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A Member Of The Novel Fikk Family Of Plasmodium Falciparum Putative Protein Kinases Exhibits Diacylglycerol Kinase Activity And Is Exported To The Host Erythrocyte, David Floyd Curtis
A Member Of The Novel Fikk Family Of Plasmodium Falciparum Putative Protein Kinases Exhibits Diacylglycerol Kinase Activity And Is Exported To The Host Erythrocyte, David Floyd Curtis
Electronic Theses and Dissertations
Plasmodium falciparum is one of four species known to cause malaria in humans and is the species that is associated with the most virulent form of the disease. Malaria causes nearly two million deaths each year, many of these occurring among children in under-developed countries of the world. One reason for this is the prevalence of drug resistant strains of malaria that mitigate the efficacy of existing drugs. Hence, the identification of a new generation of pharmacological agents for malaria is extremely urgent. The recent identification of a group of novel protein kinases within the Plasmodium falciparum genome has provided …
Explorations & Redefinitions Of New Media Aesthetic Concepts In Contemporary Art Culture, Phillip S. Delacruz
Explorations & Redefinitions Of New Media Aesthetic Concepts In Contemporary Art Culture, Phillip S. Delacruz
Electronic Theses and Dissertations
My thesis pursues the exploration, invention, and redefinition of the role of Aesthetics through artistic practices of 3d digital graphics, 2d print, video, and sculpture. Aesthetic research altruistically generates visual installations informed by utopian idealism, science and technology centric culture, pop culture iconography, art history, international contemporary art and design.
The Generation And Scavenging Of Radicals Via Cerium And Nanoceria, Eric Glenn Heckert
The Generation And Scavenging Of Radicals Via Cerium And Nanoceria, Eric Glenn Heckert
Electronic Theses and Dissertations
Cerium is the most abundant of the rare earth metals, found on average at a level of 66 parts per million in the earth's crust. The unique redox properties of cerium and cerium oxide nanoparticles have led to its use in a wide variety of industrial and commercial uses such as oxygen sensors, fertilizers and as a catalyst to remove toxic gases in automobile exhaust. The use of cerium has also garnered interest in the nanotechnology field. Nanoceria has been generated in its oxide form as nanoparticles and nanorods. Recently, nanoceria has been shown to protect against oxidative stress in …
Moonflowers And Other Stories, Sarah Bethany Prevatt-Harris
Moonflowers And Other Stories, Sarah Bethany Prevatt-Harris
Electronic Theses and Dissertations
Moonflowers and Other Stories is a collection of short stories focusing on complex relationships among characters who are estranged from their families and their pasts; some seek to reestablish connections, while others decide to simply walk away. All of the stories are set in Florida. In "Stained Glass," Abby returns home after seventeen years to help care for the father who disowned her. In "Blue Green Red," Melaney is compelled to find her brother after years of lying about his existence. Selina, the protagonist of "Fatty Walsh" is so embarrassed by her family she will not tell her friend Alucia …
Seasonal And Diel Patterns Of Manatee Habitat Use, Monica Ann Ross
Seasonal And Diel Patterns Of Manatee Habitat Use, Monica Ann Ross
Electronic Theses and Dissertations
State and Federal agencies have created sanctuaries and speed zones to help reduce manatee mortality while incorporating the recreational and commercial resource needs of these same habitats for humans. Specific habitat resources are considered necessary to increase manatee survivorship. We have only recently begun to address how manatees use some of these resources based on physiological or reproductive strategies. In this study, I quantified patterns of habitat use during seasonal and diel periods for different sex and reproductive manatee classes using data from a radio-telemetry study conducted by the Florida Fish and Wildlife Conservation Commission during 1991-1996. I used five …
Two Blades Come Together: Stories, Mark Edward Pursell
Two Blades Come Together: Stories, Mark Edward Pursell
Electronic Theses and Dissertations
This collection of seven short stories details the emotional triumphs and complications of characters whose lives are altered by issues of sexuality and disconnection. An adolescent girl feels her father slipping away from her and, in turn, willfully destroys the imaginary world of the boy she babysits; a speech therapist struggles to make headway with a young patient while finding himself unable to communicate with his ex-lover; a gay poet cheats on his boyfriend in a desperate attempt to fuel his failing art. The dramatis personae of Two Blades Come Together is comprised of individuals who struggle towards grace and …
Frat Star, Nathan Andrew Holic
Frat Star, Nathan Andrew Holic
Electronic Theses and Dissertations
