Digital Commons Network^™

Riluzole As A Dual-Targeted Radiosensitizer For Osteosarcoma: Targeting Tumor Cells And Angiogenic Vasculature To Enhance Single High-Dose Radiotherapy Efficacy, Pooja P. Rao

Dissertations, Theses, and Capstone Projects

Osteosarcoma (OS), the most common primary bone malignancy of children and young adults, is intrinsically radioresistant, and outcomes for patients with unresectable or metastatic disease have not improved in over four decades. Single-dose radiation therapy (SDRT) is a potent modality against radioresistant, highly vascularized sarcomas, but its application in OS is constrained by dose-dependent normal tissue toxicity. Radiosensitizers achieving tumor control at lower doses therefore offer a direct route to widening the therapeutic window. Critically, OS radioresistance is not tumor-cell-autonomous. It emerges from two coordinated compartments: aberrant DNA repair and antioxidant capacity intrinsic to the tumor cell, and a radioprotective, …

Mesoscopic Scaling Of Microwave Transmittance And Disorder-Induced Alignment, Israel Kurtz

Dissertations, Theses, and Capstone Projects

This thesis presents microwave measurements and numerical simulations of wave propagation and transmission through random mesoscopic waveguides. We analyze the scaling of mesoscopic microwave conductance, including departures from Ohm’s law near channel openings, which are frequencies at which new propagating modes enter the system, and the evolution of modal phase alignment within the medium, which leads to the observed diversity of transmission eigenvalues. We extend the transmission matrix formalism to all sample depths using the flux matrix, which relates the flux amplitude within the sample to the incident flux, and decompose the flux at each sample depth into forward- and …

Self-Organized Criticality In Biased Activated Random Walk, Joshua Meisel

Dissertations, Theses, and Capstone Projects

We demonstrate many of the conjectured universality and self-organized criticality (SOC) properties of the interacting particle system Activated Random Walk (ARW) in the setting of one-dimensional biased walks, as formulated for instance in Levine and Silvestri’s 2024 survey. Namely, there exists the same limiting critical state for two finite ARW models, as well as for the infinite model as the density approaches its critical value from below. Many of the desired properties hold, including heavy-tailed avalanches, but spatial correlations decay exponentially fast, a deviation from the SOC paradigm. Nonetheless, the obtained decay rate vanishes with the bias. Since the critical …

The Impact Of Gun Control Policies On Firearm-Related Deaths: A Two Decade State-By-Year Analysis, Rabana Tajrin

Dissertations, Theses, and Capstone Projects

This report analyzed firearm-related deaths rates in the United States at the state level over a two decade period between 2000 to 2019. The study used a state-by-year analytical framework created from the U.S. Gun Deaths by County, 1999–2019 dataset (Eltom, 2019) in order to examine national trends, state-level differences, changes over time, geographic concentration, and regional variation. The analysis focused on firearm-related deaths by adjusting for population size differences (i.e., the crude firearm-related death rate) across U.S. states from 2000 to 2019. These analyses indicated that firearm-related deaths increased nationally during the study period. Total firearm-related deaths rose from …

Cognitive-Affective And Somatic Depressive Symptom Domains Related To Psychological Mechanisms And Sociodemographic Factors, Danielle B. Hazeltine

Dissertations, Theses, and Capstone Projects

Major depressive disorder is prevalent, chronic, and heterogeneous, including cognitive- affective (e.g., maladaptive beliefs or thinking patterns and sad mood) and somatic (e.g., fatigue, appetite, or sleep changes) symptom domains. While depression domains have been long theorized, research examining psychological mechanisms underlying this distinction is limited. Preliminary research suggests cognitive-affective symptoms relate more strongly to cognitive mechanisms (cognitive bias, perseverative thought), somatic symptoms relate more strongly to behavioral mechanisms (behavioral inhibition/activation), and gender, race, and ethnicity moderate these relationships. This study examined whether cognitive-affective and somatic symptom domains differentially relate to cognitive and behavioral mechanisms, and whether these relationships are …

Authoritarianism, Hostility And Threat: An Analysis Of American Political Podcasts Surrounding The 2024 Presidential Election, Noah D. Cohen

