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Ligand-Based Drug Design : I. Conformational Studies Of Gbr 12909 Analogs As Cocaine Antagonists; Ii. 3d-Qsar Studies Of Salvinorin A Analogs As Kappa Opioid Agonists, Deepangi Pandit

Dissertations

Ligand-based drug design (LBDD) techniques are applied when the structure of the receptor is unknown but when a series of compounds or ligands have been identified that show the biological activity of the interest. Generally, availability of a series of compounds with high activity, with no activity, and also with a range of intermediate activities for the desired biological target is required. It is common that structures of membrane-bound proteins (for example, monoamine transporter proteins and opioid receptor proteins) are unknown as these proteins are notoriously difficult to crystallize.

In Part I of this study, analogs of the flexible dopamine …

Long Exposure Point Spread Function Estimation From Solar Adaptive Optics Loop Data, Jose Marino

Dissertations

Adaptive optics (AG) systems provide partial correction to wavefront distortions introduced by the Earth's atmosphere. They have become an essential tool to obtain diffraction-limited observations from ground-based telescopes. However, the AG correction is only partial and post-processing with a good estimate of the point spread function (PSF) is required.

PSF estimates are impossible to measure directly during solar observations due to the lack of point sources in the field-of-view. Moreover, the highly variable day-time seeing conditions require the estimated PSF to be simultaneous with the captured image. A method is presented to estimate the long-exposure PSF of AG-corrected solar observations …

Construction Of Fasr Subsystem Testbed And Application For Solar Burst Trajectories And Rfi Study, Zhiwei Liu

Dissertations

The construction of the Frequency Agile Solar Radiotelescope (FASR) Subsystem Testbed (FST) and observational results are described. Three antennas of Owens Valley Solar Array (OVSA) have been upgraded with newly designed, state of art technology. The 1-9 GHz RF signal from the antenna feed is transmitted via broadband (45 MHz-9.5 GHz) optical fiber links to the control room. The RF is then downconverted to a 500 MHz, single-sideband signal that can be tuned across the 1-9 GHz RF band. The data are sampled with an 8-bit, 1 GHz sampling-rate digitizer, and further saved to a computer hard disk. The full-resolution …

Reliability Studies Of Tin/Hf-Silicate Based Gate Stacks, Naser Ahmed Chowdhury

Dissertations

Hafnium-silicate based oxides are among the leading candidates to be included into the first generation of high-Κ gate stacks in nano-scale CMOS technology because of their distinct advantages as far as thermal stability, leakage characteristics, threshold stability and low mobility degradation are concerned. Their reliability, which is limited by trapping at pre-existing and stress induced defects, remains to be a major concern.

Energy levels of electrically active ionic defects within the thick high-Κ have been experimentally observed in the context of MOS band diagram for the first time in Hf-silicate gate stacks from low temperature and leakage measurements. Excellent match …

Central And Peripheral Autonomic Influences : Analysis Of Cardio-Pulmonary Dynamics Using Novel Wavelet Statistical Methods, Anne Marie Petrock

Dissertations

The development and implementation of novel signal processing techniques, particularly with regard to applications in the clinical environment, is critical to bringing computer-aided diagnoses of disease to reality. One of the most confounding factors in the field of cardiac autonomic response (CAR) research is the influence of the coupling of respiratory oscillations with cardiac oscillations.

This research had three objectives. The first was the assessment of central autonomic influence over heart rate oscillations when the pulmonary system is damaged. The second was to assess the link between peripheral and central autonomic control schema by evaluating the heart rate variability (HRV) …

Design And Performance Of Cdma Codes For Multiuser Communications, Radharani Poluri

Dissertations

Walsh and Gold sequences are fixed power codes and are widely used in multiuser CDMA communications. Their popularity is due to the ease of implementation. Availability of these code sets is limited because of their generating kernels. Emerging radio applications like sensor networks or multiple service types in mobile and peer-to-peer communications networks might benefit from flexibilities in code lengths and possible allocation methodologies provided by large set of code libraries.