This thesis, a social novel in the tradition of Tom Wolfe's The Bonfire of the Vanities and Michael Chabon's The Amazing Adventures of Kavalier and Clay, is all at once an attentive first-person study of a twenty-something man close to his cracking point in his first post-college job, a detailed expose of national fraternities, and the sweeping panoramic view of an entire generation of over-programmed college students searching for direction. Frat Star follows a fragile college graduate named Charles Washington, who takes a position as an "Educational Consultant" with a national fraternity in his first semester after graduation. For sixteen …
Physical Characteristics Of An Individual: The Identification Of Biomarkers For Biological Age Determination, Michelle Alvarez
Physical Characteristics Of An Individual: The Identification Of Biomarkers For Biological Age Determination, Michelle Alvarez
Electronic Theses and Dissertations
It is now a matter of routine for the forensic scientist to obtain the genetic profile of an individual from DNA recovered from a biological stain deposited at a crime scene. Potential contributors of the stain must either be known to investigators (i.e. a developed suspect) or the questioned profile must be searched against a database of DNA profiles such as those maintained in the CODIS National DNA database. However, in those instances where there is no developed suspect and no match is obtained after interrogation of appropriate DNA databases, the DNA profile per se presently provides no meaningful information …
Using Computer Simulation Modeling To Evaluate The Bioterrorismresponse Plan At A Local Hospital Facility, Robert Bebber
Using Computer Simulation Modeling To Evaluate The Bioterrorismresponse Plan At A Local Hospital Facility, Robert Bebber
Electronic Theses and Dissertations
The terrorist attacks of September 11th, 2001 and the subsequent anthrax mail attack have forced health care administrators and policy makers to place a new emphasis on disaster planning at hospital facilities--specifically bioterrorism planning. Yet how does one truly "prepare" for the unpredictable? In spite of accreditation requirements, which demand hospitals put in to place preparations to deal with bioterrorism events, a recent study from the General Accounting Office (GAO) concluded that most hospitals are still not capable of dealing with such threats (Gonzalez, 2004). This dissertation uses computer simulation modeling to test the effectiveness of bioterrorism planning at a …
The Rebirth Of Consciousness, Urszula Blaszak
The Rebirth Of Consciousness, Urszula Blaszak
Electronic Theses and Dissertations
Human beings encounter cascades of a plethora of experiences, one after another, every single microsecond of our lives. There are many things happening around. The world is full of events and occurrences. As they happen, the mind reacts to every individual input. This is a very exhausting and difficult. Thus, people have developed a process of self-defense against this horrible mishmash of information. Their minds have this amazing capacity of sorting them out and making sense out of them. Humankind's survival depends on that. If one does not sort all this information out, one might not be able to make …
Glutamate Excitotoxicity In Epilepsy And Ischemia, Mangala Meenakshi Soundarapandian
Glutamate Excitotoxicity In Epilepsy And Ischemia, Mangala Meenakshi Soundarapandian
Electronic Theses and Dissertations
'Excitotoxicity' represents the excitatory amino acid mediated degeneration of neurons. Glutamate is the major excitatory neurotransmitter in the brain. Glutamate excitotoxicity has been implicated in a number of neurodegenerative disorders like Stroke, Epilepsy, Alzheimer's disease and traumatic brain injury. This neurotoxicity is summed up by the 'glutamate hypothesis' which describes the cause of neuronal cell death as an excessive release of glutamate causing over excitation of the glutamate receptors and subsequent increase in influx of calcium leading to cell death. An effort to counteract this neurotoxicity has lead to the development of glutamate receptor antagonists that can effectively serve as …
In Search Of: Stories From The Ones Left Behind, Mayra Lizzette Velez
In Search Of: Stories From The Ones Left Behind, Mayra Lizzette Velez
Electronic Theses and Dissertations
In Search Of: Stories from the Ones Left Behind introduces five young women-- June, Leila, Kiss, Marianne, and Alma-- who struggle to impede loved ones from abandoning them. One woman confronts her worst fears when she finds out about her husband's affair with a mutual friend; one comes to terms with her sister's poor lifestyle choices; another copes with her mother's sudden marriage; and yet another figures out that in order to keep her fiance, she must be willing to take on responsibilities foreign to her. And then there is the story of Alma, a contemplative but naive seventeen-year-old girl …
Lim Kinase 1 Modulates Expression Of Matrix Metalloproteinases And Associates With Gamma-Tubulin: Dual Role In Invasion And Mito, Tenekua Tapia
Lim Kinase 1 Modulates Expression Of Matrix Metalloproteinases And Associates With Gamma-Tubulin: Dual Role In Invasion And Mito, Tenekua Tapia
Electronic Theses and Dissertations
