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Characteristics Of Refractivity And Sea State In The Marine Atmospheric Surface Layer And Their Influence On X-Band Propagation, Douglas Matthew Pastore

Electronic Theses and Dissertations

Predictions of environmental conditions within the marine atmospheric surface layer (MASL) are important to X-band radar system performance. Anomalous propagation occurs in conditions of non-standard atmospheric refractivity, driven by the virtually permanent presence of evaporation ducts (ED) in marine environments. Evaporation ducts are commonly characterized by the evaporation duct height (EDH), evaporation duct strength, and the gradients below the EDH, known as the evaporation duct curvature. Refractivity, and subsequent features, are estimated in the MASL primarily using four methods: in-situ measurements, numerical weather and surface layer modeling, boundary layer theory, and inversion methods.

The existing refractivity estimation techniques often assume …

Applications Of Artificial Intelligence To Improve Coastal Ocean Modeling, Dongliang Shen

Electronic Theses and Dissertations

Numerical Modeling (NM) is widely used to simulate and predict hydrodynamic processes and marine particle movements in coastal oceans, particularly during extreme weather events and emergencies. NM offers the capability to realistically simulate multiple state variables and fill gaps caused by scarce observations. However, inherent uncertainties exist in all NMs, primarily arising from the following three factors: 1) insufficient observations leading to uncertain model initial and boundary conditions, 2) inevitable truncation errors due to coarse model resolution, and 3) imperfect physics parameterization schemes for sub-grid processes, especially those related to waves. The consequences of these uncertainties are that 1) even …

The Role Of E-Liquid Constituents In E-Cigarette-Induced Cardiac Arrhythmia And Autonomic Imbalance., Cory Kucera

Electronic Theses and Dissertations

Introduction. Accumulating evidence indicates that exposure to electronic cigarettes (e-cigs) promotes sympathetic dominance and electrophysiologic instability in the heart, potentially culminating in arrhythmogenesis. E-liquids contain various formulations of nicotine and flavorings, but the effects of specific e-liquid constituents and their concentrations on e-cig-induced autonomic imbalance and electrical dysfunction are unresolved. To that end, we tested the hypothesis that e-cigs modify cardiac autonomic balance and ventricular arrhythmogenesis in mice dependent on e-liquid constituent type and concentration. Methods. Using a crossover design and a serial exposure regimen, ECG-telemetered male C57BL/6J mice underwent whole-body exposure to e-cig aerosols generated from e-liquids containing different …

Using Graphic Novels To Teach Economics Content To High School Students With Extensive Support Needs., Caroline Mae Fitchett

Electronic Theses and Dissertations

The purpose of social studies instruction in school is to facilitate the growth of competent citizens (National Council for the Social Studies [NCSS], 2013). Despite the recognized benefit of social studies instruction, emphasis on this subject has decreased over time, and has ultimately been termed a “dispensable subject” (Fitchett & Haefner, 2010). Social studies is an even more marginalized subject area for students with disabilities (Zakas et al., 2013). Expanding the research in this area is not only necessary to improving social studies academic content acquisition but is also likely to facilitate greater independence for students post-school – and by …

Changes To Water Quality And Discharge In An Urban Stream In Southwest Jefferson County., Karina Henson

Electronic Theses and Dissertations

Mill Creek is the largest watershed in Southwest Jefferson County, where thousands of people live and work. Streams in the watershed have historically been channelized and altered to promote drainage, and stream health is of major concern. Louisville MSD is currently developing a watershed plan for Mill Creek by seeking understanding of current stream conditions. This paper will focus on historical trends in stream discharge and water quality. Peak and daily discharge, dissolved oxygen, specific conductance, and temperature data from USGS gages at Mill Creek and the Mill Creek Cutoff was analyzed to understand how water quality and flow rates …

Characterization Of The Immunoglobulin Lambda Chain Across Diverse Human Populations., William Gibson

Electronic Theses and Dissertations

The adaptive immune system relies on a diverse set of over one hundred immunoglobulin (IG) genes across three genomic loci that are variably combined to form antibodies (Ab). The IG Lambda locus is one of two loci which encodes the IG light chain. The complexity of the IGL locus severely limits the effective use of standard short-read sequencing, limiting our knowledge of population diversity in these loci. We leveraged single molecule real-time (SMRT) long-read sequencing in conjunction with IGL-targeted DNA capture to develop the method IG-Cap for accurate and high-throughput sequencing of the IGL locus. We benchmarked this method using …