Walsh codes are linear phase and zero mean with unique number of zero crossings for each sequence within the set. DC sequence is part of the Walsh code set. …

In Vitro Studies Of Degradation And Bioactivity Of Aliphatic Polyesther Composites, Georgia Chouzouri

Dissertations

In spite of numerous publications on the potential use of combinations of aliphatic polyester composites containing bioactive fillers for bone regeneration, little information exists on the combined in vitro mechanisms involving simultaneously diffusion for polymer degradation and bioactivity through nucleation and growth of apatite in simulated body fluid (SBF) solution. The objective of this study is to contribute to the understanding of the fundamentals in designing non-porous, solid materials for bone regeneration, from experimental data along with their engineering interpretation.

Bioactivity, in terms of apatite growth, was assessed through several experimental methods such as scanning electron microscopy (SEM), energy dispersive …

Comparative Immune Function In Wild Birds, Kevin David Matson

Dissertations

Over the last several decades, interest in quantifying immune function in comparative studies of wild animals has grown appreciably. Now, the field of ecological immunology is undergoing a transition, and ¿second generation¿ studies are being designed and carried out. With a greater appreciation of the complexity of immune systems, these second generation studies are commonly distinguished from their antecedents by making comparisons using multiple assays and including multiple species. I worked to advance this transition by developing novel approaches to comparative immunology, exploring the interrelationships among indices of immune function, and applying multiple indices to a question of comparative avian …

The Role Of Local And Regional Factors In The Foraging Ecology Of Birds Associated With Polylepis Woodlands, Grace Patricia Servat-Valenzuela

Dissertations

Understanding the extent to which patterns of functional structure are repeated in space and the scale at which different factors (local and regional) operate to explain community patterns are of important in community ecology. I studied the extent of spatial variation in foraging ecology of birds in the Polylepis community, a vegetation system of the Andes, in regard to variation in local (vegetation structure, floristic composition, food resources) and regional factors (biogeography). Specifically, I studied foraging ecology of nine insectivorous bird species (and the assemblage they conform) across twelve disjunct woodlands embedded in three biogeographic regions of the Peruvian Andes. …

Challenges Of Administering A Sino-U.S. Joint Venture Campus In China, Osman Ozturgut

Dissertations

Abstract With the recent globalization movement and decline in foreign student enrollment in universities in developed countries like the U.S., universities are looking for ways to bring education to the student rather than waiting for students to come for education. Therefore, opening a branch campus abroad and bringing education to the student became an alternative for U.S. universities to bringing students to their campuses. This qualitative study explored the political, economic, socio-cultural, and educational challenges of administering a Sino-U.S. joint-venture campus in the People¿s Republic of China. China American University (CAU) is an educational joint venture between China Investment Company …

E-Portfolios: Their Impact On Preservice Teachers' Self-Directed Learning And Computer Technology Skills, Yufang Carole Huang

Dissertations

Students in the Teacher Education Program at the University of Missouri-St. Louis have to complete their professional E-portfolios to be certified for the program. An E-portfolio demonstrates a future teacher¿s knowledge, skills, and abilities acquired through teaching and learning. Five qualitative case studies were investigated to understand how E-portfolios impact preservice teachers¿ self-directed learning readiness (SDLR) and computer technology skills (CTS). Data were gathered from the preservice teachers¿ pre- and post-questionnaires, interviews, observations, and their completed E-portfolios. Two internship students and three student teachers were observed creating their E-portfolios during a 16-week semester. During the period, some sought assistance from …

Bioengineering Of Protein Nanotubes And Protein Nanomaterial Composites, Thilak Kumara Mudalige

