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Rational Design And Investigation Of Polypeptide Multilayer Films And Capsules, Ling Zhang

Doctoral Dissertations

Three major concerns in the science of materials today are control over structure and function at the molecular level, biodegradability, and scalability of production. Polymeric materials, notably polyelectrolyte multilayer films, have shown considerable promise in all these areas, and for rational development of multifunctionality. Polypeptides constitute an especially interesting class of polyelectrolyte, given their inherent biodegradability, means of control over structure, methods of large-scale synthesis, and ability to encode biological information. Relatively little is known, however, about polypeptide multilayer films, despite recent advances in the general area.

In this dissertation, ten heteropolypeptides were designed and synthesized by Fmoc chemistry. These …

Reliability -Aware Optimal Checkpoint /Restart Model In High Performance Computing, Yudan Liu

Doctoral Dissertations

Computational power demand for large challenging problems has increasingly driven the physical size of High Performance Computing (HPC) systems. As the system gets larger, it requires more and more components (processor, memory, disk, switch, power supply and so on). Thus, challenges arise in handling reliability of such large-scale systems. In order to minimize the performance loss due to unexpected failures, fault tolerant mechanisms are vital to sustain computational power in such environment. Checkpoint/restart is a common fault tolerant technique which has been widely applied in the single computer system. However, checkpointing in a large-scale HPC environment is much more challenging …

A Finite Difference Method For Studying Thermal Deformation In Two-Dimensional Micro Scale Metal Thin Films Exposed To Ultrashort Pulsed Lasers, Haojie Wang

Doctoral Dissertations

Ultrashort-pulsed lasers have been attracting worldwide interest in science and engineering because the lasers with pulse durations on the order of sub-picoseconds to femtoseconds possess capabilities in limiting the undesirable spread of the thermal process zone in a heated sample during material processing at the microscale. Prevention of thermal damage is an important factor for success of ultrashort-pulsed lasers in real applications. The thermal damage induced by ultrashort pulses is intrinsically different from that induced by long-pulse or continuous lasers. It occurs after the heating pulse is over and involves the shattering of thin metal layers (without a clear signature …

Biomedical Applications Of Polypeptide Multilayer Nanofilms And Microcapsules, Jai Simha S. Rudra

Doctoral Dissertations

The past few years have witnessed considerable growth in synthetic polymer chemistry and physics, biomaterials science, and nano-scale engineering. Research on polypeptide multilayer films, coatings, and microcapsules is located at the intersection of these areas and are promising materials for applications in medicine, biotechnology, environmental science. Most envisioned applications of polypeptide multilayers have a biomedical bent. This dissertation on polypeptide multilayer film applications covers key points of polypeptides as materials, means of polymer production, film preparation, film characterization methods, and key points of current research in basic science. Both commercial and designed peptides have been used to fabricate films for …

Uncertainty And Error In Laser Triangulation Measurements For Pipe Profiling, Michael Kenneth Swanbom

Doctoral Dissertations

Underground pipeline infrastructure often receives insufficient attention and maintenance. Those responsible for ensuring the continuing functionality of this infrastructure primarily use subjective information in their decision making, and standards defining the level of damage acceptable before repair or replacement are difficult to implement. Laser pipe profiling is a relatively new technology that has emerged to take a step toward the objective assessment of buried assets. A laser profiler is a device that traverses a section of pipe, taking measurements of radius around the circumference of the inner pipe wall at multiple locations along the length of the pipe. The accuracy …

Code-Level Modeling Of The Hodgkin -Huxley Neuron Model Using An Open Source Version Of Spice, Anthony Stuart Carver

Doctoral Dissertations

There have been numerous studies presented in the literature demonstrating proof of principle neural-electronic circuitry. Some of these studies involve simulations of neural detection using synthetic electronic circuitry, while others involve simulations of neural excitation using external electronics. A common feature of these studies is the simplicity of the overall circuit topology. Some of these studies implement the circuit equations in conventional numerical ordinary differential equation solvers. This process involves the algebraic manipulation of the circuit equations which is a tedious process for all but the simplest circuit topologies. As the overall complexity of the network topology increases, the numerical …

