Digital Commons Network^™

Pharmacological Characterization Of Novel Serotonin Transporter Inhibitors Identified Through Computational Structure-Based Virtual Screening, Michael Wasko

Electronic Theses and Dissertations

Depression is a mental health disorder affecting greater than 350 million people worldwide with roughly 7% of the United States population diagnosed as of 2017. The selective serotonin reuptake inhibitors (SSRIs) have been the mainstay of pharmacotherapies for depression for the last 40 years. The SSRIs target the serotonin transporter (SERT), a monoamine transporter (MAT) responsible for terminating serotonergic neurotransmission. The SSRIs are not perfect therapeutics and suffer from delayed response times, inconsistent efficacy among patients, and often produce intolerable side effects. Therefore, a strong need exists to develop new antidepressants that are more efficacious and have fewer adverse effects. …

Examining The Intersectionality Of Religious Faith, Spirituality, And Healthcare Communication, Felix Okeke

Electronic Theses and Dissertations

This dissertation is my own contribution in responding to the concern raised by certain communication scholars. Their concern was that little research and few publications have been done in the communication field by communication scholars that trace the relationship among religious faith, spirituality, and healthcare communication. While Parrott (2004) describes this apparent neglect as “collective amnesia,” others label it “religion blindness.” Thus, in trying to trace this relationship, this project uses Christian, biblical, and bioethics backgrounds to establish the value, sacredness, and dignity of human life, since these concepts make healthcare and healthcare communication necessary in the first place. These …

The Contribution Of A Global Ethics Approach To Health And The Environment In The Niger Delta Region, Augustine Wayii

Electronic Theses and Dissertations

ABSTRACT

THE CONTRIBUTION OF A GLOBAL ETHICS APPROACH TO HEALTH AND THE

ENVIRONMENT IN THE NIGER DELTA REGION

By

Augustine Lezorgia Wayii, M. ED, M.A.

May 2020

Dissertation supervised by Gerard Magill, PhD

The dissertation presents a global ethics approach that connects health and the environment in the context of the Niger Delta Region. The people of the Niger Delta region in Nigeria are experiencing major catastrophes that connect health and the environment. In the bid to ameliorate these pivotal problems, this dissertation undertakes an ethical analysis that connects health and the environment. Insofar as these problems can be characteristic …

Stakeholders' Perceptions Of Inherent Barriers To The Potential Implementation Of Ultrasound In The Prehospital Setting Between The Saudi Red Crescent Authority And The National Guard Hospital, Maher Alsulami

Electronic Theses and Dissertations

This exploratory study was designed to illuminate both the obstacles and the opportunities inherent in the current medical emergency systems within the kingdom of Saudi Arabia in relation to the possible inclusion of ultrasound machines to assist both Saudi Red Crescent Authority professionals and emergency physicians in the hospital. The research explored the issue of implementing the ultrasound from the perspective of multiple institutions: The Saudi Red Crescent Authority and the National Guard Hospital. The research explored multiple healthcare professionals within both organizations including paramedics, EMTs, emergency doctors, and Saudi Red Crescent station administrators.

The purpose of this qualitative method …

Fluoride Removal With Augmented Bentonite In Drinking Water And Community Perceptions In Arusha, Tanzania, Kara Okular

Electronic Theses and Dissertations

High fluoride concentrations in drinking water affect millions of people around the world. The World Health Organization recommended a fluoride concentration in drinking water of ≤ 1.5 mg/L; fluoride above this concentration can cause long-term dental and skeletal fluorosis. Fluoride imparts no taste to water; therefore, people do not realize that they are ingesting high fluoridated water. Researchers sought to develop a material to remove fluoride from drinking water through sorption. Aluminum was used to form a double ionic layer on the bentonite clay surface. Once mixed in contaminated water, a coagulant, ferric sulfate, was used to separate the bentonite …

Control Of Corrosion On Ss316l Using Surface Initiated Polymers, Alexander Rupprecht

