Digital Commons Network^™

Computational Modeling Of 3d-Printed Lactobacillus-Antibiotic Scaffolds For Bacterial Vaginosis., Veeresh P. Rai

Electronic Theses and Dissertations

The standard treatment for bacterial vaginosis (BV) is currently antibiotics, such as metronidazole, clindamycin, or tinidazole. These antibiotics are highly effective in getting rid of bacteria in the female reproductive tract (FRT); however, there are some bacteria that provide benefits to the FRT which also get expunged. While there are many strains of bacteria that play a beneficial role in the FRT, lactobacilli are among the most important. These bacteria are responsible for maintaining a healthy environment in the FRT via pH regulation by lactic acid metabolism. Antibiotics eliminate all bacteria from an environment, including lactobacilli, and as a result, …

Decisive Neutrality, Restricted Decisive Neutrality, And Split Decisive Neutrality On Median Semilattices And Median Graphs., Ulf Högnäs

Electronic Theses and Dissertations

Consensus functions on finite median semilattices and finite median graphs are studied from an axiomatic point of view. We start with a new axiomatic characterization of majority rule on a large class of median semilattices we call sufficient. A key axiom in this result is the restricted decisive neutrality condition. This condition is a restricted version of the more well-known axiom of decisive neutrality given in [4]. Our theorem is an extension of the main result given in [7]. Another main result is a complete characterization of the class of consensus on a finite median semilattice that satisfies the axioms …

Translating Particulate Hexavalent Chomium-Induced Chromosome Instability, Loss Of Homologous Recombination Repair And Targeting Of Rad51 From Human Lung Fibroblasts To Human Bronchial Epithelial Cells., Idoia Meaza Isusi

Electronic Theses and Dissertations

Particulate hexavalent chromium [Cr(VI)] is a well-established human lung carcinogen. RAD51, a key protein in homologous recombination repair pathway, is inhibited after prolonged exposure to Cr(VI), leading to an increase in chromosome instability after prolonged exposures in human lung fibroblasts. chromosome instability is the proposed driver of Cr(VI) carcinogenesis. Since tumors from chromate workers develop from epithelial cells, we sought to translate these findings from human bronchial fibroblasts to human bronchial epithelial cells. We hypothesized Cr(VI) inhibits RAD51 after prolonged exposure leading to an increase in chromosome instability in human bronchial epithelial cells (BEP2D). We characterized the cytotoxicity and measured …

Part-Time., Anthony Mark Piedmonte

Electronic Theses and Dissertations

This thesis is a creative writing project in prose covering the first 70 pages of a novel manuscript titled Part-time. Part-time will center around a 25-year-old medical school dropout starting a new job at a neighborhood golf clubhouse and gym. This coming-of-age narrative follows Danny as he struggles with his sexual identity, student debt, and job outlook after returning to the privileged community he grew up in. This sample will introduce the major characters, the clubhouse setting, and the forming relationship dynamics. By the end of these pages, readers will gain insight into how the part-time employees of the Longwood …

Charting The Unknown: Examining The Prevalence And Correlates Of Seconday Traumatic Stress In Kentucky Probation And Parole Officers., Amanda Marie Roberts

Electronic Theses and Dissertations

The purpose of this dissertation was to discern the prevalence and magnitude of both exposure to traumatic events and Secondary Traumatic Stress (STS); as well as potential correlates of STS in a group of Probation and Parole officers in the state of Kentucky Department of Corrections (KY DOC). Participants (N=302) completed a written survey which asked them to indicate demographic variables (age, gender, and ethnicity), as well as several important occupational variables, namely years of experience in the KY DOC, caseload volume, prison work experience, and whether or not they are responsible for a sexual offender caseload. Participants were also …

Effects Of Chemosensory Experience And Context On Consummatory Behaviors., Saphira M. Chiu

Electronic Theses and Dissertations

Eating food generates associations between odors and tastes (i.e., flavor) that guide future choices. Experience with an odor-taste mixture links an odor with a taste’s quality and hedonic value, resulting in a preference for an odor paired with a palatable taste over an odor paired with an unpalatable taste. However, experience with a neutral stimulus (i.e., latent inhibition) or environment (i.e., context) can influence the formation of conditioned associations. Here, I used a two-bottle brief-access task to determine whether rats display an innate preference between unpaired odors (isoamyl acetate and benzaldehyde), how preexposure to the unpaired odors impacts mixture-dependent consummatory …