Growth And Behavior Of Chondrocytes On Nano Engineered Surfaces And Construction Of Micropatterned Co-Culture Platforms Using Layer-By-Layer Platforms Using Layer -By -Layer Assembly Lift-Off Method, Jameel Shaik

Doctoral Dissertations

Several approaches such as self-assembled monolayers and layer-by-layer assembled multilayer films are being used as tools to study the interactions of cells with biomaterials in vitro. In this study, the layer-by-layer assembly approach was used to create monolayer, bilayer, trilayer, five, ten and twenty-bilayer beds of eleven different biomaterials. The various biomaterials used were poly(styrene-sulfonate), fibronectin, poly-L-lysine, poly-D-lysine, laminin, bovine serum albumin, chondroitin sulfate, poly(ethyleneimine), polyethylene glycol amine, collagen and poly(dimethyldiallyl-ammonium chloride) with unmodified tissue-culture polystyrene as standard control. Three different cell lines—primary bovine articular chondrocytes, and two secondary cell lines, human chondrosarcoma cells and canine chondrocytes were used in …

Position And Orientation Correction For Pipe Profiling Robots, Andrew John Dettmer

Doctoral Dissertations

Sewer pipelines are prevalent, important, valuable, unnoticed, and often in a state of disrepair. Pipeline inspection is essential for effective management of wastewater systems and is now mandated for many municipalities complying with the Governmental Accounting Standards Board Statement 34 and EPA regulations. Pipe inspection robots are routinely used to inspect underground pipelines for cracks, deformations, leaks, blockages and other anomalies to prevent catastrophic failure and to ensure cost effective maintenance and renewal. Most existing pipe inspection robots only collect video footage of pipe condition. Pipe profiling technology has recently been introduced to allow for measurement of the internal coordinate …

Analysis And Prediction Of Effectiveness For Residential Hvac Ductwork, Jinson J. Erinjeri

Doctoral Dissertations

An analysis of residential HVAC ductwork has been performed. Ductwork in 55 homes in Northern Louisiana was tested to determine duct leakage by means of using various measurement techniques to determine the differences between the existing methods as well as the revised method developed in this project referred to as Generalized Subtraction Correction Algorithm (GSCA). A protocol to measure and estimate return leaks at operating pressure was developed. The weighted average return leakage for the homes sampled was determined to be 115 cfm at operating pressure whereas the weighted average duct leakage was determined to be 348 cfm at 25 …

Chitosan Paste From Crawfish Shells As A Synthetic Bone Graft Material: Preparation, Characterization And Animal Study, Jerome G. Saltarrelli Jr.

Doctoral Dissertations

Bone loss associated with musculoskeletal trauma or metabolic diseases often requires bone grafts. Autograft or allograft bones are limited in supply. Therefore, development of synthetic bone graft materials is an active area of research. For several years the biomaterials group at LSUHSC-Shreveport has been investigating the use of chitosan purified from crawfish shells using a process patented by my research advisor, Dr. Debi Mukherjee.

Chitin is a polysaccharide that exists in fungi, exoskeleton of insects and outer shell of crustaceans. It is biocompatible, osteoconductive, antimicrobial, biodegradable, non-toxic, haemostatic, fungicidal, and the second most abundant natural polysaccharide on earth. Removal of …

The Design And Performance Of Pressure Pipe Liners Under Static And Cyclic Loading, Shanhai Guan

Doctoral Dissertations

Cured-in-place pipe (CIPP), is a widely used trenchless technology. Based on the current liner design method, American Society for Testing and Materials (ASTM) F2207-02, several aspects are studied for the effect on estimating the long-term performance of the liners.

While estimating the liner burst pressure, the effect from host pipe material properties, liner material properties, defect geometry, liner creep properties and loading condition should be considered. The burst pressure calculated based on the existing method is overestimated and this allows an increased risk of structural failure before the expected design life is reached.

Compared with cast-iron, a PVC host pipe …

Drug Loading And Release From Polypeptide Multilayer Nanofilms, Yang Zhong

Doctoral Dissertations

Polypeptides, linear macromolecules, are formed from amino acid residues by linkage of peptide bonds. Proteins are polypeptides too, with more complex conformations contributing to specific functionalities. Disulfide bonds are very important to maintain the structure and functions of proteins, which will form between two cysteine (Cys) residues under oxidizing circumstance.

