Digital Commons Network^™

Pointing The Zinc Finger On Protein Folding: Energetic Investigation Into The Role Of The Metal-Ion In The Metal-Induced Protein Folding Of Zinc Finger Motifs, Inna Bakman-Sanchez

Dissertations, Theses, and Capstone Projects

Interactions between inorganic metal-ion cofactors and organic protein scaffolds are important for the proper structure and function of metalloproteins. Zinc finger proteins (ZFPs) are an example of proteins with such crucial metal-protein interactions. Incorporation of the Zn(II)-ion into ZFPs allows for their correct folding into structures that can carry out vital biological functions which include gene expression and tumor suppression. In addition, engineered ZFPs have shown to be promising genetic therapeutics in the clinic. And yet, there is still a gap in a quantitative understanding of the energetic contribution of the metal-protein interactions towards the structure and function of these …

Structural And Functional Brain Markers Of Trauma-Related Symptoms, Glenn Blessington

Dissertations, Theses, and Capstone Projects

The neurocircuitry model of posttraumatic stress disorder suggests an association between trauma-related symptoms and abnormalities in the structure and function of limbic and prefrontal brain regions. Evidence also suggests that these structural and functional abnormalities are related. We tested the relation between whole brain white matter integrity, resting-state functional connectivity of a fronto-limbic network, and trauma-related symptoms in 22 trauma-exposed women. We hypothesized that components of whole brain white matter would correlate with components of resting connectivity within a fronto-limbic network. We used parallel independent component analysis (pICA) to test the associations between whole brain fractional anisotropy (FA) maps and …

Emotion In Mind, Kathryn E. Pendoley

Dissertations, Theses, and Capstone Projects

Emotions consume our thoughts and drive our actions. If you had different emotions, or no emotions at all, the way you move in the world and understand your place in it would be completely different. We need a satisfactory theory of emotion for a complete science of the mind. In this dissertation, I consider two of the most compelling theories of emotion: broad perceptualism – the view that emotions either are themselves perceptual or include a perceptual aspect as at least a part – and constructionism – the theory that emotions are self-interpretive thoughts. I find that perceptualist thinking fails …

360º Video And Language Documentation: Towards A Corpus Of Kanien'kéha (Mohawk), Joseph Pentangelo

Dissertations, Theses, and Capstone Projects

Robust documentation is a major goal of documentary linguistics. Recognizing spoken language as a multimodal phenomenon, researchers working in this field broadly agree that video is an improvement over audio-only recording. At the same time, video is limited by the format’s frame, which permits only a relatively small portion of the visual field to be recorded at any given time. This results in much data being lost, as the documenter must decide where to aim their camera, necessarily leaving out more than they record.

In this dissertation, I apply 360º video to language documentation for the first time. 360º video, …

The Emergence Of Ecosystems-Based Fisheries Management From The Groundfish Crisis In New England: An Actor-Network Theory Analysis, Catherine King

Dissertations, Theses, and Capstone Projects

This research investigates the emergence of ecosystems-based fisheries management (EBFM) for New England's marine fisheries in the context of the "crisis" that is escalating in its groundfish fishery. Close observations of the practices of fisheries scientists in coordination with managers at the New England Fisheries Management Council, with focus on how knowledge is being produced and employed, allows for understanding EBFM as an emergent construction produced by networks of associations between actants, human and non-human, material and semiotic, and not strictly as a policy prescription informed by experts on biology, ecology, and socio-economics. This analysis identifies and elucidates the multiplicity …

Being And Becoming: Voice And The Performance Of Self By Black And Brown Women Members Of An Educational Space Organized In Whiteness, Anamaria Correa

Dissertations, Theses, and Capstone Projects

This dissertation joins the voices of experiences of Black and Brown individuals in elite white spaces of independent schools. As a qualitative research project this study utilizes narrative, I Poems, and art-ifacts to create an ecology of experiences illustrating the past and the resiliency of the present. This research disrupts status quo narratives of lauded diversity efforts of excellent private school education and is a call to action for accountability in anti-racist owning up and restructuring of independent school spaces, leadership, governance and cultural practices. Undergirded by Critical Race Feminist Theory as the theoretical framework this dissertation presents the intersectional, …

