Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Dissertations

Discipline
Institution
Keyword
Publication Year
Publication Type

Articles 31 - 60 of 7696

Full-Text Articles in Entire DC Network

"A Door To The Future." A Case Study In Exploratory And Culturally Sustaining Theater Curriculum, Verónica Meza Jul 2026

"A Door To The Future." A Case Study In Exploratory And Culturally Sustaining Theater Curriculum, Verónica Meza

Dissertations

This study addresses the persistent inequities in access to quality arts education for Latino immigrant and linguistically diverse communities in California. Despite progressive initiatives such as Proposition 28 (The Arts and Music in Schools Act) and the California Arts Council's Racial Equity Statement, systemic barriers prevent Latino and immigrant students from benefiting equitably from the arts. The central objective of this project is to understand how an exploratory, culturally sustaining theater curriculum can serve as a transformative and healing vehicle for adult immigrant Latino students, providing emotional protection, cultural affirmation, and language preservation within a U.S. educational context. This qualitative …


Effect Of Virtual Reality Intervention Of Postoperative Pain In Pediatric Surgical Patients, Tara L. Kempker Jul 2026

Effect Of Virtual Reality Intervention Of Postoperative Pain In Pediatric Surgical Patients, Tara L. Kempker

Dissertations

Problem: Pediatric surgical procedures are associated with preoperative anxiety. Preoperative anxiety is associated with higher postoperative pain. Multiple studies have found that decreasing preoperative anxiety using Virtual Reality (VR) Intervention also decreases postoperative pain scores and use of rescue analgesics in postoperative care units (PACU). However, there is no standardized protocol for use of VR interventions and in our institution, VR was not utilized at all.

Methods: This quality improvement (QI) initiative utilized a quasi-experimental design and convenience sampling. Quantitative data was collected during visits for scheduled operative visits for pediatric surgical patients ages seven to 18 years …


Sleep Disturbances Affect Sleep Quality Of Hospitalized Adults, Tonjia Hardesty Jul 2026

Sleep Disturbances Affect Sleep Quality Of Hospitalized Adults, Tonjia Hardesty

Dissertations

Abstract

Background: Sleep disturbances affect the quality of sleep hospitalized adults experience, possibly extending patient recovery time. Treatment of insomnia frequently includes pharmacological interventions exposing patients to potential side effects, leading to negative patient outcomes.  The purpose of this project was to determine if a sleep hygiene toolkit including eye masks, earplugs, advocacy cards, and removal of nicotine patches at bedtime would improve patient sleep quality without use of pharmacological interventions.

Methods: A descriptive observational design was used in this quality improvement (QI) project. A convenience sample of 37 (N =37) participants over the age of 18 years and …


Psychotropic Medication Use In Older Adults In A Long-Term Care Facility: Implications For Screening Tool, Callie M. Johnson Jul 2026

Psychotropic Medication Use In Older Adults In A Long-Term Care Facility: Implications For Screening Tool, Callie M. Johnson

Dissertations

Psychotropic medication use in older adults aged 65 years and older residing in the long-term care facility has a complex issue in the high use of psychotropic medications. Older adults residing  in long-term care (LTC) facilities are affected and prescribed at least one psychotropic or antidepressant medication.


Enhancing Well-Being: Implementing Weekly Social Interventions For Older Adults In Independent Living, Rosa Huang Jul 2026

Enhancing Well-Being: Implementing Weekly Social Interventions For Older Adults In Independent Living, Rosa Huang

Dissertations

Loneliness and social isolation significantly impact the physical and mental well-being of older adults. This quality improvement project implemented an eight-week social intervention designed to reduce loneliness and enhance well-being through weekly sessions incorporating mindfulness exercises, gratitude journaling, and structured socialization activities. The intervention was delivered by nursing students to a sample of residents in a Midwestern independent living community. While most standardized measures of loneliness and mood did not show statistically significant changes, the project resulted in a statistically significant increase in social network engagement as measured by the Lubben Social Network Scale-6 (LSNS-6). The findings suggest that group-based …


Defining Contractile And Age-Specific Remodeling In Atrial Fibrillation, Hannah Cizauskas Jul 2026

Defining Contractile And Age-Specific Remodeling In Atrial Fibrillation, Hannah Cizauskas

