Digital Commons Network^™

Targeting Hif/Coregulator Complexes In Cancer: Characterizing Fragile Fold And Inhibitor Binding Sites Of Arnt, Xingjian Xu

Dissertations, Theses, and Capstone Projects

Hypoxia-inducible factors (HIFs) are transcription factors that play crucial roles in regulating adaptive cellular responses to low oxygen concentrations (hypoxia). Structurally, HIFs are heterodimers composed of one of three α-subunits (HIF-1α, -2α, and -3α) and a β subunit (HIF-β, also known as ARNT), with the heterodimerization mediated by the tandem PAS domains (PAS-A and PAS-B) found within both proteins. Dysregulation of the HIF pathway has been implicated in various types of cancers, contributing to cancer cell survival, tumor growth and progression, and resistance to therapies, resulting in poor treatment outcomes. As such, HIF-specific inhibitors have been extensively investigated as novel …

Design, Synthesis, And Kinetic Study Of The First Generation Phenyloxadiazole Compounds And The Second Generation Phenyloxadiazole Compounds And Highly Selective Hydroboration Of Alkenes, Ketones And Aldehydes Catalyzed By A Well-Defined Manganese Complex, Haisu Zeng

Dissertations, Theses, and Capstone Projects

This thesis focuses on two projects. In the first project, my goal was to discover a new variant of phenyloxadiazole compounds that could exhibit increased thiol-reactivity during bioconjugation processes. To achieve this, I synthesized several phenyloxadiazole derivatives and subjected them to NMR kinetic studies to assess their reactivity with a model thiol. Based on the results, I was able to identify a phenyloxadiazole analog that demonstrated enhanced reactivity, which included a chlorine atom located in the meta-position of the phenyl ring.

I provided a detailed description of the synthesis and characterization of the newly discovered phenyloxadiazole analog and demonstrate its …

Teaching Beyond ‘Kings Leopold’S Ghost’: New Sources And Voices In A Global History Curriculum On The Democratic Republic, Jen Chapin

Dissertations, Theses, and Capstone Projects

The complicated history of the Democratic Republic of Congo is not typically part of high school curricula, yet events and historical trends concerning this nation connect with many key topics and themes, including feudalism, Haitian Revolution, New Imperialism, genocide, World War I & 2, Decolonization movements, Cold War politics, neo-colonialism/globalization, modern China’s economic power, authoritarianism, cult of personality, grassroots democracy movements, responses to climate change, etc. Designing and delivering a rigorous yet accessible curriculum on Congo poses a challenge for teaching beyond “King Leopold’s Ghost”, meaning, working past the prevalence of materials focusing on Belgian king’s genocidal two-decade rule over …

Changing Homelands: The Election Of Menachem Begin And The Diplomatic Campaign To Bring Ethiopian Jews To Israel, Abraham Silberstein

Dissertations, Theses, and Capstone Projects

This thesis examines diplomatic efforts by Israel, the United States, and non-governmental organizations to facilitate the immigration of Ethiopian Jews to Israel. While much of the historical literature on this topic has focused on the 1980s and 1990s, when tens of thousands of Ethiopian Jews were airlifted to Israel, this thesis largely considers the mid-late 1970s. For the first 25 years of its existence, the State of Israel had not been eager to see Ethiopian Jews enter the country, and the government deemed them non-Jews for the purposes of immigration. This started to change in 1973, when the Sephardi Chief …

Extinction Of Threat Memory Via Reconsolidation Interference: A Behavioral Intervention Meta-Analysis, Chris M. Andrae

Dissertations, Theses, and Capstone Projects

Threat memories are created when an aversive stimulus is paired with other stimuli such that the associated stimuli elicit the same reaction as the unpleasant one. Anxiety disorders are usually treated with exposure to aversive stimuli. Emotional memories can be altered through a process called reconsolidation interference. Consolidated memories are dynamic: reminders of previous experiences prompt the reactivation of a previously-encoded memory; destabilization of the memory opens it to update. While a memory is updating, it is labile. If extinction training occurs during reconsolidation (i.e., shortly after reactivation), the conditioned stimulus will no longer elicit the conditioned response. Thus, previously-encoded …

Examining The Effect Of Talker Familiarity Using Familiar And Unfamiliar Talkers On Noise-Vocoded Speech Perception In Normal-Hearing Listeners: A Training Study, Daria N. Collins

