Digital Commons Network^™

Oncolytic Tanapoxvirus Variants Expressing Mil-2 And Mccl-2 Regress Human Pancreatic Cancer Xenografts In Immunocompromised And Immunocompetent Cann.Cg-Foxn1Nu/Crl Nude Mice, Scott David Haller

Dissertations

Pancreatic ductal adenocarcinoma (PDAC) is the fifth leading cause of cancer-related death in Western countries. The incidence of PDAC has increased over the last 40 years and is projected to be the second leading cause of cancer death by 2030. Despite aggressive treatment regimens, prognosis for patients diagnosed with PDAC is very poor; PDAC has the lowest 5-year survival rate for any form of cancer in the United States (US). PDAC cases are rarely detected in early stage when surgical resection can be performed and few, approximately 20%, are suitable for surgical resection which remains the only curative treatment when …

Development Of Flexible Hybrid Electronics For Sterilization And Structural Health Monitoring Applications, Arnesh Kumar Bose

Dissertations

No abstract provided.

Model Predictive Controller Design For Internal Combustion Engines Based On The Second Law Of Thermodynamics, Muataz Abotabik

Dissertations

Energy resources depletion and worldwide strict emissions policies pose challenges that automotive manufacturers try to overcome through researching advanced powertrain technologies such as lean-burn gasoline, direct injection, homogeneous charge compression ignition engines, powertrain electrification, etc. Most of these developments have been focused on conventional internal combustion engines (ICE) emissions and performance enhancements. Most ICE control strategies are built based on the First Law of Thermodynamics (FLT) i.e., to deliver a specific load requirement, enhancing thermal efficiency, etc. The FLT doesn’t account for in-cylinder high temperature thermodynamics process irreversibilities that cause losses in the work potential; up to 25% of the …

The Experiences Of Undergraduate Saudi Students In The Stem Trajectory: A Closer Look At Major Choice And Persistence Intentions, Manal Almalki

Dissertations

STEM fields (Science, Technology, Engineering, and Mathematics) are a key source of economic progress in many countries. As the Kingdom of Saudi Arabia works toward an innovative and knowledgeable economy, more qualified national professionals in STEM are needed. Nevertheless, the problem of STEM attrition is still insufficiently explored in Saudi Arabia, which may indicate a gap between skills of the Saudi workforce and the country’s need for economic development. Therefore, this study attempts to provide more information about the STEM trajectory in Saudi Arabia, underline possible attrition points that require more attention, deliver a better understanding of the factors that …

Centering Culture And Relationships In Learning: Culturally Responsive Teaching In Higher Education, Valerie Vistain

Dissertations

In colleges and universities all across the United States, the amount of culturally and linguistically diverse students has increased significantly. Research has shown that when educators can develop educational practices and curricula that account for and incorporate students’ cultural frameworks, outcomes improve for culturally and linguistically diverse students. Culturally responsive teaching is a pedagogical approach that does just that. This research project aimed to bring to light the various ways that general education professors define and enact culturally responsive teaching practices. It further illustrates how students receive and interpret these culturally responsive approaches. Using the general education college within a …

Activities Negatively Influencing Retention Of African American College Students And Leadership Strategies To Increase Retention, Melvaughn Thompson

Dissertations

The purpose of this study was to recognize the decrease in retention of African American college students. What are some of the reasons for a decrease in retention and what do the leaders do about it? Leadership can develop and implement to recruit and increase retention of some of these African American academic students. The college dropout rates on college campuses overall are 40%, with 30% of these students being freshman and sophomores. The theoretical framework for this study is based on the expectancy theory of motivation which is a process theory of motivation (Vroom, 1964). An individual's motivation (Valence) …

The Elementary School Principal's Influence On Teacher Hiring Practice & Decision Making, Courtney Goodman

