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Interaction Of 2-Arachidonoyl Glycerol With The Glutamatergic System In Anxiety, Monica S. Gole
Interaction Of 2-Arachidonoyl Glycerol With The Glutamatergic System In Anxiety, Monica S. Gole
Electronic Theses and Dissertations
No abstract provided.
Development Of A Prototype Bi-Layered Patch With Asymmetric Release For Ocular Drug Delivery, Kanchan Hippalgoankar
Development Of A Prototype Bi-Layered Patch With Asymmetric Release For Ocular Drug Delivery, Kanchan Hippalgoankar
Electronic Theses and Dissertations
No abstract provided.
The Effect Of Ethynylestradiol, Benzo[A]Pyrene And A Mixture Of The Two On The Sex Change Event In The Hermaphroditic Bridled Goby, Coryphopterus Glaucofraenum, Lindsay R.K. O'Donahue
The Effect Of Ethynylestradiol, Benzo[A]Pyrene And A Mixture Of The Two On The Sex Change Event In The Hermaphroditic Bridled Goby, Coryphopterus Glaucofraenum, Lindsay R.K. O'Donahue
Electronic Theses and Dissertations
No abstract provided.
Synthesis Of Analogues Based On The Opioid Alkaloid Mitragynine, Marco A. Arribas
Synthesis Of Analogues Based On The Opioid Alkaloid Mitragynine, Marco A. Arribas
Electronic Theses and Dissertations
Opioid analgesics such as morphine and its derivatives are the most frequently prescribed narcotics for the treatment of severe and chronic pain. Among other side effects caused by the administration of these opioid analgesics, physical dependence and addiction are the most undesirable ones. Currently, pharmacological approaches to treat opioid dependence include mainly methadone and LAAM (mu-agonists), buprenorphine (mu-partial agonist) and clonidine (alpha2-adrenergic agonist). Considering the negative aspects of the relapsing nature correlated to opioid dependence, it is important to search for new ways to overcome this problem. The scope of this work is to study novel compounds based on the …
Ethnographic Reflection On Group Formation In Blizzard's "World Of Warcraft", John Christopher Spottke
Ethnographic Reflection On Group Formation In Blizzard's "World Of Warcraft", John Christopher Spottke
Electronic Theses and Dissertations
Cyberanthropology or the anthropology of cyber space/culture is an emerging subfield of cultural anthropology that deals with the varied integration of human beings and technology. This specialized area of study focuses on topics ranging from new technologies used in ethnographic research to information and communication technologies utilized by specific societal groups. Communication technology encompasses the World Wide Web, email, and online multiperson interactive spaces such as chatrooms and video games. In this work, I ethnographically investigate human social interactions in the online gaming realm of World of Warcraft. On the whole, the expanding numbers of virtual communities in existence today …
Taxonomy Versus Phylogeny Phylogeography Of Marsh Rabbits Without Hopping To Conclusions, Rosanna M. Tursi
Taxonomy Versus Phylogeny Phylogeography Of Marsh Rabbits Without Hopping To Conclusions, Rosanna M. Tursi
Electronic Theses and Dissertations
Subspecific taxonomic designations solely based on morphological characters can often lead to erroneous assumptions about the evolutionary history of populations. This study sought to investigate evolutionary questions and conservation implications associated with morphological subspecific designations of island populations. To this end, I focused my attention on the Lower Keys of Florida, a unique chain of islands with well-known geologic history and rich in endemic, endangered subspecies. I employed genetic analyses to evaluate historical variation and contemporary restriction of gene flow between the endangered Lower Keys marsh rabbit (Sylvilagus palustris hefneri) and its sister mainland taxa. A Bayesian phylogeny using 1063 …
Preparation And Characterization Of Lyophilized Cyclodextrin Complexes Of A Hemisuccinate Ester Of Delta-9-Tetrahydrocannabinol For Transmucosal Delivery, Sampada Bhaskar Upadhye
Preparation And Characterization Of Lyophilized Cyclodextrin Complexes Of A Hemisuccinate Ester Of Delta-9-Tetrahydrocannabinol For Transmucosal Delivery, Sampada Bhaskar Upadhye
Electronic Theses and Dissertations
Delta-9- Tetrahydrocannabinol (THC) is the primary active ingredient of the plant Cannabis sativa (marijuana), responsible for the majority of the pharmacological effects. The most promising clinical applications of THC approved by the Food and Drug Administration (FDA) are for the control of nausea and vomiting associated with chemotherapy and for appetite stimulation of AIDS patients suffering from anorexia and wasting syndrome. The only dosage form currently approved by FDA is an oral, soft gelatin capsule (e.g. Marinol®). In addition, orally administered THC from Marinol® has shown slow and variable absorption due to low oral solubility and first pass metabolism. Our …
Epistemology Of The Prophet : A Queer Reading Of Flannery O'Connor's Wise Blood / Jordan Youngblood, Jordan Youngblood
Epistemology Of The Prophet : A Queer Reading Of Flannery O'Connor's Wise Blood / Jordan Youngblood, Jordan Youngblood
Electronic Theses and Dissertations
No abstract provided.