Dissertations, Theses, and Capstone Projects

Auditory training studies utilizing stimuli that are applicable to real-world processing of speech have been shown to improve speech perception abilities in normal hearing populations, those with hearing loss, and cochlear implant wearers. In particular, exposing normal hearing adults to noise-vocoded speech via auditory training studies has been shown to not only simulate the perceptual experience of a cochlear implant wearer, but have demonstrated promising improvements on speech perceptual abilities via the training paradigm. Additionally, studies have highlighted various variables that impact speech perception, including, talker familiarity. Talker familiarity has been shown to enhance speech perception both in listeners with …

Examining The Effect Of Training Using Natural And Noise-Vocoded Sentences On Noise-Vocoded Speech Perception In Normal-Hearing Listeners, Alexis Leiderman

Dissertations, Theses, and Capstone Projects

Auditory training has been shown to be an intervention strategy that may improve speech perception abilities in individuals with and without hearing loss. Within the cohort of individuals with hearing loss, auditory training has also been shown to have an improvement on speech perception in cochlear implant users. In several training studies, normal-hearing listeners have been exposed to noise-vocoded speech using auditory training paradigms to mimic how cochlear implant users may in turn be affected by these paradigms. These studies have highlighted certain areas for improvement in speech perception abilities based off of the training paradigms put in place. Several …

Germanic Latin Lyric Diction: Regional Variations In Germany, Switzerland, And Austria, James A. Worley

Dissertations, Theses, and Capstone Projects

In this dissertation, I discuss the various regional Latin lyric diction practices in Germany, Switzerland, and Austria and the extent to which Germanic Latin diction (also termed German Latin diction), Italianate Latin diction, and Roman Latin diction are performed beginning circa 1950 until 2022. I argue that Germanic Latin lyric diction is not standardized throughout Germany, Switzerland, and Austria. First, I explore Roman and Italianate lyric diction practices compared across various sources in order to distinguish between Latin pronunciation choices, then I discuss trends in Germanic Latin lyric diction “rules.” Extensive tables in appendices A (Roman Latin) and B (Germanic …

Writing As Liberation: Challenging Yemeni Patriarchal Practices, Sheema Alamari

Dissertations, Theses, and Capstone Projects

Patriarchal societies create an environment where men hold power and women are often treated as second-class citizens or are often held as having an inferior status. Throughout history and across cultures, literature has provided a platform for writers to share their stories and express themselves. However, Yemeni women have often been silenced and marginalized due to limited education and censorship. In recent times, Yemeni and Yemeni-American women have turned to storytelling as a means of creative expression and emotional release. This thesis analyzes Zubaida “Jasmine” Sharif’s memoir, Caged in America: One Woman’s Journey Through the Veil, and Nadia Al-Kowkabani's …

Does Political Advertising Persuade? A Quantitative Assessment Of The Effects Of Campaign Contact In The Context Of Race, Ethnicity, And Immigrant Origin In New York City Council Primary Elections From 2001 Through 2017, Laura M. Tamman

Dissertations, Theses, and Capstone Projects

Through a quantitative analysis of the relationship between New York city council campaigns’ spending and election results between 2001 and 2017, controlling for key factors such as incumbency, I find substantial and statistically significant positive effects for radio advertising on election outcomes. I find small but significant effects for mail, and smaller sized effects for canvassing. My findings underscore the need for further study of the role of ethnic and community media outlets, such as radio, in shaping voter behavior. Moreover, I argue that the fixation of the current persuasion literature on television ads in presidential general elections misses critical …

Understanding The Afghan Diaspora: Exploring The Factors Driving Migration And The Impact Of Migration Policies On Recent Afghan Evacuees Resettling In The United States, Aya H. Mohamed

Dissertations, Theses, and Capstone Projects

Afghanistan has been at war with the West since the late 1900’s, remaining in a state of constant turmoil. During the Cold War (1979), Afghanistan had fought a war with the Soviet Union, known as the Soviet- Afghan War. During this time, Afghanistan was invaded by both the Soviet and US, creating a ground for terrorism and the rise of the Taliban in Afghanistan. In order to then eradicate the terrorist regime, the Taliban, the United States went to war with Afghanistan in 2001. The Taliban were suppressed by U.S. forces until August 2021, during which President Biden executed a …

