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Analysis Of Diterpenoid Alkaloids From American Aconitum Using Lc-Ms Metabolomic Methods, Yi Zhao

Dissertations, Theses, and Capstone Projects

Analysis of Diterpenoid Alkaloids from American Aconitum Using LC-MS Metabolomic Methods

by

Yi Zhao

Advisor: Edward J. Kennelly

Aconitum plants have been used as a traditional medicine in Asian countries for millennia to treat pain, rheumatism, syncope, fever, and other conditions. These therapeutic effects are mainly due to the bioactive diterpenoid alkaloids accumulated in the roots. Comparing with the large records and studies of Asian Aconitum and their medicinal use and the broad bioactive compounds, American Aconitum has been rarely investigated, not to mention how American Aconitum has been used medicinally. Based on previous phylogenetic and chemotaxonomic studies of Aconitum …

Bridging Data Gaps In Retinal Imaging: From Structural Domain Adaptation To Topology-Aware Synthesis, Gözde Merve Demirci

Dissertations, Theses, and Capstone Projects

Comprehensive visualization of the retina is essential for diagnosing and monitoring blinding diseases such as Diabetic Retinopathy and Retinopathy of Prematurity (ROP), where pathological changes often extend beyond a single field of view. Despite significant advances in automated retinal image analysis, clinical deployment remains limited by two fundamental data gaps: a structural learning gap, arising from scarce expert annotations and poor generalization across imaging domains, and a spatial coverage gap, caused by the difficulty of acquiring multi-view retinal images in fragile populations. Although these challenges are often addressed independently, this dissertation argues that they are tightly coupled: accurate, …

Allyship And Affect: Qualitative Investigations Into Social Transformation, Michael Lucinda Jane Greer

Dissertations, Theses, and Capstone Projects

Allies have faced several critiques in feminist philosophy. Some have argued that they lack the requisite political interests to be motivated to dismantle the social structures from which they stand to benefit. Others have argued that the epistemic limitations resulting from their social privilege are insurmountable. Yet others have argued that allyship is too individualistic a concept, preferring a more collectivist concept like solidarity. However, there remain privileged individuals who understand themselves as complicit in perpetuating oppressive forms of life, and who wish to transform themselves and work in coalition across difference to dismantle structural oppression. How ought these individuals …

Distinguishing Between Complex Post-Traumatic Stress Disorder And Post-Traumatic Stress Disorder: The Role Of Childhood Maltreatment, Catherine Harris

Dissertations, Theses, and Capstone Projects

The current study examined whether court-substantiated childhood maltreatment may be associated with increased risk for Complex PTSD (CPTSD) and whether individuals with CPTSD and individuals with PTSD could be distinguished in terms of complex trauma exposure. Children with documented cases of abuse and neglect prior to age 11 were matched on age, race, sex, and approximate family socioeconomic status with children without documented histories of maltreatment (controls) and both groups were followed prospectively into adulthood. Participants (N = 1,196) were assessed using a DSM-III-R based structured interview of PTSD symptoms and other self-report measures of psychiatric symptoms at mean age …

Intimate Partner Violence And Emotion Regulation Among Emerging Adults: Investigating The Roles Of Dispositional Mindfulness And Executive Function In The Context Of A Laboratory-Induced Stress Paradigm, Mikell Bursky

Dissertations, Theses, and Capstone Projects

Intimate Partner Violence (IPV) is a major public health concern that impacts an estimated 10 million men and women in the United States annually. IPV refers to a range of physical, sexual or psychological forms of aggression committed against a current or former romantic partner in the context of a relationship. The highest rates of IPV are observed in emerging adulthood, a developmental period between the ages of 18 to 25 that is significant for the transition from adolescence into adulthood, and the establishment of first meaningful intimate relationships. Although distal risk factors for IPV such as violence in the …

Teaching Third Graders To Read Multisyllable Words: Segmentation Versus Whole Word Reading, Jolie D. Heath

Dissertations, Theses, and Capstone Projects

In the early years of elementary school when children are still learning to read, they are presented with words of increased syllable length, and orthographic and morphological complexity in the texts they read.  Although multisyllabic words comprise 90% of words in the English lexicon and carry important linguistic information for expanding vocabularies and comprehension of content, few studies have focused on teaching middle elementary children to read multisyllabic words.  Many children lack strategies to identify these longer more complex words accurately and easily, leading to reading difficulties that place weaker readers at higher risk for school related problems and limit …

