Digital Commons Network^™

Unique Osmoregulatory Morphology In Primitive Sharks: An Intermediate State Between Holocephalan And Derived Shark Secretory Morphology, Matthew Eric Larsen

Electronic Theses and Dissertations

Discovery of an unusual rectal gland in the Atlantic sixgill shark, Hexanchus vitulus, led to examination of rectal glands in 29 species of epipelagic and deep-sea sharks. Eight of 14 deep-sea species of sharks had digitiform glands that were previously assumed to be characteristic of elasmobranchs (N=281; mean width-length ratio ± SD = 0.18 ± 0.07). Hematoxylin-and-eosin stained sections from deep-sea sharks were similar to those from shallow water sharks. Glands from the family Somniosidae were kidney bean-shaped (N = 3; mean width-length ratio ± SD = 0.46 ± 0.05); whereas those from the families Echinorhinidae and Hexanchidae appeared lobulate …

The Effectiveness Of Localized Ultrasound And Aptamer Surface Modification On Nanoemulsions For Drug Delivery To Spheroids., Daniel A. Hodge

Electronic Theses and Dissertations

Cancer is a group of diseases that affects 1.6 million and kills nearly 600,000 Americans each year. The National Cancer Institute defines it as “diseases in which abnormal cells divide without control and can invade nearby tissues” and it is often treated with one or more of the following: chemotherapy, radiation, surgery. The expense for these treatments is expected to rise to $156 billion by 2020. Localized delivery can improve effectiveness and cancer survival rates, decrease the cost of treatment, and decrease the side effects of chemotherapy. This paper addresses models for this localized delivery through nanoemulsions. Nanoemulsions are a …

Reconstructing The Death Star: Myth And Memory In The Star Wars Franchise, Taylor Hamilton Arthur Katz

Electronic Theses and Dissertations

Mythic narratives exert a powerful influence over societies, and few mythic

narratives carry as much weight in modern culture as the Star Wars franchise. Disney’s 2012 purchase of Lucasfilm opened the door for new films in the franchise. 2016’s Rogue One: A Star Wars Story, the second of these films, takes place in the fictional hours and minutes leading up to the events portrayed in 1977’s Star Wars: Episode IV – A New Hope. Changes to the fundamental myths underpinning the Star Wars narrative and the unique connection between these film have created important implications for the public memory of …

The Relationship Between The Dark Tetrad Using The Hexaco Personality Models In Relationship To Mental Toughness In College Athletes, Michael K. Ryerson

Electronic Theses and Dissertations

Dark Triad has been examined before in previous literature many different times. The Dark Tetrad is recently new to the field and does not have the same amount of literature as the Triad. The Dark Triad and Tetrad have been examined with the Big Five Personality model numerous times and have been negatively correlated in the previous research. However, most of the research examined did not use Honesty-Humility that the HEXACO Personality Model has incorporated into the Big Five Personality model. The topic of mental toughness has been researched numerous times since its acceptance as a personality trait. The difficulty …

The Effects Of Mindful Meditation On Stress, Resilience, And Work-Family-School Conflict, James Kunz

Electronic Theses and Dissertations

Previous research on mindful meditation (MM) has not sufficiently examined the efficacy of guided MM on perceived stress, role conflict, and other constructs using a cell phone mobile application. Stress and role conflict are experienced by a significant proportion of the public and have substantial negative consequences on mental and physical health (Lupien, McEwen, Gunnar, & Heir, 2009; Byron, 2005).Stress and role conflict can be lessened through mindful meditation (Spijkerman, Pots, & Bohlmeijer, 2016; Michel, Bosch, & Rexroth, 2014). The current research examined the effectiveness of guided mindful meditation compared to a music-listening control group on four stress-related variables: mindfulness, …

Student Athlete Retention And Performance In Agriculture: An Analysis Of A Mentorship Program, Nick Cates

Electronic Theses and Dissertations

This qualitative research study focuses on the effectiveness of the athletic academic mentoring and advising program at Stephen F. Austin State University and its potential to replicate a similar program in the agriculture program. With emphasis on increasing the effectiveness of the current mentoring program, increasing student retention in agriculture, and improving the transition for high school students going into college, this study utilizes a questionnaire comprised of seven questions to determine how 14 former and current student-athletes that were enrolled in agriculture felt about the mentoring program and agriculture department. Many of the challenges faced by students, such as …

