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A Submodular Optimization Framework For Never-Ending Learning : Semi-Supervised, Online, And Active Learning., Wael Emara
Electronic Theses and Dissertations
The revolution in information technology and the explosion in the use of computing devices in people's everyday activities has forever changed the perspective of the data mining and machine learning fields. The enormous amounts of easily accessible, information rich data is pushing the data analysis community in general towards a shift of paradigm. In the new paradigm, data comes in the form a stream of billions of records received everyday. The dynamic nature of the data and its sheer size makes it impossible to use the traditional notion of offline learning where the whole data is accessible at any time …
The Use Of Mathematical And Computational Models To Define The Role Of Mutation And Infection In Colorectal Cancer., Chandler D. Gatenbee 1982-
The Use Of Mathematical And Computational Models To Define The Role Of Mutation And Infection In Colorectal Cancer., Chandler D. Gatenbee 1982-
Electronic Theses and Dissertations
Research over the past twenty five years has led to the development of the hypothesis that colorectal cancer is caused by the accumulation of mutations in tumor suppressor genes and proto-oncogenes. The last ten years has also revealed that the common JC Virus (JCV) is frequently found in colorectal tumors. This has led to the hypothesis that the virus, which is known to cause tumors in the lab, may playa role in colorectal cancer. However, the presence of JCV in colorectal tumors does not necessarily indicate a cause-effect relationship. Unlike in vivo and in vitro studies, mathematical and computational modeling …
The Art Of Natality : Virginia Woolf's And Kathe Kollwitz's Aesthetics Of Becoming., Jennifer Brooke Goldberg 1973-
The Art Of Natality : Virginia Woolf's And Kathe Kollwitz's Aesthetics Of Becoming., Jennifer Brooke Goldberg 1973-
Electronic Theses and Dissertations
Though Virginia Woolf’s and Kathe Kollwitz's personal histories and specific cultural circumstances were quite different, their aesthetics share fundamental qualities. This dissertation demonstrates that both artists affirm memory, the maternal, and creativity as coalescent, and through doing so assert a principle of connectivity that counters the turmoil of their times. Through this constellation, Woolf’s and Kollwitz's aesthetics exude faith in the continued viability of beauty and of possibility, faith that a commitment to becoming will undermine the sources of hopelessness that enshroud the modem world. Channeling their losses into their creative endeavors, Woolf and Kollwitz appropriated crises from their pasts …
Ridge Preservation Comparing The Clinical And Histologic Healing Of An Intrasocket Allograft Vs. A Facial Overlay Xenograft Using A Bioresorbable Barrier Membrane., Evmenios Poulias
Electronic Theses and Dissertations
Aim. The efficacy of ridge preservation procedures using grafting materials and barrier membranes has been well established in the literature. However, the loss of horizontal width even with the utilization of intrasocket only guided bone regeneration procedures can lead to loss of soft and hard tissue contour or even compromise implant placement. The primary aim of this study was to compare ridge preservation using an intrasocket mineralized particulate cancellous allograft to an intrasocket mineralized particulate cancellous allograft plus a facial overlay with a particulate bovine xenograft, both covered with a bioresorbable barrier membrane. Clinical and histologic data was used to …
Gain And Loss Of Functional Locomotor Recovery Following Contusive Spinal Cord Injury In The Adult Rat., Krista Layne Caudle
Gain And Loss Of Functional Locomotor Recovery Following Contusive Spinal Cord Injury In The Adult Rat., Krista Layne Caudle
Electronic Theses and Dissertations
Activity-based rehabilitation in the form of overground or body weight-supported treadmill (BWST) locomotor step training has become the most widely accepted therapy translated from preclinical animal research to spinal cord injury (SCI) patients. However, locomotor training does not provide the level of functional locomotor recovery that animal models are interpreted to promise because preclinical studies have used complete spinal cord transections that do not sufficiently mimic the clinical presentation. Furthermore, animal models do not include the same standard of care, immobilization with stretch/range-ofmotion manual therapies, SCI patients receive. Therefore, we have developed an experimental animal model that includes aspects of …
