Digital Commons Network^™

Hot-Melt Mixing Of Partially Miscible Active Pharmaceutical Ingredient-Polymer Mixtures, Min Yang

Dissertations

Solid dispersion/solution processes for producing pharmaceutical oral dosages such as hot-met extrusion (HME) have received increasing attention by industry and academe because they can enhance drugs’ solubility and even bioavailability to a great extent by converting drugs from crystalline to amorphous form. HME can be carried out at two process temperature regimes: one where T_process > T_m of the drug and the T_g of the polymer (or the T_m for the case of semi-crystalline polymers); the other at T_m > T_process > T_g (T_m for the case of semi-crystalline polymer). Processing below the drug’s …

Approximate String Matching Methods For Duplicate Detection And Clustering Tasks, Oleksandr Rudniy

Dissertations

Approximate string matching methods are utilized by a vast number of duplicate detection and clustering applications in various knowledge domains. The application area is expected to grow due to the recent significant increase in the amount of digital data and knowledge sources. Despite the large number of existing string similarity metrics, there is a need for more precise approximate string matching methods to improve the efficiency of computer-driven data processing, thus decreasing labor-intensive human involvement.

This work introduces a family of novel string similarity methods, which outperform a number of effective well-known and widely used string similarity functions. The new …

Superarmed Glycosyl Donors In Chemical Glycosylation, Hemali Deepthika Premathilake

Dissertations

Only recently has the tremendous biological significance and therapeutic potential of carbohydrates and conjugates thereof (glycoproteins, glycolipids, proteoglycans, etc.) begun to emerge. As the appreciation for the biological roles of carbohydrates a growing demand for efficient and scalable methods towards the synthesis of these challenging molecules has become even more imperative. This has led to the development of a variety of expeditious strategies for oligosaccharide assembly. Amongst these strategies, the so-called armed-disarmed strategy introduced by Fraser-Reid is of particular attractiveness as it allows for chemoselective oligosaccharide synthesis. Recently, the conformational changes as well as the strategic placement of common protecting …

Family Structure And Risk Factors: An Investigation Into Emotional And Behavioural Outcomes For Nine-Year-Olds., Zara Lafferty

Dissertations

This study examined the relationship between family structure and risk factors for children’s emotional and behavioural outcomes at 9 years of age. Family structure in this study is defined as; married, separated, divorced, widowed and never married families. Three risk factors were identified from the literature; economic deprivation, maternal depression and life events. This study is a cross sectional quantitative analysis of the ‘Growing Up in Ireland’s’ child cohort (9 year olds) dataset. This is nationally representative sample of 9 year old children living in Ireland; the sample was collected through a two-stage, stratified random sampling approach. Of the 8,568 …

Biochar From Agricultural Byproducts For Improved Soil Quality And Carbon Sequestration, Djaafar Rehrah

Dissertations

Soil carbon sequestration has emerged as an innovative approach that may offer a low-risk and an efficient way to mitigate climate change and replenish soil fertility. In various agricultural production systems, byproducts are produced in significant amounts from crop residues such as pecan shells (PC), peanut shells (PS), and cotton gin (CG) that can be used to produce biochar and applied to agricultural soil first to sequester C and second to enhance plant growth by supplying and retaining nutrients, improving soil physical and biological properties. The objectives of this study were to (a) produce biochars from different byproducts (PC, PS, …

Analytical Strategies For Drug Residues In Various Matrices In A Regulatory Laboratory., Geraldine Dowling

Dissertations

Abstract

Today, in modern farming practices veterinary drugs are given to food-producing animals. The generic term “veterinary drugs” covers a broad variety of classes of chemical compounds and the list of drugs is enormous and it is a significant analytical challenge in regulatory control to provide monitoring programmes. The major concerns in veterinary drug usage are the presence of harmful residues that may be introduced into the human food chain. The aim of this research is the development of analytical methods capable of screening and confirming increased numbers of these residues in target matrices by Gas Chromatography Tandem Mass Spectrometry …

