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Sensitized Photooxidation Of Prenylated Compounds: Mechanisms Of Downstream Dark Effects And Phototoxicity Priming, Shakeela Jabeen

Dissertations, Theses, and Capstone Projects

This thesis consists of four chapters as detailed below.

Chapter 1 discusses a singlet oxygen priming mechanism. Airborne singlet oxygen derived from photosensitization of triplet dioxygen is shown to react with an alkene surfactant (8-methylnon-7-ene-1 sulfonate) leading to ‘ene’ hydroperoxides that in the dark inactivate planktonic E. coli. The ‘ene’ hydroperoxide photoproducts are not toxic on their own, but they become toxic after the bacteria are pretreated with singlet oxygen. The total quenching rate constant (k_T) of singlet oxygen of the alkene surfactant was measured to be 1.1 × 10⁶ M⁻¹ s^{− …}

Prenatal Choline Supplementation During Maternal Obesity Alters Offspring Response To Western Diets, Hunter W. Korsmo

Dissertations, Theses, and Capstone Projects

Maternal obesity has led to an increase in adverse offspring developmental outcomes and a greater risk for long-term metabolic diseases. Choline, a semi-essential nutrient, can be incorporated into phosphatidylcholine (PC) as well as sphingomyelin (SM) and donate its labile methyl group for the remethylation of homocysteine after choline is oxidized to betaine. Prenatal choline insufficiency has been related to maternal obesity and metabolic diseases, such as metabolic associated fatty liver disease (MAFLD). Choline may interact with maternal obesity to influence the programming offspring.

Chapter 1 presents an introduction of choline and the various clinical outcomes associated with choline supplementation during …

Nmr Study Of Materials For Energy Storage Devices, Nishani K. Jayakody

Dissertations, Theses, and Capstone Projects

Nowadays there is serious concern as to how much longer the world’s consumption of fossil fuels can continue as regards its effects on the environment. Renewable forms of energy are being looked at attentively. However, for a continuous use of intermittent sources, storage of energy is necessary. For this reason, batteries, fuel cells, and capacitors still objects of intense research with the aim of further improving their properties and features.

In this research work, Nuclear Magnetic Resonance (NMR) Spectroscopic techniques were used to study materials for use as electrolytes in rechargeable lithium-ion batteries and materials for use as dielectrics in …

"Cerulean Skies" By Maria Schneider: A Formal And Semiotic Analysis, Jonathan Heim

Dissertations, Theses, and Capstone Projects

Expressivity, imagery, and narrativity have long been touted as hallmarks of big band composer Maria Schneider’s style. This perception is widely accepted by critics and casual commentators, but are these attributions merely metaphorical or do they speak to observable dimensions of Schneider’s compositional style? This dissertation aims to address the narrative and expressive dimensions of Schneider’s music by combining aspects of formal analysis with concepts from music semiotics. The centerpiece is an analysis of “Cerulean Skies” (2006), the longest work to date in Schneider’s oeuvre with a duration of approximately twenty-two minutes. “Cerulean Skies” is distinct in its expansiveness and …

Pervasive Nonarbitrariness: Meaning From Form In Natural Language, David J. Neely

Dissertations, Theses, and Capstone Projects

It is generally assumed that the expressions of a natural language are largely arbitrary. That is, any expressions that display a nonarbitrary connection between what their utterances sound like and what they mean are small in number and of no real theoretical importance.

This thesis challenges such a position. I argue that nonarbitrariness is a pervasive feature of natural language and that understanding the sound/meaning connections that exist in language is necessary if to appreciate how languages work.

I begin, in Chapter 1, by showing that many theorists are committed to the idea that nonarbitrary sound/meaning connections are of little …

Humoring The Third Republic: Le Rire In French Politics And Popular Culture, 1894–1918, Andrew C. Kotick

Dissertations, Theses, and Capstone Projects

This dissertation studies the illustrated satirical periodical Le Rire in its historical context between its debut during the Dreyfus Affair and the conclusion of World War I. Adopting a multivalent approach to the historical study of graphic humor, it argues that Le Rire constitutes a significant corpus of evidence for understanding the political, commercial, social, and cultural novelties of its time, and maintained an ambivalent relationship with the young institutions and functionaries of the French Third Republic. As France’s leading satirical periodical, Le Rire served as a powerful medium for broadcasting nascent and extreme ideas to a mass reading public …