Dissertations

In the role of a building principal, the hiring process is among the most critical components of the job, particularly hiring the right people for the right positions. Yet, hiring approaches vary from principal to principal, building to building, district to district. This study surveyed and interviewed principals and administrators about their hiring processes to determine the most effective and evidence-based approaches to hiring. It identifies several strategies to streamline the hiring process, including using a common set of tools for hiring, adhering to a set timeline for the hiring process, and focusing on criteria for hiring decision-making. This research …

Narratives Of Black Female Elementary School Teachers: Navigating The Normative Discourse Of Whiteness, Thera Tilmon

Dissertations

This narrative research study illuminates the experiences of Black elementary school teachers as they navigate through whiteness on their identity journey. The purpose of this study was to examine the counter-narratives of identity by Black female elementary school teachers within the discourse of Whiteness that remains dominant in the U.S. culture and public school system. This study included semi-structured interviews with six participating teachers from several school districts in a large Midwestern metropolitan city. critical race theory, Black feminist theory, intersectionality, and transcendental theories comprised the theoretical underpinnings of the study. Narrative research design was employed for data analysis resulting …

The Design, Synthesis, And Characterization Of Copper-Based Metal-Organic Frameworks For Their Investigation Against Cancer And Their Effect As Anti-Microbial Agents, Sandy Elmehrath

Dissertations

A wide range of nanomaterials have been developed for biomedical applications, such as drug delivery, biomedical imaging, and sensors. Nanomaterials can include nanoparticles (NPs) and nanofibers with various dimensions that are both natural and synthetic. A successful nanomaterial, for use in biological applications, is characterized by its biocompatibility, biodegradability, intrinsic high surfaces area, high interconnected porosity, and functionality. These features were achieved with the development of metal-organic framework (MOF) nanostructures. MOFs are assemblies of metal ions and organic linkers that are built into different geometries and can exist in all dimensions (up to 3-D). The choice of linkers with well-defined …

Prevalence Of Lost Time Injuries And Fatalities Among Construction Workers In Al Ain, United Arab Emirates (Uae), Ghuwaya Humaid Alnuaimi

Dissertations

Migrants account for more than 80% of the total population of the United Arab Emirates (UAE). Few population-based data were available about the burden of lost time injuries (LTIs) and fatalities among migrant workers employed in the construction industry. The proposed study aimed to estimate the prevalence of LTIs and associated factors, and fatalities among construction workers in Al Ain, of Abu Dhabi Emirate in the UAE. A cross-sectional study design was used to estimate the prevalence of LTIs resulting in one or more than a day of sick leave in a random sample (n=1,626) of male construction workers in …

Diagnostics Of Dementia From Structural And Functional Markers Of Brain Atrophy With Machine Learning, Tetiana Habuza

Dissertations

Dementia is a condition in which higher mental functions are disrupted. It currently affects an estimated 57 million people throughout the world. A dementia diagnosis is difficult since neither anatomical indicators nor functional testing is currently sufficiently sensitive or specific. There remains a long list of outstanding issues that must be addressed. First, multimodal diagnosis has yet to be introduced into the early stages of dementia screening. Second, there is no accurate instrument for predicting the progression of pre-dementia. Third, non-invasive testing cannot be used to provide differential diagnoses. By creating ML models of normal and accelerated brain aging, we …

One-Stage Blind Source Separation Via A Sparse Autoencoder Framework, Jason Anthony Dabin

Dissertations

Blind source separation (BSS) is the process of recovering individual source transmissions from a received mixture of co-channel signals without a priori knowledge of the channel mixing matrix or transmitted source signals. The received co-channel composite signal is considered to be captured across an antenna array or sensor network and is assumed to contain sparse transmissions, as users are active and inactive aperiodically over time. An unsupervised machine learning approach using an artificial feedforward neural network sparse autoencoder with one hidden layer is formulated for blindly recovering the channel matrix and source activity of co-channel transmissions. The BSS sparse autoencoder …

Optimizing Speed Profiles For Sustainable Train Operation With Wayside Energy Storage Systems, Leon A. Allen

Dissertations

Large hauling capability and low rolling resistance has put rail transit at the forefront of mass transportation mode sustainability in terms of congestion mitigation and energy conservation. As such, rail vehicles are one of the least energy-intensive modes of transportation and least environmentally polluting. Despite, these positives, improper driving habits and wastage of the braking energy through dissipation in braking resistors result in unnecessary consumption, extra costs to the operator and increased atmospheric greenhouse gas emissions.