Electronic Theses and Dissertations

Pitting corrosion is arguably one of the most destructive and dangerous forms of corrosion, resulting in damage to structures, the environment, and public health. In addition, damage caused to structures such as bridges, pipelines, and boats, corrosion also has a profound effect on the biomedical community. Implanted metallic devices (i.e., vascular stents and artificial joints) are prone to pitting corrosion caused by aggressive ions present in extracellular fluid. To provide a corrosion-resistant surface on SS316L, films of poly(styrene), poly(methyl acrylate), and poly(methyl methacrylate) were formed using surface-initiated atom transfer radical polymerization (SI-ATRP). The resulting hydrophobic polymer films had a fractional …

The Effect Of Holding Time Of Whole Mare Blood On Concentration Of Progesterone, Clarissa Menefee

Electronic Theses and Dissertations

The objective of this study was to evaluate if holding time had an effect on mare whole blood progesterone levels. This research was completed using 12 mares, with blood being collected on multiple cycles to get a total of 28 separate blood collections. At each collection 5 vials of blood were taken for different time treatments of 0, 12, 24, and 48 hours. The 0 hour was centrifuged within 30 mins of collection and the other 4 were refrigerated at 4℃ until the specific time treatment was finished. After they were centrifuged all the samples were stored in the freezer …

Species Distribution Modeling For Arid Adapted Habitat Specialists In Zion National Park, Sam Driver, Chris M. Schalk, Daniel Unger, David Kulhavy

Electronic Theses and Dissertations

The Arizona toad (Anaxyrus microscaphus) and Jones’ waxy dogbane (Cycladenia humilis var. jonesii) are habitat specialists with historical ranges in the desert southwest and specifically, Zion National Park (ZION). The machine learning method, MaxEnt, constructed species distribution models (SDMs) in ZION for the two study species at 30 m and 900 m spatial resolutions using climate, topographic, and remotely sensed data. Additionally, 900 m forecasting models were constructed to observe the shifts in suitable habitat for the years 2050 and 2070, based off two representative concentration pathway scenarios. Results indicate promising predictive power for both high …

An Invasive Species As A Threat To Native Biodiversity: Larval Competition Between Native Anurans And An Invasive Treefrog, Mckenzie Wasley

Electronic Theses and Dissertations

Cuban Treefrogs (Osteopilus septentrionalis) are established in Florida and Louisiana and have invasive potential further westward, possibly impacting native anurans at multiple life stages. In anurans, competition at the larval stage can decrease adult fitness through slower development and smaller size at metamorphosis, ultimately decreasing recruitment rates. To examine the potential impacts of O. septentrionalis at the larval life-history stage, I quantified activity levels and growth of their tadpoles and those of two anurans native to eastern Texas: Green Treefrogs (Hyla cinerea) and Gulf Coast Toads (Incilius nebulifer). Tadpoles of the three species were …

Through The Devil's Mirror: The Villain And The Sinthomosexual As Manifestations Of The Death Drive, Andrew Markus

Electronic Theses and Dissertations

Lee Edelman’s No Future: Queer Theory and the Death Drive (2004) offers a model for reading queer sexuality and societal place very much in line with that which begins to emerge in early Gothic literature, including Matthew Lewis’s The Monk: A Romance (1796). The Gothic villain aligns with Edelman’s sinthomosexual to illustrate a pattern of victimization and retaliation which results in both the villain and sinthomosexual’s persistent abjection from the social order. However, a close reading of Lewis’s narrative for its depiction of psychological trauma rooted in sexual expression suggests that this queer negativity is not the sum total of …

Tree Canopy Effects On Roof-Harvested Rainwater In East Texas, Kimberly Gamez

Electronic Theses and Dissertations

Nine experimental metal roofs with rainwater harvesting systems were constructed and water quality parameters were measured in 2016-2017 in order to evaluate the effects of arboreal overhang on roof-harvested rainwater quality collected in East Texas. Three treatments were evaluated: Rainwater collected from roofs without any overhanging tree vegetation, rainwater collected from roofs under predominantly Southern yellow pine tree cover, and rainwater collected from roofs under predominantly hardwood tree cover. Rainwater was collected from these roofs for one year. The effects of canopy cover on water quality parameters, comparison to drinking water standards, first-flush efficiency, and seasonal effects were evaluated.