Morphological Comparison Of Visual Pathway Projections To The Temporal Lobe From Cortical Area Vi And The Tectorecipient Zone Of The Pulvinar Nucleus In The Tree Shrew (Tupaia Belangeri)., Donna Dillihay
Electronic Theses and Dissertations
The secondary visual pathway, from the retina through the superior colliculus and pulvinar nucleus has been linked to spatial attention (Snow et aI., 2009; Arend et aI., 2008) movement planning and motor response to visual stimuli (Wilke et aI. 2010; Grieve et aI. 2000). The tree shrew temporal cortex receives input from the tecto-recipient pulvinar nucleus, composed of the dorsal (PD) and central (PC) subdivisions (Lyon et al. 2003a). We looked at the projections from this pathway to the temporal cortex and compared them to the VI projections to the temporal cortex in the tree shrew. Our focus was to …
Integrated Modeling And Analysis Methodologies For Architecture-Level Vehicle Design., Rostyslav Lesiv
Integrated Modeling And Analysis Methodologies For Architecture-Level Vehicle Design., Rostyslav Lesiv
Electronic Theses and Dissertations
In order to satisfy customer expectations, a ground vehicle must be designed to meet a broad range of performance requirements. A satisfactory vehicle design process implements a set of requirements reflecting necessary, but perhaps not sufficient conditions for assuring success in a highly competitive market. An optimal architecture-level vehicle design configuration is one of the most important of these requirements. A basic layout that is efficient and flexible permits significant reductions in the time needed to complete the product development cycle, with commensurate reductions in cost. Unfortunately, architecture-level design is the most abstract phase of the design process. The high-level …
Regulation Of Vascular Smooth Muscle Cell Phenotype., Joshua Kuimeta Salabei
Regulation Of Vascular Smooth Muscle Cell Phenotype., Joshua Kuimeta Salabei
Electronic Theses and Dissertations
Vascular injury and chronic arterial diseases such as atherosclerosis and restenosis result in exposure of vascular smooth muscle cells (VSMCs) to increased concentrations of growth factors triggering a change from a contractile to a synthetic phenotype. The mechanisms by which growth factors trigger VSMC phenotype transitions remain unclear. Because phenotype switching involves the removal of contractile proteins, we hypothesized that autophagy is an essential modulator of VSMC phenotype. Also, the conversion to the synthetic phenotype is accompanied by cellular changes that trigger metabolic changes to meet the increasing demands for cellular energy. Little is known however about the contributions of …
A Novel High Yield Process For Gold Sulfide Nanoparticle Synthesis Via Shifting Equilibrium Of Self-Assembly Reaction., Dhruvinkumar Patel
A Novel High Yield Process For Gold Sulfide Nanoparticle Synthesis Via Shifting Equilibrium Of Self-Assembly Reaction., Dhruvinkumar Patel
Electronic Theses and Dissertations
Gold nanoparticles (AuNPs) have attracted enormous attention in the field of nanotechnology for applications such as, immunoassay, drug delivery, contrast enhancement and tumor therapy. The typical range of gold nanoparticles varies from 1– 150 nm; there are many different subtypes of AuNPs mainly based on size, shape, and optical properties including: gold nanospheres, nanorods, nanocages, and nanoshells. The main advantage of using gold nanoparticles is the large surface-to-volume ratio; this will allow the particles to be functionalized with drugs and/or targeting agents to create many novel applications. Many AuNPs have another advantage as well, they can be fabricated to either …
Biogenic Amine Levels Correlate With Time Of Day, Age, Light Cycle, And Aggressive State In The Flesh Fly, Sarcophaga Crassipalpis, Veronica L. Fregoso
Biogenic Amine Levels Correlate With Time Of Day, Age, Light Cycle, And Aggressive State In The Flesh Fly, Sarcophaga Crassipalpis, Veronica L. Fregoso
Electronic Theses and Dissertations
The biogenic amines serotonin (5HT), dopamine (DA), and octopamine (OA) have been indicated in the regulation of behaviors, including aggression. The flesh fly, Sarcophaga crassipalpis, was used to investigate ontogenetic and circadian changes in amines and aggression. Heads of male flies were analyzed for amine content using high performance liquid chromatography with electrochemical detection (HPLC-ECD) at 3 time points on each of 4 consecutive days in 2 light cycles, 12:12 LD and 15:9 LD. Both DA and OA levels decreased with age. Light-cycle dependent differences were observed for all amines in overall levels and patterns of change throughout the …
Towards A Fluid Solid Interaction Model Of A Dynamic Lung, Justin C. Jacobs
Towards A Fluid Solid Interaction Model Of A Dynamic Lung, Justin C. Jacobs
Electronic Theses and Dissertations