High Water-Responsiveness Of Peptidoglycan And Its Water-Responsive Mechanism, Haozhen Wang

Dissertations, Theses, and Capstone Projects

Water-responsive materials that reversibly deform in response to humidity changes show great potential for developing muscle-like actuators for miniature and biomimetic robotics. This thesis demonstrates that peptidoglycan exhibits ultrahigh water-responsive actuation energy and power densities, which are orders of magnitude higher than those of frequently used actuators, such as piezoelectric actuators and dielectric elastomers. Surprisingly, peptidoglycan exhibits an energy conversion efficiency of ~66.8%, which could be attributed to its super-viscous nanoconfined water that efficiently translates water’s movement to peptidoglycan’s mechanical deformation. The systematic water-responsive characterizations of peptidoglycan from different microorganisms and peptide crystals indicate that enhanced H-bonding interactions in water-responsive …

Essays On Inequality, Growth, And Economic Policy, Philipp E. Erfurth

Dissertations, Theses, and Capstone Projects

This dissertation consists of three chapters that study inequality and regional economics in a historical and development context.

The first chapter examines regional inequality among Habsburg regions from the 19th century to today’s EU by using Geographic Information Systems (GIS) software to recreate historical regions in present-day projections. The findings suggests that regional disparities are markedly higher today than in the 19th century, despite rapid convergence in the past two decades. The study thus provides evidence of retrospective determinism in the study of the Habsburg economy and suggests that, although regional EU policy has been successful over the past two …

Nmr Characterization Of Novel Materials For Battery Electrolyte Applications, Sahana Bhattacharyya

Dissertations, Theses, and Capstone Projects

The extensive application of renewable and non-renewable energy storage devices in commercial products and services and the global warming have created significant motivations to accelerate research in battery technology. In addition, the risk factors generated by the high heat generation and flammability of the batteries are being addressed by inventing new renewable or non-renewable energy resources that do not release greenhouse gases into the atmosphere. This thesis discusses the applications of Nuclear Magnetic Resonance (NMR) Spectroscopy in characterizing and understanding novel battery materials as potential battery electrolytes. Works discussed include: the variable temperature characterization of water-based solid polymer electrolyte for …

Teaching Siblings To Encourage And Praise Play: Supporting Interactions When One Sibling Has Autism, Holly R. Weisberg

Dissertations, Theses, and Capstone Projects

Sibling relationships may be strained when one sibling is typically developing (TD) and one has a diagnosis of autism spectrum disorder (ASD). TD siblings have been taught to encourage play in their siblings with ASD but there is limited literature examining the impact of intervention on the quality of the siblings’ relationships. In this study, we taught four TD siblings to encourage and praise play skills in their siblings with ASD as well as self-monitor those play skills. We measured changes in social-communicative behaviors during siblings’ interactions. All TD siblings learned the targeted play skills and increased social-communicative behaviors. Only …

Unsuk Chin’S Hyper-Sheng: Sonic And Structural Development In Šu For Sheng And Orchestra, Hyun-Kyung Lee

Dissertations, Theses, and Capstone Projects

The Korean composer Unsuk Chin (b. 1961) is constantly exploring new sonic experiences in her works; her concerto Šu for Sheng and Orchestra (2009) is drawing considerable attention, as it is Chin’s first piece written for an Asian instrument. This study begins with a simple inquiry How does Chin combine an Asian instrument (sheng) with the Western orchestra? To answer this question, this research examines Chin’s treatment of the sheng and the development of the orchestra in partnership with the solo instrument, focusing on the creation of what she terms a “hyper-sheng:” the solo sheng and the orchestra collaboratively producing …

The Bright And Dark Sides Of Upward Social Comparison: Knowledge Sharing And Knowledge Hiding Directed At High Performers, Soohyun (Ashley) Lee

Dissertations, Theses, and Capstone Projects

The present research investigated when and why employees might share or hide their work information from coworkers who perform better than themselves. Drawing from social comparison theory (Festinger, 1954) and social exchange theory (Blau, 1964), I predicted that upward social comparison would lead to both pleasant reactions (inspiration, perceived gain of work resources) and unpleasant reactions (envy, perceived loss of work resources), which in turn would differentially affect knowledge sharing/hiding behaviors targeting high-performing coworkers. I further predicted that individual differences in directing behaviors toward goals (goal orientation) and task structures requiring reliance on coworkers (task interdependence) would moderate the relationships …

Grammar Competition Explored In Two Case Studies: The Null Subject Stage In English-Speaking Children And The Variation Observed In Old English, Soumik Dey

Dissertations, Theses, and Capstone Projects

Grammar competition theory postulates that variation in a speaker is the result of different grammars competing against each other. This study performs an analysis of two case studies of empirical observations attributed to possible grammar competition — subject drop in English-speaking children and variation observed in Old English.

