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Iron And Iodine-Mediated Reactions, Xiaochen Liu

Dissertations, Theses, and Capstone Projects

This thesis work focuses on developing facile, low-cost, and environmentally friendly reactions, specifically the iron and iodine-mediated reactions, including (1) iron-catalyzed reductive ring-opening of 3,5-disubstituted isoxazoles and isoxazolines in aged N-methyl-2-pyrrolidone (NMP*), (2) iodine-mediated C-N bond cross-coupling reactions between amides and aldehydes, and (3) ICl-mediated functionalization of β-alkoxy alkynes – synthesis of α-iodo-γ-chloro-ketones.

Chapter I provides a background introduction on previous synthesis and applications of β-enaminones and 1,3-diketones that play as synthons or ligands. Ring-openings of heterocycles, such as isoxazoles and isoxazolines have attracted great attentions. A newly developed iron-catalyzed reductive system was established upon our previous palladium-catalyzed research. …

Cross-Sectional Variation Of Stock Options Behavior, Meng Tian

Dissertations, Theses, and Capstone Projects

This dissertation consists of three chapters that examine the cross-sectional behaviors of option implied volatility skew and option risk premiums/returns as well as their term structures, using the structural factor model approach as well as the machine learning techniques.

Chapter 1: The introduction discusses the motivation of this dissertation, interlinks and the main findings of the three chapters.

Chapter 2: The slope of the option implied volatility plot against the strike reflects the risk-neutral skewness of the underlying security's conditional return distribution. We identify two principal risk sources that contribute to the cross-sectional variation of individual stock options' implied volatility …

The Rainforest Is Burning: Trials And Triumphs Working Towards Conservation In Rural Madagascar, Kathryn Alessi

Dissertations, Theses, and Capstone Projects

In late 2019, I spent almost four months in Ranomafana, Madagascar, a region in the southeast that houses tropical rainforest. The research I conducted is not analyzed in this capstone. Instead, I decided to write about my personal experience through a series of reflections that explore the difficulties I faced, as well as the moments of joy. Much of the information presented in this capstone and white paper come from my own experience and copious conversations I had with other people in Madagascar. Several of these conversations were recorded in my diary and fieldnotes, but most were recounted from my …

Contracting In Direct Asset Sales, Xin Yuan

Dissertations, Theses, and Capstone Projects

Using a unique, hand-collected dataset of direct asset sales agreements in the SEC filings, I provide the first large-sample evidence on how contracting mechanisms are used to mitigate information frictions in these important transactions. The conflict of interests is unique because the scarcity of asset-specific financial information makes target assets difficult to value and monitor, especially when such transactions are usually consummated in a short period. I first show an extensive use of representations and warranties, covenants, and special payment arrangements in these contracts when severe information asymmetry exists between buyers and sellers. Importantly, further results suggest that these contracting …

The Effect Of Anticipatory Anxiety On Fear Extinction Learning, Daniela C. Echeverria

Dissertations, Theses, and Capstone Projects

Adaptive regulation of fear is dependent on successful fear extinction learning; therefore, investigating factors that both enhance and diminish fear extinction learning is a critical line of research. In the present study, we induce mild anticipatory anxiety during fear extinction learning in an attempt to modulate how participants extinguish fear memory. In the experiment, we apply a classic three-day fear learning protocol to both control participants (N = 20) and an experimental group (N = 20) with fear acquisition, fear extinction, and fear recovery phases; each phase is separated by a period of 24 hours and we use a skin …

Hierarchical Hyperbolicity Of Graph Products And Graph Braid Groups, Daniel James Solomon Berlyne

Dissertations, Theses, and Capstone Projects

This thesis comprises three original contributions by the author concerning hierarchical hyperbolicity, a coarse geometric tool developed by Behrstock, Hagen, and Sisto to provide a common framework for studying aspects of non-positive curvature in a wide variety of groups and spaces.

