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Academic And Non-Academic Variables As Predictors Of Nclex-Rn Success Among Traditional Associate Degree Students At Southern Adventist University, Christine Moniyung

Dissertations

Problem

The School of Nursing at Southern Adventist University offers both Associate of Science and Bachelor of Science in nursing degrees. A majority of the students who sit for the NCLEX-RN are associate of science in nursing graduates. The pass rate dropped from 94.9% in 2010 to 88.8% in 2011. The pass rate went up to 93.3% in 2012, but dropped again by almost 5% in the following year, and to an all-time low of 76.5% in 2014.

Unlike most AS nursing program student populations in the nation, the majority of SAU students are young and considered traditional-age college students. …

Under-Represented Students' Engagement In Secondary Science Learning: A Non-Equivalent Control Group Design, Joy J. Vann-Hamilton

Dissertations

Problem.

A significant segment of the U.S. population, under-represented students, is under-engaged or disengaged in secondary science education. International and national assessments and various research studies illuminate the problem and/or the disparity between students’ aspirations in science and the means they have to achieve them. To improve engagement and address inequities among these students, more contemporary and/or inclusive pedagogy is recommended. More specifically, multicultural science education has been suggested as a potential strategy for increased equity so that all learners have access to and are readily engaged in quality science education. While multicultural science education emphasizes the integration of students’ …

The Relationship Between Episodes Of Dissociative Amnesia, Symptomology Of Post-Traumatic Stress Disorder, And Childhood Sexual Abuse, Jennifer E. Perkins

Dissertations

Problem. Identifying the possibility of a significant relationship between childhood sexual abuse, symptoms of Post-Traumatic Stress Disorder (PTSD), and episodes of dissociative amnesia is both relevant and useful in the therapeutic setting. Identifying indicative factors for a history of childhood sexual abuse and including them in a standardized therapeutic assessment will assist therapists in planning future treatment. This study used secondary data to examine the relationship between childhood sexual abuse, symptomology of PTSD, episodes of dissociative amnesia, and selected demographic characteristics.

Method. This quantitative study used a therapist-completed data collection tool which compiled brief client demographics, episodes of dissociative amnesia, …

Design, Synthesis, And Biological Evaluation Of Folate Targeted Photosensitizers For Photodynamic Therapy, Laura Jean Donahue

Dissertations

Photodynamic therapy (PDT) is used to treat cancer, and involves a highly conjugated molecule, called a photosensitizer (PS), which is excited by wavelengths of light from visible to infrared. Photosensitizers that are highly conjugated will absorb longer wavelengths (600 – 900 nm), and have the potential to destroy cells of deeper tissue cancers. In PDT, a PS is administered to the patient, and after an appropriate time delay, the tissue is then exposed to light of a specific wavelength necessary for excitation of the PS. A transfer of energy can take place between the excited PS and oxygen that is …

Regulation Of Cxcr4 Intracellular Trafficking By Ubiquitin, Justine Elizabeth Kennedy

Dissertations

G protein-coupled receptor (GPCR) sorting into the degradative pathway is important for attenuating signaling. Perturbations in this process can manifest in a variety of diseases. Upon agonist activation of the chemokine receptor CXCR4, a GPCR, it is rapidly ubiquitinated, internalized to endosomes and sorted for degradation in lysosomes via the endosomal sorting complex required for transport (ESCRT) pathway. This process culminates in attenuation of CXCR4 signaling. CXCR4 overexpression and increased CXCR4 signaling have been associated with several pathologies including immune deficiency disorders and over 23 cancers. Yet the mechanisms governing the regulation of CXCR4 signaling remain elusive.