An Exploration Of Stepfamily Experiences Of Young People In Ireland., Audrey Mcgee

Dissertations

This qualitative research study conducted semi-structured interviews to explore the stepfamily experiences of ten individuals, aged eighteen to twenty four years. The findings indicated that the stepfamily brought challenges and a range of benefits to the participants’ life experiences. The key difficulties pertained to issues regarding conflict, lack of communication and complex challenges. The cited benefits of stepfamily experiences included improved financial resources, an additional parental figure, a sense of stability, opportunities for personal growth and the gaining of additional siblings. One significant finding of the study was the positive enduring bonds that some individuals made with stepparents and stepsiblings. …

Descriptions Of Childhood Trauma, Effects Of The Trauma, And How Adults Moved Through The Trauma To Normalized Behavior, Alice Katherine Schaaf

Dissertations

Problem. People who are not able to overcome the effects of childhood trauma often waste their human potential on substance abuse and illegal and illicit lifestyles; they end up in prison, uneducated, or develop self-destructive behavior. They often struggle with poor learning and social skills and are not able to be successful in life. However, some individuals do succeed. This study interviewed eight individuals who suffered childhood trauma and developed ways of overcoming that trauma to live prosperous, productive, and, in many regards, full lives.

Method. This qualitative study used interviews to explore how adults traumatized as children described childhood …

Leadership Programs Designed To Develop Creative Leaders : A Multi-Case Study, Karen Tilstra

Dissertations

Problem. The topic of this study is creative leadership and how it is developed. Three creative leadership development institutes were studied to determine how each provided leadership development: Leadership Development Institute on the campus of Eckerd College in St. Petersburg, Florida; International Center for Creative Leadership on the campus of Buffalo State College at University of New York, in Buffalo, New York; and the Banff Centre, in Banff, Alberta, Canada. The purpose of this study is to describe the approach and specific components of these three leadership development programs that attempt to deliver training that produces leaders who practice creative …

Environmental Literacy Of Seventh-Day Adventist Teachers In The Parochial Schools Of The Florida Conference Of Seventh-Day Adventists, Michael Murdoch

Dissertations

Problem. In the United States, there is an environmental literacy problem. Americans possess limited knowledge about the environment and environmental issues, and they display limited positive action regarding the environment in which they live. Moreover, there is a debate whether a Christian’s interpretation of Gen 1:28 leads either to a lower or to a higher environmental literacy. Does the Seventh-day Adventist teaching community reflect these problems? These are the problems which this dissertation seeks to help solve.

Purpose. The purpose of this study was to attempt to assess the environmental literacy of a group of teachers in Seventh-day …

Serine 910 Phosphorylation Of Focal Adhesion Kinase Is Critical For Costamere Assembly, Miensheng Chu

Dissertations

Tyrosine-phosphorylated FAK is required for the hypertrophic response of cardiomyocytes to growth factors and mechanical load, but the role of FAK serine phosphorylation in this process is unknown. Endothelin-1 (ET-1; 1-100nM, 2-30min) and other hypertrophic factors induced a time- and dose-dependent increase in FAK-S910 phosphorylation in neonatal rat ventricular myocytes (NRVM). FAK-S910 phosphorylation required ET_AR-dependent activation of PKCδ and Src via parallel Raf-1→MEK1/2→ERK1/2 and MEK5→ERK5 signaling pathways. Using co-immunoprecipitation, TIRF-microscopy and FRAP, ET-1 stimulation of NRVM expressing a nonphosphorylatable, S910A-FAK mutant decreased the interaction of paxillin and vinculin within costameres. This interaction was important in stabilizing α-actinin within …

The Voice Of The Negro: African American Radio, Wvon, And The Struggle For Civil Rights In Chicago, Jennifer Searcy

Dissertations

Little historical research has been done on the role that radio stations in the northern United States played in spreading information related to the Civil Rights Movement. Owned and operated by Chess Records label owners Leonard and Phil Chess, the Chicago radio station WVON 1450 AM, "The Voice of the Negro," was one of the most popular African American radio stations in the country during the 1960s. This dissertation explores how WVON served not only as a lucrative marketing outlet for the label's music and for the national rhythm and blues and soul music industry, but also as a driving …