Children in an English-speaking environment drop subjects early on during acquisition. Orfitelli and Hyams (2012) find that young English-speaking children mistakenly interpret imperative null subject utterances as declaratives. They suggest that this misinterpretation can be attributed to performance factors, which leads to grammar competition and subsequently subject drop in English children. We …

Using Protonation Microstates And Hydrogen Bond Networks To Track Proton Transfer Pathways In Complex I, Umesh Khaniya

Dissertations, Theses, and Capstone Projects

Complex I, NADH-ubiquinone oxidoreductase, is the first enzyme in the mitochondrial and bacterial aerobic respiratory chain. It pumps four protons through four transiently open pathways from the high pH, negative, N- side of the membrane to the positive, P-side driven by the exergonic transfer of electrons from NADH to a quinone. Three protons transfer through subunits descended from Mrp antiporters, while the fourth, E-channel is unique. Because of the complex possible paths thorough the many buried polar residues and lack of high-resolution crystal structure, the path for protons through the E-channel is elusive.

In this dissertation, the E-channel proton pumping …

Essays On Federalism And Local Finance In China, Jiakai Zhang

Dissertations, Theses, and Capstone Projects

This dissertation consists of three chapters that cover topics on federalism and local finance in China.

Chapter 1 - Economic Growth, Fiscal Inequality and Fiscal Decentralization: Evidence from China.

This paper investigates the impact of inequality in the geographic distribution of fiscal resources on regional economic growth under fiscal decentralization policy in the context of China's experience, using panel data for 28 provinces over the period 1987–2010. In the recent past, the structure of decentralized government in China has undergone two significant fiscal reforms: the ``Fiscal Responsibility System" (FRS) in 1987-1993, and the ``Tax Sharing System" (TSS) in 1994. I …

"Secession's Moving Foundation": Fugitive Slave Rendition And The Politics Of American Slavery, Evan Turiano

Dissertations, Theses, and Capstone Projects

This dissertation examines the political conflict over fugitive slave rendition from the era of the American Revolution through the passage of the 1850 Fugitive Slave Law. It pays particular attention to the struggle over the legal rights due to African Americans accused of being fugitive slaves. Slaveholders claimed an absolute property right over accused fugitive slaves and argued that any recognition of legal remedies for accused runaways threatened that right. Free African Americans and their allies in the abolitionist movement asserted that Black people accused of having escaped slavery were due a legal process. This was a vital protection against …

The Moral Economy Of Ordinary Belarussians And A Critical Examination And Re-Evaluation Of The 2020 Post-Electoral Uprising, Geoffrey Blank

Dissertations, Theses, and Capstone Projects

This study is three studies in one: First, a qualitative study of the moral economy of ordinary Belarussians based on E.P Thompson’s class-based economic conception of moral economy, as applied to complex socio-economic systems by Reinarman (1987). Second, a critical and broad examination and re-evaluation of the August 9, 2020 post-electoral uprising. And third, an examination of both the West’s hostility toward Belarus’ largely state-owned socially-oriented economic model (often considered market socialism) and toward President Lukashenka, and, of the West’s commitment to overthrowing President Lukashenka and Belarus’ largely state-owned socially-oriented economic model, through its sponsorship of color revolution, “democratization,” regime …

Analog Matters: Labels, Cassettes, And Alternative Economies In Argentina’S Independent Music Scenes, Maria Agustina Checa

Dissertations, Theses, and Capstone Projects

This dissertation is a multi-sited ethnographic study of current cassette production and circulation in Argentina. It analyzes the work of independent labels that record music available online onto cassette tapes, incorporating a variety of music styles. I examine practices of production, circulation, and exchange, and the alternative economies performed around cassettes, with particular attention to the materialities constituting these processes. Through cassettes, I conceptualize and trace "relational value," a notion to understand objects with different kinds of social agencies valued for their abilities to generate connections. Relational value is a theoretical construct that emerges from the ground-up approach to studying …

Role Of The G Protein Beta Gamma Subunits In Serotonin Transporter Dynamics, Nora Awadallah

Dissertations, Theses, and Capstone Projects

Serotonin is a vital neurotransmitter and hormone with significant roles in almost every organ system. In the central nervous system, serotonin mediates physiological functions that in turn guide behavior and mood. Here, serotonin is released from serotonergic neurons and exerts its effects through serotonin receptors. Regulation of serotonin neurotransmission is important for the maintenance of its physiological functions; thus, extracellular serotonin must be sequestered to limit the intensity and duration of serotonin transmission. Disproportionate transmission is strongly linked with neurological and psychiatric ailments.

