Investigating The Consequences Of Conjugated And Secreted Isg15 On Coronavirus Pathogenesis, Mudassir Syed Ali

Dissertations

Coronaviruses have evolved a breadth of mechanisms to antagonize host innate immune responses. One widely studied mechanism is the ability to deconjugate ISG15 from target proteins in a process called deISGylation, which is catalyzed by the papain-like protease (PLP) domain of viral non-structural protein (nsp) 3. Since PLP activity is required for viral replication, it has been challenging to generate an infectious virus with a PLP that maintains protease activity but has lost deISGylase activity. In this study, we generated a chimeric MHV-A59 with its PLP2 domain replaced with that of the human coronavirus HKU1, which has been documented to …

Interrogating The Dispersal Process And Relevant Genes In Vibrio Fischeri, Jeremy Esin

Dissertations

Biofilms are aggregates of bacteria encased in a matrix that shields bacteria from environmental hazards. These structures are formed in response to cues from the environment and drive colonization of new niches. Biofilms can be both beneficial and detrimental. Largely, research focuses on biofilms that have negative outcomes in clinical, environmental, and economical settings. However, the value of beneficial biofilms is recognized and studied. The marine bacterium Vibrio fischeri is part of a model system for studying symbiotic biofilms in a eukaryotic host. V. fischeri produces a transient biofilm at the surface of a specialized light organ and then disperses …

Developing Full Performance Interpreters: Cultivating Interdisciplinary Mindsets And Skillsets To Engage Audiences In Climate Change, Women's History, And Other Contested Heritage Topics, Delia A. Lister

Dissertations

Heritage sites immerse visitors in places where the impacts of climate change are readily apparent. They are also powerful places to elevate untold stories of women and girls. Heritage site interpreters interact daily with audiences who bring diverse lived experiences, different levels of subject matter knowledge, and multiple perspectives on climate change and the role of women in history. Every visitor interaction has a set of meanings, values, and narratives that visitors knowingly or unknowingly espouse. To interpret contested heritage topics, such as climate change and women’s history, interpreters must cultivate interdisciplinary mindsets and skillsets. The purpose of this basic …

A Design Based, Mixed Method Study On Evaluating Traditional Grading Practices And The Implications For Mastery Learning And Educational Equity In A Midwestern School District, Christina Kirchner

Dissertations

“Grades are an essential currency of our schools. Schools, colleges and employers use grades to determine many important, and in some cases, life-altering decisions-college admission, financial aid and scholarships, athletic eligibility, promotion, retention, awards, and supports” (Feldman, 2018, p. 3). Grading is not addressed in teacher preparation programs, or within professional development during teachers’ careers; teachers have chosen their own way to grade guided by their own personal experiences, uninformed of research or best practice. Using a human centric, design-based approach, the researcher identified multiple discrepancies with grading practices among the K-12 school organization. Within the discrepancies, other issues were …

Narratives Of Jewish American Public School Educators Amid Rising Antisemitism Post October 7, 2023, Cassandra Schwartz

Dissertations

This study investigated how Jewish American public school educators are responding to rising antisemitism post-October 7, 2023. While research exists on global antisemitism, the experiences of Jewish educators within the unique context of American public schools represent a significant and under-explored gap in academic literature. A qualitative narrative research approach, grounded in critical theory, was employed. Data were collected through semi-structured interviews with eight Jewish American public school educators and analyzed thematically. The findings revealed participants’ experiences of a heightened sense of fear and silence from colleagues and institutions, leading to feelings of isolation and being unsupported. Critically, this study …

The Fault Line: Understanding Tension Between Industry And Higher Education Institutions In Sustained Partnerships, David Lawrence

Dissertations

This study investigates the dynamics that influence tensions in industry–higher education partnerships and identifies effective navigation factors in sustainable partnerships. Despite the increasing prevalence, such partnerships face high failure rates due to inherent tensions. This research explores how partners from industry and higher education institutions successfully navigate these tensions using a qualitative case study approach.