We show that any graph product of finitely generated groups is hierarchically hyperbolic relative to its vertex groups. We apply this to answer two questions of Genevois about the electrification of a graph product of finite groups. We also answer two questions of Behrstock, Hagen, and Sisto: we show that the syllable metric on a graph product forms a …

Molecular Mechanisms Underlying Cell Fate Choice Within Specific Retinal Lineages, Estie Schick

Dissertations, Theses, and Capstone Projects

During development, retinal progenitor cells (RPCs) divide to form all of the cell types that make up the retina. Multipotent RPCs are competent to generate all retinal cell types, while restricted RPCs form specific lineages of cells. In particular, one genetically-defined RPC type preferentially gives rise to cone photoreceptors and horizontal cells. Many of the mechanisms that are responsible for directing cell fate choice within this lineage are unknown. This thesis largely focuses on examining the development of specific cell types and subtypes from restricted RPCs and on investigating the gene regulatory events that underlie cone photoreceptor and horizontal cell …

Strategic Default And Moral Hazard In Real Estate: Insights From Machine Learning Applications, Arka Prava Bandyopadhyay

Dissertations, Theses, and Capstone Projects

Strategic default has been the achilles heel in academic finance for decades. By definition, whether a default has occurred due to strategic motive is unobservable. Moreover, a household has only so many avenues of conducting a strategic default. I use the context of commercial mortgages as property value as well property cashflow co-determine the default decision of these borrowers. I tease out the different strategic aspects of default from the ones emanating from liquidity constraints. The recent advances in Deep Neural Network (DNN), the advent of big data and the computational power associated with it has enabled me to disentangle …

El Pueblo Unido: How Threats Increased Latinx Turnout In Arizona’S 2020 General Election, Conner Martinez

Dissertations, Theses, and Capstone Projects

Latinx voter turnout in the United States has persisted to remain below White, Black, and Asian Americans. In 2020, county level data shows Latinx turnout reached historic levels in Arizona’s 2020 general election (Pew Research 2020; Census 2020). But throughout the past two decades, Latinx’s in Arizona have faced some of the harshest anti-immigrant policies in the nation. Currently, the literature on Latinx mobilization shows mixed results on the impact of political threats on Latinx turnout (Jones-Correa et al. 2018). Through in depth interviews with Latinx organizational leaders who managed mass mobilization efforts in 2020, this paper explores the role …

Targeting Ampa Receptor Modulation During Early Life Adversity: A Mediator For Threat Associated Memories, Roseanna M. Zanca

Dissertations, Theses, and Capstone Projects

Early life adversity (ELA) is the exposure to a single or to multiple traumatic events before the age of 18 that go beyond the child’s coping. These adverse events are often exacerbated during adolescence particularly when cognitive performance is compromised. Adolescents who experienced ELA may show symptoms of post-traumatic stress disorder (PTSD), while not vividly recalling the early life trauma. These individuals show atypical connectivity between prefrontal-amygdala and hippocampus, all of which is associated with an increased risk of experiencing a traumatic event again later in life. While clinical research has increasingly stressed the importance in addressing the long-lasting consequences …

Toward The Black Indian Ocean: Race And The Human Project In The Afro-Asian Imagination, Micheal A. Rumore

Dissertations, Theses, and Capstone Projects

“Toward the Black Indian Ocean: Race and the Human Project in the Afro-Asian Imagination” asks the question: why hasn’t the Indian Ocean been typically theorized as an African diasporic site? While the burgeoning discipline of Indian Ocean studies frequently positions notions of oceanic “cosmopolitanism” as a way of engaging with universalist anticolonial aspirations, the field has been limited by static conceptions of the African continent. In response, this dissertation argues that the marginalization of Black Africans in conceptions of Indian Ocean cosmopolitanism reflects a colonial provenance and attempts to delineate this representational history. Theoretically, I engage with Black feminist critiques …

Examining The Effect Of Longstanding Deafness On Health Literacy: A Systematic Review, Sara S. Payami

Dissertations, Theses, and Capstone Projects

Objective: This systematic review aims to evaluate whether deafness has a significant effect on one’s health literacy skills, and, if there is a difference between health literacy of a normal hearing individual compared to that of a Deaf individual. Disparities in health literacy unique to the Deaf experience are identified.

