Digital Commons Network^™

Modeling And Debiasing Feedback Loops In Collaborative Filtering Recommender Systems., Sami Khenissi

Electronic Theses and Dissertations

Artificial Intelligence (AI)-driven recommender systems have been gaining increasing ubiquity and influence in our daily lives, especially during time spent online on the World Wide Web or smart devices. The influence of recommender systems on who and what we can find and discover, our choices, and our behavior, has thus never been more concrete. AI can now predict and anticipate, with varying degrees of accuracy, the news article we will read, the music we will listen to, the movies we will watch, the transactions we will make, the restaurants we will eat in, the online courses we will be interested …

A Modeling Platform To Predict Cancer Survival And Therapy Outcomes Using Tumor Tissue Derived Metabolomics Data., Hunter Allan Miller

Electronic Theses and Dissertations

Cancer is a complex and broad disease that is challenging to treat, partially due to the vast molecular heterogeneity among patients even within the same subtype. Currently, no reliable method exists to determine which potential first-line therapy would be most effective for a specific patient, as randomized clinical trials have concluded that no single regimen may be significantly more effective than others. One ongoing challenge in the field of oncology is the search for personalization of cancer treatment based on patient data. With an interdisciplinary approach, we show that tumor-tissue derived metabolomics data is capable of predicting clinical response to …

Fluid Structure Interactions Within A Common Rail Diesel Injector., Russell Prater

Electronic Theses and Dissertations

The internal flow of a high-pressure diesel injector is simulated numerically to investigate the complex transient flow structures and the unsteady forces imparted to the injector needle that result from the asymmetric flow fields developed during operation. The gas-liquid two phase flow is simulated using a mixture model with the cavitation numerically modeled using the Zwart-Gerber-Belamri model. Both the k-ε model and the detached eddy simulation (DES) model are used, and the numerical results are compared. This dissertation looks at the internal flow of a generic injector at different lifts and characterizes the flow parameters at high lift and low …

Critical Thinking Or Critical Creativity: Applying De Bono's Six Thinking Hats To Speech-Language Pathology Education And Practice., Samantha Hahn

Electronic Theses and Dissertations

Decision-making is a fundamental skill that health care professionals use daily which involves the interaction of many cognitive systems. Critical and lateral thinking are two approaches to decision-making often cited in literature. Critical thinking emphasizes reasoning and systematic analyzation, while lateral thinking encompasses imagination and creativity. Speech-language pathology (SLP) is a prime example of a profession that amalgamates creative processes with organized methodologies. Edward de Bono described six styles of lateral thinking – each style is equated to a colored “hat”. This study sought to determine if an association exists between a given SLP student’s level of clinical experience and …

Discovering The Pathways And Go Terms Associated With Mettl3 Modified Circular Rnas In The Embryonic Cerebral Cortex Of Mice., Dunia Zedan

Electronic Theses and Dissertations

Circular RNAs (cirRNAs) are a class of RNA molecules that result from the alternative back-splicing events that join the 3’ and 5’ ends normally present in the linear RNA molecules. It has been published that cirRNAs can function as gene regulators and as “microRNA sponges” to negatively control the functions of microRNAs. While many studies have been conducted to understand the regulatory roles of Mettl3 in linear messenger RNAs, fewer contributions were applied to understand the impact of Mettl3 modified cirRNAs on gene expression and on the regulation of different KEGG biological pathways and GO terms. This thesis was conducted …

Transformation., Jingshuo Yang

Electronic Theses and Dissertations

My works mainly show my perception of life and my change of thought. The world is full of changes, and the pandemic has disrupted our lives. Many people, including me, are confused about the world. Philosophy and my observation and thinking about the world helped me to have a clearer understanding of the world. My paintings Licia, Butterfly Woman, and Live with Covid reflect my understanding of German philosopher Arthur Schopenhauer's theory of empathy. Within my art, I also use another German Philosopher Theodor W. Adorno's theory of the culture industry to deepen my understanding of some social phenomena. My …