CXCR4 is ubiquitinated …

Influence Of Maternal Prior Life Adversity On The Psycho-Neuroendocrine-Immune Profile During Pregnancy, Karen J. Kotz

Dissertations

Pregnancy is accompanied by a multitude of physical and psychological changes. Adaptation to these changes through reduced anxiety and attenuated stress responsiveness is necessary across gestation and into the postpartum period for optimal maternal-infant health. In contrast, exposure to higher amounts of stressors during pregnancy can disrupt neuroendocrine-immune processes required for successful pregnancy outcomes. Evolving evidence demonstrates that exposure to adversity early in life has long-lasting effects on stress response systems that alter stress reactivity during adulthood. Given this evidence, it is posited that women who experience greater pre-pregnancy adversity during their childhood are at greater risk for negative maternal-infant …

The Global Dystopian: Twenty-First Century Globalization, Terrorism, And Urban Destruction, Ryan Frank Peters

Dissertations

The new millennium has witnessed a staggering outpouring of literature, film and art which depict dystopian and post-apocalyptic societies. These stories have come in the form of massively popular films like the Matrix and Hunger Games trilogies; Emmy-winning television adaptations such as The Walking Dead; and Pulitzer Prize-winning novels like Cormac McCarthy’s The Road, or Kazuo Ishiguro’s Booker Prize-nominated Never Let Me Go. In the last five years, a wave of critically-lauded video games – The Last of Us, Bioshock Infinite, and Dishonored come immediately to mind—have depicted dystopian worlds while reaching mass audiences. Combined, The Last of Us and …

The Role Of Alveolar Macrophages In Pulmonary Inflammation After Intoxication And Burn Injury, Jill Ann Shults

Dissertations

A positive blood alcohol concentration is detected in nearly half of burn patients admitted to the emergency room. The combined insult of being intoxicated at the time of burn injury results in more clinical complications, in comparison to non-intoxicated burn patients. Severe burn, with or without inhalation injury, is a common predisposing factor for the development of acute respiratory distress syndrome (ARDS). Exacerbated pulmonary inflammation and a net result of insufficient gas exchange underlie the large percentage of burn fatalities due to pulmonary complications. Previous studies in our laboratory indicate a drastic elevation in pulmonary inflammation in a mouse model …

Mechanisms Of Estrogen Receptor Alternative Splicing And The Consequences For Aging In The Female Brain, Cody Lee Shults

Dissertations

The advances in healthcare and scientific knowledge have resulted in longer life expectancies in women. These advanced ages in women now means that they are experiencing the effects of age-related changes in the body for much longer periods of time, mainly reproductive senescence, resulting in the loss of circulating ovarian hormones. The age at which menopause occurs has not changed, resulting in women now living over a third of their lives in a postmenopausal state.

The major circulating estrogen produced by the ovaries, 17β-estradiol (E2), has many homeostatic effects in the body like neuroprotection and cardioprotection. Hormone replacement therapy (HT) …

Effects Of Aggregated Alpha-Synuclein On Cultured Neuronal Cells, David Freeman

Dissertations

α-synuclein dysregulation is a critical aspect of Parkinson's disease pathology. Recent studies have observed that α-synuclein aggregates are cytotoxic to cells in culture and that this toxicity can be spread between cells. However, the molecular mechanisms governing this cytotoxicity and spread are poorly characterized. Recent studies of viruses and bacteria, which achieve their cytoplasmic entry by rupturing intracellular vesicles, have utilized the redistribution of galectin proteins as a tool to measure vesicle rupture by these organisms. Using this approach, we demonstrate that α-synuclein aggregates can induce the rupture of lysosomes following their endocytosis in neuronal cell lines. This rupture can …

The Dialectics Of Secularism And Revivalism In Turkey: The Case Of Said Nursi, Zubeyir Nisanci

Dissertations

This dissertation analyzes Said Nursi's revivalist discourse and mobilization strategies in the context of the development of secularism in Turkey. This study starts with the exploration of the development of the secularist movement and its discourse with regard to philosophical foundations of (1) the construction of reality, (2) the self and (3) the society. This is followed by the analysis of Said Nursi's discourse of revivalism before and after the establishment of the Turkish Republic with respect to these three areas and by the exploration of the discourse and mobilization strategies of the Nur Movement (established by Said Nursi) vis-à-vis …

Extended Treatment Window Exists For Improving Sensorimotor Recovery Using Anti-Nogo A Immunotherapy In Adult Rats With Chronic Stroke Deficits, Katherine Marie Podraza

