Digital Commons Network^™

Targeting Eya1 Phosphatase Activity In Mll-Rearranged Leukemia, Lola Badmus

Dissertations

MLL-rearranged (MLL-r) leukemia is an aggressive subset of acute leukemia, accounting for up to 10% of adult and 70% of infant AML and ALL cases. These leukemias are driven by MLL fusion proteins, which recruit epigenetic cofactors to dysregulate gene expression, leading to poor prognosis and resistance to conventional chemotherapy. Previous lab work identified EYA1’s role in leukemogenesis, establishing it as a therapeutic target in MLL-r leukemia. EYA1, is a transcriptional coactivator and protein tyrosine phosphatase (PTP). Originally a gout medication, benzbromarone (BBR), was identified in an NCI Diversity Set screen as an EYA1-specific PTP inhibitor. BBR provides a tool …

Interrogating The Dispersal Process And Relevant Genes In Vibrio Fischeri, Jeremy Esin

Dissertations

Biofilms are aggregates of bacteria encased in a matrix that shields bacteria from environmental hazards. These structures are formed in response to cues from the environment and drive colonization of new niches. Biofilms can be both beneficial and detrimental. Largely, research focuses on biofilms that have negative outcomes in clinical, environmental, and economical settings. However, the value of beneficial biofilms is recognized and studied. The marine bacterium Vibrio fischeri is part of a model system for studying symbiotic biofilms in a eukaryotic host. V. fischeri produces a transient biofilm at the surface of a specialized light organ and then disperses …

Developing Full Performance Interpreters: Cultivating Interdisciplinary Mindsets And Skillsets To Engage Audiences In Climate Change, Women's History, And Other Contested Heritage Topics, Delia A. Lister

Dissertations

Heritage sites immerse visitors in places where the impacts of climate change are readily apparent. They are also powerful places to elevate untold stories of women and girls. Heritage site interpreters interact daily with audiences who bring diverse lived experiences, different levels of subject matter knowledge, and multiple perspectives on climate change and the role of women in history. Every visitor interaction has a set of meanings, values, and narratives that visitors knowingly or unknowingly espouse. To interpret contested heritage topics, such as climate change and women’s history, interpreters must cultivate interdisciplinary mindsets and skillsets. The purpose of this basic …

A Design Based, Mixed Method Study On Evaluating Traditional Grading Practices And The Implications For Mastery Learning And Educational Equity In A Midwestern School District, Christina Kirchner

Dissertations

“Grades are an essential currency of our schools. Schools, colleges and employers use grades to determine many important, and in some cases, life-altering decisions-college admission, financial aid and scholarships, athletic eligibility, promotion, retention, awards, and supports” (Feldman, 2018, p. 3). Grading is not addressed in teacher preparation programs, or within professional development during teachers’ careers; teachers have chosen their own way to grade guided by their own personal experiences, uninformed of research or best practice. Using a human centric, design-based approach, the researcher identified multiple discrepancies with grading practices among the K-12 school organization. Within the discrepancies, other issues were …

Technology Infusion In Higher Education Curriculum: A Case Study Of The Strategic Educational Leadership Program, Chloe R. Kiser

Dissertations

This program evaluation examines the integration of technology-infused curricula in the Strategic Educational Leadership (SEDL) program at National Louis University (NLU). With the growing need for digital competence in educational leadership, especially highlighted during the COVID-19 pandemic, the study used the International Society for Technology Education (ISTE) Standards for Education Leaders to guide recommendations for curriculum enhancement. A mixed-methods approach explored how faculty currently infuse technology, key outcomes of aligning with ISTE standards, essential digital skills for doctoral students, and challenges faculty face in implementation. Findings revealed a shared interest among faculty and students in practical, real-world technology applications. The …

The Impact Of Restorative Practices Intervention On School Culture, Lisa Peloquin