Beyond Accuracy In Machine Learning., Aneseh Alvanpour

Electronic Theses and Dissertations

Machine Learning (ML) algorithms are widely used in our daily lives. The need to increase the accuracy of ML models has led to building increasingly powerful and complex algorithms known as black-box models which do not provide any explanations about the reasons behind their output. On the other hand, there are white-box ML models which are inherently interpretable while having lower accuracy compared to black-box models. To have a productive and practical algorithmic decision system, precise predictions may not be sufficient. The system may need to have transparency and be able to provide explanations, especially in applications with safety-critical contexts …

Machine Learning Approaches For Early Prediction Of Hypertension., Heba Elsayed Mohamed Kandil

Electronic Theses and Dissertations

Hypertension afflicts one in every three adults and is a leading cause of mortality in 516, 955 patients in USA. The chronic elevation of cerebral perfusion pressure (CPP) changes the cerebrovasculature of the brain and disrupts its vasoregulation mechanisms. Reported correlations between changes in smaller cerebrovascular vessels and hypertension may be used to diagnose hypertension in its early stages, 10-15 years before the appearance of symptoms such as cognitive impairment and memory loss. Specifically, recent studies hypothesized that changes in the cerebrovasculature and CPP precede the systemic elevation of blood pressure. Currently, sphygmomanometers are used to measure repeated brachial artery …

Statistical Methods For Assessing Drug Interactions And Identifying Effect Modifiers Using Observational Data., Qian Xu

Electronic Theses and Dissertations

This dissertation consists of three projects related to causal inference based on observational data. In the first project, we propose a double robust to identify the effect modifiers and estimate optimal treatment. Observational studies differ from experimental studies in that assignment of subjects to treatments is not randomized but rather occurs due to natural mechanisms, which are usually hidden from the researchers. Many statistical methods to identify the treatment effect and select the optimal personalized treatment for experimental studies may not be suitable for observational studies any more. In this project, we propose a exible outcome model to select the …

Di•As•Po•Ra: Displaced, Not Erased., Betty Álvarez

Electronic Theses and Dissertations

This thesis is based on my artistic endeavors and research founded in my culture, family, the history of the United States government’s intervention in El Salvador, and the current political climate Latin Americans face today in the United States. I work within multiple mediums to resurrect pieces of my culture that are being forgotten or left behind due to assimilation. I accomplish this through revisiting and reinterpreting traditions. I aim to bring awareness of the Latin experience in a racially divided United States through artistic expression and my own personal experiences. My works are made to feel whimsical and playful, …

Hybrid Machine And Deep Learning-Based Cyberattack Detection And Classification In Smart Grid Networks, Adedayo Aribisala

Electronic Theses and Dissertations

Power grids have rapidly evolved into Smart grids and are heavily dependent on Supervisory Control and Data Acquisition (SCADA) systems for monitoring and control. However, this evolution increases the susceptibility of the remote (VMs, VPNs) and physical interfaces (sensors, PMUs LAN, WAN, sub-stations power lines, and smart meters) to sophisticated cyberattacks. The continuous supply of power is critical to power generation plants, power grids, industrial grids, and nuclear grids; the halt to global power could have a devastating effect on the economy's critical infrastructures and human life.

Machine Learning and Deep Learning-based cyberattack detection modeling have yielded promising results when …

“I Think It's Male Privilege”: A Qualitative Study Of Personal, Behavioral, And Socio-Environmental Factors Influencing High Risk Sexual Behavior And Hiv Transmission Among Heterosexual Adult Males In Ghana., Nana Ama Aya Erzuah Bullock

Electronic Theses and Dissertations

There are roughly 340,000 adults and children living with HIV. Despite the progress in the global response and the lowing of infections, HIV rates in Ghana remain stable. Cultural and societal norms that exist at a given time and place influence masculine socialization and behavior. These norms promote heterosexual men’s engagement in high-risk sexual behaviors which result in HIV infections. Factors such as HIV knowledge, risk perception, male condom use, HIV testing, and counseling which minimize the risk of HIV, are also influenced by these norms. Men have been identified as assets and advocates for behavior change and social responsibility …

The Roles Of Pon2 In Mitochondrial Physiology, Lung Tumor Cell Proliferation, And Lung Tumorigenesis., Aaron Whitt