Dissertations

Atrial fibrillation (AFib) is the most common cardiac arrythmia worldwide and is characterized by hallmarks including electrical, fibrotic, and hemodynamic remodeling, each of which can cause or be caused by alterations in the contractile apparatus. However, there is little known about contractile remodeling in AFib. While our current understanding of AFib lacks contractile remodeling, it also largely ignores the contribution of aging-induced remodeling. Aging is the strongest risk factor for AFib development, with most patients diagnosed with AFib over the age of 70, and aging also involves the three molecular hallmarks of AFib, which could explain increased susceptibility of AFib …


Monitoring And Short-Term Forecasting Of Atmospheric Air Pollutants Using Deep Neural Networks, Prasanjit Dey Jul 2026

Monitoring And Short-Term Forecasting Of Atmospheric Air Pollutants Using Deep Neural Networks, Prasanjit Dey

Dissertations

Accurate forecasting of near-surface atmospheric air pollutants such as PM2.5, NO2, SO2, CO, and O3 remains a critical scientific and societal challenge. This difficulty arises from several factors, including nonlinear pollutant dynamics, sparse ground monitoring net works, heterogeneous satellite observations, and strong cross-pollutant interdependencies. Substantial advances have been achieved in temporal deep learning, probabilistic modeling, satellite-based estimation, physics-informed methods, and foundation models. However, these paradigms have largely evolved in isolation. As a result, existing systems are often station-dependent or pollutant-specific and optimized for a single forecasting task. This limits their robustness and generalizability across regions and heterogeneous data regimes.

This …


Don't Force Me To Explain: Rethinking Access Outside Of Compulsory Transparency, Rhea Ienni Jun 2026

Don't Force Me To Explain: Rethinking Access Outside Of Compulsory Transparency, Rhea Ienni

Dissertations

My dissertation is concerned with better understanding the barriers disabled people encounter while attempting to procure access both at the institutional level, and in their everyday lives. Within disability and accessibility literature, there are many discourses on what disability is and what access means. However, there are few people who explore the harmful consequences of disabled people being forced to “prove” they are disabled to an ableist world to get their basic needs met, and my dissertation intervenes in this gap. Within current US policy, if a disabled person requires access support at the institutional level, they must provide medical …


Being Desi At School: Exploring The Racialized School Experiences Of South Asian American Youth, Prabha Kaundinya Jun 2026

Being Desi At School: Exploring The Racialized School Experiences Of South Asian American Youth, Prabha Kaundinya

Dissertations

Schools in America have been central areas for racialization, and as an immigrant, racial-ethnic minority population, South Asian American (SAA) students have been subjected to a variety of racialization processes (S. J. Lee et al., 2017; Rice, 2017, 2019; Subedi, 2013). However, what is known about SAA educational experiences is often based on celebratory stereotypes that proclaim their uniform success while neglecting attention towards the diversity of their needs (including academic, social-emotional, or mental health needs; Saran, 2015; Ngo & Lee, 2007; P. Patel & Patel, 2017; Pedraza & Guillaume, 2023; N. Sharma et al., 2020). This dissertation uses a …


Responsive Rigor And Strategic Care: Faculty Praxis For Holistic Student Success In The Community College, Jennifer Elizabeth Kelley Jun 2026

Responsive Rigor And Strategic Care: Faculty Praxis For Holistic Student Success In The Community College, Jennifer Elizabeth Kelley

Dissertations

This qualitative study examines how community college faculty conceptualize, communicate, and enact academic rigor and care in their teaching practice. While post-pandemic debates have positioned rigor and care as opposing forces—evident in the "Rigor Wars" that framed care as performative laxity and rigor as gatekeeping—community college faculty successfully integrate these practices to support holistic student success. This research addresses critical gaps in higher education scholarship, which has studied rigor and care separately, focused primarily on four-year institutions, and overlooked faculty perspectives on how integration occurs in practice. Drawing on a single-case study of 38 faculty members at a large Midwestern …


A Qualitative Study Of Gratitude Practice Among Won Buddhist Older Adults And Implications For Gerontological Social Work, Sungsim Lee Jun 2026

A Qualitative Study Of Gratitude Practice Among Won Buddhist Older Adults And Implications For Gerontological Social Work, Sungsim Lee