How Do Secondary Science Teachers Understand And Implement Technological Design In Their Classrooms?, Kathryn H. Heroux

Dissertations

This qualitative, phenomenological study examined how ten secondary science teachers from a variety of different schools around the country understand and implement technological design in their classrooms. The results of this study indicate that these teachers were drawn to the tenets of technological design because of its inherent challenge to their own pedagogical strategies, and its ability to stimulate and motivate their students. The future of science education with respect to technological design is examined, and compared with the standards that will emerge in the new science standards soon to be finalized and circulated.

Image Slavery And Mass Media Pollution: Examining The Sociopolitical Context Of Beauty And Self Image In The Lives Of Black Women, Jennifer Richardson

Dissertations

The ways in which African American women negotiate the intersections of popular media, dominant discourses of beauty, and identity are rarely explored. This work brings into focus how African American women consume, understand, and make meaning of mediated images and representations of African American women. In order to inform this particular research project, this study engages a constellation of literature and theoretical perspectives and explores historical representations of African American women and beauty messages they contain. Throughout this process I examine concepts of identity formation; discuss connections between sexuality and the politics of imagery; and investigate linkages between structural racism, …

Molecular Mechanisms Regulating Chemokine Receptor Cxcr4 Signaling And Trafficking, Rohit Malik

Dissertations

CXCR4 is a G protein-coupled receptor (GPCR) that binds to the chemokine, stromal cell-derived factor-1 (SDF-1alpha; a.k.a. CXCL12). The SDF-1alpha/CXCR4 signaling axis plays an essential role during embryogenesis in the development of the heart, brain and vasculature and in the adult mediating immune cell trafficking and stem cell homing to the bone marrow. Dysregulation of SDF-1alpha/CXCR4 signaling is linked to several pathological conditions, including cardiovascular disease, immunological disorders as well as cancer growth and metastasis. However, the mechanisms that govern CXCR4 signaling remain poorly understood. In this dissertation project, we attempt to further our understanding of the molecular mechanisms that …

An Investigation Of The Phospholamban-Serca Regulatory Interaction With Fluorescence Resonance Energy Transfer, Philip Adam Bidwell

Dissertations

With Fluorescence Resonance Energy Transfer (FRET), we are able to detect changes in the structure and affinity of the PLB-SERCA regulatory complex in live cells. Using this approach, we have detected a high level of PLB-SERCA interaction even at Ca2+ concentrations known to fully relieve PLB inhibition of SERCA, suggesting that dissociation is not required for relief of inhibition. We also detect no real-time change in PLB-SERCA binding over the course of a single Ca2+ transient in paced myocytes. The effect of Ca2+ on the PLB-SERCA interaction is best described as a reduced affinity with no change in the structure …

Receptor-Mediated Hypertrophic Signaling Via Protein Kinase D And Histone Deacetylase 5 In Adult Myocytes, Chia-Wei Jenny Chang

Dissertations

Hemodynamic stress and neurohumoral signaling are common causes of cardiac hypertrophy. These extrinsic stress stimuli typically act on GPCR and induce a cascade of signal transduction to re-program terminally differentiated myocytes to grow in length or width. The compensatory hypertrophic response can enhance cardiac output briefly due to increased work load. However, prolonged stress results in maladaptive changes in the heart and gradually deteriorates ventricular function to supply blood throughout the body. Sustained hypertrophic signaling can also progress toward heart failure.