Social And Structural Factors In The Development Of Baltimore's Low Back Vowels, Aidan J. Malanoski

Dissertations, Theses, and Capstone Projects

This dissertation is concerned with the low back vowels of Baltimore English: what low back systems occur, and how these systems have changed among Black and white Baltimoreans. I draw on two sources of data: 48 interviews that I conducted with natives of Baltimore and its inner suburbs, and 18 oral history interviews that were conducted from 1978 to 1981. In Chapter 3, I argue for the inclusion of the pre-rhotic sets START and NORTH in typologies of English low back vowels. With these sets included, several previously unattested low back systems are found in Baltimore. These are united by …

Social Media-Based Social Comparisons Among Socially Anxious Young Adults: The Role Of Cognitive Reappraisal, Jennifer L. De Rutte

Dissertations, Theses, and Capstone Projects

Social media is a central context for social interaction and self-evaluation among young adults. For those with elevated social anxiety, these environments may be especially salient because they provide frequent opportunities for social comparison. Although upward social comparison on social media has been linked to poorer emotional outcomes, less is known about its experimental effects among socially anxious young adults or whether upward and downward comparison have distinct effects that extend to later socially evaluative situations. The present study examined these questions in 84 socially anxious young adults randomly assigned to view simulated Instagram feeds eliciting upward comparison, downward comparison, …

Potential Energy Landscape Formalism For Quantum Liquids, Yang Zhou

Dissertations, Theses, and Capstone Projects

Atomic delocalization due to nuclear quantum effects (NQE) remains poorly understood in low-temperature liquids near the glass state and during vitrification. Many liquids can be described accurately by treating their nuclei as classical particles, but this approximation fails for light elements such as He and H₂, small hydrogen-containing molecules such as water, and systems in which zero-point motion or isotope-substitution effects are important. Developing a general thermodynamic and statistical-mechanical description of such liquids has been challenging. This dissertation extends the potential energy landscape (PEL) formalism, originally developed for classical liquids and glasses, to liquids that obey quantum mechanics and exhibit …

Dancing In Circles: Bon Dance As Performance Of The Past, Travis Robb Kim

Dissertations, Theses, and Capstone Projects

This capstone project traces the contours of the Japanese folk dance tradition of Bon Dance in Hawaiʻi through the nuances of public scholarship, diaspora, and racial capitalism by producing an original play which aims to perform the knowledge and praxis which the performance ritual puts forward. Treating Bon Dance as muse, the original play examines the necessity of turning to the past in order to disrupt a future made inevitable by oppressive systems; a fiction that comments on and critiques the predictive and generative technologies that have embedded themselves into society at large. Through intertwining conversations that explore prophecy and …

"Is This America?" Fannie Lou Hamer, Humanity, Citizenship And The Struggle For Inclusive Democracy, Rhonda Chambers

Dissertations, Theses, and Capstone Projects

This thesis examines the life, political rhetoric, and enduring legacy of Fannie Lou Hamer, focusing on how her lived experiences under Jim Crow shaped the development of a distinctive political voice grounded in dignity, moral conviction, and democratic struggle.  Born into a Mississippi sharecropping family and denied the educational and political opportunities afforded to white Americans, Hamer developed an understanding of injustice through the realities of racial and economic oppression. Her experience with segregation, voter suppression, violence, and the Black church became central to the way she understood citizenship and was able to articulate the demands of freedom.

Through an …

Mapping The Water Quality Of Jamaica Bay, New York (1996-2024): Principal Component Analysis And K-Means Clustering, Sneha Srivastava

Dissertations, Theses, and Capstone Projects

Jamaica Bay, located along the southeastern coast of New York City, acts as a biodiverse estuary of wetlands, meadows, and salt marsh islands. The purpose of this study is to analyze the water quality conditions of the region over time, comparing locations around the bay to identify hyperlocal features that influence larger trends in the hydrological system. Ten variables were used as water quality indicators, including total Kjeldahl nitrogen, salinity, pH, Secchi disk depth, and total phosphorus, among others, across five stations in the bay, between 1994 and 2024. After data cleaning and standardization methods were applied, principal component analysis …

Optimizing Nanoparticle Quality And Function In Applied Research, Angela M. Fried