Because the pulmonary system is a site for both environmental particulate contamination, as well as drug delivery into the body, numerous research groups have focused on precisely understanding its inner-workings. Past research has demonstrated the need to realistically model the lung walls in order to accurately capture the complex airflow profile throughout all of the branches. Since this is paramount to properly replicating particulate transport in the lung, computational fluid dynamics simulations on their own are inadequate, as they cannot account for lung wall dilation. Only by coupling the fluid and solid domains can natural lung behavior can be effectively …
Digital Media's Transformative Role In Education: Beyond Potential To Essential, Ming-Tso Chien
Digital Media's Transformative Role In Education: Beyond Potential To Essential, Ming-Tso Chien
Electronic Theses and Dissertations
Achieving effective learning via digital media continues to be a major concern in contemporary education. The daily use of all forms of digital media is part of our lives and therefore becomes a key component of education. Educators must consider the process of digital media curriculum as a learning model and form of experience adapted to education. This means the significance is on how to learn as well as what to learn. This study demonstrated how the implementation of digital media curriculum via the Scratch game-making project contributed to middle school students' interaction with the entire educational process. The goal …
Adventures In The Classroom Creating Role-Playing Games Based On Traditional Stories For The High School Curriculum, Csenge Virág Zalka
Adventures In The Classroom Creating Role-Playing Games Based On Traditional Stories For The High School Curriculum, Csenge Virág Zalka
Electronic Theses and Dissertations
The goal of this thesis is to develop a template for turning traditional stories into role-playing games for the high school curriculum. By developing 3 sample games based on Greek mythology, Arthurian legends, and a widespread folktale type, I explored the process of creating games that fit the limits of secondary classrooms and can be used to address specific educational standards. The sample games were tested with groups of high school and college students, and the results of the testing sessions evaluated in a narrative case study format. Feedback from the testing sessions was incorporated in the template, the final …
Cursorial Adaptations In The Forelimb Of The Giant Short-Faced Bear, Arctodus Simus, Revealed By Traditional And 3d Landmark Morphometrics, Eric Randally Lynch
Cursorial Adaptations In The Forelimb Of The Giant Short-Faced Bear, Arctodus Simus, Revealed By Traditional And 3d Landmark Morphometrics, Eric Randally Lynch
Electronic Theses and Dissertations
The paleobiology of the Pleistocene North American giant short-faced bear, Arctodus simus, has eluded paleontologists for decades. Its more gracile form has led past researchers to myriad intepretations of the locomotion and feeding ecology of this species. While earlier studies have focused on craniodental morphology and simple postcranial indices, it is forelimb morphology that represents a direct compromise between locomotor and foraging behavior. The study here uses traditional and 3D landmark morphometrics to more completely compare the 3-dimensional shape of the major forelimb elements and their muscle attachment sites between A. simus, extant ursids, and other carnivorans. Results …
Landmark Analysis Of Musteloid Carnassials Applied To Taxonomic Identification And Examination Of Sexual Dimorphism And Regional Morphotypes, Joel Alvin Christine
Landmark Analysis Of Musteloid Carnassials Applied To Taxonomic Identification And Examination Of Sexual Dimorphism And Regional Morphotypes, Joel Alvin Christine
Electronic Theses and Dissertations
Guy Wilson Cave (GWC) in Sullivan County, Tennessee holds many late Pleistocene mammal fossils. Based on visual morphology, several partial mandibles with lower carnassial from GWC appeared to be musteloids. Geometric morphometrics has been successfully used to identify fragmentary fossils, so a landmark based, 2 dimensional technique was applied to identify the GWC musteloids using the lower carnassial. Digital images of several GWC fossils and of extant reference musteloids were combined using morphometric programs tpsDIG1, tpsUtil, and tpsSuper. Statistical data analysis was performed in PASW Statistics. Results successfully separated Mephitis mephitis (striped skunk) from M. macroura (hooded skunk) and Martes …
A Meta-Analytic Review Of Cooperative Learning Practices In Higher Education: A Human Communication Perspective, William Patrick Huddy
A Meta-Analytic Review Of Cooperative Learning Practices In Higher Education: A Human Communication Perspective, William Patrick Huddy