Inhibition Of Ras As A Novel Therapeutic Approach In Luminal B Breast Cancer., Raphael Ngozichi Jigo

Electronic Theses and Dissertations

Historically, the RAS oncoprotein has not been implicated in breast cancer due to less than 1% of breast cancer cases bearing oncogenic RAS mutations. Recently, however, it has been reported that greater than 60% of Luminal B breast cancer cases have a decreased expression of negative RAS regulators RASAL2 and DAB2IP. Thus, in many Luminal B breast cancers, RAS remains in a constitutively active state without mutation, in turn driving oncogenesis. To date, there are no FDA-approved direct inhibitors of wild type RAS. We have developed a direct RAS inhibitor that acts on wild type RAS using in silico drug …

Investigation Of Possible Inflammatory Response After Ultrasound And Microbubble Procedure In The Spinal Cord., Jenna Wilkerson

Electronic Theses and Dissertations

The purpose of this experiment is to explore the inflammatory effects of focused ultrasound paired with intravenously delivered microbubbles when used in the lumbar spinal cord. There are currently very few pharmaceuticals that can successfully enter the blood spinal cord barrier (BSCB). This technique used at the lumbar enlargement might allow targeted treatment of pathologies involving the spinal cord.

To test the possible inflammatory response of this technique, an animal experiment was performed. 15 animals were given a T12 laminectomy and allowed to fully recover. Once recovered, all animals received FUS+MB at L2 and were euthanized in groups of five …

Development And Application Of A Microfluidic Platform For Quantifying Intra-Tumoral Compressive Stress., Zachary P. Fowler

Electronic Theses and Dissertations

Cancer progression is linked to the emergence of aberrant mechanical signaling in the tumor microenvironment. Modulation of extrinsic signals, such as ECM stiffness and composition, have been thoroughly explored. However, the development of solid stresses within the tumor remains poorly understood. To address this, we have developed a microfluidic platform that generates deformable alginate microbeads that allow for the quantification of compressive stresses generated within a growing glioblastoma (GBM) tumorsphere. PDMS microfluidic devices were fabricated via SU-8 mold with channels ranging from 10µm-40µm in diameter. Fluorescently labeled sodium alginate underwent a cross-linking reaction within the device to generate monodisperse beads …

Addition Of Process Control Experiment To Unit Operations Ii Laboratory., Bradley Esselman

Electronic Theses and Dissertations

Process control is an essential aspect of manufacturing, contributing to improved process safety, efficiency, product consistency, and energy optimization. Chemical engineers are often responsible for ensuring the safe, efficient, and cost-effective operation of industrial processes, and process control plays a pivotal role in accomplishing this.

Chemical engineering students at the University of Louisville complete the course, Elements of Process Control, during the second semester of their fourth year. This lecture-based course offers limited hands-on, practical experience. To supplement the lack of hands-on experience in the classroom, a new process control experiment was designed and implemented into the Unit Operations …

Secondary Educator And Administrator Perceptions Of Positive Behavior Interventions And Supports And Student Academic Achievement, Cynthia Everitt

Electronic Theses and Dissertations

This qualitative study addresses secondary educator perceptions of Positive Behavioral Interventions and Supports (PBIS) and student academic achievement. PBIS is a proactive approach with a multitiered framework. When used properly, PBIS can be a tool for school faculty to establish behavioral expectations and procedures, prevent disruptive behavior, and improve the school climate and culture. This phenomenological study was conducted using two secondary schools in West Virginia. Participants were identified and chosen through purposive sampling techniques according to their years of experience teaching and utilizing PBIS interventions.

The data for this study included unstructured, open-ended interviews based on three research questions. …

Analyzing The Influence Of Mathematics Intervention Teacher Actions On Students' Mathematics Identities: An Examination Of Bipoc Student Perceptions And Past Learning Experiences., Sydni P. Morris

Electronic Theses and Dissertations

This dissertation examines mathematics education's past and present state in the United States, emphasizing mathematics intervention instruction. This dissertation includes a complex and critical analysis of intervention practices and historical and structural inequities based on race present in these interventions and mathematics education. In combination, it examines the construct of mathematics identities, their role in student success with mathematics, and trends surrounding mathematics education and its impact on populations of students of color. Using Critical Race Theory as an underlying framework and Critical Counter-Narrative as a methodology, it argues a need for marginalized student voices to be present in the …