My dissertation research focuses on the hypertrophic signaling in adult cardiac myocytes in response to neurohumoral stimuli, ET-1 and …

The Development Of Science Identity: An Evaluation Of Youth Development Programs At The Museum Of Science And Industry, Chicago, Sam Cole

Dissertations

The following dissertation presents findings from a year-long evaluation of informal scientific education programs at the Museum of Science and Industry in Chicago, Illinois. Science identity, rather than scientific knowledge, was the analytic lens through which the programs' effectiveness was assessed. A goal of the Museum generally, and the programs specifically, is to increase public identification with the field of science. Science identity was assessed using a novel survey instrument and three focus groups. Hierarchical linear models found a positive relationship between time enrolled in the Science Minors program and the development of science identity. These analyses also point to …

Towards A Multidimensional Model Of Adaptation For African American Adolescents Exposed To Racial Discrimination, Jamila Cunningham

Dissertations

The purposes of the current study were to 1) examine the associations of racial discrimination to internalizing symptoms, externalizing symptoms and perceived life satisfaction in African American adolescents, and 2) determine Africultural cluster profiles based on indicators of racial socialization, racial identity and culturally relevant coping strategies 3) examine whether cluster profile buffers stress exposed African American adolescents from increased internalizing symptoms, anger and decreased life satisfaction. One hundred-fifty-one African American adolescents (grades 9th - 12th) from four high schools and a community group from a major Midwest city and a major city from the Southeast reported on exposure to …

Coping Mechanisms Among Lebanese First-Time College Students, Rita Doumit

Dissertations

No abstract provided.

Aliens Found In Waiting: Women Of The Ku Klux Klan In Suburban Chicago, 1870-1930, Sarah Elizabeth Doherty

Dissertations

"Aliens Found in Waiting" is a case study of the Walosas Club chapter of the Women of the Ku Klux Klan in the suburban Chicago community of Oak Park, Illinois. Through the use of a rare manuscript collection this study provides a glimpse into the daily lives of suburban Klanswomen grappling with changing demographics in the village where they lived. Examination of the Walosas Club also provides a new context for the study of suburban history. New suburban historians have traditionally viewed suburbs as battlegrounds for the intersection of race, class and gender. Oak Park adds religion as an agent …

Effects Of Functional Communication Training (Fact) On The Communicative, Self-Initiated Toileting Behavior For Students With Developmental Disabilities In A School Setting, Jinnie Kim

Dissertations

Far less is known about the effects of functional communication-based toileting interventions for students with developmental disabilities in a school setting. Furthermore, the currently available toileting interventions for students with disabilities include some undesirable procedures such as the use of punishment, unnatural clinic/university settings as opposed to more natural school/home settings, and prompt-based as opposed to communicative, self-initiating skills. The current study examined the effectiveness of FCT on the incidence of communicative, self-initiated toileting and of toileting accidents without any punishment components, which were often considered as necessary in traditional toileting procedures. A multiple baseline design was used for the …

Effects Of Binge Alcohol Exposure On Canonical Wnt Signaling During Fracture Repair, Kristen Leigh Lauing

Dissertations

Excessive alcohol consumption is associated with increased fracture risk, delayed bone healing and fracture non-union. Binge alcohol consumption has occurred in 25-40% of all orthopaedic trauma cases. The canonical Wnt pathway, through tight regulation of stabilized beta-catenin, plays an essential and pivotal role in the formation of new bone and cartilage to initiate bone repair. We sought to determine the molecular mechanisms behind alcohol-related fracture complications by testing the hypothesis that binge alcohol exposure deregulates canonical Wnt signaling in the fracture callus, leading to impaired healing.

To test this, C57BL/6 or beta-catenin/TCF-reporter male mice were exposed to intraperitoneal alcohol or …

Analysis Of Illicit Drugs, Their Metabolites And Other Micropollutants In Water By Liquid Chromatography Tandem Mass Spectrometry, Deepika P. Panawennage

Dissertations

The goal of this project is to develop liquid chromatography tandem mass spectrometry (LC/MS/MS) methods for the analysis of different, novel micropollutants in waste water and natural water. Micropollutants are compounds that can exert adverse environmental and human health effects at low concentrations. Most of these compounds include personal care products and pharmaceuticals, such as antibiotics and controlled substances. In the first part of this study, we focused in the analysis of illicit drugs and drug metabolites because these analyses have the potential to serve as markers of drug abuse. We have detected over sixteen different illicit drugs and their …