Methods: A comprehensive search the utilizing various peer-reviewed databases was conducted via the City University of New York’s (CUNY) Graduate Center Library to identify relevant studies published after 2009. Inclusion criteria incorporated quantified studies which commented on the health literacy of d/Deaf communities in the U.S. published from 2009 to …

Computational Modeling Of Water And Proteins In Drug Discovery, Anthony Cruz Balberdy

Dissertations, Theses, and Capstone Projects

This thesis aims to improve how structural and thermodynamic properties of water on protein surfaces can be exploited to aid early stage drug discovery and lead optimization. We first discuss our development of SSTMap, a public domain software suite that maps out the properties of water on biomolecular surfaces. We then show the utility of these maps in describing differences in binding affinities between congeneric pairs of ligands. We then discuss our use of solvation maps in the prospective discovery of novel binders to cytochrome C peroxidase. Finally, we present our creation and validation of a homology model of Interleukin-24 …

A Lasting Impression: Higher Education’S Effects On Mass Polarization In The Us, Bradley Highfield

Dissertations, Theses, and Capstone Projects

Political polarization has been growing exponentially over the past few decades, not only with political elites and party activists, but also in the mass public. During the same period of time, the United States has also seen an exponential increase in higher education attainment. This paper examines the possible relationship higher education and elite political polarization may have in regards to the increasing polarization within the American electorate. Additionally, I aim to extrapolate how collegiate institutions create an increase in ideological polarization, as well as affective partisanship, while synthesizing Political Science studies on the effects of college education towards political …

The Integration Of Art, Architecture, And Identity: Alfred Kastner, Louis Kahn, And Ben Shahn At Jersey Homesteads, Daniel S. Palmer

Dissertations, Theses, and Capstone Projects

During the New Deal, the United States government created the Jersey Homesteads co-operative in order to help a group of Jewish immigrant garment workers from New York City during the economic downturn of the Great Depression. This dissertation examines how a 1930s utopian enclave utilized modernist art and architecture to express the radical back-to-the-land agrarian idealism and socialist ideology of its settlers. The flat-roofed, concrete buildings that housed these Jewish garment workers were designed by German architect Alfred Kastner (1900-1975), with his then unknown assistant Louis I. Kahn (1901-1974). These unornamented, functionalist buildings adapted avant-garde European architectural forms into an …

Very Two, Very One: Reading As Friendship, Amelia Marini

Dissertations, Theses, and Capstone Projects

“Very Two, Very One: Reading as Friendship” embarks upon what the American philosopher John Dewey might describe as an act of “cultivated naïveté” by asking the reader to imagine that one of the study of literature’s highest goods is the feeling of friendship that it can inspire between the studious reader and the multivalent text. This dissertation proposes that our readerly interactions with texts have many of the same interpersonal complexities and satisfactions of lived friendship, and the chapters that follow will offer a vocabulary for describing those complex interactions in ways that allow us to speak, write, and think …

Daily Benefits Of Leader Dogs In Addition To Medical Treatment For Individuals With Usher Syndrome: A Case Study, Samantha H. Zwolan

Dissertations, Theses, and Capstone Projects

Background: Adults with Usher syndrome seeking audiologic rehabilitation and treatment often experience everyday difficulties that are not fully resolved using typical medical treatments. This case study examines the difficulties faced by individuals diagnosed with Usher syndrome in their everyday life, including quality of life, safety, and social issues. Additionally, the non-medical benefits that leader dogs can provide such individuals is also presented.

Method: A thorough literature review was performed to provide background information regarding Usher syndrome and the impact it has on the hearing and vision of affected individuals. A related literature review was performed to examine the role …

Standing Trans Before The Law, Kyla Bender-Baird

Dissertations, Theses, and Capstone Projects

In the 1960s, trans people in the United States began asserting their rights, petitioning courts for name changes, updating sex markers on birth certificates and other identity documents, and confirming whether their marriages were legal. However, it was not until the mid-2000s that courts began recognizing trans discrimination claims. While trans people enjoyed numerous legal inroads under the Obama administration, within its first two years, the Trump administration had effectively reversed these legal gains. Being vulnerable to the political winds contributes to a feeling of legal precarity, which, in turn, shapes how trans people think about and approach the law. …

Developing Supramolecular Tripeptides With Sequence Tunable Visible Absorbance And Emission, Mona Tayarani Najjaran