Significant …

Early Life History Of Tarpon (Megalops Atlanticus) In South Carolina Estuaries: Assessment Of Juvenile Recruitment And Validity Of Aging And Back-Calculation Methods, Garrett M. Elmo

Electronic Theses and Dissertations

No abstract provided.

Residency, Diel Movement, And Tidal Patterns Of Large Juvenile Bull Sharks (Carcharhinus Leucas) In Winyah Bay, Sc, Jeremy Lee Arnt

Electronic Theses and Dissertations

No abstract provided.

Inter-Annual To Inter-Decadal Spatiotemporal Effects Of Storm And Nourishment Events In North Myrtle Beach, South Carolina, Christina Mary Boyce

Electronic Theses and Dissertations

No abstract provided.

Development And Applications Of Condensed Phase Cavity Ring-Down Spectroscopy For Studies Of Electrochemical And Interfacial., Shadi Ahmad Alnaanah

Electronic Theses and Dissertations

This dissertation reports the development of ultra-sensitive platforms based on the laser cavity ring-down spectroscopic (CRDS) technique to enable optical and spectroelectrochemical investigations in the condensed phase of matter at challenging scenarios. Firstly, an electrically-active solid/liquid interface for the evanescent-wave cavity ring-down spectroscopy (EW-CRDS) was developed to specroelectrochemically investigate redox events. By coating the interface of total internal reflection of the EW-CRDS platform with a high quality optically transparent and electrically conductive indium tin oxide thin film (ITO), we demonstrated that sufficiently long ring-down times can be achieved to allow for spectroelectrochemical investigations of redox species at solid/liquid interfaces at …

Perceptions Of Executive Functions And Self-Care Actions In Major Depressive Disorder., Melanie G. Walters

Electronic Theses and Dissertations

This dissertation encompasses a study of the effect of impaired executive functions on decision-making and self-care of depressive illness. The first chapter provides an introduction and summarizes the body of literature on the executive functions and its association with depressive symptoms. The second chapter contains the second of two systematic reviews which examines conceptualizations of executive functions, classical and current measures used to assess the executive functions, and challenges and limitations related to current methods of assessment. The third chapter describes the development of a vignette technique and its use in a study to examine the association of depressive symptoms …

Undergraduate Students Use Moral Reasoning And Belief In Genetic Determinism In Response To A Crispr/Cas9 Socioscientific Issue., Katie M. Seiter

Electronic Theses and Dissertations

This dissertation explores how students reason about genetic engineering socioscientific issues (SSIs) related to a recently developed, powerful genome editing technology called CRISPR/Cas9. It is divided into three chapters. Chapter One describes an exploratory study that characterized students’ moral reasoning using a sociocultural theoretical framework. I used content analysis and logistic regression to investigate how academic and social factors influenced moral reasoning. Students generally opposed the use of CRISPR/Cas9 technology for non-medical enhancements, and the moral considerations used were influenced by genetics knowledge level and demographic variables such as gender and socio-economic status. Further investigation of moral perspectives for students …

The Impact Of A Digital Intervention On Perceived Stress, Resiliency, Social Support, And Intention To Leave Among Newly Licensed Nurses: A Randomized Controlled Trial, Lisa Concilio

Electronic Theses and Dissertations

The nursing shortage has been deemed a public health crisis with the turnover rate of newly licensed nurses (NLNs) growing (Robert Wood Johnson Foundation, 2014). One out of five NLNs are leaving the profession due to work dissatisfaction and feelings of inadequacy (National Academy of Medicine, 2017). NLN attrition during the first year of hire has been associated with feelings of overwhelming stress and decreased sense of support which negatively impact patient safety (Spence Laschinger et al., 2016). As seasoned nurses are attempting to retire amidst a nursing shortage (American Association of Colleges of Nursing, 2018), NLNs require more support …