Electronic Theses and Dissertations
The phrase cooperative learning refers to a pedagogical learning and teaching technique in use in schools from kindergarten through higher education. The technique involves the structuring of an active classroom environment with students working in groups to discover, solve, and at its basic, provide a framework for dialogue and conversation. Cooperative learning is grounded in the development of a theory of social interdependence (Morton Deutsch) which states that individuals, working in groups, can in most cases provide for greater productivity and ideas than individuals working alone. The development of cooperative learning was greatly expanded in the late 1960’s and early …
Gender Depiction In Preschool Books: A Comparison Between Early Care And Education Classrooms In The United States And Norway, Cathrine Aasen Floyd
Gender Depiction In Preschool Books: A Comparison Between Early Care And Education Classrooms In The United States And Norway, Cathrine Aasen Floyd
Electronic Theses and Dissertations
Preschool children's perceptions around gender identity and development can be influenced by their experiences. With many children spending a portion of their day in child care, the environmental factors of these programs are important. One aspect of the environment can impact preschool children is the books that are available to them. For over 40 years, children's literature in the United States has been studied and found to be biased in their portrayal of males and females. Males were more often found as main characters and depicted as capable leaders and thinkers. Female characters were shown as weaker, often appearing in …
An Exploration Of African Folktales Among The Gullah Community Of The South Carolina Sea Islands : History, Culture, And Identity., Tytianna Nikia Maria Wells Smith 1987-
An Exploration Of African Folktales Among The Gullah Community Of The South Carolina Sea Islands : History, Culture, And Identity., Tytianna Nikia Maria Wells Smith 1987-
Electronic Theses and Dissertations
This thesis is an exploration of Black cultural space and its influence on the retention, adaptation, and transmission of African folktales during and after the antebellum era. During slavery, the survival of kinship and family helped to create an environment that existed through which African folktales were used to educate and socialize children on South Carolina Sea Islands plantations. This research conducted a literary and cultural analysis of the historical and current function of ten folktales that impart moral lessons and cultural values that encourage children in Gullah communities to appreciate their African heritage and challenge the world in which …
Narrative Of Modern Chinese Masculinity In Ha Jin's Fiction., Lezhou Su
Narrative Of Modern Chinese Masculinity In Ha Jin's Fiction., Lezhou Su
Electronic Theses and Dissertations
This dissertation consists of readings of three selected novels by Ha Jin-Waiting, The Crazed, and A Free Life. These novels cover three historical periods of Contemporary China under the rule of the Communist Party in sequence-the Mao's era (1949-1976), post-Mao era (1976-1989) and post-Tiananmen Square Incident era (1989 onwards). The readings are predominated with gender issues in the literary works, particularly with the construction and representation of contemporary Chinese masculinity. Drawing mainly on the Kam Louie's theory which pins down traditional Chinese masculinity in terms of wen (literary power) and wu (physical power)-the two concepts deeply entrenched in Confucianism, the …
Blockade Of Cxcr4 Inhibits Porphyromonas Gingivalis Colonization In Vivo And Subsequent Periodontal Bone Loss., Megan L. Mc Intosh
Blockade Of Cxcr4 Inhibits Porphyromonas Gingivalis Colonization In Vivo And Subsequent Periodontal Bone Loss., Megan L. Mc Intosh
Electronic Theses and Dissertations
Chronic periodontitis is strongly associated with composition of the oral biofilm occupying the gingival crevicular aspect of the tooth and its associated root. Some gram-negative, "red complex" bacteria instigate periodontal bone loss in patients, principal among these Porphyromonas gingivalis. P. gingivalis is a "late colonizer", indicating not only its physical location within the oral biofilm, but also the pathogenic dynamic of the interaction between P. gingivalis and the host innate immunity. Among several other subversive tactics, P. gingivalis has been shown to compel receptors vital to the orchestration of an appropriate immune response to co-associate and consequently signal in a …
Teenagers' Safety At Work : Dangerous Tasks And Safety Training., Teresa Jane Mcgeeney 1987-