Machine Learning Applications For Drug Repurposing, Hansaim Lim

Dissertations, Theses, and Capstone Projects

The cost of bringing a drug to market is astounding and the failure rate is intimidating. Drug discovery has been of limited success under the conventional reductionist model of one-drug-one-gene-one-disease paradigm, where a single disease-associated gene is identified and a molecular binder to the specific target is subsequently designed. Under the simplistic paradigm of drug discovery, a drug molecule is assumed to interact only with the intended on-target. However, small molecular drugs often interact with multiple targets, and those off-target interactions are not considered under the conventional paradigm. As a result, drug-induced side effects and adverse reactions are often neglected …

Exploring Psychological Mechanisms Underlying Plea Bargain Decisions, Melanie Close

Dissertations, Theses, and Capstone Projects

According to an economic model of plea bargaining, defendants’ plea decisions are based on their estimated trial prospects (i.e. likelihood of conviction and severity of sentence). However, information communicated during interrogations may provide defendants with misinformation about trial prospects, thus biasing their subsequent plea decisions. Furthermore, the model fails to address why innocent individuals plead guilty less often than guilty individuals even when trial prospects are identical. I investigated whether Reid-style interrogation techniques increase the likelihood of a guilty plea by inflating suspects’ estimates of the severity of the outcomes should they go to trial. I also examined whether anxiety …

Thoughts Of Becoming: Negotiating Modernity And Identity In Bangladesh, Humayun Kabir

Dissertations, Theses, and Capstone Projects

This dissertation constructs a history and conducts an analysis of Bangladeshi political thought with the aim to better understand the thought-world and political subjectivities in Bangladesh. The dissertation argues that political thought in Bangladesh has been profoundly structured by colonial and other encounters with modernity and by concerns about constructing a national identity. Negotiations between the incomplete and continuous projects of modernization and identity formation have produced certain anxieties about becoming that permeates political consciousness and ideas in the country. Though such anxieties of becoming are also shared by other postcolonial countries, the specific, though not necessarily exclusive, character of …

Eating The Heart Of Weetigo World: Decolonial Imaginaries In The Stories Of Louise Erdrich And Tomson Highway, Rebecca Lynne Fullan

Dissertations, Theses, and Capstone Projects

My dissertation asks what the decolonial possibilities of fiction are in the context of the settler colonial imaginaries particular to the United States and Canada. The ongoing process of settler colonialism demands various forms of conversion from Indigenous people: ecological/land based, religious, educational, legal, familial, but the construct of “conversion” obscures Indigenous worldviews, and indeed worlds, which function according to different principles. I interpret Erdrich and Highway's work in the context of Anishinaabe and Cree narratives and story-structures. These offer examples of what can constitute broader decolonial imaginaries, through which perception and creation of other, more liveable worlds is possible. …

Stalking And Attachment Theory: Causes And Management, Zoe Turner

Dissertations, Theses, and Capstone Projects

Stalking is an issue that has drawn increasing attention over the past four decades. Approximately 6 million Americans report being the victims of stalking each year. The psychological and physical effects of stalking can be severe, ranging from anxiety and depression to physical harm and even death. With the rise of technology and social media, cyberstalking has become an additional problem in recent years. It is vital to understand the root causes of stalking behavior from a psychological perspective in order to create appropriate management and treatment plans. The current research investigates the role of attachment theory in stalking. Within …

A Data Exploration Of Jeopardy! From 1984 To The Present, Brian S. Hamilton

Dissertations, Theses, and Capstone Projects

The gameshow Jeopardy! has been around in its current iteration—hosted by Alex Trebek—since 1984. During this time, it has accumulated data on clues, contestants, and possible strategies on how to win. Using a crowd-sourced archive called J! Archive, this project seeks to find trends in the topics that the game covers and take a deeper look into the performance of its contestants. It employs topic modeling, a text-analysis method, to organize the hundreds of thousands of archived clues and statistical analysis to rate the performance of contestants by gender. Using web-based visualization tools, the data is shown in an …