Dissertations, Theses, and Capstone Projects

Political rhetoric surrounding key events has seen sharp increases in emotionally affective speech, intergroup sentiment, and rhetoric unbecoming of democratic societies in recent years. Similarly, semi-democratic and ideologically driven speech has become increasingly normalized within an era of political polarization and hardline beliefs in modern media. Within this economy of outrage, sensational and largely unmoderated media formats, particularly podcasts, have become a mainstay of political information and discourse. This raises an important question: how does rhetoric surrounding political events construct intergroup sentiment and authoritarian rhetoric within political media, particularly American political podcasts? Further, given political podcasts’ growing social influence in …

The Cranial Nerves And Electrical Stimulation, Devin K. P. Adair

Dissertations, Theses, and Capstone Projects

Cranial nerves provide afferent pathways that enable bottom-up modulation of central autonomic and cognitive neural pathways. Because these pathways project to brainstem nuclei such as the nucleus tractus solitarius and engage neuromodulatory systems, including the locus coeruleus, electrical stimulation offers a mechanistically grounded approach to influencing brain function. This thesis tested whether active transcutaneous auricular vagus nerve stimulation (taVNS) produces physiological responses indicative of parasympathetic engagement, defined as decreases in heart rate, increases in heart rate variability, and decreases in respiration relative to a dose-matched earlobe control condition. Using cardiac and respiratory measures as physiological markers, taVNS at the tragus …

The Role Of External Factors In Shaping Carbohydrate Conformational Landscapes, Murat Yaman

Dissertations, Theses, and Capstone Projects

Carbohydrates (glycans) are among the most structurally diverse biomolecules and participate in a wide range of biological processes, including molecular recognition, cell adhesion, immune response, host-pathogen interactions, and cellular signaling. Their biological functions are governed by a complex interplay between sequence, stereochemistry, conformational flexibility, and environmental factors. However, the structural heterogeneity and dynamic nature of glycans present significant challenges for both experimental characterization and theoretical modeling. In particular, the relationships between glycan structure, conformational dynamics, and the resulting potential energy surfaces remain incomplete.

This dissertation investigates how external factors modulate the potential energy surfaces of carbohydrates through a combination of …

The Role Of Temperament In Criminal Trajectories: Development, Stability, And Predictive Power Across The Life Course, Joshua A. Lang

Dissertations, Theses, and Capstone Projects

Temperament, an individual's largely innate tendency to experience and regulate responses to their environment, has long been studied but was only recently introduced as a primary predictor of criminal behavior (DeLisi & Vaughn, 2014). While prior criminological theories have incorporated temperament-related constructs, such as negative affect (Agnew, 1992; Moffitt, 1993) and self-control (Gottfredson & Hirschi, 1990), no other theory has explicitly positioned temperament as the central factor in offending. DeLisi and Vaughn’s temperament-based theory of antisocial behavior posits that individuals with low effortful control and high negative emotionality—features of a difficult temperament—are more likely to engage in criminal behavior. Despite …

‘A Sense Of The Sea’: Grassroots Culture, Care, And Endurance In Swansea, Cymru, Katy Clark

Dissertations, Theses, and Capstone Projects

This thesis argues that under present conditions, everyday political-aesthetic life is not only about resistance or reproduction but about holding: the work of keeping people, practices, and attachment present and oriented as conditions change. Holding takes the form of care and maintenance; as practices of making, assembling, and imagining; and as the work that keeps open the possibility of renewed attachment to public things and to each other. In the field, this was named as ‘a sense of the sea’, an affective register characterized by wariness, attunement, attentiveness, orientation, and endurance. I am calling this a fragile infrastructure of …

New York City Women’S Experiences With Perinatal Depression Inquiries, Diagnosis, And Treatment Initiation, Caterina Pisciotta

Dissertations, Theses, and Capstone Projects

Perinatal depression represents a significant public health concern, yet many women who experience depression symptoms during the perinatal period (either during pregnancy and/or after birth) do not receive treatment. Initiatives, such as ThriveNYC, were designed to address these gaps by screening and treating perinatal women for maternal depression, integrating screening into routine perinatal care and strengthening pathways to treatment. Using representative survey data collected between 2016 and 2021 via the Center for Disease Control and Prevention’s Pregnancy Risk Assessment Monitoring System (PRAMS), this study examined trends in perinatal depression inquiries (a proxy for “screening”) and postpartum diagnosis, as well as …