LIM kinase 1 (LIMK1) is a unique dual specificity serine/threonine kinase containing two N-terminal LIM domains in tandem, a PDZ domain and a C-terminal catalytic domain. LIMK1 is involved in modulation of actin cytoskeleton through inactivating phosphorylation of the ADF (actin depolymerization factor) family protein cofilin. Recent studies have shown that LIMK1 is upregulated in breast and prostate cancer cells and tissues, promotes metastasis in animals and induces acquisition of an invasive phenotype when ectopically expressed in benign prostate epithelial (BPH) cells. Furthermore, overexpression of LIMK1 was associated with altered sub cellular localization of the membrane type 1 matrix metalloprotease …
The Round Barn, Susan Elizabeth Fallows
The Round Barn, Susan Elizabeth Fallows
Electronic Theses and Dissertations
The Round Barn is a novel in two parts that tells the story of two Iowa farm families during the period 1915 to 1929, a volatile time in the history of the American farm. The first part of the novel tells the story of Joe Marshall, a young man in conflict with his hard-working farmer father. At sixteen-years-old, Joe must choose whether to leave the farm to pursue his own desires or to stay where he is needed to help keep his financially strapped family afloat. Part two of the novel focuses on Mae Allinson, a woman in her early …
Retrocyclin Rc-101 Overcomes Cationic Mutations On The Heptad Repeat 2 Of Hiv-1 Gp41, Christopher Fuhrman
Retrocyclin Rc-101 Overcomes Cationic Mutations On The Heptad Repeat 2 Of Hiv-1 Gp41, Christopher Fuhrman
Electronic Theses and Dissertations
Retrocyclin RC-101, a θ-defensin with lectin-like properties, potently inhibits infection by many HIV-1 subtypes by binding to the heptad repeat (HR)-2 region of gp41 and preventing six-helix bundle formation. In the present study, we used in silico computational exploration to identify residues of HR2 that interacted with RC-101 and then analyzed the HIV-1 Sequence Database at LANL for residue variations in the HR1 and HR2 segments that could plausibly impart in vivo resistance. Docking RC-101 to gp41 peptides in silico confirmed its strong preference for HR2 over HR1, and implicated residues crucial for its ability to bind HR2. We mutagenized …
Genetic Population Structure And Breeding Parameters Of Three Pennsylvania State Threatened Darter Species: Etheostoma Camurum, E. Maculatum And E. Tippecanoe, Laura Howell
Electronic Theses and Dissertations
Little is known about the breeding parameters and population structure of three Pennsylvania darters, the bluebreast darter, Etheostoma camurum, the spotted darter, E. maculatum, and the Tippecanoe darter, E. tippecanoe. All are Pennsylvania state threatened species, and they are considered threatened or endangered in several other states throughout their range. Although some limited breeding information is available from populations in other states, the timing and duration of spawning has not been documented for Pennsylvania populations of E. camurum and E. tippecanoe. Both species occupy disjunct riffle habitats in the Allegheny River system, with stable populations in French Creek. We have …
"This Flesh Will Rise Again": Retrieving Early Christian Faith In Bodily Resurrection, J. Douglass
"This Flesh Will Rise Again": Retrieving Early Christian Faith In Bodily Resurrection, J. Douglass
Electronic Theses and Dissertations
The doctrine of bodily resurrection is fundamental to the Christian faith. Its significance is grounded in the fact that the Christian faith arises from and is dependent upon the belief that Jesus returned to life after having been dead and buried. As a result of this belief and the teaching of Christ's first followers, the early Church articulated a hope for a similar resurrection. In spite of the centrality of the doctrine of bodily resurrection for the early Church, the doctrine's present relevance is questionable. This dissertation provides an answer to the question, What does it mean to affirm faith …
The Effects Of Trivalent Arsenicals And Thioredoxin Reductase Inhibitors On Selenium Metabolism In Lung Cell Culture Models, Sarah Ryann Talbot
The Effects Of Trivalent Arsenicals And Thioredoxin Reductase Inhibitors On Selenium Metabolism In Lung Cell Culture Models, Sarah Ryann Talbot
Electronic Theses and Dissertations
Arsenic exposure, through various routes, is associated with the development of cancer of the skin, lung, liver, kidney, and bladder. Treatment of cells in culture with trivalent arsenicals has been shown to increase reactive oxygen species (ROS). In particular, monomethylarsonous acid (MMAIII), a trivalent metabolite of arsenite, is highly cytotoxic and possibly carcinogenic. Three trivalent arsenicals; arsenite, arsenic trioxide (ATO), and MMAIII, are also known inhibitors of the selenoprotein thioredoxin reductase (TrxR). Selenium, an essential micronutrient in mammals, is needed in the form of selenocysteine for activity of this enzyme and other selenoproteins. TrxR is part of a key component …
Molecular Dynamics Simulation Studies Of Dna And Proteins: Force Field Parameter Development Of Small Ligands And Convergence Analysis For Simulations Of Biomolecules, Anne Loccisano
Electronic Theses and Dissertations