Beast-Gods, Bandits, And Beggar-Kings: The Traveler In Political Thought, Nader Sadre

Dissertations, Theses, and Capstone Projects

In this dissertation, I use texts by Plato, Locke, Homer, and Gandhi to explore the political dimension of travel. I argue that travel is a proxy for practices and conditions that exceed “normal” politics. In this capacity, travel reveals what normal politics is, or is assumed to be. Travel marks a boundary of the political realm in a double sense: it may conceal or point to a pre-political source of authority; and it may provide an intimation of new political modes and orders. My analyses suggest that there is no single or consistent relationship between travel and politics. Rather, the …

Does The Word "Chien" Bark? Representation Learning In Neural Machine Translation Encoders, Emily Campbell

Dissertations, Theses, and Capstone Projects

This thesis presents experiments with using representation learning to explore how neural networks learn. Neural networks which take text as input create internal representations of the text during their training. Recent work has found that these representations can be used to perform other downstream linguistic tasks, such as part-of-speech (POS) tagging. This demonstrates that the neural networks are learning linguistic information and storing this information in the representations. We focus on the representations created by neural machine translation (NMT) models and whether they can be used in POS tagging. We train 5 NMT models including an auto-encoder. We extract the …

Role Of Influence In Complex Networks, Nur Dean

Dissertations, Theses, and Capstone Projects

Game theory is a wide ranging research area; that has attracted researchers from various fields. Scientists have been using game theory to understand the evolution of cooperation in complex networks. However, there is limited research that considers the structure and connectivity patterns in networks, which create heterogeneity among nodes. For example, due to the complex ways most networks are formed, it is common to have some highly “social” nodes, while others are highly isolated. This heterogeneity is measured through metrics referred to as “centrality” of nodes. Thus, the more “social” nodes tend to also have higher centrality.

In this thesis, …

Tidal Wetland Inundation And Vegetation Phenology From Space: A Synthesis Of Approaches For Characterizing Ecological Status And Inundation Dynamics In Tidal Wetlands With Remote Sensing Observations, Brian T. Lamb

Dissertations, Theses, and Capstone Projects

This dissertation focuses on the monitoring and characterization of tidal marshes using remote sensing-based approaches. Chapter 1 introduces the topics of wetland ecology and remote sensing. Chapters 2-4 are the main research chapters of the dissertation covering the topics of tidal marsh mapping, tidal marsh vegetation characterization, and assessment of tidal marsh inundation patterns. Chapter 5 summarizes the preceding chapters and highlights future research directions.

The primary research objective of Chapter 2 is the mapping and study of tidal marshes of the Chesapeake and Delaware Bays. This chapter also features a thematic focus on the evaluation of various forms of …

“An Instrument In The Shape / Of A Woman”: Reading As Re-Vision In Adrienne Rich, William J. Camponovo

Dissertations, Theses, and Capstone Projects

This single-author-oriented dissertation on the work of Adrienne Rich looks at her extensive body of work both in poetry, and in prose. This project considers how Rich re-visited and re-read her work over the course of her career, often making new discoveries and observations in quasi-autobiographical prose. This dissertation interrogates the ways in which these framing efforts may be in tension with both academic and journalistic narratives of her career arc. In looking at Rich’s own writing that, at times, attempts to re-contextualizes her work, even for herself, this project aims to chart out an oeuvre that functions as a …

Understanding Gender Differences In Traditional And Cyberbullying: An Evaluation Of Construct Validity Of The 2013 School Crime Supplement To The National Crime Victimization Survey, Anthony Betancourt

Dissertations, Theses, and Capstone Projects

Few measures assess cyberbullying and traditional bullying simultaneously while also reporting standards of reliability and validity. As a result, it remains unclear whether cyberbullying should be considered a separate type of bullying. This dissertation advances the literature by examining data from the 2013 School Crime Supplement to the National Crime Victimization Survey (NCVS-SCS) to provide psychometric information about the factor structure of the 2013 NCVS-SCS traditional and cyberbullying scales. Furthermore, the dissertation uses that information to evaluate if cyberbullying emerges as a unique factor. Finally, measurement invariance will determine if bullying holds the same meaning for boys and girls (e.g. …