The Effect Of Compound L19 On Human Colorectal Cells (Dld-1), Sepideh Mohammadhosseinpour

Electronic Theses and Dissertations

Colorectal cancer is the third most common type of cancer in the world and the second leading cause of death among humans. Extracts of water soluble compounds from the roots and leaves of Rumex crispus were screened for compounds that induced apoptosis in DLD-1 cells. A compound referred to as L19 was isolated using Accelerated Solvent Extraction (ASE) followed by High Performance Liquid Chromatography (HPLC). Gas chromatography coupled with mass spectrometry was used to identify the L19 as a tetrahydrofuran with a molecular weight of 72.11 g/mole. Each HPLC fraction resulted in 94.4% purity. In the present research, specific genes …

Toward A New Reading Of Cicero's De Finibus, Kelsey Ward

Electronic Theses and Dissertations

In this dissertation, I argue that Cicero has two primary, interdependent aims in De finibus: the critical assessment of the dominant ethical positions, and the education of his readers. These aims are accomplished through four key devices. First, Cicero develops flat, useful readings of the dominant ethical positions without rejecting eudaimonism itself. This allows Cicero to demonstrate Academic practices while also insisting upon the importance of virtue, which suggests the best ethical view for Cicero is a skeptically grounded eudaimonism. Second, the arrangement of the text in reverse chronological order dramatically enacts Cicero’s own alternative to the cradle argument on …

The Word: Jacques Ellul's Dialogic Response To La Technique, Jeffrey S. Bogaczyk

Electronic Theses and Dissertations

The focus of this interpretive work is primarily to bring two Ellulian metaphors into conversation with one another: la technique, and “the word.” Jacques Ellul (1912-1994), a prominent French philosopher, sociologist, and theologian, is predominantly known for his critique of what he calls la technique, an underlying system which acts as an all-encompassing feature of necessity, which privileges the values of efficiency, speed, and progress in all societal endeavors, and which serves as the predominant interpretive lens by which we can examine and understand our current historical and cultural moment. Technique had its origination in the value system of …

Jon Sobrino’S Liberation Christology And Its Implication For The “Crucified People” Of The Niger Delta Region In Nigeria., Augustine Wayii

Electronic Theses and Dissertations

The thesis was carried out to investigate Sobrino’s liberation Christology and its implication for the “crucified people” of Niger Delta region in Nigeria. The thesis became very crucial because God’s gift of oil to the Niger Delta region has become a source of sorrow and death as a result of unjust structures by the Nigerian government and the multinational oil companies. Sobrino’s liberation Christology was very much appropriate for this research work because of the way he uses the present-day crucified people to understand better the crucified Christ. The “crucified people” in the Niger Delta region like the other crucified …

Who Says You Can't Go Home?, Holly Dameron

Electronic Theses and Dissertations

Sebastian Barry is most notable for using his ancestors as the main characters in his novel. He takes small wisps of their life and tells a hauntingly, beautiful story. In The Whereabouts of Eneas McNulty, On Canaan’s Side, and The Secret Scripture, he explores the themes of exile and the importance and difficulty of home. The problem with home for all of these characters is the fact that none of them can fully return. In the first chapter, I focus on Eneas’ thought of home, which is the physical land of Ireland. The next chapter is Lilly whose home is …

Self-Organized Structures: Modeling Polistes Dominula Nest Construction With Simple Rules, Matthew Harrison

Electronic Theses and Dissertations

The self-organized nest construction behaviors of European paper wasps (Polistes dominula) show potential for adoption in artificial intelligence and robotic systems where centralized control proves challenging. However, P. dominula nest construction mechanisms are not fully understood. This research investigated how nest structures stimulate P. dominula worker action at different stages of nest construction. A novel stochastic site selection model, weighted by simple rules for cell age, height, and wall count, was implemented in a three-dimensional, step-by-step nest construction simulation. The simulation was built on top of a hexagonal coordinate system to improve precision and performance. Real and idealized …

Loss Of The Na+/H+ Exchange Regulatory Factor 1 Results In Increased Susceptibility To Cisplatin-Induced Acute Kidney Injury., Adrienne M. Bushau-Sprinkle