Mapping The Binding Site Within Integrin D2 For Carboxyethylpyrrole (Cep)-Modified Proteins, Afia Prema

Electronic Theses and Dissertations

Neutrophils and macrophages accumulate at sites of inflammation and cause chronic inflammation leading to various diseases. Therefore, to better understand chronic disease pathways it is important to investigate the properties of macrophage accumulation in inflamed tissues. The I-domain of the macrophage receptor integrin a_Db₂ plays a vital role in macrophage retention by binding to CEP (carboxyethyl pyrrole), a ligand available at inflammatory sites. This thesis mainly focuses on evaluating the binding site within integrin a_Db₂ that binds carboxyethyl pyrrole (CEP)-modified proteins. So, a recombinant plasmid construct containing the integrin I-domain was developed. Seven non-conserved …

Acute Responses To Combined Accentuated Eccentric Loading And Rest Redistribution, Sungwon Chae

Electronic Theses and Dissertations

This dissertation was 2 parts of investigations of various acute responses to high-volume combined accentuated eccentric loading and rest redistribution (AEL + RR). Resistance-trained men (n = 12, 25.6 ± 4.4 years, 1.77 ± 0.06 m, 81.7 ± 11.4 kg) completed a back squat (BS) 1 repetition maximum (1RM) and weight releaser familiarization session. Three BS exercise conditions (sets × repetitions × eccentric/concentric loading) comprised AEL + RR 5: 3 × (5 × 2) × 110/60%, AEL + RR 2: 3 × (2 × 5) × 110/60%, and traditional sets (TS): 3 × (1 × 10) × 60/60% 1RM. The …

Comparison Of The 2022 Monkeypox (Mpox) Outbreak Using Mathematical Modeling And Time Series Clustering, Mark-Daniels Tamakloe

Electronic Theses and Dissertations

Monkeypox virus (MPXV) is the causative agent of monkeypox (mpox), a rare viral disease that affects humans [1]. It is primarily found in Africa and is transmitted to humans through contact with sick animals, particularly rodents and monkeys, or through human-to-human transmission [2]. From the beginning of May 2022, cases of mpox have been recorded from non-endemic nations, and the illness has continued to be reported in other endemic nations. Majority of confirmed cases have been recorded in Europe and North America. In this thesis, we compare the spread of the outbreak across the top ten countries using a combination …

A Low Cost, Compact Electrochemical Analyzer Based On An Open-Source Microcontroller, Michael Kofi Darko Addo

Electronic Theses and Dissertations

Compared to other instruments for chemical analyses, electrochemical analyzers are relatively simple, inexpensive, easy to miniaturize and require little-to-no maintenance. However, like all commercially available instruments, commercial electrochemical analyzers like potentiostats primarily operate as black boxes with manufacturers providing little or no information about internal circuitry and programming. This practice can limit a researcher’s ability to develop new techniques or adapt an instrument for applications outside its typical use. In contrast, creators of open-source instruments release all the necessary information for reproduction of the hardware and software – minimizing such barriers to innovation in chemical analyses. Here, we report a …

Microsporidian Spores And The Integrin Binding Loop Of The Madam Protein Are Important For Integrin Signaling And Attachment To Host Cells, Cindy L. Barrett

Electronic Theses and Dissertations

Microsporidia are a distant fungal pathogen that have severe clinical consequences for the immunocompromised. Previous work identified a microsporidian pathogen protein termed Microsporidian ADAM or MADAM. This protein has close sequence homology to other ADAM proteins (A Disintegrin and Metalloproteinase) in two microsporidian species, Encephalitozoon intestinalis and E. cuniculi. ADAM proteins have a wide range of functions, including binding to integrins and host signaling. It is known that many pathogens manipulate integrins to invade host cells, and it is predicted that microsporidia are also exploiting this host target. Previous work with the MADAM protein demonstrated that this protein has a …

Overdose Prevention Behaviors And The Rural Risk Environment Among People Who Inject Drugs In Rural Appalachia, Jody Teel

Electronic Theses and Dissertations

Introduction: The entire United States has felt the effects of the overdose epidemic, but rural Appalachia has experienced disproportionate overdose deaths. This variation in overdose mortality can be attributed to the risk environment for overdose in rural Appalachia. Overdose prevention behaviors are individual level behaviors that people who inject drugs can implement that may have the potential to reduce their risk of overdose, however limited research exists regarding the utilization of those behaviors. It is important to consider how the risk environment can influence the utilization of overdose prevention behaviors among people who inject drugs. Therefore, the purpose of this …