This study presents an intelligent method for the optimization of the number and locations of wayside energy storage system (WESS) units that maximize the …

Planning Methodology For Alternative Intersection Design And Selection, Liran Chen

Dissertations

The recent publication of the 6th Edition of the Highway Capacity Manual included a chapter on Ramp Terminals and Alternative Intersections that introduces various alternative intersection designs and assesses the performance of Median U-turn, Restricted crossing U-turn and Displaced left-turn intersections. Missing from the literature is an alternative intersection selection tool for identifying whether an alternative intersection would be successful under local conditions. With limited information of organized alternative intersection research, most planners must rely heavily on their personal judgement while selecting the most suitable intersection designs. As appealing as alternative intersections are, there is no comprehensive methodology for planners …

Nondestructive Evaluation Of 3d Printed, Extruded, And Natural Polymer Structures Using Terahertz Spectroscopy And Imaging, Alexander T. Clark

Dissertations

Terahertz (THz) spectroscopy and imaging are considered for the nondestructive evaluation (NDE) of various three-dimensional (3D) printed, extruded, and natural polymer structures. THz radiation is the prime candidate for many NDE challenges due to the added benefits of safety, increased contrast and depth resolution, and optical characteristic visualization when compared to other techniques. THz imaging, using a wide bandwidth pulse-based system, can evaluate the external and internal structure of most nonconductive and nonpolar materials without any permanent effects. NDE images can be created based on THz pulse attributes or a material’s spectroscopic characteristics such as refractive index, attenuation coefficient, or …

Investigation Of Topological Phonons In Acoustic Metamaterials, Wenting Cheng

Dissertations

Topological acoustics is a recent and intense area of research. It merges the knowledge of mathematical topology, condensed matter physics, and acoustics. At the same time, it has been pointed out that quasiperiodicity can greatly enhance the periodic table of topological systems. Because quasiperiodic patterns have an intrinsic global degree of freedom, which exists in the topological space called the hull of a pattern, where the shape traced in this topological space is called the phason. The hull augments the physical space, which opens a door to the physics of the integer quantum Hall effect (IQHE) in arbitrary dimensions. In …

Improving The Performance And Evaluation Of Computer-Assisted Semen Analysis, Ji-Won Choi

Dissertations

Semen analysis is performed routinely in fertility clinics to analyze the quality of semen and sperm cells of male patients. The analysis is typically performed by trained technicians or by Computer-Assisted Semen Analysis (CASA) systems. Manual semen analysis performed by technicians is subjective, time-consuming, and laborious, and yet most fertility clinics perform semen analysis in this manner. CASA systems, which are designed to perform the same tasks automatically, have a considerable market share, yet many studies still express concerns about their accuracy and consistency. In this dissertation, the focus is on detection, tracking, and classification of sperm cells in semen …

A Self-Learning Intersection Control System For Connected And Automated Vehicles, Ardeshir Mirbakhsh

Dissertations

This study proposes a Decentralized Sparse Coordination Learning System (DSCLS) based on Deep Reinforcement Learning (DRL) to control intersections under the Connected and Automated Vehicles (CAVs) environment. In this approach, roadway sections are divided into small areas; vehicles try to reserve their desired area ahead of time, based on having a common desired area with other CAVs; the vehicles would be in an independent or coordinated state. Individual CAVs are set accountable for decision-making at each step in both coordinated and independent states. In the training process, CAVs learn to minimize the overall delay at the intersection. Due to the …

Local Learning Algorithms For Stochastic Spiking Neural Networks, Bleema Rosenfeld

Dissertations

This dissertation focuses on the development of machine learning algorithms for spiking neural networks, with an emphasis on local three-factor learning rules that are in keeping with the constraints imposed by current neuromorphic hardware. Spiking neural networks (SNNs) are an alternative to artificial neural networks (ANNs) that follow a similar graphical structure but use a processing paradigm more closely modeled after the biological brain in an effort to harness its low power processing capability. SNNs use an event based processing scheme which leads to significant power savings when implemented in dedicated neuromorphic hardware such as Intel’s Loihi chip.

