Digital Commons Network^™

Approximate Algorithms For Regulatory Motif Discovery In Dna, Hasnaa Imad Al-Shaikhli

Dissertations

Motif discovery is the problem of finding common substrings within a set of biological strings. Therefore it can be applied to finding Transcription Factor Binding Sites (TFBS) that have common patterns (motifs). A transcription factor molecule can bind to multiple binding sites in the promoter region of different genes to make these genes co-regulating. The Planted (l, d) Motif Problem (PMP) is a classic version of motif discovery where l is the motif length and d represents the maximum allowed mutation distance. The quorum Planted (l, d, q) Motif Problem (qPMP) is a version of PMP …

Essays In The Application Of Machine Learning In Development Economics, Dweepobotee Brahma

Dissertations

This dissertation comprises four essays which apply Machine Learning (ML) techniques to examine India’s progress towards meeting several child-health targets under United Nation’s “Sustainable Development Goals (SDG) 2030”. The application of novel ML techniques unmasks certain detailed empirical aspects of the road to meeting specific indicators of SDG - child mortality, malnutrition, immunization coverage and health-expenses.

The first essay employs multiple parametric and non-parametric Machine Learning (ML) techniques (LASSO, Classification Random Forest, Boosted Logistic Regression, Boosted Classification Trees) to build predictive models for the incidences of neonatal and infant mortality. A large national level household survey dataset is used. All …

Improving Protein Analysis By Desorption Electrospray Ionization (Desi-Ms), Elahe Honarvar

Dissertations

Electrospray ionization mass spectrometry (ESI-MS) is one of the most well-known and versatile techniques for analyzing a broad range of molecules and it has become one of the leading techniques to study biomolecules, such as proteins. ESI-MS can accurately determine the molecular weight of proteins and provide information about their peptide sequence, post-translational modifications as well as their interaction with other molecules.

During ESI-MS analysis, by spraying a sample of proteins, prepared in form of a solution, charged droplets are produced using an electric field. As the solvent molecules gradually evaporate from these droplets, freely hovering bare protein ions remain. …

Engaging In Self-Care: Do Mental Health Care Providers Practice What They Preach?, Nancy L. Lashley

Dissertations

Self-care has been identified as a critical protective factor against the adverse effects of career-related stress among mental health care professionals. The need for utilization of adequate self-care practices among mental health care professionals remains critical with the number of mental health care professionals endorsing clinically significant levels of anxiety, depression, and suicidal ideations. Research has identified the need and importance of self-care among mental health care providers as well as the adverse consequences of inadequate self-care. This literature review examined the methods and strategies mental health care providers are using to engage in self-care including complementary and alternative methods. …

Stonewall: Developing A Historically-And-Culturally Based Empowerment Narrative Modality For Therapeutic Treatment With Lgbtq+ Youth, Stephen Terranova

Dissertations

Despite more recent advancements in social acceptance and legislative advancements, LGBTQ+ peoples have continued to suffer from institutional and cultural oppression which has resulted in disproportionately higher levels of negative psychological outcomes, particularly for youth. The behavioral health establishment should be best-suited for addressing these concerns, but a history of stigmatizing LGBTQ+ peoples has created a paucity of population-sensitive treatment interventions which could be beneficial for use with younger people of sexually diverse identity. This paper posits that empowerment narrative therapy, with its emphasis on re-framing the stories of individuals to draw on their history of resilience to confront personal …

Policy Advocacy: Transgender Students In A Public School Setting, Rob Mcelligott

Dissertations

The purpose of this policy advocacy paper is to encourage the State of Illinois to implement a statewide policy on how school districts can best support students undergoing a gender transition. It has been proven that students in the LGBTQ community are subject to more harassment and bullying than their straight, cisgender peers. It is incumbent on schools to provide a safe, caring environment for all students. This policy was analyzed from educational, economic, social, legal, and ethical points of view. The implementation of this policy will help to guide students who are struggling with their gender identity by helping …

Model-Based Deep Autoencoders For Characterizing Discrete Data With Application To Genomic Data Analysis, Tian Tian