This investigation employed a case study design with a multi-case two-by-two holistic matrix and an interpretive, constructivist framework. Data collection involved 16 semi-structured interviews with key individuals from nine higher education institutions and five industry organizations spanning healthcare, technology, consulting, real estate development, and accounting …

Navigating Emotional Transitions: A Study Of Self-Perception And Emotion In Bio-Childfree Women Entering A Blended Family, Janine Cednick

Dissertations

The transition to a blended family is an emotional and psychological adjustment for bio-childfree individuals. The present qualitative study investigated how self-concept and emotional adjustment of bio-childfree stepmothers change when they become members of their new family. With a phenomenological approach, semi-structured interviews were conducted with 12 female participants who were bio-childfree, in a committed relationship with a partner with children, and had cohabited for one year or more. The study aimed to find out how these women cope in their new role, their emotional adjustment to their transition, and the influences that impact their well-being. Thematic analysis of interviews …

Narratives Of Latina Teacher Candidates On Subtractive Schooling Experiences And Their Language Identity, Joao Goebel

Dissertations

The subtractive nature of bilingual education in the United States has long impacted the language identities of Latinx students. Despite being raised in multilingual environments, many are schooled in systems that devalue their home languages and prioritize English-only instruction. This study explored how these dynamics influenced Latina teacher candidates’ perceptions of their own bilingualism and professional identities. The purpose of the study was to examine how Latina teacher candidates understood and constructed their language identities in the context of their K–12 and higher education experiences. The study used narrative research centered on four Latina teacher candidates enrolled in an undergraduate …

Traditional Institutions As Change Agents: Understanding Cultural Norms And Practices Promoting Gender-Based Violence In Nigerian Communities, Titilayo Ogunbambi

Dissertations

Traditional institutions in Nigerian communities hold a strong cultural foundation and significantly influence cultural norms and practices. Due to the increasing need for effective community-based approaches in addressing social and health problems on a global scale, we explore the attitudes and behaviors of traditional institutions as custodians of cultural customs and norms related to gender-based violence (GBV) and examine their potential role in ensuring community safety. By addressing harmful gendered norms and practices, traditional institutions could become key agents of change, promoting meaningful social transformations. This study explores the dynamics cultural norms and practices play in community safety, emphasizing the …

Land Access As Liberation: A Qualitative Study On Faith, Food, And Farming Of Urban And Rural Black Land Stewards In The United States, Dominique Edwards

Dissertations

Since 1920, Black farmers in the United States have held less than 2% of the nation's farmland, a direct result of race-based discriminatory policies embedded within federal, state, local, and county-level institutions (Daniel, 2013). Structural barriers—ranging from exclusionary lending practices by the U.S. Department of Agriculture (USDA) to the systematic dispossession of land through legal loopholes, heirs’ property laws, and violent racial terror—have contributed to this staggering decline in Black land ownership (Gilbert et al., 2002). The erosion of Black agrarian landholdings intensified in the latter half of the 20th century, as government programs, civil rights legislation, and technological advancements, …

Uncovering Best Practices For Professional Learning: A Focus On Dialogic Discourse, Belinda Jaquez

Dissertations

The education system rests in a paradox with an ever-changing world and classrooms frozen in time. Though technological advancements, societal changes, and policy reforms are continuously reshaping the world, classrooms have remained anchored in traditional teaching and learning practices. This study examined the relationship between professional learning programs and the quality of classroom instruction with a focus on implementing more collaborative and dialogic approaches to both student and professional learning. This research involved a multifaceted program evaluation of the learning environment centered on the learning experiences of both students and teachers. A utilization-focused evaluation approach was implemented to ensure the …

Intersecting Inequities: Latinx Access To Mental Health Services, Melissa Thorson

Dissertations

This study examined barriers to mental health service utilization among Latinx populations using data from the 2022 National Survey on Drug Use and Health (NSDUH). Through the theoretical frameworks of Minority Stress Theory and Toxic Stress Theory, the study investigated the relationships between age, language proficiency, socioeconomic status, and mental health service access among different Latinx subgroups. Statistical analyses included chi-square tests, multiple regression, and mediation analyses on a sample of Latinx adults (N = 9,852). Results indicated associations between age and English proficiency (χ² = 145.23, p < .001, Cramer's V = 0.38), with 45% of adults aged 50 and older reporting limited English proficiency. Socioeconomic analysis revealed that 32% of older Latinx adults reported family incomes below $20,000, with insurance status partially mediating the relationship between income and service utilization (indirect effect = 0.15, 95% CI [0.08, 0.23]). differences in utilization rates emerged among Latinx subgroups (F(6, 1243) = 8.76, p < .001, η² = 0.12), with Mexican-origin individuals showing higher utilization (10%) compared to Puerto Rican individuals (2-3%). Age and socioeconomic status demonstrated interaction effects (β = 0.18, p < .01), while language proficiency moderated the relationship between age and service utilization (β = 0.24, p < .001). These findings suggest that barriers to mental health service utilization among Latinx populations are complex and interconnected, requiring multilevel interventions that address linguistic, cultural, and socioeconomic factors simultaneously. Implications for healthcare policy and service delivery are discussed, emphasizing the need for culturally responsive and linguistically appropriate mental health services.