Cys containing polypeptides are designed and synthesized by F-moc (9-Fluorenylmethyloxycarbonyl) chemistry. The number and position of Cys residues can be controlled by amino acid sequences design and following peptide synthesis, which is important to gain insights on the nature of polyelectrolyte multilayer film assembly and stability.

Both commercial and designed …

Structural Behavior Of Pvc Pipe Liners Subjected To Seasonal Groundwater Loading, Qing Cai

Doctoral Dissertations

Thin-walled polymeric liners are routinely used to rehabilitate deteriorated underground pipe lines that are structurally sound but have lost their hydraulic integrity. These host pipes are said to be "partially deteriorated" since they can support soil and surface loading. For this case, the pipe liners must only be designed to withstand the pressure of the groundwater that seeps through openings in the host pipe and migrates through the small annular gap between the liner and the host pipe. This external pressure will cause the polymeric liner to slowly deform inward toward the center of the pipe, and the compressive hoop …

Data Fusion Techniques For Health Monitoring Of Aging Aircraft And Skin Cancer Detection, Kapil Gupta

Doctoral Dissertations

"Data fusion is generally practiced to enhance decision or inference making capability. Sensor and information source data may often be corrupted by noise or other factors. Data fusion can be used to improve sensor and/or information source data quality and reliability and improve detection accuracy. There are several types of data fusion, including raw data level, feature level, and decision level.

This work presents the investigation and development of image and signal processing, computational intelligence, fuzzy logic, and statistical techniques for different types of data fusion for a varied range of applications. Raw data and decision level fusion approaches are …

Energy-Aware And Secure Routing With Trust Levels For Wireless Ad Hoc And Sensor Networks, Eyad Taqieddin

Doctoral Dissertations

"This dissertation focuses on the development of routing algorithms for secure and trusted routing in wireless ad hoc and sensor network. The first paper presents the Trust Level Routing (TLR) protocol, an extension of the optimized energy-delay routing (OEDR) protocol, focusing on the integrity, reliability and survivability of the wireless network...The second paper analyzes both OLSR and TLR in terms of survivability and reliability to emphasize the improved performance of the network in terms of lifetime and proper delivery of data...The third paper proposes a statistical reputation model that uses the watchdog mechanism to observe the cooperation of the neighboring …

Moisture Effects On The Mechanical Behavior Of Flexible Pavement Subgrades, Edel Rudilio Cortez

Doctoral Dissertations

All pavement materials contain moisture in various forms and amounts. The effects of moisture on the mechanical behavior of these materials vary from small for some bound materials to very significant for some fine grained soils. Moisture effects become critical particularly during the spring thaw, but also where prolonged exposure to water sources occurs. The pavement design engineer must consider the effect of moisture on the mechanical properties of the constituent materials, and how different pavement layers interact under wet conditions.

This doctoral dissertation focuses on the effect that moisture in the subgrade has on the mechanical response and performance …

Interdisciplinary Middle School Teaming, Donna J. Cronin

Doctoral Dissertations

The purpose of this study was to determine how the substance of interdisciplinary team meetings reflects team members' beliefs regarding the middle school concept and the school practices and cultural characteristics as delineated by the National Middle School Association (NMSA, 2005), which create successful middle schools for young adolescents.

The teachers of three interdisciplinary teams in an evolving middle school in the Northeast were participants in this bounded case study where the team was the unit of analysis.

Individual team member data were collected through individual audio taped interviews and validated by questionnaire responses from each participant. Team meeting discourse …

A Statistical Approach To Understanding Microcosm Methods For Microbially Mediated Dechlorination Of Trichloroethene In Bedrock Aquifers, Stephen J. Druschel

Doctoral Dissertations

Microcosms were evaluated using statistical methods to advance the measurement and characterization abilities for in situ reductive dechlorination of trichloroethene (TCE) in fractured rock aquifers. Microcosms constructed with unincubated crushed rock in groundwater provided the best microcosm model of in situ TCE degradation, when prepared and incubated to simulate the in situ environment. Microcosms constructed with only groundwater were effective at modeling the TCE degradation only when the microcosms were amended with (total) organic carbon (TOC). Incubation of crushed rock core within the residual TCE plume caused a substantial decline in TCE degradation for biotic intrinsic microcosms, suggesting an effect …