Dissertations, Theses, and Capstone Projects

Radiology tests are among the fastest-growing categories of diagnostic analysis, and the gold standard of radiology tests is MRI.  MRI can be more informative if a contrast agent is used, and the standard of care contrasting agents (CA) are gadolinium-based.  Gadolinium is a heavy metal, toxic, and contraindicated for renal-compromised patients and the critically ill.  We propose a nanogel (NG) vehicle for an alternative organic CA.  CNs like 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPOL) and its derivatives have a variety of medical and industrial uses.  These cyclic CNs are stable, synthetic radicals with distinctive EPR/ESR signals and are helpful for various experimental applications, from …

Analyzing Harmony In Bulgarian And Bulgarian-Influenced Choral Arrangements From The Radio To The Screen, Annie Beliveau

Dissertations, Theses, and Capstone Projects

This dissertation investigates developments in arrangements and compositions made for Bulgarian choirs between 1950 and 2025. Arrangements from Bulgaria’s communist period (1944-1989), when musical radio broadcasts were tailored to promote nationalist sentiment, eventually reached the ears of foreigners on the other side of the Iron Curtain via recordings and ensemble tours. These obrabotki (arrangements of folk tunes) became popular in the “world music” boom of the 1980s, and foreign composers soon began to create new compositions for Bulgarian choirs to sing on albums and in scores for film, television, and video games. Over time, the uses of Bulgarian choir in …

Retrieval Information From Working Memory: The Output Gating Framework Perspective And Its Underlying Processes, Chen Tiferet-Dweck

Dissertations, Theses, and Capstone Projects

Working memory (WM) keeps information accessible and available for further processing. However, not all the information we maintain in WM is behaviorally relevant at any given moment. To act effectively, we must dynamically control which memory representations are accessed to support ongoing goal-directed behavior. While the mechanisms underlying the selection of single items from WM access are comparatively well-studied, less is known about the principles governing multi-item access. Existing models of WM access imply that selecting multiple items should take longer and be more error-prone than single-item access. Yet, paradoxically, prior studies have shown that retrieving all items in WM …

Urban Counterpoint (1992–2003): The Piano Music Of Ed Bland, Joseph Vaz

Dissertations, Theses, and Capstone Projects

This dissertation analyzes the piano music of Ed Bland, a politically and philosophically vocal composer active in the second half of the twentieth century, whose music draws on both the European and American twentieth-century avant-garde, and on African American vernacular music genres from ragtime to hip-hop. A review of the historical and personal context for these pieces, and a detailed examination of the compositional processes used in this music, work together to demonstrate how Bland thought about the relationship between different musical genres and languages.

Through this combination of theory of musical genre, historical and biographical study, and detailed analysis …

Investigating The Role Of Striatal Cholinergic Interneuron D2 Receptors In Behavioral Flexibility, Janyn J. Alfred

Dissertations, Theses, and Capstone Projects

Dopamine (DA) and acetylcholine (ACh) interact within the striatum to shape reward-based learning and choice behavior. DA D2 receptors on cholinergic interneurons (CIN D2Rs) were genetically knocked out to investigate their role in choice allocation using a two-lever matching paradigm. Behaviorally, both knockout (KO) and wild-type (WT) mice learned the initial task equally well. When shifted to asymmetric matching schedules (VI-90 vs. VI-180), ideal matching predicts that mice should allocate exactly 67% of their total responses to the rich lever. Neither group matched as predicted by the matching law. Instead, the KO mice showed a pattern where the higher rate …

Individual Intellectual Humility As A Predictor Of Perceived Information Sharing And Perceived Shared Leadership, Mary Beth Schroeder

Dissertations, Theses, and Capstone Projects

Cross-functional problem-solving teams are often assembled to address complex challenges by combining members’ distinct knowledge, ideas, and leadership capabilities. Yet teams do not always capitalize on these collective resources, because team members do not share the information they uniquely possess. This tendency to withhold information may be lessened by intellectually humility, a personality trait marked by a desire to close gaps in one’s knowledge and openness to what others contribute.