Electronic Theses and Dissertations

Background. Acute kidney injury (AKI), an abrupt loss of kidney function which carries a high mortality and confers an increased risk of chronic kidney disease, develops in 30% of patients who receive cisplatin, a widely used chemotherapeutic agent [1], [2], [3]. The sodium hydrogen exchange regulatory factor isoform 1 (NHERF1) is a scaffolding protein that anchors multiple membrane proteins, in renal proximal tubules [4]. NHERF-1 deficient mice have aberrant localization of BBM proteins in intracellular compartments [5]. The investigators have recently demonstrated NHERF1 deficient proximal tubule cells have an underlying …

Synthesis And Characterization Of Biodiesel Fuels From Furfuryl Alcohol And Spent Coffee Grounds, Amanda Raley

Electronic Theses and Dissertations

ABSTRACT

Biodiesel can be synthesized using several different triacylglycerides, alcohols, and catalysts. In this study, fatty acid methyl esters (FAMEs) and fatty acid ethyl esters (FAEEs) were produced from their respective alcohols and coffee oil, using either a basic (K₂CO₃) catalyst or an acidic catalyst (H₂SO₄). Fatty acid furfuryl esters (FAFurEs) were produced using commercially-purchased cooking oils (canola, olive, corn, sunflower, and peanut) with furfuryl alcohol, a basic (K₂CO₃) catalyst, a co-solvent (THF), and an ionic liquid (1-butyl-3-methylimidazolium tetrafluoroborate). All samples were produced using either conventional heating methods …

T Socio-Ecology Of Managed Honeybees (Apis Mellifera) In The Louisville Metro Area., Haileigh M. Arnold

Electronic Theses and Dissertations

Humans have a long history of the practice of beekeeping to harness the power of pollination. This managed pollinator system consists of beekeepers, honeybees, and their environment. However, recent disease, pesticide use, and land use factors honeybee threaten this relationship. In the face of such concerns it is important to examine the factors that impact and can help sustain our managed pollinator systems. In this thesis, the national and Kentucky state-level policies that affect managed pollinator systems were examined and socio-ecological factors that may contribute to honeybee hive growth and losses were assessed along an urban development gradient in Louisville, …

Malaria In The Prehistoric Caribbean : The Hunt For Hemozoin., Mallory D. Cox

Electronic Theses and Dissertations

With the increase in resistance to anti-malarials and global warming trends expanding the habitation range of the mosquito vector, research highlighting the biogeographical contexts of infected populations is critical to understanding epidemiological patterns. A bioarchaeological approach to epidemiology can shed light on previous disease patterns and aid in the prediction of future outbreaks of diseases like malaria. Currently, there is no direct evidence of malaria in the Americas prior to European contact; however, skeletal, archaeological, paleoenvironmental, historic, and ethnohistorical evidence strongly suggest the presence of Plasmodium spp. malaria in indigenous Caribbean skeletal remains held in the Yale Peabody Museum of …

Killing Martin County : Resiliency In A Central Appalachian Community., David Adam Sizemore

Electronic Theses and Dissertations

Environmental stressors, anything that poses a threat to human and environmental health, are disproportionately located in marginalized communities. Coal extraction companies produce and concentrate environmental stressors in Central Appalachia, a sub-region of Appalachia with high poverty rates and economic hardship. Through destructive coal extraction methods, the coal industry has jeopardized Central Appalachian health and environmental quality. The coal industry’s power to cause destruction in Central Appalachia is a product of historical strategic initiatives. Since the late 1800s, the coal industry has forcefully altered the culture and ideology of Central Appalachians and developed relationships with local, state, and federal policymakers to …

Igniting The Imagination : Tenaciously Building A Character., Lois Abdelmalek

Electronic Theses and Dissertations

As an actor, my goal is to achieve full transformation to perform any character. During my final year of graduate school, I auditioned and received the roles of Liz Morden and Lieutenant Faddy in Our Country’s Good. I had been exposed to several acting methods in graduate school; however, I questioned if I had a solid technique to rely on. My thesis role was an opportunity to become self-aware of my process. Through imagination, I explored the historical circumstances, the text, and physical and voice work. I became conscious as never before how my creation of a character demands trusting …

Therapeutic Potential Of A Plant-Made Cholera Toxin B Subunit Variant For The Treatment Of Ulcerative Colitis., Joshua Mark Royal