Dissecting The Pennsylvania Anatomy Act: Laws, Bodies, And Science, 1880--1960, Venetia M. Guerrasio

Doctoral Dissertations

When the Pennsylvania Legislature passed a mandatory anatomy law in 1883, they were conceding to medicine and science the need for human dissection "material." The legislature was also conceding authority, entrusting physicians and scientists to regulate the messy business of human dissection. In addition to providing bodies for dissection, the Pennsylvania Anatomy Act of 1883 created a modern, state-level bureaucratic entity run by medical experts empowered with self governance: the Anatomical Board of Pennsylvania. Scholars have paid scant attention to the post grave-robbing history of anatomy and dissection in the United States. When the state engaged in body procurement for …

Inclusive Scattering Of Polarized Electrons From Polarized Protons In The Delta-Excitation Region With Blast, Octavian Florin Filoti

Doctoral Dissertations

Inclusive scattering of polarized electrons from polarized protons has been studied using the BLAST detector at MIT-Bates Linear Accelerator Center. The Bates Large Acceptance Spectrometer Toroid (BLAST) is a detector designed to study in a comprehensive and precise way the spin-dependent electromagnetic response in one and few-body systems over a large kinematic range. It has been used to measure spin-dependent scattering from the elastic to the nucleon resonance region for hydrogen and deuterium using a longitudinally polarized electron beam at a beam energy of 850 MeV stored in the MIT-Bates South Hall Ring, and polarized internal gas targets of hydrogen …

Coming To Know Reflective Practice: An Ethnography Of Novice University Teachers, Gail Fensom

Doctoral Dissertations

This ethnography investigates the cultural construction of reflection about teaching. The central setting was a two-semester practicum and seminar course in college teaching for psychology Ph.D. candidates in their third year of study at a four-year public university, Key participants were two male and two female doctoral students. Other participants included the two tenured faculty members who supervised the practicum and seminar.

Reflection was defined as the purposeful deliberation of anticipated and/or past teaching behavior, and included examination of relevant assumptions, values and beliefs. The purpose of the study was to describe and understand the reflective processes about teaching demonstrated …

Role Of The Biofilm In Metals Accumulation By Fucoid Algae And Their Surrounding Rock Surfaces, Joan Lydia Beskenis

Doctoral Dissertations

Both inanimate and animate intertidal surfaces including Fucus and Ascophyllum develop a biofilm that can bind metals contributed by non-point and point sources of pollution. The biofilm also functions as a habitat for the many organisms, i.e. bacteria, diatoms and other algal cells that are part of the biofilm and contribute to the polysaccharide matrix. Examinations of the biofilm were quantified by polysaccharide analysis using a spectrophotometer. Biofilm samples were recovered from both intertidal rock surfaces and the surface of the surrounding fucoid algae to determine if they bind Cu and Zn. Locations in Kittery, Maine differed by the amount …

Modeling Secondary Organic Aerosol Formation From Biogenic Hydrocarbons, Jianjun Chen

Doctoral Dissertations

Secondary organic aerosol (SOA) is formed generally by the oxidation of gas-phase volatile organic compounds (VOCs) to form semi- or non-volatile products that then undergo gas to particle partitioning. In this work, the Caltech Atmospheric Chemistry Mechanism (CACM) and the Model to Predict the Multi-phase Partitioning of Organics (MPMPO) were updated with detailed chemistry associated with three monoterpene species---alpha-pinene, beta-pinene, and d-limonene. The updated CACM and MPMPO modules were calibrated by ozone formation and SOA yield data for alpha-pinene, beta-pinene, and d-limonene from chamber experiments. Then, the updated CACM and MPMPO were incorporated into the Community Multi-scale Air Quality Model …

Smart Machining System Platform For Cnc Milling With The Integration Of A Power Sensor And Cutting Model, Min Xu

Doctoral Dissertations

Novel techniques and strategies are investigated for dynamically measuring the process capability of machine tools and using this information for Smart Machine System (SMS) research. Several aspects of the system are explored including system integration, data acquisition, force and power model calibration, feedrate scheduling and tool condition monitoring.