Dissertations, Theses, and Capstone Projects

The structure and machinery of living systems are based on sequence-specific peptides that are composed of just 20 amino acids. The supramolecular assembly of peptides is a result of weak non-covalent forces among the amino acid residues that lead to diverse ordered structures and properties. Rational peptide design with sequence-specific combination of the 20 genes encoded amino acids is a promising new route for the production of materials with new functional properties. Aromatic residues have been shown an important role in self-assembly through increasing the aggregation possibility. They also have shown fluorescence properties in the ultraviolet range. In this thesis …

Everyone Is Watching: Mastering The Challenge Of Caring For Infants At The End Of Life While Being Constantly Observed, Deborah A. Lawrence

Dissertations, Theses, and Capstone Projects

Nurses with specialized training care for the approximately 7% of newly born infants who are admitted annually to neonatal intensive care units in the United States. Although they receive care at advanced levels, some infants will not survive. Nurses maintain a constant presence at the bedsides of these neonates to provide end of life care in units and institutions where the gold standard is cure and rescue. The purpose of this grounded theory research study was to understand how nurses managed the challenges and demands of caring for dying infants in the context of Level III neonatal intensive care units. …

Optimization Of Materials For Magnetic Refrigeration And Thermomagnetic Power Generation, Anthony N. Tantillo

Dissertations, Theses, and Capstone Projects

The magnetocaloric effect, by which a magnetic material experiences a change in temperature due to an applied magnetic field, can be used for refrigeration. The corollary to the magnetocaloric effect -- known as the pyromagnetic effect -- is the phenomenon by which a magnetic material experiences a thermally-induced change in magnetization that can be used to harvest thermal energy. This dissertation has two main parts: one focusing on novel materials for energy harvesting; and another focusing on methods of materials discovery for refrigeration purposes. Thermomagnetic power generation (TMG) is the process by which magnetic flux, which comes from a temperature-driven …

Microbial-Host Dynamics And The Evolution Of Nearshore Diversity In Hippocampus Abdominalis, Jimiane L. Ashe

Dissertations, Theses, and Capstone Projects

Local adaptation is a fundamental concept at the core of evolutionary process. Devising means to break down larger concepts and systematically test internal mechanisms are key to understanding the driving forces behind the influence of environmental differences on biological systems. To understand dynamic processes in the natural world, we must strip away layers and confounding variables that may mask the signal we hope to understand. In this case seahorse species, Hippocampus abdominalis, or the pot-bellied seahorse, made an unlikely but ideal study system. The first layer to strip away was neutral genetic variation within the population. A multilocus genetic …

Counterstories Of Black High School Students And Graduates Of Nyc Independent Schools: A Narrative Case Study, Kahdeidra M. Martin

Dissertations, Theses, and Capstone Projects

Public youth resistance movements in 2019 and 2020 exposed the entrenchment of racism, sexism, heteronormativity, and classism across New York City independent schools (NYCIS). In order to support the imminent need for schools to provide effective diversity, inclusion, and equity supports that address broad issues of school climate, relationships, and pedagogy, there is a need to better understand the specific, hyperlocal experiences of Black/African Descendant (BAD) students, who occupy several unique, unexplored spaces in educational research. The following four research questions helped to conceptualize the experiences that support and hinder the academic success and long term well-being of BAD students …

Photosensitization And Analytical Study On Reactive Oxygen Intermediates: Self-Sorting Surface Radicals And “On-Off” Sensitizer Function Mechanisms, Sarah J. Belh

Dissertations, Theses, and Capstone Projects

This thesis consists of four chapters which are detailed below. Chapter 1 is an introductory chapter, which lays out the background and purpose of the research.

Chapter 2 describes a study of the mobility of alkoxy radicals on a surface by detection of their recombination product. A novel method called symmetrical product recombination (SRP) utilizes an unsymmetrical peroxide that upon sensitized homolysis recombines to a symmetrical product [R'OOR → R'O•↑ + •OR → ROOR]. This allows for self-sorting of the radical to enhance the recombination path to a symmetrical product, which has been used to deduce surface migratory aptitude. SPR …

Neuroplasticity Of The Corticospinal System: Applications Of Neuromodulation-Based Therapies, Alzahraa M. Amer

Dissertations, Theses, and Capstone Projects

The motor cortex and corticospinal tract are necessary for producing skilled movements. I use intermittent theta burst stimulation (iTBS), a high-frequency stimulation protocol known to promote neural plasticity, as a tool to characterize short- and long-term plasticity of the CS system.