Electronic Theses and Dissertations

Cholera toxin B subunit (CTB) is a mucosal immunomodulatory protein that induces robust mucosal and systemic antibody responses. This well-known biological activity has been exploited in cholera prevention (as a component of Dukoral® vaccine) and vaccine development for decades. On the other hand, several studies have investigated CTB’s immunotherapeutic potential in the treatment of inflammatory diseases such as Crohn’s disease and asthma. Furthermore, we recently found that a plant-made variant of CTB (CTBp) could induce colon epithelial wound healing in mouse colitis models. In this thesis, it is revealed that the wound healing effects are unique to the plant-made variant, …

A Study Of Gpr3, Gpr6, Of Gpr12 As Novel Molecular Targets For Cannabidiol., Alyssa S. Laun

Electronic Theses and Dissertations

The G protein-coupled receptors 3, 6, and 12 (GPR3, GPR6, and GPR12) comprise a family of closely related orphan receptors with no confirmed endogenous ligands. These receptors are constitutively active, capable of signaling through G protein and non-G protein mediated mechanisms. These orphan receptors have previously been reported to play important roles in many normal physiological functions and to be involved in a variety of pathological conditions. Although they are orphans, GPR3, GPR6, and GPR12 are phylogenetically most closely related to the cannabinoid receptors. Using β-arrestin2 recruitment and cAMP accumulation assays, we have recently found that the non-psychoactive phytocannabinoid cannabidiol …

The Effects Of Polychlorinated Biphenyls Exposure On Non-Alcoholic Fatty Liver Disease : Role Of Aryl Hydrocarbon Receptor., Hongxue Shi

Electronic Theses and Dissertations

Polychlorinated biphenyls (PCBs) are detectable in serum of 100% of adults in US, and has been associated with fatty liver disease in epidemiological studies. PCBs are classified as either dioxin-like (DL) or non-dioxin-like (NDL) PCB based on their ability to activate the aryl hydrocarbon receptor (AhR). We used exposures that reflect human bioaccumulation patterns, which resembles Aroclor 1260 with a low level of the DL-PCB, PCB 126. Our aim was to determine if this exposure will activate the human and mouse AhR and examine if receptor activation influences these steatotic responses due to PCB exposures. DL-PCBs exposure-induced AhR activation in …

Inflammasome Independent Leukotriene-B4 Production Drives Crystalline Silica Induced Sterile Inflammation., Bindu Hegde

Electronic Theses and Dissertations

Silicosis is an irreversible lung inflammatory disease caused by chronic exposure to crystalline silica (CS) and is one of the most prevalent occupational diseases worldwide. Lipid chemoattractant Leukotriene B₄ (LTB₄) plays an important role in neutrophilic inflammation that drives silicosis and promotes lung cancer. Previous studies in our laboratory have demonstrated that CS-induced neutrophilic inflammation and lung tumor burden in K-ras^LA1 mice is abrogated in the LTB₄-receptor deficient mice. Another pathway whose importance is well studied in the progression of silicosis is the Nalp3 inflammasome pathway. Studies have shown inflammasome- dependent IL-1b to be …

There Is Water In The World For Us : The Environmental Theories Of Alice Walker., Janae Lewis Hall

Electronic Theses and Dissertations

The emergence of African-American Environmental thought responds to the ongoing erasure of Black experiences and their perspectives on nature. Mainstream environmentalism maintains a legacy of perceived innocence and incorruptibility towards the land, while Black Environmentalism demonstrates the limitations of that ideology. Limitations include the erasure of history in regards to stealing land from Indigenous people, the brutality of slavery, legalized lynching, forced removal from the land, exploitation in sharecropping, destruction of sacred lands, heavy pollution in urban centers, and harmful environmental policies. For Black and Indigenous peoples, it is impossible to view American soil as innocent. This project surveyed the …

The Involvement Of Epithelial Cells In Arenavirus-Induced Pathogenesis., Nikole Leslie Margaret Warner

Electronic Theses and Dissertations

Mammalian Arenaviruses are a geographically and genetically diverse family of viruses, which is separated into two sub-groups; the Old World (OW) and New World (NW) groups. Of the OW viruses, Lassa virus (LASV), found endemically in Western Africa, is an important human pathogen, causing hundreds of thousands of infections, and several thousand deaths annually. Interestingly, some villages in endemic regions, up to 45% of the population show seropositivity for the virus. It is hypothesized that seropositivity is a result of natural infection through inhalation or ingestion of infectious particles. However, the exact mechanism is still unknown. LASV’s natural reservoir is …