Flirting As A Liminal Experience: A Dialogue Between A Philosophical-Phenomenological Understanding Of Liminality And An Empirical-Existential Study Of Flirting, Rune Lassen Mølbak
Flirting As A Liminal Experience: A Dialogue Between A Philosophical-Phenomenological Understanding Of Liminality And An Empirical-Existential Study Of Flirting, Rune Lassen Mølbak
Electronic Theses and Dissertations
In this dissertation I bring out concealed aspects of the lived experience of flirting by studying it neither as a subjective act nor as an objective behavior, but as a liminal event. Liminality is an anthropological concept that designates a realm of experience that falls outside identity and mutually exclusive binaries. I argue that flirting is a liminal experience in so far as it is an experience that both constitutes me through the other and is constituted by me as a way of relating to the other. What is primary is thus not self or other, but the relation or …
A Screen Of One's Own The Tpec And Feminist Technological Textuality In The 21st Century, Amy J. Barnickel
A Screen Of One's Own The Tpec And Feminist Technological Textuality In The 21st Century, Amy J. Barnickel
Electronic Theses and Dissertations
In this dissertation, I analyze the 20th century text, A Room of One's Own, by Virginia Woolf (2005), and I engage with Woolf's concept of a woman's need for a room of her own in which she can be free to think for herself, study, write, or pursue other interests away from the oppression of patriarchal societal expectations and demands. Through library-based research, I identify four screens in Woolf's work through which she viewed and critiqued culture, and I use these screens to reconceptualize "a room of one's own" in 21st Century terms. I determine that the new "room" is …
The Cytokine, Interleukin-7, Transcriptionally Regulates The Gene Expression Of The Hexokinase Ii To Mediate Glucose Utilization, Mounir Chehtane
The Cytokine, Interleukin-7, Transcriptionally Regulates The Gene Expression Of The Hexokinase Ii To Mediate Glucose Utilization, Mounir Chehtane
Electronic Theses and Dissertations
The cytokine, interleukin-7 (IL-7), has essential growth activities that maintain the homeostatic balance of the immune system. Little is known of the mechanism by which IL-7 signaling regulates metabolic activity in support of its vital function in lymphocytes. We observed that IL-7 deprivation caused a rapid decline in ATP levels that were attributable to loss of intracellular glucose retention. To identify the transducer of the IL-7 metabolic signal, we examined the expression of three important regulators of glucose metabolism, the glucose transporter, GLUT-1, and two glycolytic enzymes, Hexokinase II (HXKII) and phosphofructokinase-1 (PFK1), using an IL-7-dependent T-cell line and primary …
Interleukin-7 Differentially Regulates The Activation, Proliferation, And Homing Of T-Cells: Implications For Immunotherapy, Christina Kittipatarin
Interleukin-7 Differentially Regulates The Activation, Proliferation, And Homing Of T-Cells: Implications For Immunotherapy, Christina Kittipatarin
Electronic Theses and Dissertations
Interleukin-7 (IL-7) is an essential lymphocyte growth factor required for the survival and proliferation of mature T-cells. As a therapeutic agent, IL-7 has the potential to restore T-cell numbers following immune depletion and to promote immunity against cancers. While the survival function of IL-7 is well established, less is known about how it supports T-cell expansion, a critical feature of the immune response. To study the biological effects of IL-7 on T-cell growth, we developed an in vitro culture technique to expand T-cells ex vivo. A significant finding from our studies is that IL-7 did not induce the expansion of …
Low Cost Production Of Proinsulin In Tobacco And Lettuce Chloroplasts For Injectable Or Oral Delivery Of Functional Insulin And, Diane Burberry
Low Cost Production Of Proinsulin In Tobacco And Lettuce Chloroplasts For Injectable Or Oral Delivery Of Functional Insulin And, Diane Burberry
Electronic Theses and Dissertations