Dissertations

Flagella of Mesophilic bacteria such as E. coli are extremely ordered structures consisting of self-assemblies of flagellin 11-mers resulting in protein nanotubes of 2--3 nm inner diameter, 23 nm outer diameter, several microns in length and 5.4 nm separation between 11-mer segments. They are as a result attractive scaffolds and templates for the generation of uniform nanotubes and ordered array of nanoparticles. In this study fusion protein of bacterial flagellin (Fli C) and core thioredoxin (Trx), pFliTrx was used as peptide display on bacterial flagella. This was accomplished in the current research by introducing various peptide loops such as cysteine, …

Validating The Experiences Of Male Mexican American Community College Transfer Students Studying At Catholic Universities, Eliazer Ayala-Austin Edd

Dissertations

California's community colleges and public and private universities must collaborate to address the Tidal Wave II student enrollment surge composed mostly of Hispanic/Latinos and Asian students in order to meet the educational needs of community college transfer students (CCTSs). Avoiding the issue will result in continued neglect of CCTS within public and private institutions; possible outcomes include delayed graduation and potential attrition of at-risk students. Using Rendón's (1994) theory of student validation as the theoretical framework, this qualitative study uncovered the validating and other university experiences of male Mexican American CCTSs. This qualitative study included individual interviews of six CCT …

Communication And Leadership: Faculty Perceptions Of The Department Chair, Kathleen Czech Edd

Dissertations

With department chairs providing a critical link between faculty and administration, their leadership impacts universities on a broad level. However, chairs often report dissatisfaction with the position and experience rapid turnover. In an effort to help understand the role that communication plays in effective leadership for department chairs, this study provides an empirical test of Gibb's theory of defensive vs. supportive communication. As such, this project investigated the communication and leadership behaviors of university department chairs as evaluated by their faculty members. Specifically, 202 randomly selected faculty members from colleges and universities affiliated with the Council of Independent Colleges, Washington, …

Examining Stage Theories And The Predisposition To Lead Within The Homosexual Community, David Robert Blair Edd

Dissertations

An application of homosexual stage-based self-integration theory suggests that until gay individuals have become fully self-integrated, their capacity for leadership within the community is diminished. Unfortunately, now more than ever before, leadership is needed in dealing with such pressing community issues as the disproportionately high suicide rate among gay teens, the ongoing struggle for gays to become fully self-integrated individuals, bringing equal rights to the gay population, and of course, developing a base of strong gay leaders to meet the ongoing challenges facing this population. To test the self-integration-leadership hypothesis, this study surveyed 150 men in gay Internet chat rooms …

Teachers' Perceptions Of A 360-Degree Feedback Process, Catriona Collins Moran Edd

Dissertations

In recent years, the 360° feedback process, which originated in the business world in the 1980s, has been increasingly used for the purpose of teacher evaluation. When this is done, feedback from peers, parents and students, as well as teacher self-reflection and student achievement data, are used in addition to more traditional evaluation strategies. Despite its growing popularity, however, there have been very few published studies about the impact of the 360° feedback process in the business world and even fewer in the field of education. The overarching purpose of this qualitative study was to discover teachers' perceptions of a …

A Mixed Methods Study On Cbam And The Adoption Of Thin Client Computers By Adolescents, Cynthia Sistek-Chandler Edd

Dissertations

Although stages of change and adoption of innovation dynamics have been examined for adult populations, comparable research for adolescents is limited. Applying a change instrument grounded in Concerns-Based Adoption Model (CBAM) to an adolescent population, this study investigates perceptions of 45 middle school students who used thin client portable computers in a one-to-one program at home and at school for 3 years. A mixed methodology design identified which of the 7 stages of concern students passed through and why some students adopted the innovation more readily than others. The Change Facilitator Stages of Concern Questionnaire, a modified version of CBAM, …

The Lived Experience Of Wives And Husbands With Coronary Heart Disease, Patricia A. Bradley Phd