Dissertations

Deep learning techniques have achieved tremendous successes in a wide range of real applications in recent years. For dimension reduction, deep neural networks (DNNs) provide a natural choice to parameterize a non-linear transforming function that maps the original high dimensional data to a lower dimensional latent space. Autoencoder is a kind of DNNs used to learn efficient feature representation in an unsupervised manner. Deep autoencoder has been widely explored and applied to analysis of continuous data, while it is understudied for characterizing discrete data. This dissertation focuses on developing model-based deep autoencoders for modeling discrete data. A motivating example of …

Probabilistic Spiking Neural Networks : Supervised, Unsupervised And Adversarial Trainings, Alireza Bagheri

Dissertations

Spiking Neural Networks (SNNs), or third-generation neural networks, are networks of computation units, called neurons, in which each neuron with internal analogue dynamics receives as input and produces as output spiking, that is, binary sparse, signals. In contrast, second-generation neural networks, termed as Artificial Neural Networks (ANNs), rely on simple static non-linear neurons that are known to be energy-intensive, hindering their implementations on energy-limited processors such as mobile devices. The sparse event-based characteristics of SNNs for information transmission and encoding have made them more feasible for highly energy-efficient neuromorphic computing architectures. The most existing training algorithms for SNNs are based …

Electrochemically Reactive Membranes For Efficient Biomass Recovery, Pollutant Degradation And Commercialization, Likun Hua

Dissertations

Micropollution in natural waters such as rivers and groundwater aquifers is a widespread problem that prevents these potentially potable sources from being used as drinking water. In the United States, approximately two-thirds of the over 1,200 most serious hazardous waste sites in the nation are contaminated with trichloroethylene (TCE), a potentially carcinogenic compound. Other emerging and environmentally persistent organic micropollutants include polyromantic hydrocarbons (PAHs), organophosphate flame retardants, endocrine disrupting compounds (EDCs), pesticides, herbicides, pharmaceuticals and personal care products (PPCPs). Membrane filtration is one of the most efficient separation processes widely used for water treatment and pollutant removal. However, traditional membrane …

A Multimodal Approach To Investigate Brain Reorganization After Spinal Cord Injury Using Functional Magnetic Resonance Imaging And Functional Near-Infrared Spectroscopy, Keerthana Deepti Karunakaran

Dissertations

Traumatic Spinal Cord Injury (SCI) results in structural and functional neurological changes at both the brain and the level of the spinal cord. Anatomical studies indicate decreased grey matter volume in sensorimotor and non-sensorimotor regions of the cortex following SCI; whereas, neurophysiological findings mostly report altered functional activity in the sensorimotor nodes of the cortex, subcortex, and cerebellum. Therefore, it is currently unknown whether tissue atrophy observed in non-motor related areas has any concomitant functional consequences. Furthermore, the neural underpinnings of adaptive neuroplasticity after SCI is not well-defined in the current literature. Hence, this dissertation is a pioneer study investigating …

Minimizing Vehicular Traffic Via Optimized Land Use Development For A Sustainable And Equitable Future, Babu Veeregowda

Dissertations

Mixed-use developments and transit-oriented developments are becoming very common in urban areas in an effort to reduce sprawl. Numerous studies have shown that such programs would not be successful unless the mix of land uses and sizes is well-balanced and integrated with the surrounding neighborhood. Developers often ignore this aspect in favor of immediate financial gain and do not realize that there are sustainable financial benefits in land use optimization. In addition, professionals often work with limited logistics, resources, and technical knowledge and therefore struggle in setting goals and suggesting land uses that have less auto dependency based on travel …

Rare Event Sampling In Applied Stochastic Dynamical Systems, Yiming Yu

Dissertations

Predicting rare events is a challenging problem in many complex systems arising in physics, chemistry, biology, and materials science. Simulating rare events is often prohibitive in such systems due to their high dimensionality and the numerical cost of their simulation, yet analytical expressions for rare event probabilities are usually not available. This dissertation tackles the problem of approximation of the probability of rare catastrophic events in optical communication systems and spin-torque magnetic nanodevices. With the application of the geometric minimum action method, the probability of pulse position shifts or other parameter changes in a model of an actively mode-locked laser …

Dual Modality Optical Coherence Tomography : Technology Development And Biomedical Applications, Farzana Rahmat Zaki

Dissertations

Optical coherence tomography (OCT) is a cross-sectional imaging modality that is widely used in clinical ophthalmology and interventional cardiology. It is highly promising for in situ characterization of tumor tissues. OCT has high spatial resolution and high imaging speed to assist clinical decision making in real-time.