Dissertations

Although gratitude has been widely studied in social science, existing scholarship has largely relied on Western worldviews and quantitative research frameworks, limiting understanding of lived gratitude experiences within diverse spiritual and cultural contexts, including Eastern spiritual traditions. In Won Buddhism, originating in South Korea, gratitude holds a central place in spiritual life and is understood as an essential practice. This qualitative study explores the views of Won Buddhist older adult practitioners regarding their experiences, benefits, and challenges of engaging in spiritually grounded gratitude practice. Semi-structured interviews were conducted with 23 practitioners aged 65 and older from English-speaking Won Buddhist communities. …


Jesus-Centered Preaching: A Christocentric Approach Based On The Hermeneutical Implications Of The Gospels As Βίοι., Mark Palmer Jun 2026

Jesus-Centered Preaching: A Christocentric Approach Based On The Hermeneutical Implications Of The Gospels As Βίοι., Mark Palmer

Dissertations

The purpose of this study was to discover the implied hermeneutic of the Gospels as βίοι and to propose a congruent homiletic. The study addressed the following research questions: What is the genre of the Gospels and the resulting hermeneutic? Does current Christ-centered preaching account for his hermeneutic? Does Christological research account for intrinsic characteristics? What is the intrinsic Christology of Mark’s Gospel? What homiletical process is needed to align with the genre-based hermeneutic of the Gospels? The methodology of this study followed a four-step process: Genre research confirming the Gospels as βίοι, Christological research including the development of an …


Enhancing The Metacognitive Thinking Of Middle-Grade Multilingual Learners: A Design-Based Research Study Leveraging Dialogic Teaching, Renee R. Burns Jun 2026

Enhancing The Metacognitive Thinking Of Middle-Grade Multilingual Learners: A Design-Based Research Study Leveraging Dialogic Teaching, Renee R. Burns

Dissertations

This study explores how dialogic teaching can enhance metacognition and self-efficacy among middle school multilingual learners (MLs) who face challenges with the academic language demands of literacy tasks. Using a design-based research (DBR) methodology, specifically formative experiment, the Metacognitive Dialogic Teaching Protocol (MDTP) was implemented over seven iterative cycles. The research questions were as follows: How do dialogic interactions impact metacognition in middle-grade MLs? How does Metacognitive Dialogic Teaching affect comprehension development in these students? And how does it influence their self-efficacy? The participants included six middle-grade MLs engaged in a Tier 2 literacy intervention who initially exhibited fake reading …


Predicting Clinical Outcomes Of Non-Specific Low Back Pain By Studying The Interaction Of Clinical And Demographic Factors Of A Retrospective Data Set, Erica Michelle Fernandes Jun 2026

Predicting Clinical Outcomes Of Non-Specific Low Back Pain By Studying The Interaction Of Clinical And Demographic Factors Of A Retrospective Data Set, Erica Michelle Fernandes

Dissertations

The purpose of this research is to investigate demographic factors, including age, gender, body mass index (BMI), race, marital status, insurance type, severity of disease (initial pain level), and clinical factors such as number of visits (no. of visits) at physical therapy (PT), length of time at PT and the type of clinician either physical therapist versus physical therapy assistant (PTA), that most predict PT clinical outcomes in patients with nonspecific low back pain (NSLBP) and see if there is an interaction between demographic and clinical variables.

Methods

The current study is a retrospective, cross-sectional, observational study using secondary electronic …


The Impact Of Reliable Backup Childcare Services On Work-Life Balance And Stress Levels Among Working Parents, Christiana Arhin Jun 2026

The Impact Of Reliable Backup Childcare Services On Work-Life Balance And Stress Levels Among Working Parents, Christiana Arhin

Dissertations

The purpose of this study is to investigate the relationship between access to reliable backup childcare services, work-life balance, and stress levels among working parents. Building on Arhin’s (2025) research, this study seeks to address limitations in sample diversity and incorporate qualitative methods to gain deeper insight into these variables. Using a mixed-methods approach, the study will examine how access to backup childcare services influences work-life balance and stress levels, with a focus on capturing both quantitative trends and qualitative perspectives of working parents. By exploring these relationships, the study aims to provide a more comprehensive understanding of the role …


Campus Community Vibes: How Queer Asian American Students Navigate Their Higher Education Experiences, Nathan Nguyễn Jun 2026

Campus Community Vibes: How Queer Asian American Students Navigate Their Higher Education Experiences, Nathan Nguyễn