The Invisible Language: Unintentional Patronage And Missions Practice In Contemporary Thailand, Samuel Burton Jones

Electronic Theses and Dissertations

Patronage-clientelism is a current and important topic of discussion among the anthropological and missiological community. The effects of unintended patronage by Western missionaries in the context of Thai culture, however, are underexplored in academic research. In this study, I analyzed the effects of unintentional patronage among Western missionaries in a Thai cross-cultural ministry context. To do this I utilized a multiple case study method in which I compared four cases and analyzed for examples of how unintentional patronage is generated. I discovered that unintentional patronage was likely a result of insufficient missionary education regarding patronage-clientelism, as well as a lack …

Youth Leadership Development Programs: Participants’ Pre- And Post-Perceptions Of Leadership Life Skills Development, Courtney A. Pruner

Electronic Theses and Dissertations

Research exists on the participation of youth in various types of youth leadership development programs. However, the problem is a lack of understanding of the perception of participants’ pre- and postparticipation on their development of leadership life skills. The purpose of this quantitative, causal-comparative study was to determine how youth leadership development program participants perceive themselves in the area of leadership life skills development pre- and postparticipation in a youth leadership development program. In this study, specific consideration was given to the difference in gender and ethnic minority affiliation reporting scores. The independent variables in this study were participation in …

The Role Of Embodied Metaphor In The Relationship Between Vestibular Dysfunction, Anxiety And The Self, Kaitlyn Abrams

Electronic Theses and Dissertations

There is considerable evidence that vestibular dysfunction and anxiety are correlated. Clinical and philosophical arguments suggest that a loss of sense of self, experienced through symptoms like derealization and depersonalization, might contribute to this relationship. The present study used a mixed methods approach, including Systematic Metaphor Analysis, to analyze written short answer and quantitative survey data from one hundred and thirteen participants with vestibular disorders. The Systematic Metaphor Analysis revealed several primary metaphor concepts which elucidated the connections between concrete experience and abstract concepts in vestibular dysfunction. These included metaphors of Agency, Stability, Orientation, Self-Object, and Figure-Ground. Primary metaphors for …

Exploring The Contextual Factors And Decision-Making Process Of Risky Sexual Behavior Among Homeless Adults In Louisville, Kentucky., Sarah C. Van Heiden

Electronic Theses and Dissertations

Homelessness is a complex public health issue; individuals who experience homelessness are said to engage in risky sexual behaviors at an increased rate and experience a higher prevalence of sexually transmitted infection (STI). While the sexual behaviors of homeless adolescents are commonly studied, little is known about the sexual behaviors of the growing population of older adults, or how they make decisions to engage in sex. Three aims guided this research: 1) to describe the sexual behaviors and sexual decision-making process of homeless older adults, 2) to examine how homeless older adults evaluate the outcomes associated with engaging in risky …

Distinguishing Mustela From Neogale (Mustelidae) Through Both A Qualitative And Quantitative Analysis Of Skull And Tooth Morphology, Ronald W. Peery

Electronic Theses and Dissertations

Weasels and mink (Mustela and Neogale) can be difficult to distinguish osteologically due to similarities in morphology, thus suggesting the need for an accurate tool in distinguishing among taxa. This study utilized a combination of character state and stepwise discriminant function (DFA) analyses to examine potential distinguishing features of skull and tooth morphology. Measurements and ratios were collected from all 18 extant musteline species, as well as the extinct Neovison macrodon, Mustela rexroadensis, Mustela meltoni, Mustela gazini, and Mustela jacksoni. Unidentified musteline specimens from the Gray Fossil Site were also included. Results of …

Computational Investigations Of The Photochemical Properties Of B12-Dependent Systems: From Solution To Enzymes., Megan Toda Mackintosh