OCT can be used in both structural imaging and mechanical characterization. Malignant tumor tissue alters morphology. Additionally, structural OCT imaging has limited tissue differentiation capability because of the complex and noisy nature of the OCT signal. Moreover, the contrast of structural OCT signal derived from tissue’s light scattering properties has little chemical specificity. Hence, …

High-Performance Learning Systems Using Low-Precision Nanoscale Devices, Nandakumar Sasidharan Rajalekshmi

Dissertations

Brain-inspired computation promises a paradigm shift in information processing, both in terms of its parallel processing architecture and the ability to learn to tackle problems deemed unsolvable by traditional algorithmic approaches. The computational capability of the human brain is believed to stem from an interconnected network of 100 billion compute nodes (neurons) that interact with each other through approximately 10¹⁵ adjustable memory junctions (synapses). The conductance of synapses is modifiable allowing the network to learn and perform various cognitive functions. Artificial neural networks inspired by this architecture have demonstrated even super-human performance in many complex tasks.

Computational systems based …

Surface-Enhanced Raman Detection Of Glucose On Several Novel Substrates For Biosensing Applications, Laila Saad Alqarni

Dissertations

The small normal Raman cross-section of glucose is considered to be a major challenge for its detection by Surface Enhanced Raman Spectroscopy (SERS) for medical applications. These applications include blood glucose level monitoring of diabetic patients and evaluation of patients with other medical conditions, since glucose is a marker for many human diseases. This dissertation focuses on Surface-Enhanced Raman Scattering primarily for the detection of glucose. Some experiments also are carried out for the detection of the corresponding enzyme glucose oxidase that is used in electrochemical glucose sensors and in biofuel cells. This project explores the possibility of utilizing Surface …

The Heritage Leadership Process: Exploring Meaning Making And Social Emotional Competencies In Heritage Interpretation And Education For Sustainability, Lynn Cartmell, Tonia Herndon, Thomas Moffatt, Katy Mike Smaistrla Lampe

Dissertations

This study explores qualities identified as being critical to leadership work in heritage fields as identified by established leaders in heritage work. It also establishes a foundational definition of the term heritage leadership. After reviewing existing data to identify significant questions related to heritage leadership, the research team interviewed leaders in HIn and Education for Sustainability with a specific focus on leadership, meaning making, and social emotional competencies as guiding constructs in heritage leadership. A proposed definition of the term heritage leadership resulted: Heritage leaders aspire to serve others and to create meaningful connections to shared natural and cultural heritage …

Enzyme-Assisted Development Of Hydrogels As Medical Materials With Injectable, Biodegradable And Biocompatible Properties, Yung-Hao Tsou

Dissertations

Hydrogels were first discovered in the year 1960 by Wichterle and Lim [1], and in the following decades, they have been widely studied because of their unique characteristics including their hydrophilic nature, biocompatibility, and capacity to mimic the extracellular matrix (ECM). Hydrogels based on natural or synthetic polymers have continued to be of interest for tissue engineering and drug delivery due to their ability to encapsulate living cells and control the release rate of drugs or other bioactive molecules such as pharmaceutical proteins.

