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Transition Metal Complexes Of Novel Ligands Derived From The Cis,Cis-1,3,5-Triaminocyclohexane (Tach) Framework: Structural And Biological Studies, Gyungse Park

Doctoral Dissertations

Transition and Group IIB metal complexes of novel ligands derived from cis,cis-1,3,5-triaminocyclohexane (tach) were prepared for structural and biological activity study. Copper(II) complexes of N,N ',N″-trialkylated derivatives of tach [Cu(tach-R3)Cl2] (R = Me, Et, Pr, furanyl, and thiophenyl) were prepared from CuCl2 in MeOH or MeOH/Et2O solvent. The structures of [Cu(tach-R3)Cl2] in the solid and solution (aqueous and methanolic) states were extensively studied by UV-vis and EPR spectroscopies and were consistent to X-ray structure of [Cu(tach-Et 3)Br0.8Cl1.2] which reveals a slightly distorted square-based pyramidal geometry. Displacement of halide ions with water molecules in aqueous media was observed by the band …

The Role Of Opsonin-Independent Bacterial Adherence In The Pathogenesis Of Legionnaires' Disease, Frank Clinton Gibson

Doctoral Dissertations

Legionella pneumophila is a facultative intracellular bacterial pathogen which initiates infection of the human host by adhering to macrophages in the alveoli of the lung following which internalization and intracellular multiplication occurs. In this study a novel mechanism of opsonin-independent attachment for this organism to host cells was identified. L. pneumophila serogroup 1, strain Nottingham N7, and U-937 cells as well as primary guinea pig alveolar macrophages were used to study this adherence phenomenon.

A variety of assay methods were used to evaluate the nature of this binding event: transmission electron microscopy and scanning electron microscopy were used to visualize …

Genetic Variability And Population Structure Of Eastern White Pine In A Two Hectare Stand, Durham, New Hampshire, Petr R. Brym

Doctoral Dissertations

The genetic structure of a two hectare stand of eastern white pine (Pinus strobus L.) was studied by relating foliar allozyme composition of individual trees to tree location and age. Using starch gel electrophoresis, the trees were found to have variants for six of the seven enzymes analyzed. Trees of similar age and with common allozymes were found in clusters, suggesting that genetic structure existed in the stand. The genetic structure may have originated during establishment of several seedlings from common parents when openings were created in the canopy. Knowing that a genetic structure, such as that observed in this …

Studies On The Parasites Of Smooth Flounder Liopsetta Putnami (Gill) In The Great Bay Estuary, New Hampshire, Peter R. Burn

Doctoral Dissertations

No abstract provided.

Neurotrophic Effects In Vitro On Vertebrate Skeletal Muscle Maintenance And Amphibian Limb Regeneration, Robert Leo Carlone

Doctoral Dissertations

No abstract provided.

Metal Resistance In Alcaligenes Marinus By Production Of Extracellular Binding Agents, James Beaven Rake

Doctoral Dissertations

No abstract provided.

A Monographic Study Of The New England Coryphellidae (Gastropoda: Opisthobranchia), Alan Mitchell Kuzirian

Doctoral Dissertations

No abstract provided.

An Ecological Study Of Fucus Spiralis Linnaeus, Richard Albert Niemeck

Doctoral Dissertations

No abstract provided.

A Study Of The Arctic Wedge Clams, Mesodesma Deauratum (Turton) And Mesodesma Arctatum (Conrad) Of The Northwestern Atlantic, John Dunning Davis

Doctoral Dissertations

No abstract provided.