The Day You Begin: A Case Study Of Culturally Responsive Pedagogy In Early Childhood Classrooms, Kim Shelton

Dissertations

Culturally responsive pedagogy (CRP) has garnered growing attention in early childhood education due to its potential to cultivate inclusive and equitable learning environments for increasingly diverse student populations. This qualitative case study examines how early childhood educators perceive and implement CRP in classrooms with high concentrations of immigrant and culturally diverse students. Additionally, it explores the perceived impact of these practices on instructional effectiveness, classroom climate, and teacher-student interactions.

Data was collected through semi-structured interviews, classroom observations, and document analysis. Thematic analysis yielded four central findings: (1) teachers’ understandings of CRP varied considerably, with some demonstrating strong intentionality and others …

Through The Wire: Examining The Experiences Of Formerly Incarcerated Students In Prison Education Programs And The Wraparound Services Needed To Support Their Success, Isabel Castro

Dissertations

This qualitative study examines the experiences of formerly incarcerated individuals in Prison Education Programs (PEPs) and the wraparound services necessary to support their success. Through Schlossberg’s Transition Theory, this study explores how incarcerated students navigate educational transitions and how educators facilitate transformative learning. Using case study and narrative inquiry, interviews were conducted with fifteen formerly incarcerated PEP participants and seven educators.

Thematic analysis revealed six major themes: Access to Education in Carceral Settings, the Impact of Education on Incarcerated Individuals, Wraparound Services and Student Support, Experiences of Formerly Incarcerated Students, the Role of Educators and Program Facilitators, and Best Practices …

The Correlation Between Depression And Gendered Racism Among Black Women, Charmagne M. King

Dissertations

Black women face unique challenges related to intersecting racial and gender-based discrimination, often referred to as gendered racism. Previous research has indicated this form of oppression may significantly affect mental health, particularly depression. However, few studies have examined how gendered racism interacts with racial identity and demographic factors (e.g., age, marital status, geographical location) to predict depressive symptoms. Using a sample of 164 self-identified Black women, this study investigated the correlational relationship between gendered racism and depression among Black women and examined how gendered racism, racial identity, and key covariates (age, marital status, and geographical location) predict depressive symptomatology. The …

Identifying Success Characteristics Of First-Generation College Students: A Framework For Early Intervention In K-12 Education., Christopher Harmon

Dissertations

This dissertation examines how K–12 educators can better support first-generation college students by identifying the characteristics that promote success and developing early interventions using Wagner et al.’s (2006) 4 C’s model: Competencies, Conditions, Culture, and Context. Guided by Michael Quinn Patton’s Utilization-Focused Evaluation (UFE), it closely investigates how factors such as family background, academic preparation, finances, and social support shape first-generation students’ capacity to persist and excel in college. The research draws on interviews with first-generation doctoral students, offering a detailed, first-hand account of their educational journeys from early schooling through advanced degrees. Notably, the findings highlight the importance of …

The Rose That Grew From Concrete: Exploring The Romantic Experiences Of Black Men With Histories Of Childhood Sexual Abuse, Tatyana Nichelle Smith

Dissertations

Contemporary research typically characterizes Black heterosexual relationships by dismal marriage and divorce rates, largely ignoring the reality of how Black men develop attachments with their romantic partners and therefore continuing to perpetuate deficit perspectives of Black men (e.g., the cause of conflictual romantic relationships and “broken” Black families). What may be less understood about these relationships is the influence of childhood trauma, such as childhood sexual abuse, and Black men’s experiences of gender role conflict. Research shows that Black men’s experiences of childhood sexual abuse and socialization about masculinity have important implications for how they come to view themselves and …

Pension Participation Among Different Migrant Groups In China: Job Type, Regional Disparities, And Cross-Provincial Mobility, Boxia Xu

Dissertations

As China undergoes rapid economic transformation and urbanization, the migrant population has grown significantly. Although migrants play essential roles in the labor market, they face persistent structural barriers to pension access. Regional disparities, occupational segmentation, and cross-provincial mobility constraints affect the probability of their pension participation. While policy efforts aim to expand coverage, the fragmented nature of China’s pension system continues to hinder equitable access for migrants. As a result, ensuring pension participation among migrant groups remains a pressing challenge.