Electronic Theses and Dissertations

The photochemical properties of the B₁₂ family of molecules (cobalamins = Cbls) have been known for many years yet only until the 21^st century have applications for the light-sensitivity of Cbls come to the surface. Photolabile Cbls can be used for the delivery of therapeutics with spatial and temporal control, in the generation of hydroxyl radicals, and in nature, as demonstrated in the catalytic cycle of coenzyme B₁₂-dependent photoreceptors. This dissertation describes the use of computational methods to explore the photochemical properties of Cbl systems including antivitamins B₁₂, a thiolato-cobalamin, and the coenzyme B …

A Practical Extension To The Ab/Ba Design, My T.A Nguyen

Electronic Theses and Dissertations

In this work, we take a close look at a general extension to the traditional AB/BA
crossover design that is commonly used in clinical trials to determine the effectiveness
of new candidate drugs. While the traditional crossover design requires each patient
in the study to be measured on both treatment A and treatment B, we consider the
possibility of additional measurements being available on each patient. This produces
designs such as the AABB/BBAA design which has been used in previous studies.
A general test statistic will be derived to test for treatment effects as well as its
corresponding power function …

Soil Gypsum Content Analysis Of The Proposed Road Route Extension Of Fm 2185 In The Gypsum Plain, Culberson County, Texas, Chikaodili Ohakawa

Electronic Theses and Dissertations

Soils serve as the underlying substrate on which foundations for most structures are built. The properties of a soil type are therefore an important consideration in building engineered structures. Gypsic soils are problematic for construction of such structures. One of the main problems with gypsic soils is dissolution. Gypsum (CaSO₄·2H₂O) in soils dissolves easily creating voids which can be detrimental to the integrity of engineering structures. To mitigate this, it is important to determine the amount of gypsum present in soils, before construction is initiated.

In this study, three methods were employed in the determination of …

The Impact Of The United States Army Nurses Corps On The United States Army Fatality Rate In The Mediterranean And European Theater Of Operations During World War Ii, Joshua Benjamin Groomes

Electronic Theses and Dissertations

World War II was the most devastating war in human history in terms of loss of life. The Japanese attack on Pearl Harbor on December 7, 1941, plunged the United States into war. Less than seven thousand military nurses were on active duty at the time of the attack. By the end of the war, there were over fifty-thousand active-duty nurses. The army nurses performed under fire in field and evacuation hospitals, on hospital trains and ships, and as flight nurses on medical evacuation transport aircraft. The skill and dedication of the Army Nurses Corps insured a 95% survival rate …

Developing Digital Literacy In Digital Natives: A Quantitative Study Of Digital Literacy And Niswonger Online Students, Elizabeth Pavlovich

Electronic Theses and Dissertations

This non-experimental, quantitative study was completed to determine if Tennessee high school students who take an online, asynchronous course better their digital literacy through the environment of online learning. The study focused on the pretest and posttest scores of Niswonger Online students during the spring and summer semesters of 2021. It grouped the high school students by location, high school size, grade level, and courses taken to assess differences in digital literacy. Finally, it evaluated overall student growth in digital literacy scores after completion of an online high school course.

Data from a pretest and posttest of Niswonger Online students …

Nonprofit Narratives: How Two Organizations Use Social Media And Rhetorical Appeals To Address Issues Of Sexual And Domestic Violence, Samuel Hiester

Electronic Theses and Dissertations

Though often seen as a panacea for organizational objectives, nonprofits must be judicious in deploying social media, particularly due to resource limitations. Nonprofits deploy many types and styles of digital texts, including social media. Classical rhetorical appeals can be effective means for achieving positive impact in that context. When used correctly, these ‘digital texts’ can be leveraged for maximum engagement with audiences. This study examines both a large, national organization – the National Sexual Violence Resource Center – and a small, regional one – Branch House Family Justice Center – for not only what sort of digital texts are utilized, …

Functional Mixed Data Clustering With Fourier Basis Smoothing, Ishmael Amartey

Electronic Theses and Dissertations

Clustering is an important analytical technique that has proven to affect human life positively through its application in cancer research, market segmentation, city planning etc. In this time of growing technological systems, mixed data has seen another face of longitudinal, directional and functional attributes which is worth paying attention to and analyzing. Previous research works on clustering relied largely on the inverse weight technique and B-spline in smoothing data and assessing the performance of various clustering algorithms. In 1971, Gower proposed a method of clustering for mixed variable types which has been extended to include functional and directional variables by …