English Learners In Nyc, Raquel Neris

Dissertations, Theses, and Capstone Projects

English Learners in NYC is a Digital Humanities project that intersects Migration Studies and Foreign Language Learning Studies by presenting a podcast series about the learning experience of international students in English as a Second Language (ESL) programs at English schools in New York City. The project aims to provide visibility to the educational migration in this specific context and to promote a discussion on how international students and educators can reimagine their teaching and learning experience. It also aims to reveal ESL schools' challenges during the COVID-19 pandemic and how they incorporated digital technologies during and after this event. …

Reimagining The Inner Ear: A Morphometric Modeling Approach For Establishing Shape Change In The Evolution Of The Human Otolith System, Christopher M. Smith

Dissertations, Theses, and Capstone Projects

Our sense of balance is among the most central of our sensory systems, particularly in the evolution of human positional behavior. The peripheral vestibular system of the inner ear comprises the organs responsible for this sense; the semicircular canals (detecting angular acceleration) and otolith organs (utricle and saccule; detecting linear acceleration, vibration, and head tilt relative to gravity). The vestibular organs are often considered a single system, with most research focusing on the semicircular canals. The otolith organs, by comparison, remain largely unexplored despite their central role in balance. Consequently, this lack of knowledge limits understanding of vestibular functional morphology …

Permanent Shelter In The Empire City: Youth Experiencing Family Homelessness And Navigating The Homeless Industrial Complex With A Narrative Inquiry Approach, Henry O. Love

Dissertations, Theses, and Capstone Projects

Many studies have examined unaccompanied youth experiencing homelessness; however, a relative silence persists about the lives of youth and young adults (YYA) while in family homeless shelters. This study aims to fill the gap in the literature about the lives of youth residing in family shelters and to learn about successful transitions from adolescence to young adulthood while experiencing family homelessness. This transition interacts with various social collectives (family, peers, community), political institutions (municipal, state, and federal), and an overwhelming economic system (global racial capitalism). These complex perspectives are considered with a narrative activity-meaning system research design to understand the …

Topics For He But Not For She: Quantifying And Classifying Gender Bias In The Media, Tyler J. Lanni

Dissertations, Theses, and Capstone Projects

In this study, we used computational techniques to analyze the language used in news articles to describe female and male politicians. Our corpus included 370 subtexts for male candidates and 374 subtexts for female candidates, gathered through the New York Times API. We conducted two experiments: an LDA topic analysis to explore the data, and a logistic regression to classify the subtexts as either male or female. Our analysis revealed some noteworthy findings that suggest the possibility of developing a gender bias classifier in the future. However, to create a more robust understanding of bias, additional research and data are …

Association Strength Between Concepts As The Origin Of The "Foreign Language Effect", Emilia Ezrina

Dissertations, Theses, and Capstone Projects

Bilinguals sometimes make decisions in verbal tasks differently in their first (L1) and second (L2) language. This phenomenon is known as the foreign language effect (FLE), and it suggests strong connections between language and cognition. On the one hand, it is possible that L2 “blunts” emotional language. However, the FLE can be observed in non-emotional tasks. Therefore, it is possible that L2 requires more deliberate processing due to increased cognitive load, leading to more rational decisions. The support for each explanation is mixed.

In this thesis we propose looking for a single explanation for all instances of the FLE. After …

How Do Authoritarian Regimes Win Re-Election During An Economic Recession?, Mst Sarmin Akter Mazumder

Dissertations, Theses, and Capstone Projects

Democracies around the world continue to decline at the hands of democratic leaders elected by majority vote in free and fair elections. Turkey, one of the oldest democracies in the Middle East has experienced democratic breakdown under the leadership of Recep Tayyip Erdoğan. Similarly, Venezuela was one of the longest-running and most established liberal democracies in the Latin American region. Hugo Chávez and his successor Nicolás Maduro have turned the country into one of the most authoritarian regimes in the world. Turkey has been experiencing a prolonged economic decline for nearly a decade. Venezuela’s economy has suffered due to the …

Diggin’ In The Racial Literacy And Culturally Responsive And Sustaining Crates, Jordan Bell