Electronic Theses and Dissertations

Paraoxonase 2 (PON2) is an intracellular, multifunctional enzyme with near-ubiquitous tissue distribution. Within cells, PON2 is localized to mitochondria and endoplasmic reticulum (ER), where it mitigates the formation of reactive oxygen species (ROS). PON2’s chief enzymatic function is its lactonase activity, through which it catalyzes the hydrolysis of a bacterial quorum-sensing molecule, N-(3-oxododecanoyl)-l-homoserine lactone (C12), effectively disrupting bacterial intercellular communication and protecting against infection. C12 is produced by the opportunistic pathogen Pseudomonas aeruginosa and has been shown to disrupt various aspects of eukaryotic host cell physiology and evoke apoptotic cell death through the activity of PON2. Additionally, PON2 has garnered …

As Above, So Below: Magical Poetics And Queer Alchemy & A Planetary Spell.., Robert Eric Shoemaker

Electronic Theses and Dissertations

"Words have power": no more obvious statement has perhaps ever been made in an essay. However, the nature of that power is quite complicated, with a long and contentious history. I think of poetry as magic. Poetry is magical in the sense that it has ineffable qualities to it that enable readers to experience new thoughts and feelings when experiencing poetry, but when I say magic I mean that I think of poetry as actual, practical magic. As I will argue, poetry has magical qualities to it regardless of who is weaving the words, while intentional use of a self-aware …

The Role Of Obesity In Macrophage-Mediated Mechanisms Promoting Early-Onset Colon Cancer., Katharina Marietta Scheurlen

Electronic Theses and Dissertations

Early-onset colon cancer (EOCC) is a leading cause of cancer death among people younger than 50 years of age in the United States and is associated with metabolic dysfunction and obesity. Anti-inflammatory tumor-associated macrophages (TAM) and low Peroxisome Proliferator Activated Receptor Gamma (PPARγ) gene expression in colon cancer (CC) tissue promote tumor progression and decreased patient survival. Obesity-related hormones, such as leptin and adiponectin, have the potential to affect gene expression in TAM to promote CC progression and thereby link obesity and EOCC. The aim of this project was to identify target genes in human CC and to investigate the …

Structural And Functional Myocardial Adaptations To Task-Specific Epidural Stimulation In Chronic Spinal Cord Injury., Harley D. Ledbetter

Electronic Theses and Dissertations

Cardiovascular disease is a leading cause of mortality, and this is especially true in individuals with spinal cord injury. Decreased systemic blood pressure leads to cardiac deconditioning, thought to be related to the increased cardiovascular morbidity and mortality in this population. This study investigates effects of myocardial loading from epidural stimulation in a group of individuals with spinal cord injury to understand how changes in preload and afterload could lead to beneficial myocardial remodeling. The study conducted echocardiograms to describe the myocardial changes after training with two different types of epidural stimulation intervention: one designed to facilitate movement (Voluntary) and …

"Death Can't Touch Them Now": Aids Response And Memorialization In Louisville, Kentucky, 1982-1992., Olivia A. Beutel

Electronic Theses and Dissertations

This thesis aims to address the role of the queer community in Louisville, Kentucky during the AIDS epidemic. Beginning with the first reported AIDS death in the city in 1983 throughout the 1980s, dialogue focused on those living with AIDS, specifically on education for prevention and aid to those afflicted by the disease. Individuals in the queer community—gay men, lesbians, bisexual men and women, transgender men and women, and others—created resources that were not being provided by the larger city government. Then, in the 1990s, national attention to the AIDS Memorial Quilt encouraged people to participate in rituals of commemoration, …

Black Ads Matter: An Analysis Of Black Representation In Advertising., Elyssa Quinn Smith

Electronic Theses and Dissertations

During the summer of 2020 Black Lives Matter (BLM) became a rallying cry throughout the United States and the world. At that time, many individuals and organizations reflected on how they could better support the movement for equality, equity, and inclusion, but some of the results were ingenuine, perceived as virtue signaling or woke washing. In this thesis I explore the Black representation in advertising from three prominent car brands from both pre- and post-summer 2020. I analyze ads from Acura, Buick, and Lincoln to determine if they are synergistic and include multi-dimensional Black representation, criteria Burgess et al.’s (2020) …