Familial Regulation Of Young Children's Tv Viewing In Ghana, Clara Puni-Nyamesem

Electronic Theses and Dissertations

This study examined familial regulation of young children's TV viewing in Ghana. Participants were families with young children four through eight years enrolled at a school in the south of Ghana. An online survey of TV regulation practices of families (restrictive, coviewing, and instructive), TV viewing hours of young children, and families' perception of TV influence on their children was completed by 158 family members (mostly parents). Results showed that restrictive regulation is the most predominately used strategy in Ghana, although all 3 regulation styles were used. College educated families were significantly more likely to use restrictive regulation than families …

Student Collaboration: Early Childhood Teachers' Roles And Perspectives, Kimberly Ballantyne

Electronic Theses and Dissertations

Early childhood environments can offer valuable opportunities for student collaboration. Social interactions allow students to practice listening to each other and learn how to work together. This study focused on the roles and perspectives of early childhood educators related to student collaboration in the classroom. Six educators from one elementary school in New Hampshire participated in two focus group discussions, the first of which included a presentation on student collaboration with first graders. Participants also completed four concept maps highlighting their perspectives about student collaboration and one written reflection comparing their perspectives before and after engaging in the focus group …

Facile Nitrogen-Doping Of Screen-Printed Carbon Electrodes For Detection Of Hydrogen Peroxide, Emmanuel Nkyaagye

Electronic Theses and Dissertations

Screen-printed carbon electrodes (SPCEs) have garnered much attention as sensors due to their simplicity and relatively low cost. However, to impart necessary selectivity and sensitivity for specific applications, modification of the SPCE surface, which can involve time-consuming procedures or costly equipment/materials, is typically required. Here, a simple nitrogen-doping process based on NH₄OH was used to modify SPCEs prepared from commercially available ink for electrochemical detection of H₂O₂, a common target for biosensing strategies and indicator of cell stress. XPS studies showed that NH₄OH treatment of SPCEs led to a nearly 5-fold increase …

Genital Chlamydia Infection Is Influenced By The Female Sex Hormones Estrogen And Progesterone In Vivo, Amy Gail Gravitte

Electronic Theses and Dissertations

Chlamydia is the most common bacterial sexually transmitted infection in the United States and worldwide. It often goes unnoticed due to lack of symptoms and left untreated it can ascend the female genital tract to cause sequelae like pelvic inflammatory disease and irreversible tubal infertility. In reproductive-aged women, female sex hormones estrogen (E2) and progesterone (P4) concentrations fluctuate during the menstrual cycle and are influenced by hormonal contraceptives and hormone replacement therapy. E2 and P4 influence genital Chlamydia infection in women and mice, but these multifactorial interactions are not entirely mapped out. The complex interplay of E2 and P4 with …

Correctional Career Pathways: A Jail Reentry Program Evaluation, Grace Gass

Electronic Theses and Dissertations

There are numerous types of reentry programs available to inmates to help avoid the cycle of recidivism. There is little research on the impacts of reentry programs in jail populations. This current study sought to provide more research in this area by evaluating a local jail reentry program’s effect on recidivism. A quasi-experimental design was used to estimate the program’s effectiveness by comparing the recidivism statistics of inmates that have participated in the reentry program to a control group of inmates that did not. Inmates in the control group were matched according to their gender, age, race, and current offense …

Lipidomic Analysis Of Various Developmental Stages Of Physcomitrium Patens, Deepshila Gautam

Electronic Theses and Dissertations

Lipids maintain fluidity of the cell membrane during the lifetime of all organisms. The moss Physcomitrium patens, an early land plant, enters reproductive phase under cold (15°C) conditions relative to its gametophytes (22°C). Thus, we hypothesized that their lipid content and composition would be distinct. Using ESI-MS/MS, we showed that the content and acyl composition of 11 lipid classes varied during development. Galactolipids were abundant in gametophytes but insignificant in sporophytes; among phospholipids, phosphatidylcholine was predominant in both phases. Although, sporophytes contained around five-fold less lipids than the gametophyte, their phosphatidic acid content, which accumulates during stress, was 18-fold …