This work …

Numerical Methods For Optimal Transport And Optimal Information Transport On The Sphere, Axel G. R. Turnquist

Dissertations

The primary contribution of this dissertation is in developing and analyzing efficient, provably convergent numerical schemes for solving fully nonlinear elliptic partial differential equation arising from Optimal Transport on the sphere, and then applying and adapting the methods to two specific engineering applications: the reflector antenna problem and the moving mesh methods problem. For these types of nonlinear partial differential equations, many numerical studies have been done in recent years, the vast majority in subsets of Euclidean space. In this dissertation, the first major goal is to develop convergent schemes for the sphere. However, another goal of this dissertation is …

Effect Of Process Control Agents Used In Mechanochemical Synthesis On Properties Of The Prepared Composite Reactive Materials, Mehnaz Mursalat

Dissertations

The study explores synthesis and reactivity of new reactive materials prepared by ball milling. High-energy ball milling became a ubiquitous mechano-chemical tool to manufacture diverse powders, from pharmaceuticals or foods to alloys to new solid rocket propellants. It enabled a dramatic expansion of the range of chemical compositions obtainable; however, it did not so far, allowed one to fine-tune morphology or interfaces in the generated powders. It is shown in this work how different process control agents (PCAs) can serve to tune the powder morphology and reactivity. Commonly used as lubricants and cooling agents during milling, liquid PCAs can be …

Optimization Opportunities In Human In The Loop Computational Paradigm, Dong Wei

Dissertations

An emerging trend is to leverage human capabilities in the computational loop at different capacities, ranging from tapping knowledge from a richly heterogeneous pool of knowledge resident in the general population to soliciting expert opinions. These practices are, in general, termed human-in-the-loop (HITL) computations.

A HITL process requires holistic treatment and optimization from multiple standpoints considering all stakeholders: a. applications, b. platforms, c. humans. In application-centric optimization, the factors of interest usually are latency (how long it takes for a set of tasks to finish), cost (the monetary or computational expenses incurred in the process), and quality of the completed …

Towards Practicalization Of Blockchain-Based Decentralized Applications, Songlin He

Dissertations

Blockchain can be defined as an immutable ledger for recording transactions, maintained in a distributed network of mutually untrusting peers. Blockchain technology has been widely applied to various fields beyond its initial usage of cryptocurrency. However, blockchain itself is insufficient to meet all the desired security or efficiency requirements for diversified application scenarios. This dissertation focuses on two core functionalities that blockchain provides, i.e., robust storage and reliable computation. Three concrete application scenarios including Internet of Things (IoT), cybersecurity management (CSM), and peer-to-peer (P2P) content delivery network (CDN) are utilized to elaborate the general design principles for these two main …

Understanding The Interfacial Processes Of Reactive Nanobubbles Toward Agricultural Applications, Xiaonan Shi

Dissertations

There is a growing interest in nanobubble (NB) technology because of its diverse applications (e.g., detergent-free cleaning, water aeration, ultra-sound imaging and intracellular drug delivery, and mineral processing). NBs have a higher efficiency of mass transfer compared to bulk scale bubbles due to the high specific surface areas. The high specific surface also facilitates physical adsorption and chemical reactions in the gas liquid interface. Furthermore, the collapse of NBs creates shock waves and the formation of hydroxyl radicals (OH).