In the first part of this dissertation, dopant-free photoluminescent hydrogels formed in situ by crosslinking of biocompatible …

Temporal And Functional Cortical Aspects Related To Mirror Visual Feedback During Target-Directed Movement In Healthy And Stroke Individuals, Maryam Rohafza

Dissertations

Stroke is the leading cause of disability in the United States (American Heart Association, American Stroke Association) affecting 800,000 individuals annually (i.e., one person every 45 seconds). Therapy for stroke often uses repetitive task practice, which is difficult to perform for patients due to impairment. Mirror visual feedback (MVF) based rehabilitation uses the effect of observing the mirror reflection of volitional movement of one limb, to activate visuomotor brain areas that process movement of the opposite limb. In persons with hemiplegia due to stroke, exercising the less affected limb while observing its reflection, perceived by them as the motion of …

The Moral Certainty Or Uncertainty Of Nurses Regarding End-Of-Life Treatment Decisions, Mary Ellen Wurzbach

Dissertations

Much has been written about the importance of decision-making in nursing ethics, but few research studies have been completed which examine nurses' ethical decision-making. In order to address this absence of research, two concepts that are integral to nurses' ethical decision-making were analyzed: moral certainty and moral uncertainty. These concepts were studied in the context of the issue of withholding or withdrawing artificial nutrition and hydration. This issue was chosen as an exemplar of issues about which nurses feel morally certain or uncertain. The research questions addressed by this research were: (a) Are nurses morally certain or uncertain about whether …

An Investigation Of The Relationship Between Time Preference And Developmental Stage In The Lives Of Adult Females, Karen E. Forbes

Dissertations

Research has been conducted documenting the occurrence of biological rhythms in all aspects of life. Researchers have shown that an individual's time preference for morningness or eveningness parallels some biological rhythms. Others have shown that biological rhythms are stable across the life span. Preliminary studies have been conducted on adult developmental stages. These studies have shown that adults, like children, travel through distinct stages. This study arose when many women reported being an evening type when they were young adults, but changed to being a morning type when they had children. This study was designed to investigate whether a woman's …

The Relationship Between Health Locus Of Control, Perceived Self-Efficacy, Hardiness, And Recovery In Schizophrenia, Anne W. Bender

Dissertations

Approximately 1 out of 100 persons in the United States will be diagnosed as schizophrenic at some point in their lives. As an illness with onset in late adolescence or early young adulthood, schizophrenia has been described as having a homogeneous course of long-term chronicity. Recent literature has delineated more heterogeneity of outcome, but studies identifying factors related to recovery have been sparse. Using as a theoretical framework the stress-vulnerability model of schizophrenia, and concepts from social learning theory and existential psychology, this study examined the relationship between health locus of control, perceived self-efficacy, hardiness, and recovery, and which would …

Perinatal Mood And Anxiety Disorders, Stigma, And Social Support Among Postpartum Women, Ellen K. Fleischman

Dissertations

Purpose/Aims: The purpose of this descriptive, correlational, cross-sectional study was to examine the relationships among perinatal mood and anxiety disorder (PMAD) symptomatology, select demographics, stigma of mental illness, and social support, among inpatient postpartum women. Rationale: PMADs affect as many as 21% of childbearing women, yet these disorders are identified and treated less than half the time. There is a gap in the literature regarding the relationships among stigma, social support, and PMADs in postpartum women.

Conceptual Basis/Background: Despite recommendations from professional organizations, screening for PMADs is not consistently completed using a valid, reliable instrument. Stigma contributes to the low …

Adult Postoperative Open-Heart Patients: Anemia And 30-Day Hospital Readmission, Lindsey Ryan

Dissertations

Background. In 2013 alone, more than 4% (3.9 million) of patients discharged from a hospital were readmitted. Anemia following a surgical procedure is associated with early hospital readmission.

Purpose/Aims. The following were specific aims of this dissertation:

• Aim 1. To develop an operational definition of the term condition-based maintenance as applied to health care and discuss the applicability and effectiveness of condition-based maintenance within health care.
• Aim 2. To identify the number of adult patients undergoing elective open-heart surgery with preoperative anemia.
• Aim 3. To examine the relationship between preoperative anemia, sociodemographics, and 30-day hospital readmission rates among postoperative open-heart …

Delirium In Long Term Care Rehabilitation Residents: A Correlational Retrospective Study, Rebecca Lerma-Kjonegaard

Dissertations

Abstract Background: Delirium is associated with devastating outcomes, cognitive loss,

decreased function and an increase risk of mortality which affects patients and places a heavy burden on family and the healthcare system. The purpose of this study was to describe the relationship between select demographics, clinical characteristics, CHART- DEL-derived delirium diagnosis and ICD-10 coded discharge delirium diagnoses among Long Term Care (LTC) rehabilitation residents.