Using data from the 2014 China Migrants Dynamic Survey (CMDS), this dissertation employs logistic regression models to investigate how job …

Experimental And Computational Study Of Slow Crack Growth Of High Density Polyethylene, Abdulla Fawzi Almomani

Dissertations

This dissertation investigates the slow crack growth (SCG) behavior of High-Density Polyethylene (HDPE) under various mechanical and environmental conditions. The study combines experimental analysis and computational modeling to enhance the understanding of SCG mechanisms in HDPE, particularly in pressurized pipes and under the exposure to hydrocarbons. A novel Crack Layer (CL) theory-based SCG model is developed and validated through experimental data, offering a predictive framework for HDPE failure assessment. The main objective of this dissertation is to quantify and model the viscoelastic-viscoplastic behavior of HDPE under monotonic and cyclic loading conditions while addressing SCG kinetics in structural applications. The study …

Comparative Genotoxicological Analysis Of Occupational Pesticide Exposures: An Experimental Approach And Systematic Review, Moustafa Samy Sherif

Dissertations

This dissertation investigates the genotoxic and cytotoxic effects of pesticide exposure through three complementary research components: a systematic review of occupational pesticide exposure in Arab countries (AraSys), a systematic review on encapsulated versus conventional pesticide formulations (Encap-Sys), and experimental toxicological assessments of various pesticide formulations in human cell lines (Pyr-Ex). This experimental component includes cytotoxicity assays using propidium iodide and DNA damage assessments via alkaline comet assays in HL60 and HepG2 cell lines exposed to pyrethroid insecticides and glyphosate-based formulations.

The AraSys systematic review revealed a critical positive association between occupational pesticide exposure and DNA damage in agricultural workers in …

Machine Learning And Optimization For Intelligent Decision-Making, Elson Cibaku

Dissertations

This dissertation presents a series of innovative machine learning and optimization model designs that address complex operational challenges across logistics and power systems. By integrating advanced neural architectures with robust optimization techniques, the work delivers scalable solutions designed to improve efficiency, reliability, and decision-making in dynamic and real-world environments. The first study introduces a two-stage approach to effective vaccine distribution. This framework tackles the capacitated vehicle routing problem by combining adaptive clustering techniques with reinforcement learning and a simulated annealing pickup policy. Through extensive computational experiments, the approach demonstrates substantial improvements in routing efficiency, reducing both computational time and logistical …

The Interplay Of Accommodation And Oculomotor Vergence Within Young Adults With Binocularly Normal Vision And Typically-Occurring Convergence Insufficiency, Sebastian Fine

Dissertations

Concerted binocular coordination evoking oculomotor and refractive responses to visual stimuli are essential to daily function. Oculomotor dysfunctions can inhibit binocular responses to visually-near stimuli and have high comorbidities to accommodative dysfunctions. Three visual cues for inward (convergent) and outward (divergent) oculomotor movements, when presented concertedly create natural-viewing conditions: disparity- the binocular difference in light cast onto the fovea due to differing ocular perspectives, blur- the acuity of a visual target which stimulates accommodation, and proximal- the perceived distance of a visual stimuli based on size.

This study aims to quantitatively investigate oculomotor vergence and accommodation performances between individuals with …

Towards Explainable Ai On Graph Neural Networks: Xaig, Jiaxing Zhang

Dissertations

In the evolving landscape of artificial intelligence (AI), Graph Neural Networks (GNNs) have garnered growing prominence for their adeptness in processing graph-structured data. Despite this, the interpretability of their predictions often remains elusive. The demand for transparency and explainability in complex prediction models has reached unprecedented levels. To address this, post-hoc instance-level explanation techniques have emerged, aiming to unveil the rationale behind GNN predictions. These techniques endeavor to unearth substructures that elucidate the predictive behavior of trained GNNs.

This dissertation embarks on an exploration of Explainable AI (XAI) technologies within the realm of GNNs. Amid the challenges posed by the …

Reclaiming Data: A Participatory Action Research Study To Empower Educators, Diana Hammond

Dissertations

Abstract

Currently, the day-to-day data collection and analysis work of teachers is often only deemed valuable if it is easily observed and quantitatively recorded. Teachers are asked to produce results with an incomplete set of tools and are then personally blamed — instead of blame being placed on the structural system — when the desired results don’t manifest. This participatory action research (PAR) study challenged the status quo by asking: What if teachers were empowered to expand their definition of data to include the rich, qualitative data at their fingertips, and what if teachers’ experience and intuition were valued instead …

