2019). This study aimed to understand how sexual minority men learn – in ways potentially both helpful and unhelpful – about romantic relationships and sexual activity, and how these experiences are …

Culturally Responsive Coaching: Supervision With A Cultural Lens, Jouanna Crossland-Wells

Electronic Theses and Dissertations

Culturally Responsive Practices (CRP) are a focal point for many districts across the country. The emphasis of CRP is on how the institution enacts policies and practices for the benefit of the students they serve. This study views CRP from a different lens. The focus of this study is to 1.) center the voice of Black teachers and 2.) explore culturally responsive practices for the support and edification of the teacher from their coach/supervisor. The eight Black teacher participants and their instructional coaches engaged in interviews discussing current coaching models and the dynamics of their coaching relationships.

The relevant findings …

The Elephant In The Baithak: Tabla And Audio Technological Discourse, Tyler Thom

Electronic Theses and Dissertations

This thesis discusses how power, status, and performance practices play out between performers of tabla (North Indian hand drums) and audio engineers. To do so, I analyze engineer, performer, and music critic discourse surrounding tabla performances and technology to place it within a broader scholarly debate regarding recording technology, cultural/technological capital, technological determinism, and agency. I extend Christopher Scales’s (2012) concept of “recording culture” to “live sound culture,” or the behaviors, power struggles, and labor surrounding tabla mic’ing and amplification. I argue that audio technology separates the artist’s sound into several domains of control (stage, hall, recording, playback), each controlled …

Resisting The Historical And Geographical “Other”: The Role Of Expertise In Video Game Music, Tommy Dainko

Electronic Theses and Dissertations

Video games create rich, virtual worlds for players to explore. Game developers have often utilized exoticism, allowing players to experience the “Other” from the comfort of home. Music is a powerful tool to evoke Otherness and can reinforce stereotypes about the past and different cultures. This thesis looks at recent games where developers have collaborated with expert musicians either from the culture depicted or with expertise in historical performance practices. I document two purposes these collaborations can serve. First, the use of expert musicians creates a veneer of authenticity allowing developers to market the games as “authentic” experiences. Second, these …

Exploring The Experiences Of Hiv Positive Pregnant Women On Prevention Of Vertical Transmission Of Hiv/Aids In Rural Malawi, Gertrude Finyiza

Electronic Theses and Dissertations

Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) continues to be the primary conduct that HIV is transmitted to children worldwide. The problem of HIV/acquired immunodeficiency syndrome (AIDS) is having a great impact on the world's children. The prevalence of HIV/AIDS in Malawi continues to be a serious public health issue, especially for expectant mothers. The health outcomes of mothers and children remain significantly threatened by vertical HIV transmission, even with improvements in preventive and treatment efforts. The purpose of this thesis was to explore the experiences of HIV-positive pregnant women in Malawi. I conducted semi structured interviews with thirteen …

Spin And Charge Transport In Metallic Ferrimagnets And Disordered Magnetic Oxides, Leopoldo A. Hernandez

Electronic Theses and Dissertations

Recent efforts have been exploring the use of thin film synthetic ferrimagnets and disordered magnetic oxides for applications in spintronic devices. Due to the antiferromagnetic exchange interaction, ferrimagnetic materials offer the ultrafast dynamics of the antiferromagnetic exchange, with a net magnetization that can be influenced externally. With two, or more, competing ferromagnet sublattices, interesting properties arise that depend on the final magnetic landscape after growth of the material and it’s inherent magnetic anisotropy energies. Properties such as magnetic compensation temperatures, and perpendicular magnetic anisotropy are attractive for applications in spintronic memory and logic devices, some already being implemented in MRAM …

Comparing The Preparation Of Youth Services Librarians To Their On-The-Ground Experiences: A Grounded Theory Study Incorporating Criticism And Connoisseurship, Anne Holland

Electronic Theses and Dissertations

The purpose of this study was to better understand the on-the-ground preparation of youth services librarians, in contrast to their professional training in Master’s of Library Science (MLIS) programs. Classic Grounded Theory was the predominant methodology for this qualitative study, and elements of Criticism and Connoisseurship were also utilized. Document review, interviews, and journaling activities with ten participants were the primary methods of data collection. Key findings from this dissertation include a grounded theory explaining the current state of preparation for youth services librarianship, and multiple avenues for further study.

An Exploration Of Rural Advanced Placement Differentiation, Kristin M. Shapiro

Electronic Theses and Dissertations

Advanced Placement classes are introductory college courses taught in high school. Over 60% of all secondary gifted programs report utilizing AP classes as part of their program offerings (Callahan et al., 2017). Despite the prevalence of AP courses, there is no exact match between this particular type of programming and the needs of gifted learners (Gallagher, 2008). The use and occurrence of AP programs across the United States have not been equal, with subsequent underrepresentation of underserved groups, including rural students (Gagnon & Mattingly, 2016) in AP classes. Rural gifted students benefit from all the same classroom differentiation techniques that …

Institutional And Structural Evolution Of The U.S. Financial System 1945-2023: The Long-Wave Financial Cycle And The Role Of Thwarting Mechanisms, Shaun K. Brog

Electronic Theses and Dissertations

This thesis develops a theoretical framework that attempts to explain the dynamic interactions that lead to episodes of severe financial instability. Adapting Minsky’s Financial Instability Hypothesis to the specific characteristics of financial intermediaries and building on Ferri and Minsky’s ideas regarding the role of thwarting institutions, I propose that financial fragility is the result of a long-wave cycle in financial relations characterized by significant institutional and structural evolution within the U.S. financial system. This evolution results in a preponderance of financial activity undertaken outside the regulatory umbrella while margins-of-safety are eroded, newly innovated financial assets proliferate, and financial intermediaries become …