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Of Mice And Sigma : Conferred Antibiotic Resistance In The Salmonella Enterica Serovar Typhimurium Murine Model., Rena Margaret Wallen 1981-
Of Mice And Sigma : Conferred Antibiotic Resistance In The Salmonella Enterica Serovar Typhimurium Murine Model., Rena Margaret Wallen 1981-
Electronic Theses and Dissertations
Salmonella enterica serovar Typhimurium is an enteric pathogen capable of infecting a wide range of hosts. The manner in which this pathogen is able to interact with its host is difficult to define, as is the case with most microbes. Through the use of alternate sigma factors and other regulatory processes, S. Typhimurium is able to invade host cells to establish systemic infections, and survive the assaults of the host immune system. While most strains of S. Typhimurium are typically ampicillin sensitive, within the host, survival inside host cells may provide an escape from many antibiotics. Previous research demonstrated that …
The Paramount Ballroom In The 1930s : A Modernist Social And Architectural Space., Xi Zhang 1987-
The Paramount Ballroom In The 1930s : A Modernist Social And Architectural Space., Xi Zhang 1987-
Electronic Theses and Dissertations
The Paramount Ballroom was an innovative urban space that challenged traditional Chinese values. In doing so it played an important role in Shanghai's modernization. Traditional Confucian morality set very strict regulations on the social interaction of men and women, while, in contrast, the architectural space of the Paramount Ballroom allowed men and women to have close contact. The experience created by this architecture was not just pleasurable and fashionable; it was a sign of modernity. This study reconstructs the entertainment experience of the contemporary middle class in the newly constructed ballrooms of Shanghai. It examines how the Paramount Ballroom emerged, …
The Role Of Human Awareness On The Spatial Patterns Of The Tick-Borne Disease Human Monocytic Ehrlichiosis In Missouri., James Edward Nunn 1985-
The Role Of Human Awareness On The Spatial Patterns Of The Tick-Borne Disease Human Monocytic Ehrlichiosis In Missouri., James Edward Nunn 1985-
Electronic Theses and Dissertations
Human monocytic ehrlichiosis (HME), a tick-borne disease that has recently surfaced in the United States, exists in regions where the tick vector population is established. This study utilizes methods that look beyond identifying high-risk regions, and investigates disparate awareness, self-perceived threat, and seriousness of HME to further enhance existing spatial modeling. The Health Belief Model provides a theoretical framework that encompasses the disease ecology aspect of medical geography to understand the relationship between people and their environment by surveying participants in study regions of Missouri. Results are suggestive that awareness differs between high/low incidence regions. Furthermore, education and income were …
Art As A Media For Social Commentary : A Case Study Of Igbo Bongo Musicians, South-Eastern Nigeria., Ruth Stellamaris Opara 1980-
Art As A Media For Social Commentary : A Case Study Of Igbo Bongo Musicians, South-Eastern Nigeria., Ruth Stellamaris Opara 1980-
Electronic Theses and Dissertations
This study investigates the use of bongo music as a medium for social commentary in society. African traditional musicians, without formal education have been able to address socio-political and moral issues. The methodology includes the use of autobiographic stories and lyrical analysis. The lyrics are drawn from the musical CDs of two musicians who are of different generations. Reviews of literatures are also used to discuss the historical background of Nigeria and the Igbo people, the function of music in the life of an African culture including music, and the impact of colonization in African music. The analysis explores the …