Extracellular serotonin levels are primarily mediated by the serotonin transporter (SERT), a critically important plasma membrane protein …

An Interdisciplinary Approach To The Epistemic Value Of Moral Ambiguity, Jordan Wylie

Dissertations, Theses, and Capstone Projects

Morality is a critical aspect of life––it influences how we think, design political and legal systems, who we connect with, our norms, and the types of stories we tell. Yet, even with the well documented influence of morality on many aspects of life, exactly what makes moral themes so fascinating remains elusive. This dissertation aims to introduce Moral Worldbuilding as a theory for understanding our epistemic drives toward morally ambiguous and morally bad content.

In Chapter I, we introduce the problem of moral badness, which is not well handled by extant moral literature. To combat this, we offer a new …

Biochemical And Biophysical Characterization Of Replicative Helicase Loading By Vibrio Cholerae Dcia, Crystal Structure Of A Monoclonal Antibody Bound To A C-Terminal Fragment Of Ebna-1 From Epstein Barr Virus, Nicholas Gao

Dissertations, Theses, and Capstone Projects

DNA replication initiation is mediated by the binding of an initiator protein to genomic origins of replication to begin the process of loading replicative helicases onto the genome. The loading of the helicase requires the action of an accessory protein, named a “loader”. Studies on well-characterized loaders have outlined how the bacterial DnaB replicative helicase is loaded via mechanisms of “Ring-Breaking” by E. coli DnaC (EcDnaC)/protein P from bacteriophage lambda (LP) and “Ring-Making” by B. subtilis DnaI. Mounting evidence points to a recently discovered candidate loader, named DciA, that shows a more widespread distribution throughout bacteria than DnaC and DnaI …

A Labor Of Livingness: Oral Histories Of Formerly Incarcerated Black Women, Robin Mcginty

Dissertations, Theses, and Capstone Projects

Anchored in the political subjectivity of formerly incarcerated Black women, “A Labor of Livingness: Oral Histories of Formerly Incarcerated Black Women” is a project situated at the intersections of Black geographies and Black Feminist thought that considers a re/imagination of the ‘living prison’ experiences of formerly incarcerated Black women. I offer the term “a labor of livingness” as the liberatory articulation and everyday practices of resistance to the prison as a site of ‘living death’ that is reflective of the carceral experiences of currently and formerly incarcerated Black women. Attentive to the prison as a repository of epistemological knowledge production, …

Control Of Nonlinear Properties Of Van Der Waals Materials, Rezlind Bushati

Dissertations, Theses, and Capstone Projects

Van der Waals materials are a broad class of materials that exhibit unique optoelectronic properties. They provide a rich playground for which they can be integrated into current on-chip devices due to their nanometer-scale size, and be utilized for studying fundamental physics. Strong coupling of emitters to microcavities provides many opportunities for new exotic physics through the formation of hybrid quasi-particles exciton-polaritons. This thesis
focuses on exploring and enhancing nonlinearity of van der Waals materials through strongly coupling to microcavities. By taking advantage of the stacking order of TMDs, we show intense second-harmonic generation from bulk, centrosymmetric TMD systems. In …

Effects Of Telesimulation On The Health Literacy Knowledge, Confidence And Application Of Nursing Students, Susan Patton

Dissertations, Theses, and Capstone Projects

Background: Assessing and addressing health literacy (HL) in patients is an essential role of the nurse and a critical component of nursing student education. Yet, large gaps exist within nursing school curricula with regard to the development of HL knowledge and skills, and the confidence to implement practices that target HL. Furthermore, effective training modalities that examine the transformation of nursing students’ knowledge into practice through the development of confidence during experiential learning have not been well explored.