This study was originally designed to examine whether team intellectual humility relates to team creativity through information sharing and shared leadership. However, because of changes in the leadership development program …

Catalytic Synthesis Of Protoberberine Alkaloids And Their Evaluation As Selective Dopamine Receptor Ligands, Ashok Reddy Gudipally

Dissertations, Theses, and Capstone Projects

Dopamine regulates motor control, cognition, reward, motivation, and neuroendocrine signaling. Disruption of dopaminergic neurotransmission is closely linked to central nervous system disorders, including Parkinson’s disease, schizophrenia, addiction, and related neuropsychiatric conditions. Because these functions are mediated by multiple dopamine receptor subtypes with distinct roles in physiology and disease, the discovery of subtype-selective ligands remains an important goal in neuropharmacology. Within this context, protoberberine alkaloids, particularly tetrahydroprotoberberines (THPBs), are attractive molecular frameworks because they combine structural complexity with broad biological relevance, including measurable activity in CNS-related diseases. Prior work from our laboratory and others established (–)-stepholidine (1.60) as an important lead …

Alzheimer’S Disease And Related Dementias Risk Profiles And Health Literacy Among South Asian Seniors, Sandra A. Kennedy

Dissertations, Theses, and Capstone Projects

Alzheimer’s Disease and Related Dementias (ADRD) pose significant health challenges globally, with South Asian seniors in the United States facing elevated risks due to high rates of cardiovascular disease, diabetes, and limited health literacy. This study assessed dementia literacy and the prevalence of cardiovascular, psychosocial, and lifestyle risk factors among South Asian seniors in New York City, utilizing community-based participatory research (CBPR) principles in collaboration with India Home, a community-based organization. Fifty-six (N=56) South Asian seniors aged 55 and older (M = 69.05, SD = 6.36), primarily of Indian or Bangladeshi origin, participated in the study. Data collection involved a …

Shifting To Using Desmos Or Geogebra Graphing Calculators In High School Mathematics Classrooms, Nancy Lin

Dissertations, Theses, and Capstone Projects

Most high school math classrooms in Long Island use the Texas Instruments TI-84+ CE graphing calculator in the three Regents math courses. Texas Instruments holds approximately 80% of the market share of the international graphing calculator market. At a manufacturer's suggested retail price of $150 per TI-84+ CE, an inequitable situation exists for math learning, as underfunded schools and students from lower socioeconomic backgrounds cannot afford to purchase one for home use. Such students have less experience using the handheld graphing calculator when they take high-stakes math exams. Through case studies of four suburban school districts in New York that …

Model-Theoretic Arguments In Philosophy, Peter Susanszky

Dissertations, Theses, and Capstone Projects

This dissertation is on model-theoretic arguments in philosophy, especially those of Quine, Davidson, and Putnam. In the first part, to ground the debate, I give a rigorous introduction to the salient parts of first-order model theory. I start the second part by giving an introduction to Quine's philosophy, and how the model-theoretic arguments fit into it. After considering how Donald Davidson adopted the Quinean lesson, I move on to Putnam's model-theoretic arguments. Putnam's spin on these model-theoretic considerations significantly departs from Quine and Davidson, while retaining many of the core ideas. Most importantly, I argue that the target of Putnam's …

Possibilities Of Being: Black Women's Storytelling As Archival Undoing, Dasharah Green

Dissertations, Theses, and Capstone Projects

This dissertation constructs a discursive genealogy of Black women’s storytelling, positioning its art and aesthetics as a form of colonial archival undoing. Each chapter explores how transmission and documentation can transform—and circumvent—traditional colonial archives. Beginning at the start of the twentieth-century to present, this project traces the discursive legacies of Zora Neale Hurston, Audre Lorde, Michelle Cliff, and Staceyann Chin, examining each writer as a site of becoming as they individually (and collectively) seek to articulate an expansive idea of a Black world that constitutes a broader understanding of Black freedom. They each share a common goal of creating a …

Sec-Saxs And Sans Analyses Of The Talin•Vinculin Complex, Gilbert Reyes

Dissertations, Theses, and Capstone Projects

Focal adhesions (FA) are integrin-based cell-matrix adhesion sites composed of adaptor proteins that facilitate the generation of traction forces important for biological functions such as cell migration, embryo development, wound healing, tissue organization and stability, and immune responses. Mature FA are observed when both autoinhibited multi-domain scaffolding protein talin and membrane-cytoskeletal protein vinculin are activated and interact thus promoting the assembly and function of FA. While research has resolved truncated sections of autoinhibited talin and recruitment of vinculin due to mechanotransduction that exposes cryptic vinculin binding sites (VBS), little is known about the global modifications of full length talin in …