The Medium Of Liberation: Kurdish Language And Education Activism In Turkey, Demet Arpacik

Dissertations, Theses, and Capstone Projects

This ethnographic study examines the Kurdish language and education activism, which I argue, is an anti-colonial movement generating decolonial forms of practices as responses. Prohibited to be spoken even in private spaces until 1991 in Turkey, the Kurdish language has been an intense object of struggle between the Turkish state and the Kurdish population. What historical, political, and sociocultural forces have contributed to colonial language governmentality in Turkey against the Kurdish language and its speakers? How do Kurdish activists challenge the linguistic hegemony in their semi-formal spaces and in what ways are their practices, discourses and policies decolonial? My study …

A Defense And Expansion Of The Theory Of Capitalist Ground Rent: Speculation, Securitization, And Struggles Over Land And Housing, Francesca Manning

Dissertations, Theses, and Capstone Projects

Why are the rents so high? Who is responsible for homelessness, for urban and rural displacement? How can these problems be combatted?

Recent literature addressing these questions has pointed to gentrification and the financialization of land and housing, faulted financialized landlords, hedge funds, and the irredeemable logic of finance, and pointed to the importance of land and housing regulation to prevent displacement.

However, theories of displacement—in both land and housing, on both urban and rural terrain—suffer from a lack of an underlying theory of the logic, tendencies, and limits of ground rent extraction in capitalism.

This dissertation develops a theory …

Understanding Atmospheres Across The Stellar-Substellar Boundary, Eileen C. Gonzales

Dissertations, Theses, and Capstone Projects

Complexities in the atmospheres of sources that straddle the boundary between low-mass stars and planets drive the spectral features we observe and the fundamental parameters that we derive. In an effort to understand the underlying cause of these spectral features, this work examines low-mass stars and brown dwarfs using two approaches: distance-calibrated spectral energy distributions (SEDs) and atmospheric retrievals. SEDs allow for the determination of semi-empirical fundamental parameters, while atmospheric retrievals allow us to derive the atmospheric structure and composition, as well as extrapolated fundamental parameters for a source. Low-metallicity and high surface gravity sources, known as subdwarfs, are the …

Analysis Of Newspaper Coverage Of Psilocybin From January 1, 1989 To December 31, 2019, Dax Oliver

Dissertations, Theses, and Capstone Projects

Psilocybin is a chemical compound that has received a lot of attention from medical researchers in recent years. However, this research is not merely a medical issue but a social and political one as well. In the 1960s, psilocybin and other psychedelic compounds were widely ingested outside of clinical settings. This alarmed some of the American public, resulting in severe legal restrictions on psilocybin use and research.

Today, many psilocybin advocates hope that it will avoid the negative public sentiment of the 1960s. To help gauge public sentiment about other psychoactive compounds, some studies have examined newspaper coverage, but there …

Northwest Coast Native Art Beyond Revival, 1962–1992, Christopher T. Green

Dissertations, Theses, and Capstone Projects

Histories of “primitivism” in the avant-garde show that Euro-American modernism was always engaged in the appropriation of nonwestern and Indigenous art, with particular interest in Northwest Coast Native art forms by the Surrealists, Abstract Expressionists, and Indian Space Painters. However, there has been little consideration for how Northwest Coast Native artists chose to engage with the styles and tenets of Western modern art. To date, the history of post-war Northwest Coast Native art has been dominated by what is known as the Renaissance, a narrative in which artists pursued a neo-traditional style in modern times through the recovered and revival …

Black Parental Involvement In A Suburban School District, Walter L. Fields

Dissertations, Theses, and Capstone Projects

Since the historic decision of the United States Supreme Court in Brown v. Board of Education in 1954, Black parents in the United States have been in a continual search for public school districts in which their children would receive an education that would allow them to be productive citizens and economically self-sufficient. From the period of the Great Migration to present day, the movement of Blacks in America has been driven by a quest for opportunity. Black parents have made tremendous sacrifices in the hope of securing a good education for their children, including movement away from families, longtime …