Although it is well known that activity-dependent motor cortex (MCX) plasticity produces long-term potentiation (LTP) of local cortical circuits, leading to enhanced motor evoked potentials (MEPs), the effects produced by the corticospinal (CS) projection on spinal cord neurons have not yet been thoroughly studied. In Chapter 2, I determined if the CS tract (CST) is capable of producing LTP …

Optimism Of The Intellect, Pessimism Of The Will? A Gramscian Analysis Of Two New York Police Reform Campaigns, Christian Covington

Dissertations, Theses, and Capstone Projects

This paper attempts to analyze two recent New York police reform campaigns - one to overturn the state’s system of criminal bail release, the other to make police officer discipline transparent to the public - using theories given by Antonio Gramsci. The paper will apply the concepts of hegemony, hegemonic discourse, the intertwining of the state and civil society, the attainment of political agency amongst the subaltern, and the role ideology plays in all of these concepts, to assess the success of the reform campaigns. The paper will argue that many of these concepts are further developments of political theories …

Object Expression: Diligent Realism In The Works Of Roland Barthes, Elena Ferrante, Karl Ove Knausgaard, Valeria Luiselli, And W. G. Sebald, John Knight

Dissertations, Theses, and Capstone Projects

In the past twenty years, ambiguous yet meaningful encounters with objects have become a trope in contemporary fiction. Collections and archives, found objects and commonplace articles of modern life have especially substantiated literature that engages themes of displacement and selfhood. The method of incorporating objects into these works ranges from explicit cabinets of curiosities to more subtle appearances, but in each case material reality is the conduit for fundamental expressions of character. These authors draw the reader’s gaze toward an object as a way to indirectly articulate subjective experience, conspicuously displacing the central concerns of a text. This study examines …

Indian Classical Music In The New York Metropolitan Area: The Development Of A Transnational Ecosystem, Andre Fludd

Dissertations, Theses, and Capstone Projects

This dissertation investigates the development of North and South Indian classical music communities in the New York metropolitan area from the mid-20^th century to the present. In this investigation, I primarily focus on local musicians from diverse backgrounds and communities rather than internationally recognized stars. In the instances where I discuss famous musicians such as Ravi Shankar and Zakir Hussain, I focus on how they impacted New York metropolitan area communities particularly and what their success can teach about international Indian classical music careers. The dissertation is organized chronologically, and I highlight vital people, non-profit organizations, historical moments, and …

Functional Connectivity Changes In The Default Mode Network In Moderate-To-Severe Traumatic Brain Injury, Emily J. Haight

Dissertations, Theses, and Capstone Projects

Traumatic brain injury (TBI) patients are known to have altered functional connectivity (FC), which has cognitive and behavioral significance and bears clinical implications. Previous literature has discovered a hyperconnectivity response to TBI, most notably in the default mode network (DMN). However, the exact pattern of changes in resting FC during the first year of recovery is unknown. We used resting-state functional magnetic resonance imaging to investigate longitudinal connectivity patterns in the DMN of 28 moderate-to-severe TBI patients as compared to 33 demographically matched healthy controls (HC). FC was assessed at 3, 6, and 12 months post-injury for patients using the …

The Role Of Placental Genes On Intellectual Disability And Developmental Delay, Maedot A. Yidenk

Dissertations, Theses, and Capstone Projects

The complex interaction between gene expressions and environmental factors plays a key role in the pathogenesis of various diseases, including neurodevelopmental disorders (Lenroot & Giedd, 2008). This study aimed to evaluate first, the magnitude of association between placental gene Methyl-CpG Binding Protein 2 (MeCP2) and intellectual disability (ID) in the offspring and second, the synergy between placental gene Forkhead box protein 1(FOXP1) and developmental delay (DD) in the offspring. We focused on assessing two specific paradigms, i) placental gene expressions of MeCP2 among children that have ID vs. children without ID; and ii) placental gene expression of …