Building A Grounded Theory Of Resilience Among Survivors Of Chronic Ischemic Stroke, Erin Marie Tompkins Doan

Dissertations

Abstract

Stroke is disruptive with elusive recovery and adjustment. Beyond traditional aspects of stroke rehabilitation, literature suggests adjustment to stroke should also include intervention with focus on resilience. A gap exists between conceptualization, theoretical models, and strategies for supporting resilience in persons with chronic ischemic stroke. This three-manuscript dissertation research comprised a scoping literature review, a pilot study, and a phenomenological case study. We employed a convergent mixed methods design in which we implemented and studied outcomes of an adaptive mindfulness intervention. We implemented eight focus groups with eight adults and four individual interviews over 13 months. The Brief Resilience …

Creating A Positive Social-Emotional Learning Environment For Transgender Students: A Post-Pandemic Participatory Action Research, Mark Christopher Maranto

Dissertations

This qualitative research employing participatory action protocols (PAR) engages a limited number of gender minority adolescents (current transgender, nonbinary, and gender-fluid secondary students) and allied staff members at one large Midwestern public high school district. The principal purpose is to improve transgender secondary student schooling experiences. This study extends the current educational discourse on SEL (social-emotional learning) in post-pandemic high schools as far as the commitment to improving students' sense of belonging, growth mindset, resilience, and well-being should be a top priority for all educators. The primary researcher positions all participants as co-researchers to explore ways that could improve the …

Liberatory Love: Exploring Educators’ Perspectives In Alternative Education, Kamala J. Mallipudi

Dissertations

Establishing an operational understanding of love is difficult. The struggle is magnified when attempting to create a shared vision of love across a group of educators. As Freire (1970/2005) and Darder (2011) affirmed, academic success is advanced when educators demonstrate love as part of their praxis. Continuation high schools represent a population of at-promise students who stand to gain much when their educators employ liberatory love practices. This study examined how educators’ perceptions about liberatory love are shifted or formed when they read, discuss, and reflect on the topic with their colleagues. This study drew on critical pedagogy and engaged …

Belonging Is Resistance: Illuminating The Power Of Women Of Color Mid-Level Administrators In Higher Education, Rachelle Ann Martinez

Dissertations

Resistance has long been a mechanism through which the dominant norms of society are challenged in the name of social justice. White supremacy, heteropatriarchy, and neoliberalism make it difficult for institutions of higher education to increase diversity, advance equity, and prioritize inclusion. Although these systems of domination adversely impact the belonging of all campus stakeholders, the experiences of mid-level administrators are relatively overlooked, and feeling undervalued and underappreciated is a top reason for many, especially women and people of color, who leave the profession altogether. This qualitative study utilized narrative inquiry to understand how dominant societal norms adversely impact the …

Becoming A Beloved Community: A Restorative Reckoning For A Radical Conversion To Transform Discourse In Higher Education, Latasha Tomay Varlack-Butler

Dissertations

This dissertation critically examines the misappropriation of Restorative Justice Discourse (RJD) within three predominantly white institutions (PWIs), analyzing 59 institutional documents through Critical Discourse Analysis, Relational Critical Discourse Analysis, and Rhetorical Criticism (Fairclough, 1995; Vaandering, 2021; van Dijk, 2008). Tribal Colleges and Universities and South African institutions have emerged as exemplars of authentic RJD, countering co-optation within PWIs. The findings demonstrate that RJD as applied in PWIs is framed in ways that attenuate its transformative potential, perpetuating color-evasiveness (Bonilla-Silva, 2017) and obscuring the intersectional experiences of Black, Indigenous, and disabled communities (Crenshaw, 1991; Million, 2009).

Grounded in decolonial praxis (Smith, …

The Integration Struggles Of Myanmar/Burmese-Catholic Youth Refugees In The United States, Nant Thazin Shwe

Dissertations

ABSTRACT

Myanmar, previously known as Burma, generates a significant yearly refugee exodus stemming from ongoing ethnic conflicts, political instability, human rights violations, and the targeted persecution of Christian minority groups. Individuals seek shelter and improved opportunities in other nations. From 2011 to 2023, for example, Burmese refugees represented the largest group among U.S. refugee arrivals, accounting for 18 per cent.

Presently, there is a lack of knowledge about what the Burmese-Catholic youth refugees experiences during their integration journey into the US society. This qualitative study aimed to shed light on how the larger socio-cultural and religious environment intersects with Burmese-Catholic …