Veteran Teachers’ Perceptions On The Negative Implications Of Classroom Disruptive Behavior And Redirection Strategies, Charvelia Sharae Lewis

Electronic Theses and Dissertations

Classroom teachers are responsible for creating an environment where all students are able to receive an optimal educational experience. However, disruptive behavior demonstrated by students in classrooms often makes it more difficult for teachers to provide quality instruction to all students. The purpose of this qualitative case study was to understand the perceptions of veteran teachers related to student disruptive behavior as well as the redirection strategies utilized to decrease the occurrence of such behavior during instructional time. Along with completing an open-ended survey related to strategies used to address disruptive behavior, the veteran teacher participants shared their experiences in …

What Interventions Should Be Utilized With Alzheimer's Patients To Increase Quality Of Life?, Laci Bach

Electronic Theses and Dissertations

Alzheimer’s is a devastating disease that affects nearly 50 million people worldwide and will continue to increase exponentially with the aging of the population. The current work is an attempt to identify the needs of a subset of Alzheimer’s patient caregivers who have placed their family member to help identify the specific psychosocial needs the family member may have. This will help agency staff to tailor specific plans in their interactions with both the patient and family member to help reduce identified caregiver burden. Due to the COVID-19 restrictions only a limited number of family members (n=5) were contacted and …

Perceptions Of Special Education Supports By School Administrators, Eric P. Oxford

Electronic Theses and Dissertations

This research study analyzed the perceptions of special education supports by school administrators. Specifically, this research discussed comparative findings of perceptions of special education supports between building principals and building-based special education team chairpersons in one Massachusetts public school district. The findings are grounded in the district’s inclusive philosophy and its capability to ensure that all students are provided educational opportunities in the least restrictive educational environment. The problem studied was that many students with disabilities who are unable to find academic success within an inclusive academic environment are typically transitioned into a more restrictive—or substantially separate—alternative education setting. It …

Let Me Serve Your Majesty: Psalm 8, Matthew Fredrickson

Electronic Theses and Dissertations

The speaker in Ps 8 proclaims a desire to serve Yahweh’s heavenly power/victory by appealing to humanity’s status as God’s images (Gen 1:27) and accepting the role of Yahweh’s new servant (Isa 55:3), as a priest/minister of God (Isa 61:1-6; cf Isa 42:1). This thesis translates אשר תנה as one word in verse 2b (אשרתנה), rendered, “May I serve your heavenly power/victory!” This is illustrated (in part) by two participles in Ps 8, ינקם (v. 3) and עבר (v. 9), which refer to cosmic foes of Yahweh—“the ones who nurse” (the goodly gods in CAT 1.23) and the “one …

The Functions And Uses Of The Marker “Bita:ʕ” In Egyptian Arabic: A Corpus Analysis: Discourse And Vagueness Functions, Asmaa Taha

Electronic Theses and Dissertations

Discourse markers are used considerably in Egyptian colloquial Arabic, yet few studies examine them in colloquial Arabic. A mixed-method research design adopting a descriptive corpus-based approach is used to better understand the communicative discourse and vagueness functions of the words bita:ʕ, bita:ʕa, and bitu:ʕ in Egyptian Arabic discourse. This study also highlights the collocational behavior of bita:ʕ, bita:ʕa, and bitu:ʕ as well as their colligation patterns. A correlation is found between colligation patterns of the markers bita:ʕ and its variants and particular discourse and vagueness functions in context. Additionally, the study investigates the morphosyntactic phenomenon in which bita:ʕ has …

The Resilience Of Female Survivors Of Intimate Partner Violence In Southwest Nigeria: An Interdisciplinary Analysis, Tobi F. Oloyede

Electronic Theses and Dissertations

Female survivors of intimate partner violence (IPV) in Nigeria endure harsh and traumatic experiences that affect their rights as women and their well-being. As the phenomenon of IPV persists in Nigeria, it is not only a family problem but a critical social and psychological problem. This study examined Nigerian female survivors’ hidden strength, agency, and resilience, rather than their powerlessness and vulnerability. Analysis of survey questionnaires, interviews, and secondary scholarship reveals that some Nigerian female survivors of IPV are able to cope whilst navigating stressful and traumatic experiences. The results also show that survivors’ ability to thrive and cope under …