Vibe Diggers: The Sampling Of Brazilian Music In Hip-Hop, Romulo De Carvalho Moraes Barbosa

Dissertations, Theses, and Capstone Projects

This dissertation investigates the trend of musical borrowings of 1970s MPB (música popular brasileira) by contemporary American hip-hop producers, especially in terms of what they have called a “Brazilian vibe.” A lot has been said about sampling already from legal, sociological, and historical points of view, but less has been said about its aesthetic procedures, and even less about the wider implications of a tendency for using transnational sources. In the case of MPB, hip-hop artists seem to understand the music they sample through an often vague, intuitive representation, which fuses qualities of those recordings with an intersubjective mood, a …

Modeling And Generating Trustworthy Speech, Yuwen Yu

Dissertations, Theses, and Capstone Projects

As virtual agents become increasingly integrated into everyday communication, trust has become essential for effective human-AI interaction. Although recent advances in natural language generation and speech synthesis have significantly improved fluency and intelligibility, most systems are not designed to control how trustworthy they are perceived. As a result, a mismatch can emerge between perceived trustworthiness and actual system capability, leading to over-trust or under-trust. While trust is critical for meaningful interaction, current text-to-speech (TTS) systems are primarily optimized for naturalness and intelligibility rather than calibrated trustworthiness.

This dissertation investigates the perceptual foundations of trust in both human and synthesized speech …

The Effects Of Chronic Nicotine Exposure On Dopamine-Mediated Reinforcement Learning And Striatal Neurotransmission, Srishti Bose

Dissertations, Theses, and Capstone Projects

Tobacco is one of the most widely used substances across the United States; tobacco consumption is linked with several diseases and is one of the leading causes of preventable death in the country. Nicotine is the active substrate found in tobacco products, acting as a stimulant, which reinforces continued use. The introduction of tobacco-free options such as e-cigarettes and oral pouches has driven an increase in nicotine exposure across the population, especially in young adults. Acute nicotine use induces neuroadaptations in the mesolimbic dopaminergic system, which mediates reinforcement learning and addiction, that potentiates reward-related neurotransmission. Furthermore, there are clinical studies …

Rethinking Road Racing Standards: Comparing New York Road Runners Race Results To Running Industry Standards, Jennie Coughlin

Dissertations, Theses, and Capstone Projects

Running has undergone a third boom in participation since 2020, driven largely by people seeking fitness options that were outside and socially distanced during the COVID-19 pandemic. Social media has also allowed runners from groups that did not traditionally participate to find community. As the road racing population has expanded to include more people, some road racing industry standards have not kept up. This project assesses what the road racing community looks like and measures industry standards against the community of participants to see what changes in those standards would be needed to make them inclusive for all participants.

To …

Panopticism And Pan-Oticism: Sound-Power From Foucault To Deleuze, Eric Dillenberger

Dissertations, Theses, and Capstone Projects

From Muzak to long range acoustic devices (LRADs), the contemporary proliferation of sonic technologies for governing moods, behaviors, and potentialities complicates the virtual absence of sound within Michel Foucault's primarily visual modality of disciplinary power in Discipline and Punish, exemplified by his central conceptual model of the panopticon. This thesis develops the corollary concept of pan-oticism to theorize the transformation of sound-power and its political function within administered sonic ecologies from Foucault's disciplinary societies to Gilles Deleuze's societies of control. Within the enclosed spaces constitutive of disciplinary societies, sound-power remains subordinated to Foucault's visual logic of panopticism, extending …

Waltzing Into Silence: Time, Space, And The Afterword In Ravel’S Valses Nobles Et Sentimentales In Comparison With Schumann’S Davidsbündlertänze, Op. 6, Nora I. Bartosik

Dissertations, Theses, and Capstone Projects

This dissertation undertakes an analysis of Maurice Ravel’s Valses nobles et sentimentales for piano against the backdrop of Robert Schumann’s Davidsbündlertänze, Op. 6, a work with significant parallels in structure, character, and narrative. The Davidsbündlertänze are examined as a model for the Valses nobles et sentimentales, with an emphasis on the two works’ use of the waltz form, their structure as a series of miniature dances composed as a single cohesive work, and their inclusion of an afterword, or epilogue. The analysis draws from the extensive literature on Schumann’s piano cycles in order to apply similar techniques to …