Teenagers' Safety At Work : Dangerous Tasks And Safety Training., Teresa Jane Mcgeeney 1987-
Electronic Theses and Dissertations
Teenaged workers are twice as likely to be injured on the job as adult workers, and face a number of differences developmentally and psychosocially that present challenges for their safety at work. Little research has focused on the tasks that teenagers perform at work and what factors mediate their performance of hazardous tasks and tasks prohibited by law. Data used for this thesis was collected through a survey of 884 teenagers enrolled at two public high schools in Louisville, Kentucky in Spring 2011. Focus groups and interviews were also conducted with 42 employed teenagers in Spring 2010 to provide qualitative …
Idiopathic Pulmonary Fibrosis : Diagnosis, Management, And The Search For A Cure., Daniel Fioret
Idiopathic Pulmonary Fibrosis : Diagnosis, Management, And The Search For A Cure., Daniel Fioret
Electronic Theses and Dissertations
Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease with poor prognosis. To address this disease broadly, the candidate engaged in clinical work, literature analysis, database analysis, and laboratory work. The clinical work culminated in a case report that highlights the controversies inherent in the diagnosis and treatment of IPF. The literature analysis discusses ongoing clinical trials and challenges inherent in the management of IPF. Evaluation of a national database unveiled information about the burden of IPF on the healthcare system. Finally, the laboratory work examined the role of oxidant stress and the interaction of lung fibroblasts and lung cancer …
Child Behavioral Inhibition, Parental Overcontrol, And Parental Anxiety As Predictors Of Adolescent Anxiety., Benjamin M. Keizer
Child Behavioral Inhibition, Parental Overcontrol, And Parental Anxiety As Predictors Of Adolescent Anxiety., Benjamin M. Keizer
Electronic Theses and Dissertations
This dissertation examined the prediction of anxiety symptoms over time during developmentally significant periods - the transition to middle school (12 years old) and the transition to high school (15 years old). Specifically, relationships between child behavioral inhibition, paternal anxiety, maternal anxiety, and parental control and concurrent levels of adolescent anxiety at each time point were analyzed. Despite a strong research base supporting individual connections between child behavioral inhibition, levels of parental control, parental anxiety symptoms and adolescent anxiety, the joint longitudinal associations have received scant attention in the literature. The current study also compared two different models of adolescent …
Application Of Multivariate Statistical Methodology To Model Factors Influencing Fate And Transport Of Fecal Pollution In Surface Waters, Kimberlee K. Hall
Application Of Multivariate Statistical Methodology To Model Factors Influencing Fate And Transport Of Fecal Pollution In Surface Waters, Kimberlee K. Hall
Electronic Theses and Dissertations
Degraded surface water quality is a growing public health concern. While indicator organisms are frequently used as a surrogate measure of pathogen contamination, poor correlation is often observed between indicators and pathogens. Because of adverse health effects associated with poor water quality, an assessment of the factors influencing the fate and transport of fecal pollution is necessary to identify sources and effectively design and implement Best Management Practices (BMPs) to protect and restore surface water quality. Sinking Creek is listed on the State of Tennessee’s 303D list as impaired due to pathogen contamination. The need to address the listing of …
Pivotal Role Of Interleukin-10 On Microrna-155 Expression In Regulation Of The Monocyte Response In Hypothermia., Adrian Theophil Billeter 1984-
Pivotal Role Of Interleukin-10 On Microrna-155 Expression In Regulation Of The Monocyte Response In Hypothermia., Adrian Theophil Billeter 1984-
Electronic Theses and Dissertations
This project investigated the effect of hypothermia on the monocyte response with the goal of understanding, which intracellular processes are affected by hypothermia leading to differences in cytokine secretion. A better understanding of the effects of hypothermia on the regulation of monocyte responses would allow targeted interventions and may reduce complications and death in hypothermic surgical patients. We found the following results: 1. The three major pro-inflammatory signaling pathways, Nuclear Factor Kß, p38 and c-Jun N-terminal-Kinase (JNK) of the Mitogen Activated Protein Kinases pathway, have increased and prolonged activation with hypothermia (32°C). The extracellular signal-related kinase (Erk) pathway shows increased …