Dames, Doilies, & Divorce., Tenille Novinger
Dames, Doilies, & Divorce., Tenille Novinger
Electronic Theses and Dissertations
My work focuses on repurposing historic images and feminine objects to create a contemporary dialogue about the traditions of courtship, marriage and divorce. The use of textiles and feminine objects such as doilies, lace, slips and wallpaper serve as the visual foundation of my work. I am interested in how these objects, often combined with selected texts, create metaphors regarding relationships. Courtship, marriage and divorce are the three potential steps of a relationship. This thesis is arranged into three chapters: materials, themes, and influences found within my studio research and subsequent MA in Studio Arts Exhibition, Dames, Doilies, & Divorce …
Approaches In The Treatment Of Parkinson's Disease : A Focus On Stem Cell-Based Therapies., Tareq Al-Maqtari 1979-
Approaches In The Treatment Of Parkinson's Disease : A Focus On Stem Cell-Based Therapies., Tareq Al-Maqtari 1979-
Electronic Theses and Dissertations
Parkinson's disease (PD) is a hypokinetic movement disorder resulting from the progressive neurodegeneration of the dopaminergic nigrostriatal system in the brain and the resulting imbalance between dopamine and acetylcholine in the basal ganglia motor circuitry. Although drug-based therapy approaches have shown dramatic symptomatic improvement in patients, they do not halt the progressive nature of the disease and their long-term use is associated with distressing adverse side effects. Consequently, several studies have aimed at discovering effective non-pharmacological strategies to reduce or to eliminate the need for drugs and possibly to halt or to reverse the neurodegenerative process in PD. Surgical deep …
Specific B Alleles Matter In Phytopathogenic Ustilago Maydis., Kavita Burman Aulakh
Specific B Alleles Matter In Phytopathogenic Ustilago Maydis., Kavita Burman Aulakh
Electronic Theses and Dissertations
The smut fungus, Usti/ago maydis is an obligate parasite on maize plants in order to complete its sexual life cycle. The haploid form is self-sterile but compatible mated cells undergo a dimorphic switch from yeast like to infectious dikaryotic filaments. Mating types are determined by two unlinked loci, the a locus and the b locus. The a locus is involved in self and non-self cell recognition through production and sensing of pheromone. The b locus of compatible mating types encodes a functional transcription factor that is involved in regulation of expression of genes responsible for filamentation, virulence and pathogenicity. Both …
Rifted Paradise : Poems., Josh English
Rifted Paradise : Poems., Josh English
Electronic Theses and Dissertations
For this thesis, I wrote 28 new pages, all composed between December, 2011 and March, 2012. They are the best I've written. The other five pages are drafts from work previously written in U of L Creative Writing workshops. My poems endeavor to realign the domestic into intimate, and occasionally surreal, poems. Of the topics that most often surface in these poems, anger and the attempt and failure of intimacy are premier throughout. I discovered in my writing new ways to manage my poems, as in "THE URN BUT NOT THE ASHES," which is a quick surreal sketch in which …
Happy Death Men., Jessica Marie Fletcher 1982-
Happy Death Men., Jessica Marie Fletcher 1982-
Electronic Theses and Dissertations
Happy Death Men is a series of excerpts from a novel of the same name. It is a work of magical realism that follows in the footsteps of Haruki Murakami and Neil Gaiman. The novel consists of two main storylines, one about a widower named Henry, and the other about his grandson, Tory, both of whose experiences with the supernatural helps them overcome their respective loneliness. This novel explores the idea of being alive, but not living and the ideas of passivity versus taking an active role to change one's life.