Dissertations

Misconceptions and stereotypes about Asian American college students include the belief that they are innately academically successful and that if Asian American students struggle, their challenges do not compare to their Black/African American, Hispanic/Latine, or Native American/Indigenous counterparts (Museus & Buenavista, 2016). Contemporaneous to this, lesbian, gay, bisexual, transgender, and queer (LGBTQ) college students experience interrogation, exploration, and various levels of support regarding their sexuality and/or gender identity. At this intersection, queer Asian American students must navigate campus settings that can enhance or diminish their agency for different facets of their identities (Crenshaw, 1991; Iftikar & Museus, 2018; Ray, 2019). …


Evaluation Of Neuroplastic Changes In Psychological Intervention And Contemporary Treatments Of Depression, Taylor Severance Jun 2026

Evaluation Of Neuroplastic Changes In Psychological Intervention And Contemporary Treatments Of Depression, Taylor Severance

Dissertations

Major depressive disorder is one of the most prevalent mental health disorders worldwide. There is a vast range of treatment options for depression, with varying levels of effectiveness. Recent treatments for depression have expanded, increasing alternative treatments, and it is unknown which treatments have the largest impact on depression. This research was designed to examine the treatments of depression, with a focus on psychotherapy and contemporary treatments such as ketamine, psilocybin, and transcranial magnetic stimulation. A literature review was conducted to assess treatment outcomes and neuroplastic changes in these interventions, as well as combinations of the interventions. Data were evaluated …


Exercise Therapy For Mood Disorders In Retiring/Former Athletes, Christian Antos Jun 2026

Exercise Therapy For Mood Disorders In Retiring/Former Athletes, Christian Antos

Dissertations

This dissertation examined the potential integration of exercise therapy and psychotherapy as a treatment approach for mood-related difficulties experienced by former elite athletes during the transition out of competitive sport. Retirement from athletics is often associated with significant biopsychosocial challenges, including disruptions in identity, healthy routines, social support, and emotional well-being. Existing literature suggests that exercise may serve as an effective adjunctive intervention for improving mood and overall psychological functioning, though limited research has explored its application among retiring athletes within psychotherapeutic contexts. This literature review synthesized current research related to athletic retirement, neurobiological mechanisms associated with physical activity, and …


Effectiveness Of Monetary Policy Communication: Evidence From Textual Analysis Of Daily Newspaper Articles, Bisrat Abebe Woldesilassie Jun 2026

Effectiveness Of Monetary Policy Communication: Evidence From Textual Analysis Of Daily Newspaper Articles, Bisrat Abebe Woldesilassie

Dissertations

Monetary policy communication has become a crucial tool for central banks to shape market expectations and enhance transparency. The goal of this paper is to measure how effectively the Fed communicates monetary policy through FOMC minutes by analyzing the impact of the release of FOMC minutes on financial markets through textual sentiment analysis of daily newspaper articles. I measure the surprise in the daily news sentiment that is caused by FOMC minutes release. The surprise in the sentiment is calculated as the change in the news sentiment that is measured over three weeks prior to the release of the FOMC …


Addressing Mental Health Issues And The Effectiveness Of Cognitive Behavioral Therapy And Mindfulness-Based Interventions Among Athletes, Shelby Jones-Stachnik Jun 2026

Addressing Mental Health Issues And The Effectiveness Of Cognitive Behavioral Therapy And Mindfulness-Based Interventions Among Athletes, Shelby Jones-Stachnik

Dissertations

This literature review identifies mental health concerns among competitive athletes and evaluates psychological interventions to address these challenges. Specifically, the review explores the mental health concerns experienced by athletes engaged in high-level sport. It examines whether cognitive behavioral therapy and mindfulness-based interventions are effective approaches for improving psychological outcomes in this population. A systematic review of peer-reviewed research was conducted, and findings were synthesized to evaluate the effectiveness of cognitive behavioral therapy and mindfulness-based interventions. The review included randomized controlled trials, quasi-experimental studies, and meta-analyses examining psychological interventions in athletic populations. Findings across the literature indicate that both cognitive behavioral …


Disability Employment In Côte D’Ivoire: Human Resources Managers’ Experiences And Challenges, Kinanpy Vanessa Toure Jun 2026

Disability Employment In Côte D’Ivoire: Human Resources Managers’ Experiences And Challenges, Kinanpy Vanessa Toure