Purpose: Evaluate the effectiveness of a HL information and a HL telesimulation intervention on the HL Knowledge, Application and Confidence of first-semester …

Del Ornitorrinco A La Radio Ambulante: La Nueva Crónica Latinoamericana En La Era Neoliberal, Ulises Gonzales

Dissertations, Theses, and Capstone Projects

This dissertation explores the presence of neoliberal hegemonic imaginaries in narrative journalism written in Latin America between 1995 and 2021.

There are strong connections between a period of decline in the readership of some of the authors of the so-called “Latin American Boom,” the penetration of neoliberal economic policies in the region (with the privatization of State companies and the expansion of the telecommunications industry), and the renewed interest in non-fiction writing published by a number of print publications in the region during the last decade of the 20th Century and the beginning of the 21st Century, as in magazines …

Clustered Protocadherins Ubiquitination And Phosphorylation Regulates Surface Expression, Albert Ptashnik

Dissertations, Theses, and Capstone Projects

Clustered protocadherins (Pcdhs) are a family of 60 adhesion-like molecules forming a neural barcode. In vertebrate neurons, 60 Pcdhs are coded by a large gene cluster. Numerous axons in the cluster are coding for the different extracellular, transmembrane, variable portion of the cytoplasmic and constant cytoplasmic domains where their expression is controlled epigenetically. These proteins mediate interactions between axons, dendrites, and glial cells during neural development. Yet, Pcdhs are not strictly adhesion molecules. In the amacrine cells of the retina, Pcdhs promote avoidance of the same cell dendrites, where in the cortex Pcdhs promote interactions between dendrites and astrocytes. In …

Gospels Of (Anti)Inequality: The Politics Of Biblical Interpretation In The New Poor People’S Campaign And Capitol Ministries, Jonathan Peter Tschudy

Dissertations, Theses, and Capstone Projects

This dissertation explores the role of biblical interpretation in the politics of inequality in the United States. Building on scholarship in American Political Development that identifies ideas as integral to institution building, I analyze the interplay between biblical interpretations, organizational structures, and political strategies within two contemporary religio-political groups: the New Poor People’s Campaign (NPPC) and Capitol Ministries (CM). Methodologically, I combine in-depth, interpretative readings of primary source documents with an historical institutional analysis of the secondary literature on the role of religion in American politics. I argue that the two organizations’ elite leaders – Reverends William Barber II and …

Katharine Bement Davis: Defying Expectations As A Woman And In The Study Of Women, Ella Hester

Dissertations, Theses, and Capstone Projects

Katharine Bement Davis’ (1860-1935) life and career as a highly educated scientist and Progressive activist placed her at the forefront of various moral panic debates at the turn of the twentieth century. Davis was born into a staunch abolitionist and suffragist family in upstate New York in 1860. Her family’s politics were grounded in progressive Protestant principles which allowed her to gain access to higher education as a white woman from a middle-class family. Her education left her poised to use the latest scientific research to shape Progressive dogma in the 1910s and 1920s. Davis’ education and the groundbreaking research …

Anomalous Self-Experiences And Aberrant Salience In Schizotypy, Victoria Martin

Dissertations, Theses, and Capstone Projects

Within this investigation, the self-disorder hypothesis of schizophrenia was assessed via an illusory perceptual paradigm. It has been proposed that alteration of basic (minimal) selfhood may underlie cognitive and perceptual disturbances in psychosis (Sass, 2014). Disturbed corporeality (i.e., anomalous experience of one’s body) is an identified component of basic self-disturbance. As it is difficult to empirically capture the spontaneous occurrence of anomalous bodily experiences as they arise, the Pinocchio Illusion (PI) has been employed to capture variations in the plasticity of bodily self-experience (specifically, body boundary plasticity) (Michael & Park, 2016). The PI paradigm provides for the sensations of arm …

Workforce Diversity And Health Equity: The Role Of Schools Of Public Health, Adashima Oyo

Dissertations, Theses, and Capstone Projects

The goal to eliminate health disparities and achieve health equity has remained a consistent public health and social welfare challenge for the United States. Schools of public health, despite being disproportionately White, are charged with the important task of training a diverse workforce of master and doctoral-level public health students to protect and promote the overall health of the nation with research, policy, and practice. Experiences and practices related to the recruitment, admission, enrollment, and graduation of students of color, specifically Blacks and Latinx, warrant further research. Positive deviance theory, critical race theory, and organizational culture theory informed this research. …