Development Of Pituitary Tumor-Transforming Gene (Pttg) Transgenic Mice For The Treatment Of Ovarian Cancer., Miranda Y. Fong 1982-
Development Of Pituitary Tumor-Transforming Gene (Pttg) Transgenic Mice For The Treatment Of Ovarian Cancer., Miranda Y. Fong 1982-
Electronic Theses and Dissertations
This dissertation is a hypothesis-driven research oriented study to determine the role of the pituitary-tumor transforming gene (PTTG) in ovarian cancer, specifically if it is involved in neoplastic transformation leading to tumorigenesis through oncogene activation and the involvement of tumor-suppressor gene, p53. Furthermore, generation of a useful ovarian cancer mouse model provides a platform technology to screen for ovarian cancer diagnosis and treatment options. This dissertation is divided into four chapters covering the etiology of ovarian cancer and a novel treatment strategy for ovarian cancer. The first chapter reviews the related literature encompassing the etiology of ovarian cancer, mouse models …
The Adytum., Lexi Bass
The Adytum., Lexi Bass
Electronic Theses and Dissertations
This thesis explores the history of human spirituality and its present ambiguous place in our modern secular world. Accompanying the written thesis is documentation of my creative work by the same title. First I will describe spirituality as a fundamental aspect of the human animal as promoted by R. Joseph. I will follow human spirituality through the culture of organized religion and summon Nietzsche's The Gay Science to discuss shame, sexuality, and religion, moving on to The Birth of Tragedy to discuss the problem of spirituality in modernity. Next I will discuss power through the language of morality. An analysis …
Acting Without Expectations., Gary L. Brice
Acting Without Expectations., Gary L. Brice
Electronic Theses and Dissertations
This thesis examines my preparation for performing Leland Cunningham in Blues for an Alabama Sky by Pearl Cleage. Using the motif of personal expectations, I explore how my ideas of performance have become unbalanced. I evaluate the origin of these performance expectations and discuss how they influenced this particular process. After considering my early career, graduate school experience, and character preparation, I use the final chapter to explore the debilitating nature of these expectations. I consider how and why I can no longer accept this frame work of unrealistic performance expectations; and how through this process I have reconsidered pursuing …
The Effects Of Computer Assisted Instruction And Structured Curriculum On Struggling Mathematics Students., Amy English Hunter
The Effects Of Computer Assisted Instruction And Structured Curriculum On Struggling Mathematics Students., Amy English Hunter
Electronic Theses and Dissertations
The purpose of this study was to examine the effects of different instructional types used in a mathematics intervention setting. In recent years, school staff have implemented mathematics intervention programs to aid struggling students and improve student achievement. Advancements in technology have enticed many school staff to purchase computer-based instructional products that are used for mathematics intervention. Often computer-assisted instruction (CAI) is the only mathematics intervention students receive, however staff in the school of this study used a structured curriculum (SC) along with CAI Therefore, this study examined the effects of CAI compared to a SC delivered by a teacher. …
The Unruly Woman In Prime Time Animated Sitcoms., Sarah Pennington
The Unruly Woman In Prime Time Animated Sitcoms., Sarah Pennington
Electronic Theses and Dissertations
Utilizing the criteria for unruly women established by Kathleen Rowe, this work engages with current television scholarship on animated sitcoms in order to come to an understanding of how unruliness as a category of behavior and embodiment is expanded in prime time animated sitcoms. In looking at the ways in which unruliness functions in animated series, examples from The Simpsons, King of the Hill, South Park, Daria, and Home Movies are examined. It is through this analysis that I prove that not only do the mother characters from all of these series embody unruliness, but through their prominence in their …
Identifying Aggregatibacter Actinomycetemcomitans Periodontal Antigens By Immunoscreening., Gerald Bernard Pevow
Identifying Aggregatibacter Actinomycetemcomitans Periodontal Antigens By Immunoscreening., Gerald Bernard Pevow
Electronic Theses and Dissertations