Beyond A Divide: Reconceptualizing Digital Capital And Links To Academic Proficiency., Ryan Price

Electronic Theses and Dissertations

In the digital inequality literature, the popular notion of a “digital divide” is frequently used to discuss digital inequality; however, this framework is overly simplistic and cannot adequately capture the complex nature of digital inequality. Some scholars have adopted a framework of digital capital to attempt a multidimensional approach to this social problem, but the literature lacks consistent empirical measurements. Using U.S. data from the Programme for International Student Assessment (PISA) 2018 Survey, I seek to propose, and validate, internally consistent principal components of digital capital among 15-year-old high school students in the US. I conduct a Principal Component Analysis …

Automatic Testing Of Organic Strain Gauge Tactile Sensors., Brian P. Goulet

Electronic Theses and Dissertations

Human-Robot Interaction is a developing field of science, that is posed to augment everything we do in life. Skin sensors that can detect touch, temperature, distance, and other physical interaction parameters at the human-robot interface are very important to enhancing the collaboration between humans and machines. As such, these sensors must be efficiently tested and characterized to give accurate feedback from the sensor to the robot. The objective of this work is to create a diversified software testing suite that removes as much human intervention as possible. The tests and methodology discussed here provide multiple realistic scenarios that the sensors …

The Effects Of Previous Traumatic Experiences On Learning Outcomes: Perceptions Of Black Men Who Are Attending Community College, Willie Thomas

Electronic Theses and Dissertations

Academic underachievement among Black students, particularly Black male students, is a troubling trend that has long attracted scholarly attention. The prevailing consensus is that the shortcomings of some Black male students in academic achievement may be attributable to traumatic experiences arising from environments of violent, inner-city poverty that disproportionately affect Black men. Traumatic experiences have been shown to negatively affect Black men’s self-perception, emotions, self-image, and social and cognitive skills, with consequences in the form of measured shortfalls in retention and graduation rates. My qualitative, phenomenological study sought to explore how previous traumatic experiences of Black men affected their academic …

Examining The State Of Substance Use Treatment Among Youth And Adults In The United States, Esther Adejoke Adeniran

Electronic Theses and Dissertations

In the United States (US), substance use, misuse, and substance use disorders are significant public health problems. Additionally, the difference between needing substance use treatment (SUT) and receiving treatment is becoming more pronounced. Therefore, the aims of this dissertation include, 1) to synthesize evidence of barriers and facilitators to integrating SUT into mainstream health care (MHC) after the Affordable Care Act was nationally implemented in 2014, 2) to examine the rate of treatment completion and dropout, along with its associated factors, among youth who received Medication-Assisted Opioid Therapy (MAT), 3) to determine the relationship between prior treatment episodes and length …

High-Probability Tasks And Task Completion Rates Of Students With Emotional And Behavioral Disorders., Amy R Hall

Electronic Theses and Dissertations

This dissertation is an investigation into the effects of high-probability tasks on the task completion rates of three students diagnosed with an emotional and behavioral disorder. It begins with a close look into best practices verses common practices, examines students supports currently available in schools, and highlights gaps present in today’s educational system for students who exhibit significant challenging behaviors. The dissertation reviews literature available on the topic of high-probability tasks as a logical solution to combating gaps in behavior support and describes methodology used to investigate the strategy and its effects. It closes by presenting data, conclusions, implications, and …

The Glass Coffin: Gothic Adaptations And The Formation Of Sexual Subjectivity., Colton T. Wilson

Electronic Theses and Dissertations

It is now an almost foregone conclusion that classic depictions of vampirism resonate with contemporary queer audiences. A sympathetic response to the monster’s persecution is often the key factor in these arguments, yet little attention is paid to the textual details that prompt such a process of identification. This study posits that the iconography used to establish a connection between monstrosity and non-normative sexuality has its origins in Victorian Gothic fiction, whose descriptions of vampirism were assimilated into the discourse of the fin-de-siècle medical field known as sexology. Theories that defined homosexuality as an illness with physical and psychological symptoms …