Current treatment for type I diabetes includes delivery of insulin via injection or pump, which is highly invasive and expensive. The production of chloroplast-derived proinsulin should reduce cost and facilitate oral delivery. Therefore, tobacco and lettuce chloroplasts were transformed with the cholera toxin B subunit fused with human proinsulin (A, B, and C peptides) containing three furin cleavage sites (CTB-PFx3). Transplastomic lines were confirmed for site-specific integration of transgene and homoplasmy. Old tobacco leaves accumulated proinsulin up to 47% of total leaf protein (TLP). Old lettuce leaves accumulated proinsulin up to 53% TLP. Accumulation was so stable that up to …
Project Child And Non-Project Child School Performance On Fcat Reading, Mathematics And Writing, Julie Chappell
Project Child And Non-Project Child School Performance On Fcat Reading, Mathematics And Writing, Julie Chappell
Electronic Theses and Dissertations
Project CHILD (Changing How Instruction for Learning is Delivered) provides an avenue for educational change using a triangulated approach. Using data from the Florida Department of Education, this research studies the Project CHILD learning approach on preparing students for success on portions of the Florida Comprehensive Assessment Test (FCAT) using results from fifteen charter schools in the state of Florida, seven participating in Project CHILD and eight non-participating charter schools for the 2008-2009 school-year. Dispersion statistics such as range and standard deviation as well as independent t tests are computed to compare the percentage of students in grades three to …
The Crime Of Coming Home: British Convicts Returning From Transportation In London, 1720-1780, Christopher Teixeira
The Crime Of Coming Home: British Convicts Returning From Transportation In London, 1720-1780, Christopher Teixeira
Electronic Theses and Dissertations
This thesis examines convicts who were tried for the crime of 'returning from transportation' at London's Old Bailey courthouse between 1720 and 1780. While there is plenty of historical scholarship on the tens of thousands of people who endured penal transportation to the American colonies, relatively little attention has been paid to convicts who migrated illegally back to Britain or those who avoided banishment altogether. By examining these convicts, we can gain a better understanding of how transportation worked, how convicts managed to return to Britain, and most importantly, what happened to them there. This thesis argues that convicts resisted …
A Content Analysis Of Elite U.S. Newspapers' Coverage Of Iran, 1979 And 2005, Melissa Kamal
A Content Analysis Of Elite U.S. Newspapers' Coverage Of Iran, 1979 And 2005, Melissa Kamal
Electronic Theses and Dissertations
This study is a quantitative content analysis of the New York Times and Washington Post coverage of Iran during the period surrounding the Ayatollah Khomeini's ascension to power in 1979 as well as the period surrounding Mahmoud Ahmadinejad's election in 2005. The results showed that coverage of Iran in the elite American print media as it related to terror was higher in the period after Khomeini came to power and also in the period after Ahmadinejad's election than it was in the period immediately preceding their respective ascensions. The results also showed that there was more coverage of Iran as …
Abiotic Differences Between Green Turtle (Chelonia Mydas) Nests In Natural Beach And Engineered Dunes: Effects On Hatching Success, Martha Balfour
Abiotic Differences Between Green Turtle (Chelonia Mydas) Nests In Natural Beach And Engineered Dunes: Effects On Hatching Success, Martha Balfour
Electronic Theses and Dissertations
Habitat loss is among the biggest threats to conservation worldwide, so habitat restoration plays an increasing role in endangered species management. This is especially true for species with high site fidelity, such as nesting marine turtles. Sand replenishment is commonly used to restore coastal beaches after severe erosion events, and may affect marine turtles and other species that live or reproduce in that habitat. I investigated how abiotic characteristics of sand used in a dune restoration project at Archie Carr National Wildlife Refuge, Florida, affected reproduction of the federally-endangered green turtle (Chelonia mydas). Sand structure and composition can affect egg …