Dissertations

The American educational system, historically designed to empower a few while training the majority to be docile workers, is increasingly being called upon to promote greater equity. While some reform efforts promote highly restrictive behavioral policies to boost student achievement, these approaches often serve to recreate the oppressive school systems they seek to reform. Restorative practices, an alternative approach to school reform, emphasizes creating a culture of strong relationships, where children learn the academic and social emotional skills they need to be successful. This paper presents a case study of one urban, public school’s implementation of restorative practices, examining its …

Traditional Institutions As Change Agents: Understanding Cultural Norms And Practices Promoting Gender-Based Violence In Nigerian Communities, Titilayo Ogunbambi

Dissertations

Traditional institutions in Nigerian communities hold a strong cultural foundation and significantly influence cultural norms and practices. Due to the increasing need for effective community-based approaches in addressing social and health problems on a global scale, we explore the attitudes and behaviors of traditional institutions as custodians of cultural customs and norms related to gender-based violence (GBV) and examine their potential role in ensuring community safety. By addressing harmful gendered norms and practices, traditional institutions could become key agents of change, promoting meaningful social transformations. This study explores the dynamics cultural norms and practices play in community safety, emphasizing the …

Advancing Equity Through Social And Emotional Learning, Tosha N. Jackson

Dissertations

This study examines how Chicago Public Schools (CPS) promotes equity through social and emotional learning (SEL) within its Healing-Centered and Equity Frameworks. The research aims to evaluate the effectiveness of these frameworks in addressing trauma, fostering equitable learning environments, and implementing culturally responsive practices. Using qualitative methods, data were gathered from semi-structured interviews with four former CPS leaders and a document analysis of CPS frameworks. The analysis revealed the alignment of CPS practices with equity-focused priorities outlined by the Learning Policy Institute (Hammond et al., 2020). Findings suggest that Social-Emotional Learning (SEL) can effectively mitigate the impact of trauma and …

Culturally Responsive Intimate Partner Violence (Ipv) Service Needs Among African Immigrant Women: Examining The Impact Of Cultural Norms And Psychosocial Barriers On Safety Perceptions And Help-Seeking Behaviors, Titilayo Ogunbambi

Dissertations

Intimate Partner Violence (IPV) remains a pervasive public health and social justice issue globally, with African immigrant women in the United States facing compounded challenges as they navigate cultural, structural, and systemic barriers, including migration-related vulnerabilities and attachment to cultural values that shape their decisions and experiences. Although formal IPV services exist, they often fail to address the lived realities and culturally specific needs of this population, leading to underutilization and barriers in seeking help. This qualitative study examines how cultural norms, psychosocial barriers, and systemic inequities influence safety perceptions and help-seeking behaviors among African immigrant women survivors of IPV. …

Testing For Broad Alternatives In Stratified Contingency Tables, Nan Mi

Dissertations

In medical and social sciences fields, data are measured in terms of discrete categories. The primary question of interest involves the relationship between a set of factors and a set of response variables under studies. Moreover, the distribution of the response variables may be influenced by another set of variables called confounders. The data from such studies are summarized in 3-way tables. The hypothesis we are interested in can be expressed in terms of "no partial association" between the sub-populations and the response levels.

The methods for testing the association or independence in a 2x2 contingency table have been developed, …

A Parallel Fuzzy Logic Framework For Surgical Skill Evaluation Via Instance Segmentation And Deepsort Tracking, Mohsen M. Mohaidat

Dissertations

Manual evaluation of suturing skills during laparoscopic training is often subjective and labor-intensive, resulting in the lack of scalable and consistent feedback for trainees. This study proposes an automated framework that not only significantly reduces the need for in-person assessment by experts but also ensures scalability, thereby addressing the objectivity and cost-effectiveness limitations. While low-cost laparoscopic box trainers have become increasingly popular for residency training, performance assessment still depends on expert supervision. The proposed system aims to alleviate these limitations.