Method: A retrospective correlational design from174 LTC rehabilitation residents age 65 years or older using EMR and hard copy charts. The setting was a Southern California community hospital-based 100-bed LTC. Abstracted data included demographic characteristics (age, …

Prenatal Care Education For Women Experiencing Unplanned Pregnancy, Sharon T. Heskitt

Dissertations

This project suggested that the Prenatal Care Education Module (PCEM), a series of three brief videos lasting a total of ten minutes, may be an effective way to educate women experiencing an unplanned pregnancy about the importance of prenatal care for themselves and their babies. To assess the effect of the PCEM, the Brief Pregnancy Perception Questionnaire (B-PPQ), a tool adapted from the Brief Illness Perception Questionnaire (B-IPQ) (Broadbent, Petrie, Main & Weinman, 2006) was employed. The B-PPQ assessed participants' health care needs, their understanding of pregnancy, their emotional response to pregnancy, and current contact with a prenatal health care …

The Relationship Of Leadership Patterns To Usage Patterns And Suitability Of Information Technology For Decision-Making Of Nursing And Non-Nursing Academic Administrators In Higher Education, Martha J. Morrow

Dissertations

This dissertation describes the relationship of leadership patterns to computer usage patterns and the suitability of information technology for decision making among academic administrators in higher education in the Nursing departments and Arts and Science Departments of universities in the United States and its provinces.

Employee Engagement And Burnout: A Quantitative Study Of Their Correlations With Job/Organizational Satisfaction, Sarah Burnett

Dissertations

Since Kahn introduced the concept of employee engagement in 1990, the focus on motivating employees has been en vogue in practitioner literature. The federal government as well now measures its agencies annually on how well they implement conditions conducive to engagement. Federal agencies are also ranked annually as “Best Places to Work” based on their aggregated score on three survey items deemed to represent job/organizational satisfaction. The concept of burnout, or the so-called “erosion of engagement”, however, has received significantly less attention. To begin to fill this void in the literature, secondary survey data from the 2017 Organizational Assessment Survey …

Evolving An Ecological Way Of Thinking: Social Interactions And The Construction Of Environmentally Sustainable Behaviors In Adolescents During Expeditionary Learning, Jennifer Fruend

Dissertations

The people around us - as well as the methodical progression of education through content - often shape our relationship to the world. Currently, Earth is at a crossroads, which requires humans to act and live more sustainably with an intentional environmental ethos, whether for literal survival or for slowing Earth’s resource degradation. Situated within the models of ecological contributors such as Aldo Leopold, transformational experiences, particularly when processed with self-reflection, writing, and social interaction, can change behaviors and priorities in individuals. Additionally, by recognizing the place of social learning components in expeditionary, informal, or adventure-based education settings, the potential …

Mental Health Nurses' Imagination, Power, And Empathy: A Descriptive Study Using Rogerian Nursing Science, Maureen B. Doyle

Dissertations

The researcher developed a perspective on empathy derived from Rogers' (1970, 1994) Science of Unitary Human Beings. Building on Barrett's (1983) Rogerian theory of power as knowing participation in change, the researcher proposed that empathy and power would change relative to each other and relative to the creative manifestation of human imagination. Using a descriptive correlational design, three hypotheses predicting that empathy, power, and imagination would each be related positively to one another were tested.

Patterns Of Fatigue And Factors Influencing Fatigue During Adjuvant Breast Cancer Chemotherapy, Ann M. Berger

Dissertations

Women beginning adjuvant chemotherapy for breast cancer seek information from health professionals regarding fatigue, but knowledge regarding this distressing symptom is currently limited. The purposes of this study were to describe the patterns of fatigue and of factors influencing fatigue across the first three cycles of chemotherapy and to determine the extent to which health and functional status, chemotherapy protocol, physical activity behaviors, activity/rest cycles, nutrition behaviors and status, stress management behaviors, interpersonal relations behaviors, symptom distress and reaction to the diagnosis of cancer explain fatigue at each treatment and predict fatigue at the mid-point of the first three chemotherapy …