A key aspect of a SMS is its ability to provide synchronization between process measurements and model estimates. It permits real time feedback regarding the current machine tool process. This information can be used to accurately determine and keep track of model coefficients for the actual tooling and materials in use, providing …

It Managers, Construction Marketers, And Emergency Medical Technicians: Professional Adult Learners In Higher Education, Michael J. Michaud

Doctoral Dissertations

In this study, I examine the literacy, school, and work experiences of three professional adult learners attending Northeast State College (NSC), a four-year public university in New England. I define professional adult learners as those over the age of twenty-five who enroll in formal programs of post-secondary study for reasons having to do primarily with career advancement and/or transition. More often than not, professional adult learners work full-time and pursue their studies part-time. This project grew out of my work teaching at NSC in the late 1990s. At that time, I had a limited sense of who professional adult learners …

Analytical Model Development And Experimental Investigation Of Process Model Size Effects In Microforming, Richard M. Onyancha

Doctoral Dissertations

With the emergence of micromanufacturing technologies, a critical need to develop process models that can accurately predict the required parameters, such as process forces, has arisen. As with the manufacturing processes themselves, macroscale process models can not effectively be used at the microscale due to size effects, i.e. changes in material and process parameters with miniaturization. Size effects with respect to material properties and frictional conditions have been demonstrated in past research. This dissertation demonstrates the existence of size effects due to process model assumptions and specimen deformation.

The new models were evaluated by comparing the predicted results to both …

Sustainability Of New Hampshire's Sawmill Industry And Its Forest Resource Base, Difei Zhang

Doctoral Dissertations

Sustaining our forests is vital for a healthy ecosystem and for the future of forest industry. To sustain the regional sawmill industry as well as the associated forest resource base, the key is to track the consumption and inventory of eastern white pine (Pinus strobus L.), the most dominant commercial species in New Hampshire. This research profiled the sawmill industry in New Hampshire and Vermont in terms of production, consumption, labor characteristics and regulating economic and policy issues. We examined the sustainability of the industry and its resource base; with a specific focus on the white pine sawmill industry and …

The Comradeship Of The "Happy Few": Henry James, Edith Wharton, And The Pederastic Tradition, Sharon Kehl Califano

Doctoral Dissertations

The recent scholarly reevaluation of Henry James in terms of queer theory has created a need to reexamine James' influence on Edith Wharton and her works. In this dissertation, I explore how James introduced Wharton to a circle of friends (the "Happy Few"), a group of queer men-of-letters who provided the author with both a literal and figurative space for discovering an interiorized, masculine queer self. Specifically addressing the years between 1905 and 1910, I show in this study how Wharton's initiation into queer culture and her introduction to the pederastic tradition, as reimagined through Walt Whitman's paradigmatic "comradeship," gave …

Error Propagation In Pattern Recognition Systems: Impact Of Quality On Fingerprint Categorization, Jakub Mocny

Doctoral Dissertations

The aspect of quality in pattern classification has recently been explored in the context of biometric identification and authentication systems. The results presented in the literature indicate that incorporating information about quality of the input pattern leads to improved classification performance. The quality itself, however, can be defined in a number of ways, and its role in the various stages of pattern classification is often ambiguous or ad hoc.

In this dissertation a more systematic approach to the incorporation of localized quality metrics into the pattern recognition process is developed for the specific task of fingerprint categorization. Quality is defined …

Understanding Standing, Christopher Storey

Doctoral Dissertations

Research objectives. Psychophysical acceleration threshold is a tool for detecting deficits in dynamic postural control. Our lab has shown differences in the acceleration threshold among young adults, elderly adults, and elderly adults with diabetes. Electromyography, Semmes-Weinstein monofilaments, and hearing tests investigate the underlying physiological mechanisms for the detriments in postural control. Due to peri-sway perturbations, the motion of a person's sway affects the signal to noise ratio for perturbed stance. Since increases in sway range accompany postural instabilities, sway entrainment will allow us to investigate changes in acceleration threshold at different points in sway. The center of pressure, observed …