This study introduces a novel automated framework incorporating an optimized DeepSORT algorithm for classifying, localizing, and tracking surgical tools using …

Diagnosis By Algorithm: The Transformative Impact Of Social Media–Driven Adhd Self-Diagnosis For Women Over 30 And The Proposal Of Neurotype Strain Theory, Rebecca Lynn Sevin

Dissertations

This dissertation explores the phenomenon of adult women who self-diagnosed Attention Deficit Hyperactivity Disorder (ADHD) through content encountered on social media platforms. Drawing on interpretive phenomenological analysis of ten in-depth interviews, the study investigates the emotional, cognitive, and institutional dimensions of this self-diagnosis process. Participants, all over the age of 30, reported that social media played a transformative role in helping them recognize ADHD traits in themselves. Rather than being misinformed or seeking shortcuts, participants engaged thoughtfully with ADHD-related content, valuing lived experience itself as a meaningful source of recognition and reflection. Their engagement was not primarily with educational materials …

Assessing The Relationship Between Combat Exposure, Wartime Service, And Barriers To Substance Use Disorder Treatment In Post 9/11 Veterans., Robert Near

Dissertations

Substance use disorders (SUDs) represent a critical public health concern, particularly within military and veteran populations. The complex interplay of mental health challenges, combat exposure, and the unique stressors associated with military service contribute to a heightened vulnerability among veterans. Research from the United States Department of Veterans Affairs (USDVA) underscores the prevalence of these issues, indicating that approximately 1 in 10 veterans from the Iraq or Afghanistan wars treated by the VA are diagnosed with a SUD (Veterans Affairs, 2023). Additionally, veterans from all eras show a higher propensity for binge drinking when compared to the general population, further …

Developing Machine Learning Models And Graphene-Based Flexible Humidity And Temperature Sensors For Machine-Learning-Assisted Sensing, Seth Hajian

Dissertations

Flexible sensor technology has recently gained tremendous momentum in both academic research and industrial applications, transitioning from conceptual frameworks to practical implementations across diverse fields. This remarkable advancement can be attributed to several converging factors, including the maturation of nanomaterial science, the advancements of machine learning algorithms, and the critical demand for intelligent sensing solutions in healthcare, environmental monitoring, and industrial automation. The growing emphasis on personalized medicine and real-time health monitoring, accelerated by global health challenges, has further highlighted the necessity for accurate, cost-effective, and adaptable sensing platforms. This dissertation presents the fulfillment of three interconnected research projects focused …

Probing Shielding Tensor Components Of Amino Acids Using Nuclear Magnetic Resonance, Shiva Agarwal

Dissertations

Chirality is fundamental to terrestrial life. While most amino acids exist as nonsuperimposable mirror images, amino acids in terrestrial life are homochiral, with the L-enantiomer being ubiquitous. The detection of an excess of L-amino acids in carbonaceous meteorites suggests that extraterrestrial processes may have contributed to this enantiomeric excess (ee). One proposed mechanism, the magnetochiral model, provides a potential explanation for this phenomenon in stellar environments characterized by strong magnetic and electric fields and the presence of relativistic leptons. According to this model, subtle differences in the electronic environments of chiral amino acids under such conditions …

Investigating The Effects Of Brief Video Interventions On White Undergraduate Students’ Racial Attitudes, Alyssa Powers

Dissertations

In this experimental study, a pretest posttest between-groups design was utilized to investigate the efficacy of two brief multicultural educational video interventions in improving the colorblind and affective racial attitudes of White undergraduate students. Ninety-eight self-identified White undergraduate students from a large, Midwestern university were randomly assigned to one of three conditions: (a) viewing a video on the pervasiveness of individual racism and White privilege in the United States (True Colors); (b) viewing a video on institutional racism in the United States (Segregated by Design); (c) viewing a study tips video as the neutral control condition. Participants’ colorblind and affective …

Pension Participation Among Different Migrant Groups In China: Job Type, Regional Disparities, And Cross-Provincial Mobility, Boxia Xu

Dissertations

As China undergoes rapid economic transformation and urbanization, the migrant population has grown significantly. Although migrants play essential roles in the labor market, they face persistent structural barriers to pension access. Regional disparities, occupational segmentation, and cross-provincial mobility constraints affect the probability of their pension participation. While policy efforts aim to expand coverage, the fragmented nature of China’s pension system continues to hinder equitable access for migrants. As a result, ensuring pension participation among migrant groups remains a pressing challenge.