Computational Analysis Of The Spin Trapping Properties Of Lipoic Acid And Dihydrolipoic Acid, Matthew Bonfield

Electronic Theses and Dissertations

While the spin trapping properties of thiols have been investigated through EPR analysis and kinetics studies, few groups have studied these properties using strictly computational methods. In particular, α-lipoic acid (ALA) and its reduced form, dihydrolipoic acid (DHLA), one of the strongest endogenously produced antioxidants, show potential for being effective, naturally occurring spin traps for the trapping of reactive oxygen species. This research covers electronic structure calculations of ALA, DHLA, and their corresponding hydroxyl radical spin adducts, performed at the cc-pVDZ/B3LYP/DFT level of theory. The effects on DHLA introduced by other radicals such as ·OOH, ·OCH₃, …

School Accountability And Chronic Absenteeism In The State Of Tennessee, Heidi Campbell

Electronic Theses and Dissertations

The purpose of this quantitative, non-experimental study was to explore a possible relationship between the number of students in grades 9-12 classified as chronically absent and the inclusion of the Chronically Out of School indicator in Tennessee’s accountability model for schools and school districts. Using publicly available data from the Tennessee Department of Education, the research study examined 6 years of data from the 2014-2015 to 2019-2020 school years. Data were divided into 3 years before and 3 years after implementation.

Results of the study indicated that the mean number of chronically absent students in grades 9-12 were significantly lower …

Preparation And Study Of Bacterial Membrane Models, Enoch Asimbisa

Electronic Theses and Dissertations

Fuel molecules are organic solvents that have disruptive effects on the bacterial membrane. This is a significant barrier in biofuel production, as it limits the fuel concentration that can be achieved through fermentation. One potential way of overcoming this barrier is to identify lipid compositions that can better withstand solvent stress, for which it is important to understand how organic solvents disrupt the membrane. Use of biophysical characterization techniques to quantify physical properties like fluidity and thickness will enable us to understand the mechanism by which solvents disrupt membranes. Native membranes are very complex, and we sought to develop in-vitro …

Synthesis Of Phosphatidylethanolamine Lipids For Model Studies Of The Cell Membrane, John Hayford G. Teye-Kau

Electronic Theses and Dissertations

Concerns about global warming have resulted in a surge of research into alternatives to fossil fuels. In recent years, biofuels have gained traction due to their low environmental impact. Biofuel production most commonly employs microorganisms to convert biomass to fuel for industrial and transportation applications. Compounds made in biofuel production, however, are toxic to cell membranes and disrupt their integrity, harming the microorganisms and limiting biofuel yield. A key to overcoming this challenge is understanding how fuels interact with microorganisms’ cell membranes, which perform a host of functions, including transport, cell recognition, transduction, and movement. Phospholipids are the cell membrane’s …

Exploring Integration Between Athletic Trainers And Strength And Conditioning Coaches Among The Ncaa Division I Southern Conference Institutions, Yoshihiro Kojima

Electronic Theses and Dissertations

The purpose of this study was to explore the interdepartmental integration between athletic trainers and strength and conditioning coaches in relation to relationship, communication, collaboration, and education. Forty participants from the NCAA Division I Southern Conference, twenty-eight athletic trainers and twelve strength and conditioning coaches, completed an electronic survey during a two-week period. Collected data were analyzed by descriptive and thematic coding analyses. The results suggested participated athletic trainers and strength and conditioning coaches were interactive and collaborative. Open-ended responses identified key concepts when athletic trainers and strength and conditioning coaches communicated and collaborated. A high interaction and collaboration model …

Racial Diversity Of Texas School Teachers, Julie Ann Olguin-Phillips

Electronic Theses and Dissertations

There is a growing gap between the racial demographics of public-school teachers and their students. Teachers with demographic backgrounds similar to a school’s student population are often successful, particularly in Title 1 schools with high proportions of minority students; however, teacher turnover is high. The students in Texas public schools are a growing minority-majority population. Changes in the student body racial composition and other school-related variables could influence teacher workforce demographics. The focus of discussion of this quantitative research study is to determine the factors that predict the racial diversity of teachers in Texas high schools. The research questions addressed …