Towards Identifying Fear And Safety Network States Across Sex, Rhonda Kolaric

Dissertations, Theses, and Capstone Projects

Post-traumatic stress disorder (PTSD) is a trauma- and stressor-related disorder with a lifetime prevalence of 5-6% in men, and 10-12% in women (National Center for PTSD). Generalized anxiety disorder (GAD) is a highly prevalent anxiety- and depression-related psychiatric disorder with a lifetime prevalence of 1-2% in men, and 3-4% in women (National Institutes of Health). Both of these disorders disproportionately affect women. A hallmark feature of both disorders is the maladaptive generalization of fear, in which defensive responses extend beyond the original traumatic or threatening stimulus to neutral or unrelated cues. This overgeneralization can become debilitating, disrupting cognitive, emotional, and …

Ultrafast Spectroscopy Of Organic Materials In Strong Light–Matter Interaction And Terahertz Optics, Kamyar Rashidi

Dissertations, Theses, and Capstone Projects

Ultrafast spectroscopy is a powerful tool for investigating phenomena that occur on extremely short timescales and for probing ultrabroadband spectral responses enabled by its ultrashort laser pulses. These capabilities are essential for advancing both the fundamental understanding of light–matter interactions and the development of next-generation optoelectronic technologies. The first part of this thesis investigates the ultrafast dynamics of organic exciton–polaritons and their application to controlling molecular excited-state processes using momentum-resolved pump–probe spectroscopy. A major challenge in these systems is the dark-state problem, where photoexcitation predominantly populates long-lived excitonic reservoir states that obscure the in trinsic dynamics of the hybrid light–matter …

Parenthood And Re-Appraisal Of Childhood Maltreatment, Gayathri Cheran

Dissertations, Theses, and Capstone Projects

Background: Child maltreatment is associated with poorer physical and mental health outcomes across the lifespan.  Individuals’ appraisals of childhood maltreatment have important implications for these outcomes.  Appraisal is shaped by biological, psychological, and social-cultural factors, each of which undergoes change in parenthood.  Parenthood may prompt re-appraisal of childhood maltreatment in that being a parent evokes one’s experience of being parented.

Hypotheses: (1) Re-appraisal will be more likely in parents than non-parents.  In parents, re-appraisal will be more likely among: (2) primiparous parents, (3) parents with offspring of the same sex, and (4) parents who experienced maltreatment older in childhood (at …

Architects Of Mrna Fate: Molecular And Cellular Control Of P-Body Organization In The Drosophilia Melanogaster Female Germline, Samantha Milano

Dissertations, Theses, and Capstone Projects

Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein condensates that regulate mRNA storage, translational repression, and decay. While the biochemical principles governing condensate assembly have been extensively studied in vitro, how P-body organization is established and dynamically regulated in vivo to control specific mRNA populations remains poorly understood. This dissertation investigated the molecular and cellular mechanisms that govern P-body architecture and function in the Drosophila melanogaster female germline. First, I identified the conserved LSm protein Trailer Hitch (Tral) as a central organizer of P-body architecture. Using quantitative confocal and super-resolution microscopy combined with chemical perturbations, I showed that Tral coordinates the …

Symphonies That "Sing": Reevaluating Voices And Vocality In Mahler's Early Symphonies, Erin M. Johnston

Dissertations, Theses, and Capstone Projects

This dissertation considers the role of vocal music in Gustav Mahler’s early symphonies through the lens of the composer’s practice of self-borrowing. Mahler was known to use his own pre-existing songs as the basis for large-scale movements in his early symphonies. While scholars have long recognized the close relationship between Mahler’s songs and symphonies, existing studies have emphasized questions of biography, intertextuality, musical meaning, and quotation rather than sustained analytical investigations of vocal influence in Mahler’s large-scale symphonic forms. The present study places this vocality at the forefront of its analyses, arguing that Mahler’s reworking of his own Lieder is …

Opportunities For Learning Through Object Exploration During Early Physical Therapy: Physical Therapists’ And Caregivers’ Assistance And Interference Behaviors, Michele Goncalves Maia

Dissertations, Theses, and Capstone Projects

Early physical therapy (EPT) for infants with motor delays has traditionally emphasized motor milestone acquisition, yet growing evidence indicates that motor and cognitive development are fundamentally interconnected. Grounded in embodied cognition and developmental cascade theories, this dissertation conceptualized object exploration as a primary mechanism through which infants learn during EPT and examined how intervention approaches and adult behaviors shape opportunities for object exploration. Using retrospective analyses of video-recorded EPT sessions, two studies investigated how intervention approaches and adult behaviors influence infants' opportunities to learn through object exploration. Study 1 compared object exploration in the START-Play (SP) intervention and Usual Care …

Kitchen Table Press: A Case Study Of Regression To The Neoliberal Mean, Alaina Disalvo