Dissertations

The purpose of this feminist hermeneutic study was to discover the meaning of living in the community with a husband who has coronary heart disease (CHD). Ten women, aged 47-74 who were married from 4 to 55 years, participated in unstructured face to face interviews. The women were interviewed 6 to 18 months after their husbands were diagnosed with medically or surgically treated CHD. Audio recorded transcribed interview data were analyzed to identify the essential themes and sub-themes. Texts were interpreted guided by hermeneutic phenomenology (Gadamer 1960/1989; 1976) and van Manen's (1990) research activities. A feminist lens was applied to …

Transition To Nursing Home Of Korean-American Elders, Myungja Kim Hahm Phd

Dissertations

The purpose of this study was to explore factors affecting Korean-American (KA) elders during the transition to nursing homes in the first month following admission. The three aims of this proposed study were (1) to explore culture specific factors that affect KA elders' perspectives during the transitional period to a nursing home, (2) to identify thoughts and feelings of KA elders about their admission into a nursing home, (3) to describe the adjustment process associated with admission to a nursing home. A grounded theory design was utilized to explore KA elders' perceptions/experiences associated with adjustment to a nursing home. Open-ended, …

Factors That Motivate Or Discourage Movement Into School Leadership Positions And The Implications For Recruitment Policy And Practice, Ginger Lee Blackmon Edd

Dissertations

Public schools in the United States are facing one of the most extensive transformations in school leadership. Districts face the difficult challenge of recruiting and training school leaders who have the capacity to deal with the growing demands and responsibilities placed on school site administrators. Despite a surplus of people certified for administration, the changing demands of the principal's job precipitated by national reform efforts have left a shortage not only of qualified applicants, but also in the total number of applicants (qualified and unqualified) willing to carry the burden of the job. This study investigated the factors that influence …

An Empirical Study Of Employee Relations And Managerial Malpractice Risks In A Four-Year Public Higher Education System, Robert Lee Brown Edd

Dissertations

Over the last decade, the rapid rise in college tuitions and fees has become a national priority, with congressional committees and scholars interested in solving this persistently stubborn and often intractable problem. Although a number of reasons for this phenomenon have been discussed, one theoretically plausible but untested explanation involves the extent to which campus climate may be empirically linked to the costs of managing various legal claims against the university, including workers' compensation, employment practice, and stress claims. To test the empirical validity of this hypothesis, this study gathered campus climate and claims data from 23 campuses and 25 …

Integrating Total Disability Management In A Climate Of Change: A Case Study, Mary E. Jesko Edd

Dissertations

Integrated disability management (IDM) is a cost-containment strategy increasingly being employed by human resources and risk management departments to address occupational and non-occupational illness and injury in a consistent manner. The goal is to both reduce on-the-job injury and minimize the loss of work time due to injury or illness. Although a large number of organizations have embraced the IDM concept, implementing IDM often is difficult because of the complex array of contracts, policies, procedures, corporate cultures and structures. Although extensive research has examined leaders' influence on change in various types of businesses, to date, research has not specifically explored …

Experiences Of Sacramental Marriage, James Patrick O'Brien Edd

Dissertations

This study interprets the stories told by eight couples about their experiences approaching marriage as a religious sacrament. The eight couples represented a purposeful sample selected using the following criteria: (a) They self-identified as having a sacramental marriage within the Roman Catholic tradition; (b) they appeared to be information rich sources who could provide an emic, i.e., an insider, view of the sacramental marriage experience; (c) they participated in the Catholic Cursillo movement; (d) they engaged in observable religious practices; and (e) they parented children. Research methods included guided conversation, participant observation, and a timeline activity that asked participants to …

Effect Of Computer-Aided Instruction On Grades In Middle School Algebra, Patricia A. Taepke Edd

Dissertations

Computers and targeted software are increasingly common in the middle school algebra classroom, but the efficacy of computer-aided instruction on classroom achievement in middle school algebra remains unclear. Participants were 1452 middle-school algebra students who were seldom, occasionally, or often exposed to the algebra modules of Destination Math, an interactive mathematics software designed to be appropriate for in-school use. Data were collected over three years (2002–04) and included the cooperation of the algebra teachers, who were subsequently interviewed. Data were analyzed with ANOVA, ANCOVA, and multiple regression. Statistically significant effects were localized using pairwise tests with Bonferroni correction for multiple …