Dissertations

This study examined the critical role of human resource (HR) managers in promoting workforce integration and addressing the persistent barriers faced by people with disabilities (PWDs) in Côte d'Ivoire. Focusing on the perspectives, challenges, and lived experiences of HR managers, the research explored how inclusive workplace practices were developed and implemented within the Ivorian context. Employing a qualitative case study design, the study utilized semi-structured, scenario-based interviews and analyzed allowable public documents, specifically the Ivorian Labor Code, a relevant NGO publication addressing disability inclusion in Côte d’Ivoire, and the publicly available websites of participating organizations. This approach was intended to …


Leading With Emotional Intelligence: Strengthening Leadership Effectiveness In Early Childhood Education, Christy L. Martin Jun 2026

Leading With Emotional Intelligence: Strengthening Leadership Effectiveness In Early Childhood Education, Christy L. Martin

Dissertations

This study examined the role of emotional intelligence (EI) in leadership effectiveness within early childhood education settings. Leadership in these contexts involves navigating complex relationships, staff stress, and organizational demands, yet leadership preparation often emphasizes technical skills over emotional competencies. The study explored how EI influences leadership effectiveness and how reflective practices support leadership development. Guided by the question How does emotional intelligence impact leadership effectiveness?, the study used a mixed-methods design. Quantitative data were collected through an EI Inventory of Practices self-assessment measuring four EI domains, and qualitative data were gathered through semi-structured interviews. Findings suggest emotionally intelligent …


Mechanics And Physical Attributes Of Nature-Based Alterations: Rock Reinforcement And Urban Heat Island Assessment, Mary Chikondi Ngoma May 2026

Mechanics And Physical Attributes Of Nature-Based Alterations: Rock Reinforcement And Urban Heat Island Assessment, Mary Chikondi Ngoma

Dissertations

Ground improvement is critical to geotechnical and geo-engineering systems, where modification of the properties of geomaterials (rocks and soils) is required to maintain stability and prevent failure of infrastructure installed within and around them. This need has become increasingly important with rapid urbanization and population growth, which intensify demands on surface and subsurface systems and further challenge the performance of supporting geomaterials. As a result, there is growing interest in nature-based solutions, particularly biologically mediated processes such as biocementation, which can enhance the physical, hydraulic, and mechanical properties of geomaterials while offering environmentally sustainable alternatives to conventional ground improvement techniques. …


Enabling Ml/Ai In 6g And Future Wireless Communication With Privacy Preservation, Mec Offloading And Quantum Computing, Changshi Zhou May 2026

Enabling Ml/Ai In 6g And Future Wireless Communication With Privacy Preservation, Mec Offloading And Quantum Computing, Changshi Zhou

Dissertations

The forthcoming sixth-generation (6G) and future wireless networks are envisioned to support an unprecedented range of services, delivering ultra-low latency, massive connectivity, and intelligent real-time responsiveness. These capabilities will enable emerging applications such as extended reality (XR), autonomous vehicles (AVs), industrial robotics, and the Internet of Things (IoT) to reach their full potential. Achieving this vision requires the integration of enabling technologies such as artificial intelligence and machine learning (AI/ML) and quantum computing, which are poised to play central roles in shaping the landscape of wireless communication systems.

In AI-native, data-driven, and computing-centric 6G networks, ML models will be deeply …


Vergence Task-Based Neural Pathways With Binocularly Normal Vision And Comorbid Persistent Post-Concussive Symptoms -Convergence Insufficiency, Ayushi Sangoi May 2026

Vergence Task-Based Neural Pathways With Binocularly Normal Vision And Comorbid Persistent Post-Concussive Symptoms -Convergence Insufficiency, Ayushi Sangoi

Dissertations

Binocular dysfunctions are more prevalent in the persistent post-concussive symptoms (PPCS) population than in the general population. The most prevalent binocular disorder is convergence insufficiency (CI), affecting 3-17% of the general population and up to 10 times as many people with PPCS. CI makes it difficult to fuse or maintain fusion on targets at near, and its symptoms include double or blurry vision and headaches when performing close-range tasks such as reading, which can exacerbate PPCS symptoms. Given controversy over the subjectivity and effectiveness of diagnostic tools and symptom surveys for both PPCS and CI, understanding why CI has high …


Disentangling Non-Thermal Electron Injection And Decay In Solar Flares Using Multi-Wavelength Radio Observations, Brian Eugene O’Donnell May 2026

Disentangling Non-Thermal Electron Injection And Decay In Solar Flares Using Multi-Wavelength Radio Observations, Brian Eugene O’Donnell

Dissertations

The broadband microwave imaging spectroscopy capability provided by the Expanded Owens Valley Solar Array (EOVSA) allows new diagnostics of high-energy processes in solar flares, providing spatially and temporally resolved spectra rich in information about the acceleration and transport of energetic electrons.