Using data from the 2014 China Migrants Dynamic Survey (CMDS), this dissertation employs logistic regression models to investigate how job …

The Fault Line: Understanding Tension Between Industry And Higher Education Institutions In Sustained Partnerships, David Lawrence

Dissertations

This study investigates the dynamics that influence tensions in industry–higher education partnerships and identifies effective navigation factors in sustainable partnerships. Despite the increasing prevalence, such partnerships face high failure rates due to inherent tensions. This research explores how partners from industry and higher education institutions successfully navigate these tensions using a qualitative case study approach.

This investigation employed a case study design with a multi-case two-by-two holistic matrix and an interpretive, constructivist framework. Data collection involved 16 semi-structured interviews with key individuals from nine higher education institutions and five industry organizations spanning healthcare, technology, consulting, real estate development, and accounting …

Impact Of Student Voice In The (Dis) Engagement Of Middle School Students In Urban Elementary School And Academic Achievement, Valandra N. Lloyd

Dissertations

This formative mixed-methods evaluation study explores the impact of culturally inclusive teaching practices on student voice, engagement, and academic outcomes among middle school students in an urban elementary school. Grounded in the theoretical frameworks of Culturally Relevant Pedagogy (Ladson-Billings), Culturally Responsive Teaching (Gay), and Culturally Sustaining Pedagogy (Paris & Alim), the study addresses persistent academic disparities experienced by students of color. Using classroom observations, student surveys, student focus groups, and teacher interviews, the research examines how teacher facilitation and inclusive classroom environments affect behavioral, emotional, and cognitive engagement. Findings will inform actionable strategies to amplify student voice and promote culturally …

Navigating Emotional Transitions: A Study Of Self-Perception And Emotion In Bio-Childfree Women Entering A Blended Family, Janine Cednick

Dissertations

The transition to a blended family is an emotional and psychological adjustment for bio-childfree individuals. The present qualitative study investigated how self-concept and emotional adjustment of bio-childfree stepmothers change when they become members of their new family. With a phenomenological approach, semi-structured interviews were conducted with 12 female participants who were bio-childfree, in a committed relationship with a partner with children, and had cohabited for one year or more. The study aimed to find out how these women cope in their new role, their emotional adjustment to their transition, and the influences that impact their well-being. Thematic analysis of interviews …

Effective And Empowering Psychotherapy For Black Women: A Culturally Adapted Proposed Model, Kaylla A. Jackson

Dissertations

Black women in the United States are a minoritized group that has experienced oppression and suffering explicitly targeting their intersectional and minority identities. The intensity and frequency of stressors result in a negative impact on Black women that prompts a need to cope. Rather than relying on professional mental health care, many Black women rely on their religious and spiritual communities and other cultural and historical methods to cope with stressors. As a field and profession, clinical psychology has been overwhelmingly dominated by White individuals. The profession has a rich history of developing and perpetuating oppressive systems that have ignored …

Understanding The Afghan Newcomer Experience From The Perspectives Of Teachers And Students, Elisabeth C. Trost

Dissertations

Newcomer English learners (ELs) often arrive in the United States having fled persecution, economic or political oppression, war, or natural disasters in their country of origin. They are new to the English language, new to the American school system, at times well into their educational journey, and sometimes have missed out on significant amounts of formal schooling. Many also carry trauma from the circumstances that forced them to leave their homes. Most schools are not fully equipped to welcome these students and their families into the learning community, nor are they prepared to address the unique challenges newcomer ELs face. …