Periodontitis is a chronic, destructive inflammatory disease of the supporting tissues of the teeth with a high prevalence among adults. While the complete pathogenesis of periodontitis remains unclear, it is initiated and sustained by dental plaque containing pathogens such as Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Bacteroides forsythus, and Prevotella intermedia. Our hypothesis is that multiple antigens are recognized by human antibodies, and antigens can be identified by use of a genomic expression library. We developed an unbiased global approach to define A. actinomycetemcomitans protein antigens that elicit humoral immune responses and developed a screening method to identify periodontal antigens. We identified …
Depression In Reproductive-Age Women : Assessment Of Infectious, Endocrinological, And Immunological Correlates From An Evolutionary Perspective., Amber N. Carrier
Depression In Reproductive-Age Women : Assessment Of Infectious, Endocrinological, And Immunological Correlates From An Evolutionary Perspective., Amber N. Carrier
Electronic Theses and Dissertations
Depression is one of the most frequent causes of disability worldwide. It can affect the psychological, social, and physical wellbeing of those that suffer from it, the majority of which are women. Depression has been linked to immune activation as well as serotonin depletion through a reduction in its precursor, tryptophan. Chlamydia trachomatis infection and estrogen can influence both the immune system and tryptophan levels, thereby biochemically inducing a depressive state. If this is the case, the use of exogenous estrogen through oral contraceptive pills (OCPs) could increase depressive symptoms, while the use of antibiotics to treat C. trachomatis infection …
Sulfur Oxygenation Of Ruthenium-Dithiolate Nitrile Hydratase Mimic Enhances Ligand Lability And Hydrolysis Activity., Cesar Antonio Masitas Castillo
Sulfur Oxygenation Of Ruthenium-Dithiolate Nitrile Hydratase Mimic Enhances Ligand Lability And Hydrolysis Activity., Cesar Antonio Masitas Castillo
Electronic Theses and Dissertations
Nitrile hydratase (NHase) is a metalloenzyme that contains a non-heme iron (III) or non-corin cobalt (III) in a non-redox active role. NHase is used as biocatalyst in the industry for the hydrolysis of nitriles to arnides. The trivalent metal ions are six coordinate with the ligand sphere made up of three cysteines, two amide nitro gens, and a waterlhydroxide or nitrile substrate. Interestingly, the N2S3 active site contains two post-translationally modified cysteine residues, resulting in an unusual thiolato (RS-), sulfenate (RS(O)-), sulfinate (RS(Oh-) donor set. Synthetic work to mimic the unusual donor set by direct oxygenation of a metallodithiolate precursor …
3d Visualization Of In-Flight Recorded Data., Gyuchoon Cho 1975-
3d Visualization Of In-Flight Recorded Data., Gyuchoon Cho 1975-
Electronic Theses and Dissertations
Human being can easily acquire information by showing the object than reading the description of it. Our brain stores images that the eyes are seeing and by the brain mapping, people can analyze information by imagination in the brain. This is the reason why visualization is important and powerful. It helps people remember the scene later. Visualization transforms the symbolic into the geometric, enabling researchers to observe their simulations and computations (Flurchick, 2001). As a consequence, many computer scientists and programmers take their time to build better visualization of the data for users. For the flight data from an aircraft, …
Mad At Miles : A Black Woman's Guide To Truth : Theatre Building Using Myths, Motifs, And Archetypes., Triza Triza Cox
Mad At Miles : A Black Woman's Guide To Truth : Theatre Building Using Myths, Motifs, And Archetypes., Triza Triza Cox
Electronic Theses and Dissertations
This thesis chronicles my journey within the framework of a hero's journey, as a theatre artist in the Master of Fine Arts program at the University of Louisville's Theatre Arts Department. This thesis is divided into six chapters that explore the importance of using and understanding myths, motifs, and archetypes for character development in general and specifically for building the ensemble production from Pearl Cleage's collection of essays: Mad at Miles: A Black Woman's Guide to Truth. The Introduction explores the origins of the drive for humans to create art. Chapter One investigates my attraction to theatre through my personal …
Ethnocentric Frames Across Race : The Media's Role In Activating Ethnocentrism And Public Support For Conflict Abroad., Christopher William Ledford
Ethnocentric Frames Across Race : The Media's Role In Activating Ethnocentrism And Public Support For Conflict Abroad., Christopher William Ledford
Electronic Theses and Dissertations