In this work, injections and transport of energy and particles into the solar corona during flares are studied. This is accomplished through the development and use of the PIP_Decomp Fitter, an automated fitting tool made by the author to fit injection and precipitation/decay parameters using the spatially resolved radio spectra obtained by EOVSA. These tools are used to study …


A Generative Ai-Driven Computational Framework For Industry-Scale Discovery Of Novel Battery Materials, Joy Datta May 2026

A Generative Ai-Driven Computational Framework For Industry-Scale Discovery Of Novel Battery Materials, Joy Datta

Dissertations

The growing demand for sustainable, high-energy-density electrochemical storage has motivated the exploration of multivalent-ion batteries based on earth-abundant elements such as aluminum, calcium, magnesium, and zinc. While multivalent charge carriers offer higher theoretical energy density than lithium, their practical deployment is hindered by sluggish ion transport, strong ion-host interactions, and structural degradation of electrode materials. Identifying host materials that can reversibly accommodate multivalent ions while maintaining structural integrity remains a fundamental challenge. The dissertation develops a scalable, end-to-end computational framework that integrates density functional theory (DFT), machine learning (ML), and generative artificial intelligence (GenAI) to accelerate the discovery of next-generation …


Toward Learning-Based Reconstruction And Part Decomposition Of Man-Made 3d Geometry: Neural Implicit Representations And Scalable Supervision, Shen Fan May 2026

Toward Learning-Based Reconstruction And Part Decomposition Of Man-Made 3d Geometry: Neural Implicit Representations And Scalable Supervision, Shen Fan

Dissertations

Digital three-dimensional (3D) models are central to engineering design, analysis, and manufacturing, but learning pipelines for man-made geometry often operate on sampled carriers that do not preserve all of the structure present in exact CAD representations. This dissertation studies learning-based reconstruction and part decomposition for structured man-made 3D geometry, from general object benchmarks to CAD-derived datasets, with a focus on neural implicit representations trained from signed-distance samples, point clouds, and tessellated meshes. The goal is to make these models more accurate, more part-aware, and more consistently supervised.

First, signed distance function (SDF) reconstruction with implicit neural representations is improved through …


Glass Transition Temperature Of Plga Nanoparticles And The Application In Drug Delivery, Guangliang Liu May 2026

Glass Transition Temperature Of Plga Nanoparticles And The Application In Drug Delivery, Guangliang Liu

Dissertations

The glass transition temperature (Tg) of poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles plays a crucial role in governing molecular mobility, diffusion, and consequently, drug release kinetics. However, the interaction among residual surfactant, drug effect, nanoscale confinement, and release medium on Tg remains insufficiently characterized. This study aims to bridge this gap by correlating the thermal behavior of PLGA nanoparticles with their drug release behavior under physiologically relevant conditions.

In the present study, PLGA nanoparticles were synthesized using both nano-emulsion and surfactant-free nano-precipitation approaches. The influence of residual surfactants - poly(vinyl alcohol) (PVA) and didodecyldimethylammonium bromide (DMAB) - was systematically …


Membrane-Engineered Nanotherapeutic Platforms For Drug Delivery: Hollow Fiber Membrane Synthesis Of Lipid Nanoparticles, Biomimetic Nanocarriers, And Nanobubbles, Zhixiang Liu May 2026

Membrane-Engineered Nanotherapeutic Platforms For Drug Delivery: Hollow Fiber Membrane Synthesis Of Lipid Nanoparticles, Biomimetic Nanocarriers, And Nanobubbles, Zhixiang Liu

Dissertations

Lipid-based nanocarriers have emerged as a cornerstone technology for RNA therapeutics, enabling effective intracellular delivery for applications ranging from vaccination to gene regulation. However, current manufacturing approaches, particularly microfluidic-based platforms, face inherent limitations in scalability, throughput, and structural tunability due to their reliance on confined channel geometries and restricted mixing architectures. Addressing these challenges requires fundamentally new strategies that decouple nanoparticle formation from traditional microscale flow constraints while maintaining precise control over physicochemical properties.

This dissertation presents a comprehensive framework for the design, engineering, and application of advanced lipid-based nanocarriers, centered on a hollow fiber membrane (HFM)—assisted nanopore-mediated assembly platform. …