Building Management Bench Strength: A Qualitative Look At A Job Rotation Program, Paige Litton Creager Phd

Dissertations

Job rotation programs are known in the organizational development field as one of the primary components used in a successful employee development program. To date little research has gone beyond the quantifiable reporting of practices. The view of program participants has been unaccounted for, and consequently the organizational development field has lacked a holistic understanding of how employees succeed and fail in these programs. This research offers a current perspective on job rotation: A means of accelerating the development of high potential employees in order to build a strong management bench. A qualitative grounded theory approach was used to investigate …

Stakeholders’ Perspectives Of A Catholic K-8 School As A Caring Community, Marci-Anne Hanks Edd

Dissertations

Many educators and researchers have found that caring school communities positively affect students’ behavior, academic achievement, and socioemotional development. Students’ basic needs of feeling cared for must be met for them to realize their full potential. The purpose of this study was to investigate stakeholders’ perceptions of a Catholic K-8 school as a caring community. Stakeholders included parents, teachers, administrators, staff members, and sixth through eighth grade students. The following research questions were posed for this study: (1) What are the different stakeholders’ perceptions of the school as a caring community? (2) Are there significant differences in perceptions between the …

An Investigation Of The Community-Based English Tutoring Program (Cbet), Barbara J. Pongsrikul Edd

Dissertations

Currently in the California K-12 public schools, approximately 25% (about 1.5 million) of the students know little or no English, and their numbers are increasing. Because of this diverse student population, a research study by the Gevirtz Research Center in 2005 reports that it is necessary to develop educational programs that help language-minority families understand and participate in the school system in ways that will support the academic success of their children. As a result of the Proposition 227 Initiative in California, statewide family literacy programs were established as Community-Based English Tutoring (CBET) programs to provide adult English language instruction …

Emerging Elements Of Leadership In A Complex System: A Cognitivist Approach, Kirsten Suzanne Hanson Edd

Dissertations

As our world grows increasingly complicated at an intensified pace, leaders must be facile managers of complexity if organizations and society are to productively and peacefully evolve. Today’s global corporations are microcosms of complexity and have the potential to affect life for almost all other species. However, many organizations have not yet become aware of themselves as “living” and still operate as industrial age institutions with rationalist thinking traditionally dominating management practice. Many factors impact an organization’s overall effectiveness. Yet, executive leaders are seen as having the ability to influence change and play a vital role in helping people navigate …

A Concerns-Based Adoption Model Study Of University Instructors Engaged In Faculty Development For Enhancing Learning With Technology, James W. Julius Edd

Dissertations

For over a decade, theorists have suggested that higher education institutions are in the midst of a shift from an emphasis on student access to instruction to student success in learning. Digital technologies are one “lever” increasingly touted as a means to improve teaching and learning in higher education. Because serious efforts at technology integration not only require competence with the technologies, but also often result in changes to instructional methods, colleges and universities are urged to consider faculty development needs. This study detailed how instructor change unfolded in response to a faculty development program intended to enhance the use …

Principals’ Leadership And Its Association With Whether Or Not Their Schools Meet District/State Peformance Goals, John Mark Rainey

Dissertations

The study focuses on the principals’ leadership and empowerment as a curriculum leader in meeting district and state mandated performance goals. The No Child Left Behind (NCLB) Act of 2001 represents a key increase in the role of the federal government in public education.

The research questions in the study addressed the levels of principals’ instructional leadership and empowerment as associated with number of years as teacher, number of years as principal, participation in an aspiring principal program, school size, school locale, and whether their school passed district or state accountability test.

As to principals’ leadership, principals reported that they …