Dissertations, Theses, and Capstone Projects

This thesis examines the idealistic founding of Kitchen Table: Women of Color Press in 1980 and its slow downfall, culminating in the cession of ownership of the Press to a university in 1992. It traces the ideological development of Kitchen Table Press’s key founders, Barbara Smith and Audre Lorde, and their respective relationships to the ideologies of other renowned feminist figures of the era, specifically June Jordan and Adrienne Rich. It examines the history of the Press through historical, intersectional, affective, and socialist lenses. This thesis argues that neoliberal pressures can bend even the most radical organizations away from their …

Managing Migration And Political Change: Lessons From Sweden’S 2015 Asylum Crisis For South Korea’S Emerging Immigration Era, Sean Lee

Dissertations, Theses, and Capstone Projects

The purpose of this capstone project is to analyze how two nations that have little in common in terms of geography or politics have been required to deal with immigration issues in ways that their institutions did not anticipate. One nation has been dealing with immigration-related issues for some time now, while the other nation has yet to do so. In 2015, when Sweden received approximately 162,000 asylum applications in one year alone, Sweden’s housing systems were strained, many of the municipalities were unable to keep up with the demand, and the political climate began to shift in ways that …

The Impact Of Multi-Brand Promotions On Visual Distinctiveness And Consumer Choice, Melanie Isabel Paul Austin

Dissertations, Theses, and Capstone Projects

In cluttered retail environments, marketers must often decide whether to showcase a brand alone in a single-brand promotion, or alongside other brands in a multi-brand promotion. Prior research has explored the role that different retail promotions play in consumers’ choice contexts. This research explores how multi-brand promotion versus single-brand promotions impact consumers’ purchase behavior. Study 1 uses secondary scanner data to show that multi-brand promotions lead to significantly higher sales of the promoted product compared to single-brand promotions. Study 2 replicates our secondary data findings in a quasi-field study with actual choice behavior. A series of lab studies again confirm …

An Inferential Analysis Of Lexical Networks, Christopher D. Gravelle

Dissertations, Theses, and Capstone Projects

Lexical networks are graphs where words are treated as nodes, and relations between words are treated as edges. The adoption of lexical networks in psycholinguistics is impeded by a lack of readily available inferential methods, which limits work to purely descriptive analyses with little ability to make inferences about what variables account for lexical network structure. The current research explores the use of latent space network models as a method for analyzing lexical networks. Latent space network models are latent variable regression models, which model the presence or strength of edges by estimating pairwise distances between nodes in a latent …

New Age Spirituality In Post-Secular Turkey: Navigating Secular Sensibilities And Class Privilege, Zeynep Ozbarlas

Dissertations, Theses, and Capstone Projects

The conflict between religion and secularism has been one of the major forces shaping Turkey’s socio-political landscape since the late nineteenth century. With the radical secular turn during the founding of the Turkish Republic, secularism remained the dominant force until the rise of political Islam in the 1980s. This dissertation, grounded in ethnographic fieldwork, argues that New Age spirituality, adopted by the secular upper-middle class, has become an alternative venue for the reproduction of secular sensibilities and socio-economic privilege in contemporary Turkey, at a time when the two-decade tenure of the Erdoğan regime has undermined secular hegemony.

Although New Age …

Goddess In A Trash Can: Religious Ritual Disposal In New York City Public Parks, Zoe Oro-Hahn

Dissertations, Theses, and Capstone Projects

Practitioners of Afro-Caribbean religions, including Santería, Vodou, Espiritismo, and Las 21 Divisiones, utilize the New York City Public Parks system to hold rituals, connect with spirits and ancestors, and dispose of religious remains leftover from trabajos (workings) and brujería (witchcraft). Utilizing photos from Van Cortlandt Park in the Bronx, my thesis considers the religious, political, social, and practical rationale behind this phenomenon, explores the rituals occurring, and provides policy suggestions that balance religious needs of practitioners with the safety and wellbeing of New York City’s parks.

Assessing The Influence Of Disability Views On Perceptions Of Hearing Aids Among Older Korean Adults, Stasha Lee

Dissertations, Theses, and Capstone Projects

Background

Age-related hearing loss, also known as presbycusis, is highly prevalent among older adults, yet hearing aid adoption remains low, in part due to concerns about stigma and negative social perceptions. This study aimed to examine whether attitudes towards disabilities influence perceptions of individuals wearing hearing aids among older Korean adults. It also explored the potential effects of cultural identity and the age of the individual wearing the hearing aid on these perceptions.