Machinima And Video-Based Soft Skills Training, Curtis Conkey
Machinima And Video-Based Soft Skills Training, Curtis Conkey
Electronic Theses and Dissertations
Multimedia training methods have traditionally relied heavily on video based technologies and significant research has shown these to be very effective training tools. However production of video is time and resource intensive. Machinima (pronounced 'muh-sheen-eh-mah') technologies are based on video gaming technology. Machinima technology allows video game technology to be manipulated into unique scenarios based on entertainment or training and practice applications. Machinima is the converting of these unique scenarios into video vignettes that tell a story. These vignettes can be interconnected with branching points in much the same way that education videos are interconnected as vignettes between decision points. …
Integrating Universal Design For Learning Concepts Into Secondary General Education Instructional Methods Courses, Kimberly Pawling
Integrating Universal Design For Learning Concepts Into Secondary General Education Instructional Methods Courses, Kimberly Pawling
Electronic Theses and Dissertations
Because many general education teachers feel unprepared to provide students with disabilities with appropriate instruction, changes to teacher education programs are needed (Burdette, 2007; Smith et al., 2010). Teacher education programs need to integrate content regarding instructional methods for teaching and accommodating students with disabilities in secondary, general education classrooms (Burdette, 2007; Smith et al., 2010). The results of the research should provide insight (1) to determine if integrating instruction on UDL into preservice SGE students' instructional methods courses will increase students' knowledge of UDL and (2) to determine if integrating instruction on Universal Design for Learning (UDL) will affect …
The Impact Of Universal Design For Learning-Representation Practices On Concept Maps And The Development Of Quality Scientific Explanations, Lisa A. Finnegan
The Impact Of Universal Design For Learning-Representation Practices On Concept Maps And The Development Of Quality Scientific Explanations, Lisa A. Finnegan
Electronic Theses and Dissertations
The purpose of this action research project was to determine how my practice of implementing Universal Design for Learning-Representation (UDL-R) principles influenced my students’ understanding of content and enhanced their ability to organize their knowledge using concept maps. A secondary purpose of this action research project was to determine if student created concept maps served as a useful tool to enrich students’ written scientific explanations. Students in this study completed concept maps and wrote explanations about adaptations before and after participating in lessons enriched with UDL-R principles that included the use of multimedia sources, website searches, and trade books. The …
Magnetic Nanosensors For Multiplexed Bacterial Pathogenesis Identification, Charalambos Kaittanis
Magnetic Nanosensors For Multiplexed Bacterial Pathogenesis Identification, Charalambos Kaittanis
Electronic Theses and Dissertations
Developing diagnostic modalities that utilize nanomaterials and miniaturized detectors can have an impact in point-of-care diagnostics. Diagnostic systems that (i) are sensitive, robust, and portable, (ii) allow detection in clinical samples, (iii) require minimal sample preparation yielding results quickly, and (iv) can simultaneously quantify multiple targets, would have a great potential in biomedical research and public healthcare. Bacterial infections still cause pathogenesis throughout the world (Chapter I). The emergence of multi-drug resistant strains, the potential appearance of bacterial pandemics, the increased occurrence of bacterial nosocomial infections, the wide-scale food poisoning incidents and the use of bacteria in biowarfare highlight the …
Geographic Variation In Post-Mating Immune Gene Expression In Drosophila Melanogaster, Cheryl Ann Pinzone
Geographic Variation In Post-Mating Immune Gene Expression In Drosophila Melanogaster, Cheryl Ann Pinzone
Electronic Theses and Dissertations