Awareness And Utilization Of Smart Mobile Devices And Mobile Apps As Teaching Tools For Community College Faculty, Denise Sherry Malloy

Electronic Theses and Dissertations

Over 90% of faculty members in higher education have access to smart mobile devices. However, data are lacking about community college faculty members’ use of smart mobile devices and applications for instruction and content delivery. The purpose of this study was to examine Tennessee community college full-time faculty’s use of smart mobile devices, to determine if there were any significant differences in the mean scores measuring attitudes and use of smart mobile devices by generational age grouping, teaching discipline, rank, years of teaching and to determine if Tennessee community college faculty members who under-utilize mobile technologies for teaching also hold …

Samuel Daniel’S Lyric Reception: The Role Of Poet-Critics From Wordsworth To Winters, Caleb Mcghee

Electronic Theses and Dissertations

The Elizabethan poet Samuel Daniel was popular in his day, producing lyric, dramatic, and narrative poems. Contemporary anthologies, however, memorialize him primarily as a lyric poet, one that usually gets few entries. My thesis shows how Daniel had a minor reputation as a lyric poet by the 1960’s, despite having high-profile admirers. These well-known poet-critics who engaged with his work are essential to analyzing his lyric reputation: owing to the Romantic emphasis on the lyric, I begin with William Wordsworth and Samuel Taylor Coleridge’s reception of his lyrics in the 19th century. I then analyze the turn of the century …

Identifying The Need For Trained Machinists In The Greater Tri-Cities Area, Bradley Stufflestreet

Electronic Theses and Dissertations

Machinists are skilled tradespeople responsible for running a variety of machine tools to produce precision components for end-users or use in other manufacturing. This project identifies the current and future change in the number of machinists in the Tri-Cities area, especially the five-county service area of Northeast State Community College. Using an industry survey, the need for machinists is identified and evaluated to understand local employers’ needs. The results indicate industry needs more machinist to keep up with demand, as 6 out of 14 companies have open positions and, 8 reported difficulty filling openings. Furthermore, most companies are growing or …

Pre-Entrance Factors And Student Success In An A.A.S. Nursing Program, Connie Marshall

Electronic Theses and Dissertations

The purpose of this study was to evaluate the relationship of pre-entrance factors and the success of students in an Associate of Applied Science (A.A.S.) degree nursing program at a community college in East Tennessee. The criterion variable was success in the nursing program. Success was defined as academic success in all nursing courses and completion of the nursing program to graduation. The predictor variables of pre-entrance factors were gender, age, Health Education Systems, Incorporated (HESI) A2 scores, Pell Grant eligibility, pre-nursing GPA, and prior licensure. The data for this non-experimental secondary analysis were derived from the electronic database in …

Kids These Days: Corporate Social Responsibility And Generational Influence On Consumer Intention, Maya Mathis

Electronic Theses and Dissertations

Millennials are known for being a unique generation that places a high value on improving their community. They are also unlike any other generation because they are harder to market to since they are more aware of common marketing strategies used by companies today. Millennials want to improve the community and expect others to do the same. Corporate Social Responsibility (CSR) is a popular topic and has gained momentum in research over the years; understanding the relationship between CSR and millennials is important due to the generational shifts. Therefore, this study examines the importance of CSR to different generations and …

Teacher Retention In Secure Residential Settings, Daniel Froemel

Electronic Theses and Dissertations

A phenomenological study was conducted to identify the factors associated with job retention among teachers in secure residential treatment centers in Tennessee. Central to this investigation was the exploration of how residential teachers perceive they are supported in their position, how teachers in residential settings perceive the culture of the facility, and what factors are associated with teacher retention in secure residential settings. Through a series of fifteen interviews, common themes emerged from the coding that provided insight into these questions.

Teachers who had worked in residential settings for more than five years seemed to have very strong internal belief …