In the first part of this dissertation, CHARMM force field parameters for DNA minor groove-binding polyamides were developed. The parameterization involved the subdivision of the polyamides into model compounds, which were calibrated against MP2/6-31G(d) data. To test the new parameters, fourteen 10 ns molecular dynamics crystal simulations have been carried out on a DNA/polyamide complex at low (113K) and high (300K) temperatures. Of the 18 helical parameters examined, only one (stagger) is found to be statistically significant from the crystal structure with a t-test at the 95% confidence level. For the high temperature, stagger is non-significant at the 97% confidence …
Fate Of The Vegetal Yolky Cells In The Direct Developing Frog Eleutherodactylus Coqui, Uma Karadge
Fate Of The Vegetal Yolky Cells In The Direct Developing Frog Eleutherodactylus Coqui, Uma Karadge
Electronic Theses and Dissertations
The Puerto Rican tree frog, Eleutherodactylus coqui, is a striking example of a deviation from the indirect mode of development among amphibians. E. coqui does not have an intermediate tadpole stage. It hatches out directly as a free-living froglet, deriving nutrition from the yolky material attached to its intestine. The innermost of the three germ layers, the endoderm, forms the lining of the gut. In the amphibian model Xenopus laevis, the endoderm originates from the vegetal hemisphere. The cells, which are originally present on the vegetal surface of the embryo, end up forming the definitive gut. They, thus, provide nutrition …
Tourist Trap: On Being Raised In Award-Winning Sand, Catherine Jane Carson
Tourist Trap: On Being Raised In Award-Winning Sand, Catherine Jane Carson
Electronic Theses and Dissertations
The literary essays in this collection explore the relationships between mind, body, and environment as the narrator explores Orlando, her beachfront hometown of Sarasota, and other "tourist traps." The traditional and experimental essays here question how residents make popular vacation destinations their own and how much trust one can put in strangers, neighbors, city planners, theme-park designers, and lovers. Dance floors, hybrid bikes, flying elephants, swing sets, and swimming pools fill these pages. Worries spiral like disco lights on dance floors, and cultural forces press down with the constant pressure of pedal strokes. With the embodiment of place comes connection …
Modeling And Partitioning The Nucleotide Evolutionary Process For Phylogenetic And Comparative Genomic Inference, Todd Castoe
Modeling And Partitioning The Nucleotide Evolutionary Process For Phylogenetic And Comparative Genomic Inference, Todd Castoe
Electronic Theses and Dissertations
The transformation of genomic data into functionally relevant information about the composition of biological systems hinges critically on the field of computational genome biology, at the core of which lies comparative genomics. The aim of comparative genomics is to extract meaningful functional information from the differences and similarities observed across genomes of different organisms. We develop and test a novel framework for applying complex models of nucleotide evolution to solve phylogenetic and comparative genomic problems, and demonstrate that these techniques are crucial for accurate comparative evolutionary inferences. Additionally, we conduct an exploratory study using vertebrate mitochondrial genomes as a model …
Identification And Suitability Of A Non-Anthropomorphic Meta-Language Framework In Military Applications, Gilbert Cardona
Identification And Suitability Of A Non-Anthropomorphic Meta-Language Framework In Military Applications, Gilbert Cardona
Electronic Theses and Dissertations
Humans carry mental models concerning the behaviors, looks, and operation of products, tools, and items used in their daily lives. When these items do not fit a user's conceptual model confusion and inefficiency occur. There are four basic types of mental models based on interactive activities: 1) instructing, 2) conversing, 3) manipulating and navigating, and 4) exploring and browsing. This thesis will focus on the conversing conceptual model and its application to communications between human-agent teams to best fit a user's mental model for that communication. A non-anthropomorphic framework does not exist for use in military applications such as; target …
Spacecraft Loads Predictionvia Sensitivity Analysis And Optimization, Tom Braswell
Spacecraft Loads Predictionvia Sensitivity Analysis And Optimization, Tom Braswell
Electronic Theses and Dissertations
Discrepancies between the predicted responses of a finite element analysis (FEA) and reference data from test results arise for many reasons. Some are due to measurement errors, such as inaccurate sensors, noise in the acquisition system or environmental effects. Some are due to analyst errors precipitated by a lack of familiarity with the modeling or solver software. Still others are introduced by uncertainty in the governing physical relations (linear versus non-linear behavior), boundary conditions or the element material/geometrical properties. It is the uncertainty effects introduced by this last group that this study seeks to redress. The objective is the obtainment …