The Role Of Cyp33 In Mll Mediated Gene Repression, Steven D. Poppen

Dissertations

Mixed Lineage Leukemia (MLL) is a multidomain protein whose gene is translocated in a subset of AML leukemias. Translocation of the MLL gene is present in approximately five percent of adult acute leukemias and ten percent of pediatric leukemias (Daser, A 2004, Look, A 1997, Huret, J 2001) Patients presenting in the clinic at the time of diagnosis with an MLL fusion have been shown to respond poorly to treatment and have a worse prognosis than matched wild type MLL patients (Rubnitz, J 1994, Rubnitz, J 1999). Novel therapies therefore are needed in order to more effectively treat patients with …

A Qualitative Exploration Of The Influence Of Racism On Identity Development For African American Adolescent Males, John Corey Steele

Dissertations

The life circumstances facing African American adolescent males are reported with a fair amount of frequency by numerous media outlets in our society. Reports generally communicate negative circumstances facing African American adolescent males in the educational, economic, social, and political arenas. These sorts of life experiences have the potential to have a tremendous impact on the lives and development, particularly identity developmental process of young African American men; however, few research efforts have been devoted to specifically exploring the identity development process of African American adolescent males. Therefore, the purpose of this study was to examine the meaning of being …

The Effects Of Smooth Muscle Cells On Engineered Microvasculatures In Fibrin Hydrogels, Areck A. Ucuzian

Dissertations

Capillaries are comprised of two cell types: the endothelial cells (ECs) which line the lumen of the capillary, and the supporting pericytes which are closely apposed to the abluminal surface of the capillary wall (sometimes called mural cells). These pericytes are phenotypic derivations of mesenchymal organ stromal cells (from smooth muscle cells and fibroblasts in blood vessels, for example), are recruited and incorporate into the neocapillaries, and are known to mediate reciprocal interactions with ECs during angiogenesis. The overall purpose of this project is to determine how smooth muscle cells (SMCs) affect angiogenesis during microvascular development in fibrin hydrogels using …

Leadership Team Actions That Manifest Collective Autonomy And Their Impact On Student Growth And Curriculum, Brian Keith Wegley

Dissertations

To be successful in the age of accountability, principals and all school leaders need to continue to build their capacity to lead meaningful, systemic and sustainable student improvement efforts that incorporate the required areas of reading and mathematics. A review of the educational literature revealed several studies that identified the limitations of America's current school accountability movement and described the narrowing of curriculum as a negative side effect of No Child Left Behind.

Educational research on leadership included a multitude of studies and leadership models for implementing change; this study focused on ideas contained within Zmuda, Kuklis and Kline's (2004) …

Beyond Utility, Rights, And Care: An Alternative Approach To Global Poverty, Timothy Weidel

Dissertations

In this dissertation, I argue in favor of an alternative approach to the problem of global poverty, one that is distinct in significant ways from current philosophical approaches of utilitarianism, human rights, or an ethic of care. While these approaches have their merits, I will argue that they are all insufficient (in various ways) to deal with the problem of global poverty. Given their shortcomings, a new approach is needed. My alternative ethical approach contains two major facets: It provides a compelling moral motivation to act to end global poverty, and it also suggests specific initiatives that will prove effective …

Using Robust Standard Errors To Combine Multiple Regression Estimates With Meta-Analysis, Ryan T. Williams

Dissertations

Combining multiple regression estimates with meta-analysis has continued to be a difficult task. A variety of methods have been proposed and used to combine multiple regression slope estimates with meta-analysis, however, most of these methods have serious methodological and practical limitations. The purpose of this study was to explore the use of robust variance estimation for combining commonly specified multiple regression models and for combining sample-dependent focal slope estimates from diversely specified models. A series of Monte-Carlo simulations were conducted to investigate the performance of a robust variance estimator for each of these approaches. Key meta-analytic parameters were varied throughout …