Exploring The Experiences Of Underrepresented Students Pursuing Health-Related Graduate Or Professional Programs, Alison Williams

Electronic Theses and Dissertations

For many years graduate and professional education programs for the health professions have sought to increase the diversity of their student body to include students from a wider variety of backgrounds. Increasing the diversity of healthcare providers is an essential component of addressing inequities in healthcare. However, despite initiatives to increase racial and ethnic diversity in the health professions, these professions remain largely White and female. Previous researchers have sought to identify the reasons that racial and ethnic minorities are underrepresented in healthcare, and the barriers to persistence and success. Little research exists explaining why men are underrepresented in the …

School Leader Perceptions About The Implementation And Utility Of Restorative Practices, Danielle Rutig

Electronic Theses and Dissertations

This phenomenological qualitative study examined school leaders' perceptions of using restorative practices within their schools. Participants included twelve school leaders who had experience with utilizing and implementing restorative practices. School leaders included: principals, assistant principals, deans, and administrative assistants. Research indicates that restorative practices are adapted to support specific school goals. Restorative practices are not practiced in isolation, as school leaders often couple restorative justice with social-emotional learning, trauma-informed practices, and other social-emotional supports. Restorative practices are tied closely to CASEL’s social emotional framework.

Data were collected via semi-structured interviews using a virtual platform. Themes that emerged from the analysis …

A Pandemic’S Potential To Haunt: A Longitudinal Look At The Professional Wellbeing Of Tn’S Infant And Early Childhood Mental Health (Iecmh) Workforce, Robyn A. Dolson

Electronic Theses and Dissertations

Infant and Early Childhood Mental Health (IECMH) providers engage in uniquely relational work with high-risk families that expose them to the full advantages (i.e., compassion satisfaction [CS]) and disadvantages (e.g., burn-out [BO]) of a helper role. Though the pandemic seemed poised to escalate disadvantage, most early pandemic studies found high CS alongside elevated BO. Unfortunately, as COVID-19 has continued, CS has declined while BO has increased. Given the delayed COVID-19 impact on children, these changes may be particularly acute for IECMH providers. Using a longitudinal cohort of 27 IECMH providers, this study aimed to describe and quantify changes in professional …

Reservoir Characterization Of The Utica Shale Play Using Well Log Data In Columbiana, Ohio, Tyler L. West

Electronic Theses and Dissertations

The Ordovician Utica shale play is rapidly developing throughout the Appalachian Basin. The play is a mixed carbonate-siliciclastic system that grades from primarily carbonates at its base in the Lexington/Trenton limestones into primarily shale within the Utica shale. As of January 2021, it is the third highest-producing dry shale gas play in the contiguous U.S., although it is known to produce wet gas and oil in various parts of the basin. In addition to being an unconventional reservoir, the Utica shale, an informal unit in Ohio where the main fairway is located, is a known source rock for much of …

Linguistic Features Of Metaphor, Metonymy And Narrative Gap In “The Yellow Wallpaper:” A Literary Analysis, Sherry Kaye Ms.

Electronic Theses and Dissertations

In 1890, Charlotte Perkins Gilman wrote a piece of fiction that reflected her personal experience for treatment of nervous exhaustion. The story she developed created controversy and comment after it was published and, years later, agitation among feminists who found allegories of truth in its narrative. This thesis explores the use of linguistic features employed by Gilman to establish cognitive connections between physical structures and social institutions, such as marriage and domesticity, that confine women within contractual obligations. Gilman’s use of extended metaphor challenges conventional conceptions of the home, inanimate objects, and institutional authority and her use of metonymy extrapolates …

The Initial Validation Of A Self-Care Belief And Behavior Questionnaire In The Iecmh Workforce, Julia Najm

Electronic Theses and Dissertations

The Infant and Early Child Mental Health (IECMH) workforce is essential in improving the lives of vulnerable children and families. IECMH practitioners are exposed to challenging emotional experiences which increases their risk of internalizing disorders, burnout, and emotion regulation difficulties, especially in the time of COVID-19. Thus, it is important to identify possible interventions to increase provider wellness in the face of taxing work. The construct of self-care offers a promising area of study as a possible intervention point. However, current operationalizations of self-care have been limited and have emphasized behavioral components rather than cognitive components (e.g., beliefs) pertinent to …