Dissertations, Theses, and Capstone Projects

Racial Literacy first became scholarship in 2004 with Lani Guinier and France Winddance Twine’s racial literacy works. Likewise, Culturally Responsive and Sustaining Education’s seminal work is associated with Gloria Ladson-Billings’ (1995) introduction of culturally relevant pedagogy. While racial literacy and culturally responsive and sustaining education scholarship appeared around the late 20th and early 21st centuries, these frameworks were being developed in Black educational spaces since their inception in the United States. These frameworks were created in response to rampant antiblackness throughout various periods of United States history. In recognition of pre-21st century Black educators’ contributions to racial literacy and culturally …

Neural Network Vs. Rule-Based G2p: A Hybrid Approach To Stress Prediction And Related Vowel Reduction In Bulgarian, Maria Karamihaylova

Dissertations, Theses, and Capstone Projects

An effective grapheme-to-phoneme (G2P) conversion system is a critical element of speech synthesis. Rule-based systems were an early method for G2P conversion. In recent years, machine learning tools have been shown to outperform rule-based approaches in G2P tasks. We investigate neural network sequence-to-sequence modeling for the prediction of syllable stress and resulting vowel reductions in the Bulgarian language. We then develop a hybrid G2P approach which combines manually written grapheme-to-phoneme mapping rules with neural network-enabled syllable stress predictions by inserting stress markers in the predicted stress position of the transcription produced by the rule-based finite-state transducer. Finally, we apply vowel …

Immigration Status As A Social Determinant Of Health: Provider Perspectives, Elisabeth Brodbeck

Dissertations, Theses, and Capstone Projects

This project examines how immigration is understood as a social determinant of health through the perspective of medical providers and social workers. Through the bridging of immigration studies in sociology and social epidemiology and public health, I demonstrate the need to bring these disciplines together to understand how immigration and legal status are encountered in clinical settings. I conducted a qualitative research study, specifically open-ended interviews with medical providers and social workers, to understand how providers currently screen for complex social determinants of health, and more specifically, how they engage with immigration as a factor influencing health during their patient …

Structural Anomaly Detection, Shoufu Luo

Dissertations, Theses, and Capstone Projects

As computer systems become more complex and powerful, the threat of sophisticated and persistent computer attacks increases dramatically. Traditional intrusion detection systems that rely on log analysis struggle to keep pace with these evolving threats, as the attacking trails are often buried in high-volume and high-velocity legitimate activities in the system. Despite tremendous progress in applying machine learning techniques to anomaly-based intrusion detection, such methods continue to suffer from a high false positive rate due to the diversity and variability of individual behavior.To address this problem, this thesis proposes a new framework for detecting structural anomalies in computer systems. The …

Evaluating Neural Networks As Cognitive Models For Learning Quasi-Regularities In Language, Xiaomeng Ma

Dissertations, Theses, and Capstone Projects

Many aspects of language can be categorized as quasi-regular: the relationship between the inputs and outputs is systematic but allows many exceptions. Common domains that contain quasi-regularity include morphological inflection and grapheme-phoneme mapping. How humans process quasi-regularity has been debated for decades. This thesis implemented modern neural network models, transformer models, on two tasks: English past tense inflection and Chinese character naming, to investigate how transformer models perform quasi-regularity tasks. This thesis focuses on investigating to what extent the models' performances can represent human behavior. The results show that the transformers' performance is very similar to human behavior in many …

A Consecutive Case Series Evaluation Of Tummy Time With And Without Preferred Items, Rika Ortega

Dissertations, Theses, and Capstone Projects

Tummy time is an activity for infants to practice their early motor skills. Although most pediatricians recommend tummy time, parents may avoid the procedures due to infant discomfort during this period. The present study investigated whether a preferred item functioned as a reinforcer to increase head elevation and decrease crying during tummy time with 16 consecutive, typically developing infants. The study compared the preferred items selected from a preference assessment to that of caregiver attention. In addition, we directly evaluated parental choice by allowing the mothers to select which tummy time treatment they would like to implement. We found that …

Identity, Access, And Equity: An Exploratory Mixed-Methods Study Of Mathematics Identity And Socialization In Pre-Service Teachers, Ashley Renaire Davis

Dissertations, Theses, and Capstone Projects

Teaching practices in early childhood through post-secondary learning settings continue to reproduce inequities in mathematics education despite recognition of math’s utility and its necessity for competitiveness in the global economy. For reform efforts to be successful, teachers must change the way mathematics is presented in classrooms where students often experience differences in exposure to mathematics content and time spent covering particular mathematics topics. Therefore, teachers represent a critical component in the cycle of reproduction of unequal access to mathematics. This mixed-methods study examined the processes of mathematics identity formation and mathematics socialization in a diverse sample of pre-service elementary and …