However, it remains elusive why or how NBs are stabilized in water and particularly, the states of internal pressures of NBs …

Representation Learning In Finance, Ajim Uddin

Dissertations

Finance studies often employ heterogeneous datasets from different sources with different structures and frequencies. Some data are noisy, sparse, and unbalanced with missing values; some are unstructured, containing text or networks. Traditional techniques often struggle to combine and effectively extract information from these datasets. This work explores representation learning as a proven machine learning technique in learning informative embedding from complex, noisy, and dynamic financial data. This dissertation proposes novel factorization algorithms and network modeling techniques to learn the local and global representation of data in two specific financial applications: analysts’ earnings forecasts and asset pricing.

Financial analysts’ earnings forecast …

Outdoor Operations Of Multiple Quadrotors In Windy Environment, Deepan Lobo

Dissertations

Coordinated multiple small unmanned aerial vehicles (sUAVs) offer several advantages over a single sUAV platform. These advantages include improved task efficiency, reduced task completion time, improved fault tolerance, and higher task flexibility. However, their deployment in an outdoor environment is challenging due to the presence of wind gusts. The coordinated motion of a multi-sUAV system in the presence of wind disturbances is a challenging problem when considering collision avoidance (safety), scalability, and communication connectivity. Performing wind-agnostic motion planning for sUAVs may produce a sizeable cross-track error if the wind on the planned route leads to actuator saturation. In a multi-sUAV …

Nystrom Methods For High-Order Cq Solutions Of The Wave Equation In Two Dimensions, Erli Wind-Andersen

Dissertations

An investigation of high order Convolution Quadratures (CQ) methods for the solution of the wave equation in unbounded domains in two dimensions is presented. These rely on Nystrom discretizations for the solution of the ensemble of associated Laplace domain modified Helmholtz problems. Two classes of CQ discretizations are considered: one based on linear multistep methods and the other based on Runge-Kutta methods. Both are used in conjunction with Nystrom discretizations based on Alpert and QBX quadratures of Boundary Integral Equation (BIE) formulations of the Laplace domain Helmholtz problems with complex wavenumbers. CQ in conjunction with BIE is an excellent candidate …

Design And Control Of Next-Generation Uavs For Effectively Interacting With Environments, Caiwu Ding

Dissertations

In this dissertation, the design and control of a novel multirotor for aerial manipulation is studied, with the aim of endowing the aerial vehicle with more degrees of freedom of motion and stability when interacting with the environments. Firstly, it presents an energy-efficient adaptive robust tracking control method for a class of fully actuated, thrust vectoring unmanned aerial vehicles (UAVs) with parametric uncertainties including unknown moment of inertia, mass and center of mass, which would occur in aerial maneuvering and manipulation. The effectiveness of this method is demonstrated through simulation. Secondly, a humanoid robot arm is adopted to serve as …

Atmospheric Mercury Chemistry: Detection, Kinetics, And Mechanism, Na Mao

Dissertations

The presence of mercury in the environment is of global concern due to its toxicity. The atmosphere is an important transient reservoir for mercury released by human activities and natural sources. The knowledge of atmospheric mercury chemistry is critical for understanding the global biogeochemical cycle. In the atmosphere, mercury primarily exists in three forms: gaseous elemental mercury (GEM), gaseous oxidized mercury (GOM), and particulate-bound mercury (PBM). Over the last decade, the existing knowledge of mercury cycle has dramatically changed: (1) There has been increasing evidence that current detection methods do not accurately quantify gaseous oxidized mercury and a technique which …

Towards A Cross-Layer Coupled Design Framework For Big Data Workflows, Qianwen Ye

Dissertations

The processing and analysis of big data increasingly rely on workflow technologies for knowledge discovery and scientific innovation. The execution of such workflows goes far beyond the capability and capacity of single computers and is now commonly supported on reliable and scalable data storage and analysis platforms in distributed environments, such as the Hadoop ecosystem. Workflow performance largely depends on how big data systems are configured and used. For example, the makespan of a big data workflow is affected by multiple layers of big data systems, including the parallel computing engine it runs on, the resource manager that orchestrates various …