Empowering Educational Leaders: Enhancing Administrative Leaders’ Effectiveness Through Strategic Professional Development, Elizabeth Reed

Dissertations

This study analyzed the current state of professional development opportunities for administrative leaders across ten U.S. states. The research aimed to explore trends, perceived needs, and gaps in professional learning programs for educational administrators. The central research question guiding this study asked: How do administrative leaders perceive and experience existing professional development opportunities, and what areas require strategic improvement? A mixed methods approach was used, with survey data collected from administrative leaders serving in K–12 school settings. The survey instrument was designed to assess participants' perceptions of the relevance, effectiveness, and accessibility of their current professional development experiences. Data analysis …

A Phenomenological Qualitative Study Of Sense Of Community In An Inner-City Parochial School: Expanding The Seats At The Table., Mary Andree Darnall

Dissertations

St. Angela’s School is an elementary school in the Austin area of Chicago. This phenomenological qualitative study examined Sense of Community (SOC) at St. Angela’s, operationalized as “The feeling that St. Angela School is welcoming, psychologically and physically safe, that I matter, I am respected, and that I belong.” As an inner-city, parochial school, St. Angela’s has seen extensive changes in the neighborhood and the student population, both in ethnicity and enrollment. The last two principals requested a study of its SOC to identify solutions as diminished enrollment and teacher turnover have threatened its continued existence.

Thirty-three individuals …

Intersecting Inequities: Latinx Access To Mental Health Services, Melissa Thorson

Dissertations

This study examined barriers to mental health service utilization among Latinx populations using data from the 2022 National Survey on Drug Use and Health (NSDUH). Through the theoretical frameworks of Minority Stress Theory and Toxic Stress Theory, the study investigated the relationships between age, language proficiency, socioeconomic status, and mental health service access among different Latinx subgroups. Statistical analyses included chi-square tests, multiple regression, and mediation analyses on a sample of Latinx adults (N = 9,852). Results indicated associations between age and English proficiency (χ² = 145.23, p < .001, Cramer's V = 0.38), with 45% of adults aged 50 and older reporting limited English proficiency. Socioeconomic analysis revealed that 32% of older Latinx adults reported family incomes below $20,000, with insurance status partially mediating the relationship between income and service utilization (indirect effect = 0.15, 95% CI [0.08, 0.23]). differences in utilization rates emerged among Latinx subgroups (F(6, 1243) = 8.76, p < .001, η² = 0.12), with Mexican-origin individuals showing higher utilization (10%) compared to Puerto Rican individuals (2-3%). Age and socioeconomic status demonstrated interaction effects (β = 0.18, p < .01), while language proficiency moderated the relationship between age and service utilization (β = 0.24, p < .001). These findings suggest that barriers to mental health service utilization among Latinx populations are complex and interconnected, requiring multilevel interventions that address linguistic, cultural, and socioeconomic factors simultaneously. Implications for healthcare policy and service delivery are discussed, emphasizing the need for culturally responsive and linguistically appropriate mental health services.

The Battle Is Not Ours!: The Impact Of Racial Battle Fatigue On The Career Trajectory Of Black Women Administrators At Predominantly White Institutions, Tonishea M. Jackson

Dissertations

This qualitative narrative inquiry examines the impact of Racial Battle Fatigue (RBF) on the career progression of Black women administrators at Predominantly White Institutions (PWIs). While RBF has been studied extensively among students and faculty, there has been little research exploring its influence on Black women leaders who navigate both racial and gendered power structures in organizations where they are often underrepresented and unsupported. Grounded in the theoretical framework of Intersectionality, this study explores one primary research question: What is the relationship between RBF and the career paths of Black women administrators at PWIs, including the stages in their careers …