Rethinking Human And Nonhuman Animal Relations In J. M. Coetzee's Elizabeth Costello (2003)., Rodrigo Martini Paula
Rethinking Human And Nonhuman Animal Relations In J. M. Coetzee's Elizabeth Costello (2003)., Rodrigo Martini Paula
Electronic Theses and Dissertations
For the past four decades, scholarship on the relationship between human and nonhuman animals has been growing inside the academy and sprouting ontological and epistemological concerns about the status of the Humanities as an institution. Between 1997 and 2003, South-African author and Nobel Laureate J. M. Coetzee created Elizabeth Costello, an Australian writer that delivers lectures at certain universities and causes controversy when addressing the nature of animal rights movements. This work aims at analyzing the situations in which Coetzee uses Costello to speak about the cruelty to nonhuman animals. What I argue is that in entering the conversation through …
Analysis Of Microrna Microarray (Mm Chip) Data For Aging Mice Models., Vikranth Shetty
Analysis Of Microrna Microarray (Mm Chip) Data For Aging Mice Models., Vikranth Shetty
Electronic Theses and Dissertations
The present experimental designs have unique challenges in the analysis of microRNA expression intensity levels. In this project, various Normalization techniques were discussed with different statistical techniques and their application in an analysis performed at the Genes Centre of aging on mice models. The project involved repeated measures over time, and the intra-subject correlation caused by the repeated measurements should be incorporated into the analysis, resulting in additional significant miRNAs. Collection of multiple samples from the same individuals over time from an experiment may have issues with the commonly used methodologies-these issues are discussed here. Mixed model approach is used …
Cobalt Mof-5 : A Novel Catalyst For Co2 Conversion To Carbonates., Christine Elizabeth Phillips 1989-
Cobalt Mof-5 : A Novel Catalyst For Co2 Conversion To Carbonates., Christine Elizabeth Phillips 1989-
Electronic Theses and Dissertations
As more attention is focused toward carbon dioxide emissions into the environment, conversion of CO2 to useful chemicals can utilize the extra carbon dioxide captured from power plant stack gas, instead of sequestration. The mainstream method of producing carbonates and carbamates utilizes toxic phosgene. The cycloaddition of carbon dioxide to epichlorohydrin, or other epoxides, can produce carbonates without the use of phosgene. A catalyst with high surface area, Lewis acid sites, and an affinity for carbon dioxide is required to develop carbonates using carbon dioxide. A cobalt doped metal-organic framework-5 (Co21-MOF-5) was developed to test the cycloaddition reactions with carbon …
Foreign Savings, Financialization And Minsky: How External Capital Flows Pave The Way For Financial Instability In The Face Of Increasing Risk, Marcus C. Fresques
Foreign Savings, Financialization And Minsky: How External Capital Flows Pave The Way For Financial Instability In The Face Of Increasing Risk, Marcus C. Fresques
Electronic Theses and Dissertations
Minsky's Financial Instability Hypothesis has not come without its fair share of criticism. Much ado about Minsky's endogenous business cycle theory stems from a model where boom-time profit opportunities indelibly encourage firms to finance investment by leveraging their fixed capital assets against their internal liquidity. Opposition to Minsky often points to two distinct circumstances that might discourage the external finance of investment: a rise in effective demand and increasing risk. A rise in effective demand can increase the retained earnings of a firm providing more capital to internally finance investment and investment financed from retained earning is less risky than …
Advancing Global Tobacco Control: Exploring Worldwide Youth Attitudes And Behaviors Toward Tobacco Use And Control, Sreenivas Phanikumar Veeranki
Advancing Global Tobacco Control: Exploring Worldwide Youth Attitudes And Behaviors Toward Tobacco Use And Control, Sreenivas Phanikumar Veeranki
Electronic Theses and Dissertations
Tobacco use continues to be the leading cause of preventable death in the world. The disproportionate increase in tobacco use in low- and middle-income countries needs immediate attention. Many smokers begin smoking as adolescents and are most likely to become permanent smokers. Moreover, youth are highly targeted by tobacco industry strategies. However, a gap exists in literature to understand worldwide youth tobacco use and control. The purpose of this study is to 1) identify factors that influence never-smoking youths‟ smoking susceptibility, 2) explore characteristics that influence youth exposure to environmental tobacco smoke (ETS) and 3) to delineate key determinants of …