Dissertations

Stroke related death ranks as the fourth most common cause of mortality in the United States. Current therapeutic options following stroke are limited. One potential therapy involves the use of anti-Nogo-A immunotherapy post-stroke. Our laboratory has shown that the administration of this novel treatment results in sensorimotor recovery in adult and aged rats. This therapy has been shown to be efficacious when applied immediately, 24 hours, and 1 week post-stroke in rats with mild to moderate sensorimotor deficits. In addition, recent results suggest that administration of anti-Nogo-A immunotherapy up to 9 weeks after stroke still induces functional recovery and neuroanatomical …

The Influence Of Media Violence On The Neural Correlates Of Empathic Emotional Response, Laura Stockdale

Dissertations

Decades of research on the effects of media violence have shown that exposure to violence in the media is related to increased aggression, decreased prosocial behavior, and decreased empathy. Video games, which contain some of the most graphic, realistic, justified, and rewarded aggression have been shown to increase aggressive behavior and decrease prosocial behavior. Researchers suggest that emotional face processing and inhibitory control may be important factors associated with aggressive behavior and empathy; however, few researchers have examined these variables in chronic and nonchronic violent video game players. Therefore, the goal of the current study was to understand differences in …

Eliminating Acute Myeloid Leukemia Stem Cells By Targeting The Niche Microenviromnent: Co-Inhibition Of Tnf/Il1- Jnk And Nf-Κb, Andrew Volk

Dissertations

Leukemia Stem Cells (LSCs) from Acute Myeloid Leukemia (AML) require the activity of the transcription factor NF-kB to maintain stemness and drive tumor formation. Blocking NF-kB can preferentially eliminate LSCs in vitro with minimal effects on healthy Hematopoietic Stem and Progenitor Cells (HSPCs), making NF-kB a compelling target for anti-leukemia therapies. However, blocking NF-kB in vivo can only extend survival for a short period of time before transplanted mice succumb to the disease. I propose this is due to components of the in vivo niche supporting LSC survival and compensating for the inhibition of NF-kB.

I observed patients with partially …

Profiles Of Protective Factors In Urban African American Youth Exposed To Community Violence: A Prospective Study Of Resilience, Devin Colleen Carey

Dissertations

The broad purpose of the study was to investigate the relationship between exposure to community violence and adjustment in an urban sample of African American youth living in Chicago. After years of research on community violence, there has been a call to understand the influences of all levels and systems on child adjustment, as well as to use research to promote positive outcomes and prevention of future violence (Aisenberg & Herrenkohl, 2008). With this in mind, this project used latent profile analysis to create profiles of protection based on individual, family, peer, and community factors, as well as evaluate the …

The Gut-Liver Axis Regulates Pulmonary Inflammation After Intoxication And Burn Injury, Michael M. Chen

Dissertations

The increasing prevalence of binge drinking and its high association with traumatic injury warrant further investigation into the mechanisms underlying the worsened clinical outcomes associated with this combined injury. Existing literature suggests the liver is at the center of the postburn systemic response with crosstalk between the intestinal microbiome and the liver playing an important role after injury. There is a paucity in the literature, however, regarding the role of the gut-liver axis in the common clinical scenario of burns preceded by alcohol intoxication. Previous studies in our laboratory demonstrated intoxication potentiates postburn hepatic damage and IL-6 production in a …

Negotiating Diabetes: Professional Diabetes Care Work In The U.S., Melissa Marie Gesbeck

Dissertations

The rising incidence of diabetes mellitus (types 1 and 2) transcends national borders, creating a global pandemic. The U.S. leads the world in diabetes prevalence, despite its wealth and access to sophisticated medical technologies. Within health care, there is an increasing focus on lifestyle and behavioral interventions that research suggests may be the key to reversing this trend, but thus far their effectiveness in practice is uneven at best. In order to gain a better understanding of the other factors involved in professional diabetes care work that might support or inhibit effective diabetes management, this research treats diabetes as a …

Incapacitated Fatherhood: The Impact Of Incarceration On African American Fathers, Dara Lewis