Korngold’S Compositional Style: A Comparison Of His Violin Concerto And The Film Scores Of Another Dawn, Anthony Adverse, And The Prince And The Pauper, Ji In Yang

Dissertations, Theses, and Capstone Projects

This dissertation explores the origins of Erich Wolfgang Korngold’s Violin Concerto (1945) and the derivation of much of the principal thematic material from three related film scores: Another Dawn, Anthony Adverse, and The Prince and the Pauper. (Unfortunately, the film score of Juarez, which is also related to the concerto, was not publicly available, so it is not mentioned in this dissertation.) Korngold was a child prodigy trained in Vienna from an early age, and he had a very successful career in Europe. He then accepted an offer from Warner Brothers around 1934 to work in the Hollywood film …

Investigating The Neural Mechanisms Of Unconscious And Illusory Touch Perception, Lua Koenig

Dissertations, Theses, and Capstone Projects

Despite our everyday reliance on touch, from manipulating tools to dressing ourselves, relatively little is known about the neural correlates of tactile perception. As with other modalities, our conscious, reportable experiences of touch can dissociate from the physical tactile stimulation processed by the skin. In unconscious touch perception, tactile stimuli can be processed and guide our behavior without an accompanying conscious percept. For example, we may swat away a mosquito without having consciously registered its presence on our skin. In tactile illusions, conscious tactile experiences occur without a corresponding tactile stimulus. Multisensory tactile illusions arise when stimulation of a different …

Epistemic Injustice And Sexual Violence Intervention Advocacy, Jennifer Ware

Dissertations, Theses, and Capstone Projects

In this project, I will explore how victims of sexual violence have faced epistemic injustices by reviewing the histories of two advocacy movements aimed at improving collective understanding of those experiences. In doing so, I will consider how those very activist movements may have introduced new epistemic lacunas and, even while successfully addressing some injustices, committed further epistemic wrongs as well. I will explore forms of hermeneutical resistance used by victims of sexual violence and their advocates. While these methods of resistance have been discussed elsewhere, I contribute to this ongoing work by applying these ideas to new examples. Finally, …

The Syntax And Semantics Of Korean Wh-Quantification: Wh-Npis And Wh-In-Situ, Yeonju Lee-Sikka

Dissertations, Theses, and Capstone Projects

This dissertation investigates the syntactic and semantic aspects of long-distance dependency involved in Korean wh-Negative Polarity Items (NPIs). Korean wh-NPIs consist of a wh-item and a focus particle -to meaning `also' or `even'. In all reported cases, the wh-item and -to appear adjacent to each other. However, the wh-item and -to can appear discontinuously when the NPI licenser is located in a different clause from the wh-NPI. I will call this new form of wh-NPIs "split wh-NPIs". The central claims of this dissertation are the following. The first, long-distance dependency displayed in split wh-NPIs is attained via overt movement of …

Processing Coercion In A First, Non-Dominant Language: Mandarin-English Heritage Bilinguals, Christina N. Dadurian

Dissertations, Theses, and Capstone Projects

Recent work in heritage language grammars has shown variability in L1 competence, despite high proficiency in both languages. While sources of variation have been debated, little attention has been given to the role of language dominance. This thesis uses a self-paced listening task to explicitly investigate the roles of language dominance and pragmatic competence in how heritage speakers of Mandarin Chinese process aspectual coercion in their non-dominant home language, as compared to late bilinguals. Specifically, constructions that vary in acceptability and salience in input between Mandarin and English are tested: Iterative coercion, complement event coercion of entity NPs, and perfective …

#Fired: Survivor Reactions To Facebook Firing In Organizations, Rachel Omansky

Dissertations, Theses, and Capstone Projects

Facebook firing (i.e. employee termination due to social media activity) is a novel type of termination that has developed in recent decades. Though Facebook firing is becoming increasingly common, almost no research has been conducted on this practice. Using a multi-step, multi-method approach, this dissertation attempted to better define the construct and examine its implications for inciting negative reactions from surviving employees, or those employed with the terminated employee at the time of termination, who knew or knew of the employee but were uninvolved in the incident. Study 1 details an effort to identify Facebook firing’s characteristics through a case …