An organism's immune response may vary due to pathogen pressure in its environment, as well as due to interactions with other organisms. These factors, along with geographic rules (i.e. Gloger's rule) may influence the geographic distribution of the immune response within populations of a species. Here we use real-time quantitative PCR to measure the immune gene expression in six populations collected along the eastern U.S. of Drosophila melanogaster after mating. Antimicrobial genes did not show significant differences in expression due to location, whereas we did observe differences in anti-fungal and pro-phenoloxidase (anti-macromolecule) related genes. These differences in anti-macromolecule resistance are …
Electroconvulsive Shock Ameliorates Disease Processes And Extends Survival In Huntington Mutant Mice, Akanksha Baharani
Electroconvulsive Shock Ameliorates Disease Processes And Extends Survival In Huntington Mutant Mice, Akanksha Baharani
Electronic Theses and Dissertations
Huntington's disease (HD) is a devastating autosomal dominantly inherited neurological disorder caused by an abnormal expansion of CAG trinucleotide repeats in the gene coding for the Nterminal region of the huntingtin (Htt) protein, which leads to the formation of a polyglutamine stretch. The greater the CAG repeats, the earlier the onset of the disease. The polyglutamine stretch destabilizes the Htt protein leading to misfolding, abnormal processing, aggregation, and inclusion formation. Mutant Htt protein is believed to damage and kill neurons in the striatum by a mechanism involving increased oxidative and metabolic stress, and impaired adaptive cellular stress responses. A large …
Acetazolamide-Induced Decrease Of Apical Fluid Flow In Choroid Plexus Is Independent Of The Concomitant Changes In Aquaporin-1 Expression, Pouya Alexander Ameli
Acetazolamide-Induced Decrease Of Apical Fluid Flow In Choroid Plexus Is Independent Of The Concomitant Changes In Aquaporin-1 Expression, Pouya Alexander Ameli
Electronic Theses and Dissertations
Acetazolamide (AZA), the only drug approved for treatment of hydrocephalus, is effective in only 25-30% of patients while its effect on fluid flow in the choroid plexus (CP) is unknown. The drug reversibly inhibits Aquaporin 4 (AQP4), the most highly expressed „water pore‟ in the brain, and it is postulated that it reduces cerebrospinal fluid (CSF) production by modulating AQP1 (mostly found in the apical membrane of the CP). In this study, we sought to elucidate the effect of AZA on AQP1 and fluid flow in CP. Primary CP culture from p10 Sprague-Dawley rats and TRCSF-B cell line were grown …
Estimating Diet And Food Selectivity Of The Lower Keys Marsh Rabbit Using Stable Isotope Analysis, Matthew James Gordon
Estimating Diet And Food Selectivity Of The Lower Keys Marsh Rabbit Using Stable Isotope Analysis, Matthew James Gordon
Electronic Theses and Dissertations
Understanding the effect of food abundance on feeding behavior can benefit conservation efforts in many ways, such as to determine whether impacted environments need food supplementation, whether different locations of threatened species contain different food abundances, or whether reintroduction sites are missing key components of a species’ diet. I studied the relationship between feeding behavior and food abundance in the Lower Keys marsh rabbit (Sylvilagus palustris hefneri), an endangered subspecies endemic to the lower Florida Keys. Specifically, my study set out to measure the relative abundance of the primary plants within the natural habitat of the Lower Keys marsh rabbit …
The Communication Implications And Related Experiences Associated With Transracially Adopting A Child From Vietnam, Lan Marie Malin
The Communication Implications And Related Experiences Associated With Transracially Adopting A Child From Vietnam, Lan Marie Malin
Electronic Theses and Dissertations