Methods

Ten participants completed the Attitudes and Perspectives on Persons with Disabilities (APPD) questionnaire and rated 8 different images of individuals (one younger male and one older …

New York State Excelsior Scholarship Program: A Post-Implementation Analysis Of Student Success, Eligibility, And Indebtedness – An Intersectional Study Of Black And White Female Students, Marcus I. Richardson

Dissertations, Theses, and Capstone Projects

The New York State (NYS) Excelsior Scholarship Program, introduced in 2017, was designed as a “first-in-the-nation” tuition-free initiative intended to expand college affordability for undergraduate students attending public institutions in New York State. While the program aims to increase access to higher education, its eligibility requirements, particularly the expectation that students complete 30 credits annually through continuous full-time enrollment, may disadvantage students whose academic pathways diverge from traditional enrollment patterns. This study examined the relationship between structural, financial, and academic factors and students’ ability to retain Excelsior Scholarship eligibility at the City University of New York (CUNY). Using institutional data …

Revolutionary Petunias In The Hallways: Adultification, Identity, And Black Girls’ High School Experiences, Renee Niles

Dissertations, Theses, and Capstone Projects

This thesis examines how adultification, the racialized misperception of Black girls as more mature, responsible, and self-sufficient, shapes high school experiences and identity development. Using Constructivist Grounded Theory and Black feminist epistemology, the study draws on interviews with eight Black women to explore how these experiences are interpreted over time. The study conceptualizes adultification as a form of developmental governance, an ongoing structural process that regulates perception, behavior, and identity from adolescence into adulthood.

Radiotheranostics For Gynecological Pathologies, Joni Sebastiano

Dissertations, Theses, and Capstone Projects

Molecular imaging, specifically positron emission tomography (PET), is vital for detecting disease and understanding its biological makeup. The exploitation of radiolabeled antibodies for PET imaging has proven to be indispensable to the field of molecular imaging over the last several decades. The development of radioimmunoconjugates for use in immunoPET has not only allowed for the sensitive, specific, and high-resolution detection of disease, but has also enabled a deeper understanding of the disease biology, ultimately guiding more personalized therapeutic strategies. Most typically, this technology is harnessed for the diagnosis and treatment of cancer, however more recently, the field has explored the …

Technology Disruptions In Platform Ecosystems: Ai, Market Adaptation, And Digital Resignation, Eunah Cho

Dissertations, Theses, and Capstone Projects

This dissertation examines how technological disruptions reshape behavior, competition, and user response in platform ecosystems. Bringing together two studies of generative AI in digital labor market and one study of mandatory privacy disclosure in mobile app ecosystems, it argues that platform technologies do not affect participants uniformly. Instead, their effects are mediated by market structures, competitive dynamics, and platform dependence.

The first study shows that ChatGPT shifts workers’ human capital strategies by reducing investment in specialized depth while increasing skill diversity, revealing a move from exploitation toward exploration. Yet market rewards remain uneven, as workers who integrate AI with deep …

Music Appreciation In Cochlear Implant Users: A Questionnaire, Hanna Davidson

Dissertations, Theses, and Capstone Projects

Cochlear implants provide significant benefits for speech perception in individuals with severe to profound hearing loss; however, music perception and appreciation remain challenging due to limited spectral and temporal resolution. This study examined music appreciation in post lingually deafened adult cochlear implant users, focusing on changes in enjoyment, listening behaviors, and subjective experiences following implantation. Sixteen adults completed a 36-item questionnaire assessing pre- and post-implant music engagement, perceived sound quality, and emotional responses to music. Quantitative data were analyzed using descriptive statistics and inferential statistics, and qualitative responses were analyzed thematically.

Results indicated a moderate decline in music enjoyment following …

The Hope Dionysos (After Augustus): A Post-Actian Reading Of Dionysian Imagery, Jane Horman

Dissertations, Theses, and Capstone Projects

At the center of the Roman court at The Metropolitan Museum of Art in New York stands an almost seven-foot-tall statue of an androgynous looking figure, leaning on a smaller statue of a woman. This piece, formally known as Statue of Dionysos Leaning on a Female Figure, has been nicknamed the Hope Dionysos for both the archaic statue he is leaning on, as well as the family to whose collection he belonged for many years. However, in its day, the statue occupied a complicated place in Roman culture. This paper will examine the ways in which Dionysos, specifically through …