State-Reinforced Self-Governance Of Community-Managed Open Spaces In Chicago, Il And Louisville, Ky., Willow Sequoia Dietsch

Electronic Theses and Dissertations

As urban populations rise, small greenspaces, like gardens, are increasingly important to well-being of communities, and urban sustainability as a whole. However, past development, and current political and economic challenges encumber many cities in providing adequate greenspace. Cities like Chicago, IL and Louisville, KY have turned to the communities to manage greenspaces with help from partner organizations. This thesis examines these arrangements, and compares them in terms of several potential factors, (i.e. legal authority, responsibility, and support). Semi-structured interviews of important community greenspace stakeholders, and archival sources including original documents, news articles, and government reports, were used to understand the …

Vinyl Chloride Enhances Diet-Induced Liver Injury Via Metabolic Dyshomeostasis : Critical Role Of Mitochondria., Anna L. Lang

Electronic Theses and Dissertations

Background. Vinyl chloride (VC) is an environmental toxicant and has been shown to be directly hepatotoxic at high exposures. However, recent studies suggest low-level toxicant exposure can cause subtle changes to the liver. Given the high prevalence of non-alcoholic fatty liver disease (NAFLD) in the United States, it is important to determine the impact of low-level toxicant exposure on the progression of underlying liver injury when combined with other factors. Therefore, the overarching goal of this dissertation was to develop a model of VC co-exposure with high-fat diet (HFD) and to determine the mechanisms by which VC contributes to the …

Functional And Structural Impact Of The Loss Of The Leucine-Rich Repeat Protein Lrit1 In The Mouse Retina., Catherine Ann Cobb

Electronic Theses and Dissertations

Mutations in genes encoding the leucine-rich repeat (LRR) proteins nyctalopin and LRIT3 lead to complete congenital stationary night blindness because they are critical to depolarizing bipolar cell function in the retina. LRIT3 has two closely related family members, LRIT1 and LRIT2. In silico analyses of publicly available RNA-Seq data showed that Lrit1 was highly expressed in the retina. Here I describe the expression pattern and impact of loss of LRIT1 on retinal function. To enable these studies, we used CRISPR/Cas9 technology to create an Lrit1^-/- mouse line. Retinal morphology and morphometry analyses showed no gross changes in retinal structure …

The Styles Of Criminology : Writing Among The Stars., Ethan Maxwell Higgins

Electronic Theses and Dissertations

This study investigates how criminological writing style is "a [more] complicated terrain" than we realize in criminology (Butler, 1990, p. xix). Data is drawn from interviews with forty of the one hundred most influential criminological writers (Walters, 2015) to explore perceptions of good writing in the field, namely in describing writing practices, norms and values. Thus, the findings of this study come in three chapters. The first two result chapters explore the terrain of writing in criminology by presenting perceptions of best practices and values of good writing. The third results chapter then examines these perceptions within a lens of …

Gender And Leadership In Animal Sheltering Organizations., Jennifer Blevins Sinski

Electronic Theses and Dissertations

This study explores the connection between gender, leadership and implementation of best practice strategies to reduce or eliminate euthanasia of healthy, adoptable companion animals in animal sheltering organizations. The purpose of this mixed methods study utilizing an online survey and in-depth interviews is to explore the impact of gender and animal sheltering leadership on organizational policies, as well as workers’, and volunteers’ attitudes toward reducing euthanasia in sheltering organizations. It is anticipated that the knowledge generated from this research will provide new insights into animal sheltering policies and procedures and inform sheltering organizations about the connection between gendered leadership in …

The Effects Of Habitat And Connectivity On Tropical Ant Ecology And Behavior., Benjamin Jacob Adams

Electronic Theses and Dissertations

This dissertation explores the role that physical connections among and within habitats play in determining the local diversity and behaviors of cursorial organisms. Understanding the processes that regulate local community assembly and that contribute to the maintenance of species diversity is a cornerstone of community ecology. Ants are a useful model for studies of local communities because they are abundant and fulfill a variety of ecological roles. Chapter one of the dissertation examines the how lianas (woody vines) function as connective structures among tree crowns and how these connections affect arboreal ant community structure within a tropical forest canopy. Trees …