This study investigated the communication experiences of adoptive parents of children transracially adopted from Vietnam. Though adoption has been extensively studied in communication research, transracial adoptions involving children from Vietnam has not. Thus, this study examined adoptive parent communication experiences using dialectic theory and relational dialectics. By examining adoptive parents’ communication with their adopted child and others, we can determine tensions that occur in different communication experiences. Data were collected through eight qualitative in-depth interviews conducted with adoptive parents of children from Vietnam. Openness with both strangers and the adopted child(ren) and preservation of key aspects of the adopted children’s …
A Wearable Head-Mounted Projection Display, Ricardo F. Martins
A Wearable Head-Mounted Projection Display, Ricardo F. Martins
Electronic Theses and Dissertations
Conventional head-mounted projection displays (HMPDs) contain of a pair of miniature projection lenses, beamsplitters, and miniature displays mounted on the helmet, as well as a retro-reflective screen placed strategically in the environment. We have extened the HMPD technology integrating the screen into a fully mobile embodiment. Some initial efforts of demonstrating this technology has been captured followed by an investigation of the diffraction effects versus image degradation caused by integrating the retro-reflective screen within the HMPD. The key contribution of this research is the conception and development of a mobileHMPD (M-HMPD). We have included an extensive analysis of macro- and …
Transplantation Of Ips Cells Reduces Apoptosis And Fibrosis And Improves Cardiac Function In Streptozotocin-Induced Diabetic Rats, Sarah Elizabeth Neel
Transplantation Of Ips Cells Reduces Apoptosis And Fibrosis And Improves Cardiac Function In Streptozotocin-Induced Diabetic Rats, Sarah Elizabeth Neel
Electronic Theses and Dissertations
Background: Streptozotocin (STZ) induced diabetes leads to various complications including cardiomyopathy. Recent data suggests transplanted bone marrow stem cells improve cardiac function in diabetic cardiomyopathy. However, whether modified ES, iPS cells, or factors released from these cells can inhibit apoptosis and fibrosis remains completely unknown. The present study was designed to determine the effects of transplanted ES cells overexpressing pancreatic transcription factor 1 a (Ptf1a), a propancreatic endodermal transcription factor, iPS cells, or their respective conditioned media (CM) on diabetic cardiomyopathy. Methods: Experimental diabetes was induced in male Sprague Dawley rats (8-10 weeks old) by intraperitoneal STZ injections (65 mg/kg …
A Kachina By Any Other Name: Linguistically Contextualizing Native American Collections, Rachel Elizabeth Maxson
A Kachina By Any Other Name: Linguistically Contextualizing Native American Collections, Rachel Elizabeth Maxson
Electronic Theses and Dissertations
Museums collect and care for material culture, and, increasingly, intangible culture. This relatively new term for the folklore, music, dance, traditional practices, and language belonging to a group of people is gaining importance in international heritage management discourse. As one aspect of intangible cultural heritage, language is more relevant in museums than one might realize. Incorporating native languages into museum collections provides context and acts as appropriate museology, preserving indigenous descriptions of objects. Hopi katsina tihu are outstanding examples of objects that museums can re-contextualize with native terminology. Their deep connection to Hopi belief and ritual as well as their …
Applied Design: An Exploration Of Arts Integration Through Theatrical Design In The Fourth Grade Classroom, Alicia Fuss
Applied Design: An Exploration Of Arts Integration Through Theatrical Design In The Fourth Grade Classroom, Alicia Fuss
Electronic Theses and Dissertations
The purpose of this action-research study is to explore a new pedagogical tool for myself as a teaching artist: Applied Design. My ideas around Applied Design are rooted in the field of Creative Drama, and grew out of a desire to explore theatrical design in the same process-centered way that Creative Drama explores informal and improvisational drama techniques. To this end, I attempt to determine how the use of Applied Design affects both student engagement and student understanding when applied as an interdisciplinary tool to Language Arts curriculum. For the purposes of this study, I introduced Applied Design as a …