This study revisits Kinder's and Kam's (2007; 2009) studies that provided political scientists with a theoretical and operational definition of ethnocentrism-our tendency to partition the world into in-groups and out-groups. They assert that the activation of ethnocentrism hinges on elite framing and issue-attention. In addition, they have shown whites to be more ethnocentric than blacks, generally. This thesis begins with, and after conducting a framing experiment, accepts the hypothesis that the media frame news ethnocentrically and that frames have a greater effect on activating ethnocentrism, fear, and support for war across white Americans than black Americans. Furthermore, my empirical analysis …
Cloning, Heterologous Expression In Yeast, And Biochemical Characterization Of Recombinant Putative Glucosyltransferase Clones 9 And 11 From Grapefruit (Citrus Paradisi), Anye Wamucho
Electronic Theses and Dissertations
Flavonoids are plant secondary metabolites that play diverse roles in plants and human health. These compounds in most part exist in the glucosylated form. Grapefruit accumulates high levels of glucosylated flavonoids. Plant secondary product glucosyltransferases (GTs) catalyze the glucosylation reaction, but due to low homology at both the nucleotide and amino acid sequence level of different GTs, it is not possible to ascribe function based on sequence only. The hypotheses that PGT clones 9 and 11 are plant secondary product GTs and are biochemically regulated were tested. PGT 9 has been cloned into Pichia pastoris using the pPICZA and pPICZAα …
Genetic Polymorphisms In The Folate Metabolizing Pathway And Breast Cancer Survival., Nandita Das
Genetic Polymorphisms In The Folate Metabolizing Pathway And Breast Cancer Survival., Nandita Das
Electronic Theses and Dissertations
Genes in folate metabolizing pathway are responsible for modulating key enzymes in folate metabolisms necessary for DNA synthesis and repair and influence DNA methylation. Irregularity in DNA methylation may modify tumor phenotype response to chemotherapy and abnormal DNA synthesis, and repair may lead to carcinogenesis. This dissertation project tested the hypothesis that the key genes in the folate metabolizing pathway, namely Methylenetetrahydrofolate reductase (MTHFR) , betaine-homocysteinemethyltransferase (BHMT) , 5-methyltetrahydrofolate-homocysteine (MTR), 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) , and serine hydroxymethyltransferase (SHMT1) and folate receptor 1 (FOLR1) influences all- cause and breast cancer-specific mortality and the association between the genes in the folate …
Applications Of Solid State Nmr To Cardiolipin And Elastin., Tatiana Victorovna Krivokhizhina 1981-
Applications Of Solid State Nmr To Cardiolipin And Elastin., Tatiana Victorovna Krivokhizhina 1981-
Electronic Theses and Dissertations
This dissertation has five chapters. Following an introduction, chapter two describes an investigation of the hypothesis that cardiolipin has a proton storage function in mitochondrial membranes. Chapters three and four present a novel NMR study of the elastic mechanism in elastin. Directions for the future research are given in the last chapter. To investigate the hypothesis that cardiolipin has a proton storage function, we have used 31p, 1H and 13C NMR. A single axially symmetric 31p pattern with reversed anisotropy compared to the static pattern is observed from pH 4 to 9 for tetraoleoyl cardiolipin (TOCL). This confirms that (a) …
Co-Option And Adaptation Of Novel Gene Duplications For Pheromone Activity In A Dusky Salamander., Kari Anne Leichty 1987-
Co-Option And Adaptation Of Novel Gene Duplications For Pheromone Activity In A Dusky Salamander., Kari Anne Leichty 1987-
Electronic Theses and Dissertations
For more than a hundred million years, male plethodontid salamanders have utilized non-volatile, proteinaceous courtship pheromones to regulate female mating receptivity and promote mating success. These pheromones - which are delivered after courtship has commenced and do not act as chemical attractants - are delivered from a male's submandibular (mental) gland to the female salamander either by an olfactory mode or transdermally. For approximately 20 years, research on plethodontid courtship pheromones has focused on those involved in olfaction, using the red-legged salamander (Plethodon shermani) as a model. However, the olfactory system is a relatively recent adaptation (~20 million years ago) …
Vikings, Merchants, And Pirates At The Top Of The World : Y-Chromosomal Signatures Of Recent And Ancient Migrations In The Faroe Islands., Allison Mann
Electronic Theses and Dissertations
The Faroe Islands are a small archipelago in the North Atlantic. With a current population of approximately 49,000 individuals and evidence of high levels of genetic drift, the Faroese are thought to have remained highly homogeneous since their settlement by Vikings around 825 CE. Despite their geographic isolation, however, there is historical evidence that the Faroese experienced sporadic contact with other populations since the time of founding. This study set out to distinguish the signal of the original founders from later migrants. Twelve Y-chromosomal STR markers were scored for 139 Faroese males. Median-joining networks were constructed to determine the phylogenetic …