Dissertations

This project examines the ways that incarceration can shape the meaning and performance of fatherhood. Using 109 surveys and 30 in-depth interviews, three dominant themes emerged that constitute a model father identity standard: 1) being there for their children; 2) being an example for their children; and 3) providing their children with love, basic needs, and protection. The findings indicate that prison environment and post-incarceration restrictions do not support fathers’ ability to perform their roles as fathers, or the maintenance of healthy relationships between fathers and their children. Specifically, it disrupts the father identity confirmation process. As a result, relational …

Backlash Against Working Mothers, Kala Jean Melchiori

Dissertations

Research by Rudman and colleagues (2012) has detailed how people who defy social stereotypes (called vanguards) experience discriminatory backlash for acting counter-stereotypically. In the present research, I took Rudman's Backlash and Stereotype Maintenance Model (BSMM) and applied it to working women and working mothers. Due to the different content of the stereotypes of working women versus working mothers, I predicted that the process through which perceivers engage in backlash against the two groups is different. I used the theory of Ambivalent Sexism to shape my predictions for how working mothers are vulnerable to different forms of backlash than working women …

Research And Reality: Towards Responsible Medical Research For Catholic Universities, Michael Patrick Mccarthy

Dissertations

It is frequently noted that 90% of medical research stands to benefit only 10% of the population. While others dispute the numbers, there is little doubt that disparities exist in the global agenda for medical research. One needs no clearer example of research—not to mention public health and health care delivery—disparities than the Ebola outbreak that plagues West Africa. Despite these disparities, Catholic universities continue to engage in the social practice of medical research that deviates very little from the national funding priorities established through the National Institute for Health.

This dissertation argues that these unjust disparities are perpetuated by …

Characterization Of The Effect Of Anti-Nogo-A Antibody Treatment On Sensorimotor Recovery After Traumatic Brain Injury, Stephen Nawara

Dissertations

Estimates indicate that over 5 million Americans are currently living with Traumatic Brain Injury (TBI) related disability. Much effort has been put into enhancing functional recovery with physical therapy and other rehabilitative approaches. These strategies are thought to function by facilitating the brain’s innate capacity for neuroregeneration and neuroplasticity. However, the success of these strategies may be limited due the presence of growth- and plasticity- inhibiting factors expressed in the adult brain.

The presence of the membrane protein Nogo-A has been associated with reduced neurite outgrowth in vitro, identifying it as one such molecule. In addition, rodents treated with antibodies …

Gender-Homogenous Mentoring, Spiritual Wellbeing, And Self-Efficacy Beliefs In African American Male Adolescents: A Test Of Three Models, Toussaint David Whetstone

Dissertations

Many African American male adolescents mature without the influence of an adequate social model, or a positive, same sex (or gender-homogenous) mentor. Thus, it may be difficult for African American male adolescents to reach adulthood having developed the perceived capability to be successful within specific domains that American society commonly associates with a healthy life course trajectory. A large body of research has suggested that vicarious experience or role modeling is a primary source of efficacy information in a variety of life domains. Research has also suggested that modeling effects are enhanced if the subject and model are similar, especially …

Wavelet Estimators In Nonparametric Regression Model And Simulation Study, Yunzhu He

Dissertations

Nonparametric regression is a fundamental tool in data analysis. Wavelet analysis has been proved to be a powerful statistical technique in the nonparametric regression. Wavelet’s appealing advantages make this approach very popular in a wide range of practical applications in many fields. In this dissertation, we consider the nonparametric regression model with correlated noise by using wavelet methods. One of the main purposes of this dissertation is to perform an extensive simulation study to some wavelet methods for the univariate nonparametric regression model with long- range and short-range dependent noise and to make comparisons to performance of the wavelet approaches. …

A Study Of Margin Setting In Pattern Recognition :Algorithm, Performance And Application, Yi Wang

Dissertations

Margin setting is a novel supervised learning algorithm for pattern recognition. In this research, we studied margin setting in terms of its algorithm, performance, and application. The algorithm and performance were studied from a new perspective: margin. Margin measures the associated distance from the data to the classification boundaries. Margin is an important design parameter that has a direct impact on the performances of margin setting. The performance impact of margin was comprehensively analyzed in two aspects. First, given the fact that margin setting generates a spherical decision boundary in pattern recognition, we proposed a novel approach that combines margin …