Black Women Burdening: The Process Of "Unburdening" Realism In Dennis Mcintyre's Split Second., Brandi L. Threatt

Electronic Theses and Dissertations

Black women who dramatize reality can experience a transference of burdens if realistic plays reflect their lived experiences. Burdens affect truthful character development and impact the mental, emotional, physical, social and spiritual well-being of Black actresses. This thesis will use the Fall 2021 University of Louisville production of Dennis McIntyre’s Split Second as a case study. Gender and Race studies along with an auto-ethnographic research approach will be used to examine how my portrayal of Alea in Split Second contributed to Black Woman Burdening, a phrase I created to examine how Black fatigue can negatively and specifically affect Black women …

It's All Fun And—: A Rhetorical Analysis Of Space In The Pandemic., Erica Von Proctor Lewis

Electronic Theses and Dissertations

This exhibition and document explore spatial rhetoric during the pandemic, utilizing materiality and relational aesthetics to reflect on the different ways in which the public and private are made distinct from one another. In doing so, Lewis addresses new cultural navigations of shared spaces, both digital and corporeal, public and private. In addition, the artist also examines the faulty social and institutional systems that the pandemic brought to light, such as socioeconomic dynamics and voter suppression, while utilizing Kenneth Burke’s concept of the terministic screen. Games are a central theme throughout the exhibition, as they are often coded as “home” …

Risk Gameplay Analysis Using Stochastic Beam Search, Jacob Gillenwater

Electronic Theses and Dissertations

Hasbro’s RISK, first published in 1959, is a complex multiplayer strategy game that has received little attention from the scientific community. Training artificial intelligence (AI) agents using stochastic beam search gives insight into effective strategy when playing RISK. A comprehensive analysis of the systems of play challenges preconceptions about good strategy in some areas of the game while reinforcing those preconceptions in others. This study applies stochastic beam search to discover optimal strategies in RISK. Results of the search show both support for and challenges to traditionally held positions about RISK gameplay. While stochastic beam search competently investigates gameplay on …

Using The Raap Strategy To Promote Communication Skills For Students With Multiple Disabilities, Hannah Millard

Electronic Theses and Dissertations

The purpose of this study was to examine the effects of the RAAP strategy on students with multiple disabilities and their ability to produce multi-symbol messages. Using a single-case, multiple probes across participants design, 4 students with multiple disabilities participated in this study. They were taught how to answer reading comprehension questions through the RAAP strategy and access to a communication/core board.

Results indicated a functional relation between the RAAP strategy and the student’s multisymbol messages. Three of 4 students increased their multi-symbol messages and made progress with the intervention as it was planned. One student needed the intervention to …

The Impact Of Sea-Level Rise In Numerically Modeled Landfalling Hurricanes: Katrina And The Gulf Coast., Serenity Nadirah Mercuri

Electronic Theses and Dissertations

With climate change, landfalling hurricanes become an increasing threat to coastal regions. However, the interactions between the coastal landscape and landfalling hurricanes are often overlooked when addressing sea-level rise outside of inundation and independent of sea surface temperature. This study analyzed the potential impacts regarding structure and intensity as a result of sea-level rise in the Gulf of Mexico using the WRF-ARW numerical model coupled with a 1D ocean model. Analysis showed that 10 m windspeed from landfall forward was higher in modified coastlines, and minimum sea-level pressure post-landfall was consistently lower for modified runs where storms maintain a higher …

A Machine Learning Approach For Reconnaissance Detection To Enhance Network Security, Rachel Bakaletz

Electronic Theses and Dissertations

Before cyber-crime can happen, attackers must research the targeted organization to collect vital information about the target and pave the way for the subsequent attack phases. This cyber-attack phase is called reconnaissance or enumeration. This malicious phase allows attackers to discover information about a target to be leveraged and used in an exploit. Information such as the version of the operating system and installed applications, open ports can be detected using various tools during the reconnaissance phase. By knowing such information cyber attackers can exploit vulnerabilities that are often unique to a specific version.

In this work, we develop an …