Sustainable To The Core: Essays On Strategy And Sustainability, Junghoon Park

Dissertations, Theses, and Capstone Projects

This dissertation investigates the intricate relationship between business strategies and sustainability. A growing awareness has emerged among firms about the importance of embracing sustainability—integrating the environmental, social, and economic implications of their actions and decisions into their core strategies—to attain long-term success and competitive advantage. In this context, strategic management research has primarily concentrated on the benefits that firms and their stakeholders can derive from adopting and executing sustainability initiatives. Despite the numerous efforts made by firms to tackle sustainability concerns, pressing issues persist. This situation raises questions about the effectiveness of strategic management research in guiding firms to embed …

Misogyny In Contemporary Populist Authoritarianism, Maxine Mannheim

Dissertations, Theses, and Capstone Projects

The regression of rights for women and the LGBTQ community, as well as the freedoms of religious and ethnic minorities are coinciding with the global rise in populist authoritarianism. However, the link between misogyny, gendered narratives, and populist authoritarianism remains understudied and requires further elaboration. There can be no full investigation of modern populism, nor the political leaders who utilize it, without an understanding of the gender dynamics that permeate populist and authoritarian politics. I argue that misogyny is interwoven in populist authoritarianism, and that it is a defining characteristic observable in the ways in which leaders manipulate the emotions …

Searching For Mami & Abuelita: Reimagining Ethnic Studies Praxis Through Women Of Color Feminisms, Art, And Archiving, Wendy S. Barrales

Dissertations, Theses, and Capstone Projects

Weaving art-based methods, women of color (WOC) feminisms, digital participatory archiving (PAR-chiving), and Ethnic Studies pedagogy, this dissertation investigates how I explored and produced knowledge collectively with young women of color that reimagines classrooms as learning spaces for liberation. This dissertation, searching for mami & abuelita, is an extension of the women of color archive (wocarchive) a digital storytelling project documenting, preserving and sharing the experiences of our matriarchs of color. This project, born out of an interview with my abuelita Aída about her life in rural Veracruz, sought out to document and preserve the stories of women of color …

The Study Of Excitons In 2d Novel Materials And Their Van Der Waals Heterostructures In The Magnetic Field, Anastasia Spiridonova

Dissertations, Theses, and Capstone Projects

This research focuses on the direct and indirect excitons in Rydberg states in monolayers, bilayers, and van der Waals heterostructures composed of 2D semiconductors in the presence of the external magnetic field. In our work, we report binding energies of direct and indirect excitons in Rydberg states, the energy contribution from the magnetic field to the binding energies of magnetoexcitons, and diamagnetic coefficients (DMCs) of magnetoexcitons.

We study isotropic materials: transition metal dichalcogenides, TMDCs (WSe₂, WS₂, MoSe₂, MoS₂), and Xenes (silicene, germanene, stanene), and anisotropic materials: phosphorene and transition metal trichalcogenides, TMTCs …

Muscling Through: Athletic Women In Victorian Popular Representation, 1864–1915, Julia G. Fuller

Dissertations, Theses, and Capstone Projects

“Muscling Through” reconstructs an overlooked history of strong female bodies in the nineteenth century. It argues that popular representations of athletic women introduced a new category of identity that was distinct from women’s traditional relational and social roles. The project’s central figure is the hyper-able “Sportswoman,” who bridges the gap between two familiar versions of the Victorian woman’s body: the mid-century ideal of docile, domesticated femininity and the sturdy, capable women who enter universities, professions, and public spaces en masse just before the turn of the century. Representationally, the Sportswoman figures a range of attitudes, from anxious to aspirational, toward …

A Sociology Of Gab: A Computational Analysis Of A Far-Right Social Network, Nga Than

Dissertations, Theses, and Capstone Projects

This dissertation examines the racial discourse circulated on Gab, a microblogging and social networking platform, by the far right to proliferate hate speech, and how the far-right discourse has evolved on the platform. Gab was created 2016 in response to mainstream social media’s increase of content moderation and deplatforming of extremist users to curtail hate speech and harassment. The platform gained a substantial number of new users after the Charlotteville incident of 2017. In this thesis, I examine the creation of Gab, as an alternative social media platform, as a strategic site of socio-technical innovation, as well as the important …