Perceptions Of Gender In Young Consumers Of Animated Films., Katherine Barnes 1980-
Perceptions Of Gender In Young Consumers Of Animated Films., Katherine Barnes 1980-
Electronic Theses and Dissertations
The purpose of this study was to investigate the gender stereotyping of two animated films by boys and girls (N=25). Based on Bern's (1983) gender schema theory, it was hypothesized that children would stereotype Aladdin as being for males and Pocahontas as being for females, based on the gender of the lead character. Interviews with participants (five to six years old) revealed that they did not gender stereotype the two films. A majority of both boys and girls liked the two films and felt they were for boys and girls. However, they did not think a girl could rescue another …
Parasitic Nematodes In Humans : Exploring The Host-Parasite Dynamic Through Historical, Biological, And Public Health Evaluations Of Infection., Erin Christine Welsh 1987-
Parasitic Nematodes In Humans : Exploring The Host-Parasite Dynamic Through Historical, Biological, And Public Health Evaluations Of Infection., Erin Christine Welsh 1987-
Electronic Theses and Dissertations
This thesis investigated infection dynamics of parasitic nematodes at both the population and individual levels by exploring evolutionary and historical aspects of infection as well as how host-parasite interactions influence virulence. In particular, this thesis sought to answer questions of how host populations have influenced the spread of infection and how transmission determines infection virulence, with a final goal of understanding how eradication programs for parasites can be developed or improved with this knowledge. The host-parasite dynamic was explored throughout history, with particular focus on the ways host populations have shaped infection distribution in present, historic, and prehistoric times. Then, …
Bawdy Badges And The Black Death : Late Medieval Apotropaic Devices Against The Spread Of The Plague., Lena Mackenzie Gimbel 1976-
Bawdy Badges And The Black Death : Late Medieval Apotropaic Devices Against The Spread Of The Plague., Lena Mackenzie Gimbel 1976-
Electronic Theses and Dissertations
This thesis examines a large corpus of enigmatic pilgrimage badges dating from roughly 1350-1500 CE. The badges were brought to light during archaeological excavations of water sites throughout the Schelde Estuary in the Netherlands, the riverbanks of the Seine in France, and the Thames in England. A small selection of the iconography of the corpus includes: ambulant vulvas on stilts, winged and crowned pudenda pilgrims complete with pilgrims' staffs and rosaries, couples having sex, and ambulant winged phalli. The few scholars who have attempted their study have labeled the badges as erotic, obscene, rude, naughty, and pornographic. The advanced study …
Stabilization Of The Cardiac Nervous System During Cardiac Stress Induces Cardioprotection, David D. Gibbons
Stabilization Of The Cardiac Nervous System During Cardiac Stress Induces Cardioprotection, David D. Gibbons
Electronic Theses and Dissertations
The cardiac nervous system consists of nested reflex feedback loops that interact to regulate regional heart function. Cardiac disease affects multiple components of the cardiac nervous system and the myocytes themselves. This study aims to determine: 1) how select components of the cardiac nervous system respond to acute cardiac stress, including myocardial ischemia (MI) and induced neural imbalance leading to cardiac electrical instability, and 2) how neuromodulation can affect neural-myocyte interactions to induce cardioprotection. Thoracic spinal cord stimulation (SCS) is recognized for its anti-anginal effects and ability to reduce apoptosis in response to acute MI, primarily via modulation of adrenergic …
The Use And Effects Of Ecofriendly Surfactants In The Meat Rendering Industry In The United States., Pamela Arnold
The Use And Effects Of Ecofriendly Surfactants In The Meat Rendering Industry In The United States., Pamela Arnold
Electronic Theses and Dissertations
Meat is a major component of the diet of an American. However, humans do not consume one-third to one-half of each animal raised for their needs. The leftover materials are subjected to processing in the meat rendering industry. The rendering industry turns the waste material into value added ingredients. During the rendering process, air pollutants are released. These air pollutants are odor nuisances in residential areas around rendering plants. These pollutants can be controlled by the use of multistage packed towers. The packed columns used by the rendering industry are distinctive because of the addition of animal fat in the …