Signal Processing Of An Ecg Signal In The Presence Of A Strong Static Magnetic Field, Aditya Gupta
Signal Processing Of An Ecg Signal In The Presence Of A Strong Static Magnetic Field, Aditya Gupta
Electronic Theses and Dissertations
This dissertation addresses the problem of elevation of the T wave of an electrocardiogram (ECG) signal in the magnetic resonance imaging (MRI). In the MRI, due to the strong static magnetic field the interaction of the blood flow with this strong magnetic field induces a voltage in the body. This voltage appears as a superimposition at the locus of the T wave of the ECG signal. This looses important information required by the doctors to interpret the ST segment of the ECG and detect diseases such as myocardial infarction. This dissertation aims at finding a solution to the problem of …
Learning Human Behavior From Observation For Gaming Applications, Christopher Moriarty
Learning Human Behavior From Observation For Gaming Applications, Christopher Moriarty
Electronic Theses and Dissertations
The gaming industry has reached a point where improving graphics has only a small effect on how much a player will enjoy a game. One focus has turned to adding more humanlike characteristics into computer game agents. Machine learning techniques are being used scarcely in games, although they do offer powerful means for creating humanlike behaviors in agents. The first person shooter (FPS), Quake 2, is an open source game that offers a multi-agent environment to create game agents (bots) in. This work attempts to combine neural networks with a modeling paradigm known as context based reasoning (CxBR) to create …
Fate Of Nitrogen And Phosphorus Species From A Black And Goldtm Nugget Mix In A Laboratoy Column Simulated Septic Tank Drainfiel, Timir Shah
Electronic Theses and Dissertations
The presence of nitrates and phosphorus in ground water is a worldwide problem. A septic tank with drainfield that is conventionally designed does not typically remove nitrogen in the form of nitrates. The main risks are in "Blue baby" syndrome and suspected carcinogenic effect of nitrates on humans and the nutrient enrichment of receiving waters. In some areas nitrate and phosphorus removal are essentially required. Thus the information in this report concentrates on using media in the drainfield for the removal of nitrogen and phosphorus. Extensive work has been conducted in the past few decades in order to find suitable …
Image-Space Approach To Real-Time Realistic Rendering, Musawir Shah
Image-Space Approach To Real-Time Realistic Rendering, Musawir Shah
Electronic Theses and Dissertations
One of the main goals of computer graphics is the fast synthesis of photorealistic image of virtual 3D scenes. The work presented in this thesis addresses this goal of speed and realism. In real-time realistic rendering, we encounter certain problems that are difficult to solve in the traditional 3-dimensional geometric space. We show that using an image-space approach can provide effective solutions to these problems. Unlike geometric space algorithms that operate on 3D primitives such as points, edges, and polygons, image-space algorithms operate on 2D snapshot images of the 3D geometric data. Operating in image-space effectively decouples the geometric complexity …
Biostability In Drinking Water Distribution Systems In A Changing Water Quality Environment Using Corrosion Inhibitors, Bingjie Zhao
Biostability In Drinking Water Distribution Systems In A Changing Water Quality Environment Using Corrosion Inhibitors, Bingjie Zhao
Electronic Theses and Dissertations
In this study, the bacterial growth dynamics of 14 pilot drinking water distribution systems were studied in order to observe water quality changes due to corrosion inhibitor addition. Empirical models were developed to quantity the effect of inhibitor type and dose on bacterial growth (biofilm and bulk water). Water and pipe coupon samples were taken and examined during the experiments. The coupons were exposed to drinking water at approximately 20°C for at least 5 weeks to allow the formation of a measurable quasi- steady-state biofilm. Bulk water samples were taken every week. In this study, two simple but practical empirical …
Individual Identification Of Polar Bears By Whisker Spot Patterns, Carlos Anderson
Individual Identification Of Polar Bears By Whisker Spot Patterns, Carlos Anderson
Electronic Theses and Dissertations
Many types of ecological studies require identification of individual animals. I developed and evaluated an automated identification system for polar bears (Ursus maritimus) based on their whisker spot patterns. First, I measured the reliability of using whisker spot patterns for identification from polar bear photographs taken in western Hudson Bay. This analysis involved estimating the complexity of each whisker spot pattern in terms of its information content. I found that 98% of patterns contained enough information to be reliable, and this result varied little among three different observers. Based on these results, I implemented a computer-aided identification system for polar …