Contributors To Infant Sleep: Factors Influencing Sleep Consolidation In Five- To Seven-Month Olds, Amber Leigh Evenson

Dissertations

Sleep is a universal construct that receives much attention in media and science, at least partially due to its importance as an essential component in development, health, and wellbeing. While undeniably vital, infant sleep is often variable and relatedly perplexing to parents. Around five-to-seven months of age, infants enter a time of quantifiable developmental change, impacting relational, cognitive, motoric, communicative and sleep behaviors. Because adequate sleep is considered one of the most indispensable precursors for developmental gains, factors that impact the progression of sleep are of interest. The current study utilized Ecological Theory to examine what variables impact sleep consolidation, …

Herbert Spencer And His American Audience, Joel F. Yoder

Dissertations

The philosopher Herbert Spencer (1820-1903) is little remembered today, but in the late nineteenth century he was a world-renowned figure and widely read. Spencer was popular in his native England, but even more highly regarded in America. Modern scholars generally understand this popularity as stemming from Spencer’s social Darwinism—that is, his belief that natural selection does and should operate on humans to improve mankind. On the other hand, many of those who have studied Spencer’s work claim that he was not a social Darwinist at all. It is my contention that Spencer was a social Darwinist, but that other aspects …

Synchrophasor Assisted Efficient Fault Location Techniques In An Active Distribution Network, Anil Khanal

Dissertations

Reliability of an electrical system can be improved by an efficient fault location identification for the fast repair and remedial actions. This scenario changes when there are large penetrations of distributed generation (DG) which makes the distribution system an active distribution system. An efficient use of synchrophasors in the distribution network is studied with bidirectional power flow, harmonics and low angle difference consideration which are not prevalent in a transmission network. A synchrophasor estimation algorithm for the P class PMU is developed and applied to identify efficient fault location. A fault location technique using two ended synchronized measurement is derived …

Military Millennials As Next Generation Leaders: Do Leadership Traits Matter?, Phillip Michael Green

Dissertations

Employers are constantly evaluating individuals to fill leadership roles within their organizations to extract the highest return from their resources and investments. Millennials, born between 1982 and 2000 (Howe and Strauss, 2000), represent the youngest and newest generation entering the workforce. A sub-population of this generation consists of military veterans returning to the United States after the wars in Iraq and Afghanistan. This quantitative study examines the leadership traits of the military Millennials that have transitioned to civilian life and compares this population segment with Millennials without a military background. To compare the two groups of the generational cohort, a …

Examining The Relationship Between Student Engagement And Stem Persistence At An Hbcu, Saundra Yates Evans

Dissertations

A growing imbalance in the demand for a science and technology workforce and the declining availability of a science and technology talent pool is challenging America’s world dominance in research and innovation, economic performance, and quality of life. Contributing to this imbalance is flatness in the trend of students selecting science, technology, engineering and mathematics (STEM) majors coupled with decreasing rates of retention in STEM disciplines. Many research studies and reports emphasize that incorporating the untapped talents of Americans who are underrepresented in STEM disciplines--African-Americans, Hispanics, and women--is necessary to increase the pipeline of STEM graduates. A synthesis of college …

Photoluminescence Of Cadmium Selenide-Based Quantum Dots In The Presence Of A Metal Oxide, Kira D. Patty

Dissertations

Quantum dots (QDs) are semiconductor nanocrystals that self-assemble from solution and come in a variety of shapes, sizes, and materials. Due to their extremely small sizes, QDs exhibit atom-like quantum mechanical properties that make them highly desirable for many applications and for fundamental research in quantum mechanics. Further, when continuously irradiated, the intensity of QD emissions can increase over time; a phenomenon referred to as photo-induced fluorescence enhancement (PFE). For almost every application that deals with the optics of QDs, the enhancement of their quantum efficiency and control of their photoluminescence properties is highly desirable. This research explores how the …