Geometric Morphometric Analysis Of Modern Viperid Vertebrae Facilitates Identification Of Fossil Specimens, Lance D. Jessee

Electronic Theses and Dissertations

Snake vertebrae are common in the fossil record, whereas cranial remains are generally fragile and rare. Consequently, vertebrae are the most commonly studied fossil element of snakes. However, identification of snake vertebrae can be problematic due to extensive variation. This study utilizes 2-D geometric morphometrics and canonical variates analysis to 1) reveal variation between genera and species and 2) classify vertebrae of modern and fossil eastern North American Agkistrodon and Crotalus. The results show that vertebrae of Agkistrodon and Crotalus can reliably be classified to genus and species using these methods. Based on the statistical analyses, four of the …

Investigation Of The Protein Components In A Periplasmic Mechanism Regulating Bacterial Morphology, Alexandra Pulliam

Electronic Theses and Dissertations

Salmonella is a leading bacterial cause of foodborne illness worldwide. During a previous study investigating the enzymes responsible for regulating cyclic-di-GMP concentrations, a mutant in the cyclic-di-GMP-specific phosphodiesterase STM3615 was identified that displayed a phenotype characterized by decreased survival on agar plates and a shorter bacterium length. I was able to determine that the periplasmic domain of STM3615 was responsible for this phenotype, not the enzymatic phosphodiesterase domain. Based upon a bioinformatic analysis of the protein, I then hypothesized that the periplasmic domain of STM3615 was interacting with a periplasmic protein to give rise to this phenotype. To identify this …

Development Of A Comprehensive Staff Development Program About Outpatient Diabetes Clinic Care For Patients With Type 1 And Type 2 Diabetes Mellitus, Cynthia G. Sanders

Electronic Theses and Dissertations

The purpose of this DNP project was to evaluate if focused staff education about the many aspects of outpatient diabetes care has the potential to increase knowledge and impact attitudes about diabetes in staff providing care to patients with type 1 and type 2 diabetes mellitus. Diabetes is a disease with wide ranging implications, in terms of cost, consumer health, and quality of life, for populations worldwide, including the United States. It is critical that staff who participate in the care of patients with diabetes mellitus have a role-specific educational foundation to support their contribution to patient care. The researcher …

Investing In Your Employees: Understanding The Impact Organizational Commitment Has On Staff Retention, Vanessa Lynne Mcwhirt

Electronic Theses and Dissertations

High employee turnover in higher education has been an issue for decades, and successfully integrating newly hired staff (NHS) into their new job and the organization can be challenging for human resources and leadership. New employee orientation and onboarding programs can assist NHS. The author of this paper conducted a Utilization-Focused evaluation of the Thriving at DU program at the University of Denver (DU) to improve the program. The study examined the perceptions of how 12 student and academic affairs professionals made meaning of organizational commitment in the workplace throughout their onboarding experience.

The major findings of this evaluation aligned …

A Virtual Method For Establishing Femoral Stem Position In Total Hip Arthroplasty, Samuel Mattei

Electronic Theses and Dissertations

Total hip arthroplasty (THA) is one of the most successful orthopedic surgeries performed, in which the hip joint is reconstructed to improve functionality and decrease pain in the joint. Despite the success of these procedures, femoral stem misalignment remains an area that influences THA success. The relationship between the femoral stem geometry and implanted femoral stem size and orientation is underreported due to limitations in the collection of radiographic data used for clinical pre-operative templating. Furthermore, the influence of anatomic measurements on the direction and size of the femoral stem are not considered due to imaging technique and difficulties associated …

Finite Element Modeling Of Patient-Specific Total Shoulder Arthroplasty, Ignacio Rivero Crespo

Electronic Theses and Dissertations

Total Shoulder Arthroplasty (TSA) is a surgical procedure designed to improve joint functionality by replacing the articulation between the humeral head and the glenoid fossa. Anatomic Total Shoulder Arthroplasty (aTSA) and Reverse Total Shoulder Arthroplasty (rTSA) are two types of replacement surgery to relieve pain and restore function of the shoulder. The overall goal of this study was to evaluate the effects of variation of certain patient and implant alignment parameters that may influence long-term outcomes of these surgical procedures, including kinematics, joint loads and contact mechanics. Computational models of six TSA subjects, three aTSA and three rTSA, were created …