Narratives Of Latina Teacher Candidates On Subtractive Schooling Experiences And Their Language Identity, Joao Goebel

Dissertations

The subtractive nature of bilingual education in the United States has long impacted the language identities of Latinx students. Despite being raised in multilingual environments, many are schooled in systems that devalue their home languages and prioritize English-only instruction. This study explored how these dynamics influenced Latina teacher candidates’ perceptions of their own bilingualism and professional identities. The purpose of the study was to examine how Latina teacher candidates understood and constructed their language identities in the context of their K–12 and higher education experiences. The study used narrative research centered on four Latina teacher candidates enrolled in an undergraduate …

Building Bridges: Union Efforts To Address Stress Among Educational Staff, Theodore Michael Hamilton

Dissertations

This mixed-methods study examines the relationship between administrative support and educator stress and burnout in a post-COVID unionized school district. Grounded in Bronfenbrenner’s Ecological Systems Theory, the Job Demands-Resources (JD-R) model, and the Transactional Model of Stress and Coping, the study surveyed 102 educational professionals and conducted semi-structured interviews with union delegates. Quantitative findings revealed that 75% of staff worked beyond contracted hours, and 63% assumed additional unpaid responsibilities. Lower levels of perceived administrative support were significantly correlated with higher burnout and greater intent to leave the profession. Qualitative thematic analysis identified key stressors, including inconsistent administrative communication, escalating student …

The Heart Of The Defense: Exploring The Relationship Between Emotional Intelligence, Cultural Competence, And Client-Centered Lawyering In Public Defense, Cherise Burdeen

Dissertations

This dissertation explores the relationship between emotional intelligence (EI), cultural competence, and client-centered lawyering (CCL) within the public defense system. Using a mixed-methods design, this study analyzed quantitative data from 96 White public defenders and qualitative data from a focus group of 7 experienced public defense trainers. Because of the disparate racialized impact of the criminal legal system and anti-Blackness as a foundational component of the United States, cultural competence was operationalized as antiracism. Pearson correlations revealed significant, positive relationships between EI and CCL, r = .483, p < .001; antiracism and CCL, r = .356, p < .001; and EI and antiracism, r = .225, p = .027). Regression analyses indicated that EI significantly predicted both antiracism (β = .225, p =.027) and CCL (β = .483, p < .001), and that antiracism independently predicted CCL (β = .260, p =.004). A combined model including both EI and antiracism accounted for 29.7% of the variance in CCL scores, R² = .297, p < .001. Qualitative findings revealed that CCL and cultural competence are often viewed by attorneys as intuitive or already mastered, yet training on these skills typically provokes emotional dysregulation and resistance. The qualitative and quantitative analysis resulted in the Emotion-First Praxis Theory (EFPT), which posits that EI is a prerequisite for antiracist and client-centered practice, and that if contextualized in antiracist work, emotionally developed White facilitators should work with White people, to prepare them for the kinds of collaborations needed to ensure tangible results. Recommendations are offered to improve antiracism work in and beyond public defense systems. Future research should validate the CCL measure with clients, expand sampling, and empirically test EFPT in diverse settings.

Land Access As Liberation: A Qualitative Study On Faith, Food, And Farming Of Urban And Rural Black Land Stewards In The United States, Dominique Edwards

Dissertations

Since 1920, Black farmers in the United States have held less than 2% of the nation's farmland, a direct result of race-based discriminatory policies embedded within federal, state, local, and county-level institutions (Daniel, 2013). Structural barriers—ranging from exclusionary lending practices by the U.S. Department of Agriculture (USDA) to the systematic dispossession of land through legal loopholes, heirs’ property laws, and violent racial terror—have contributed to this staggering decline in Black land ownership (Gilbert et al., 2002). The erosion of Black agrarian landholdings intensified in the latter half of the 20th century, as government programs, civil rights legislation, and technological advancements, …