Digital Commons Network^™

Elucidating The Role Of Kmt2d In Her2+ Breast Cancer, Emily Ma

Dissertations

Breast cancer is the second leading cause of cancer-related deaths among women in the US. Histone modifications are common epigenetic changes that have been implicated in several breast cancers, including HER2+ breast cancers. Current therapies, such as trastuzumab, block the HER2 receptor to reduce tumor growth. Unfortunately, HER2+ breast cancers have found ways to overcome these therapies, leading to tumor resistance, metastases, and poor survival outcomes. A better understanding of the underlying mechanisms contributing to HER2+ breast cancer resistance may lead to the discovery of novel therapeutic strategies to improve patient outcomes.One prognostic marker for poor survival in women with …

Factors That Affect The Rate Of Preterm Birth: An Examination Of The Inter-Related Impacts Of Social Determinants, Behavior And Physical Health Status, Krystal Michelle Hunter

Dissertations

The work seeks to examine the factors that have significant relationships to the rate of preterm birth (PTB) along with its cost to society.

There are four papers within this work. This purpose of the first paper is to measure the impact that healthy behaviors have on the rate of PTB when modeled with other factors like household demographics, community deprivation, chronic disease and mental health. This work finds that positive health behaviors has a negative relationship with PTB. The interaction between body mass index (BMI) and social class and its relationship to PTB is examined in the second paper. …

Exposing And Fixing Causes Of Inconsistency And Nondeterminism In Clustering Implementations, Xin Yin

Dissertations

Cluster analysis aka Clustering is used in myriad applications, including high-stakes domains, by millions of users. Clustering users should be able to assume that clustering implementations are correct, reliable, and for a given algorithm, interchangeable. Based on observations in a wide-range of real-world clustering implementations, this dissertation challenges the aforementioned assumptions.

This dissertation introduces an approach named SmokeOut that uses differential clustering to show that clustering implementations suffer from nondeterminism and inconsistency: on a given input dataset and using a given clustering algorithm, clustering outcomes and accuracy vary widely between (1) successive runs of the same toolkit, i.e., nondeterminism, and …

Crash Injury Severity Prediction With Artificial Neural Networks, Rima Abisaad

Dissertations

Motor vehicle crashes are one of our nation's most serious social, economic and health issues. They are the leading cause of death among children and young adults, killing approximately 1.35 million people each year. Providing a safe and efficient transportation system is the primary goal of transportation engineering and planning. To help reduce traffic fatalities and injuries on roadways, crash prediction models are used to forecast the injury severity of potential crashes and apply precautionary countermeasures accordingly. Most of these models are reactive as they use historical crash data to categorize crash-related factors. Recently, advancements have been made in developing …

Coherent Control Of Dispersive Waves, Jimmie Adriazola

Dissertations

This dissertation addresses some of the various issues which can arise when posing and solving optimization problems constrained by dispersive physics. Considered here are four technologically relevant experiments, each having their own unique challenges and physical settings including ultra-cold quantum fluids trapped by an external field, paraxial light propagation through a gradient index of refraction, light propagation in periodic photonic crystals, and surface gravity water waves over shallow and variable seabeds. In each of these settings, the physics can be modeled by dispersive wave equations, and the technological objective is to design the external trapping fields or propagation media such …

Iii-Nitride Nanostructures: Photonics And Memory Device Applications, Barsha Jain

Dissertations

III-nitride materials are extensively studied for various applications. Particularly, III-nitride-based light-emitting diodes (LEDs) have become the major component of the current solid-state lighting (SSL) technology. Current III-nitride-based phosphor-free white color LEDs (White LEDs) require an electron blocking layer (EBL) between the device active region and p-GaN to control the electron overflow from the active region, which has been identified as one of the primary reasons to adversely affect the hole injection process. In this dissertation, the effect of electronically coupled quantum well (QW) is investigated to reduce electron overflow in the InGaN/GaN dot-in-a-wire phosphor-free white LEDs and to improve the …

On Resource-Efficiency And Performance Optimization In Big Data Computing And Networking Using Machine Learning, Wuji Liu

Dissertations

Due to the rapid transition from traditional experiment-based approaches to large-scale, computational intensive simulations, next-generation scientific applications typically involve complex numerical modeling and extreme-scale simulations. Such model-based simulations oftentimes generate colossal amounts of data, which must be transferred over high-performance network (HPN) infrastructures to remote sites and analyzed against experimental or observation data on high-performance computing (HPC) facility. Optimizing the performance of both data transfer in HPN and simulation-based model development on HPC is critical to enabling and accelerating knowledge discovery and scientific innovation. However, such processes generally involve an enormous set of attributes including domain-specific model parameters, network transport …

Electro-Chemo-Mechanics Of The Interfaces In 2d-3d Heterostructure Electrodes, Vidushi Sharma

Dissertations

Unique heterostructure electrodes comprising two-dimensional (2D) materials and bulk three dimensional (3D) high-performance active electrodes are recently synthesized and experimentally tested for their electrochemical performance in metal-ion batteries. Such electrodes exhibit long cycle life while they also retain high-capacity inherent to the active electrode. The role of 2D material is to provide a supportive mesh that allows buffer space for volume expansions upon ion intercalation in the active material and establishes a continuous electronic contact. Therefore, the binding strength between both materials is crucial for the success of such electrodes. Furthermore, battery cycles may bring about phase transformations in the …

The Role Of Microorganisms In Rare Earth Elements Bioaccumulation, Maedeh Soleimanifar

Dissertations

Rare earth elements (REE) are valuable raw materials in our modern life. Extensive REE application from electronic devices to medical instruments and wind turbines, and non-uniform distribution of these resources around the world, make them strategically and economically important for countries. Current REE physical and chemical mining and recycling methods could have negative environmental consequences, and biologically-mediated techniques could be applied to overcome this issue.

In this research, the first objective is to investigate the bioextraction of cerium oxide and neodymium oxide nanoparticles (REE-NP) by a pure culture Methylobacterium extorquens AM1 (ATCC®14718™). Results show that adding up to 1,000 ppm …

Fluorescence Probes For Bioimaging: Synthesis, Photophysical Properties And Applications, Mehrun Nahar Uddin

Dissertations

Fluorescent probes are a vital tool in the study of cell imaging. There are many types of fluorescent probes ranging from inorganic and organic nanoparticles to organic molecules. When used judiciously, they can help provide essential information on cellular structure and function. The introduction of two-photon microscopy has expanded the need for new probes, in particular near-infrared (NIR) absorbing and emitting fluorescent probes. The photochemical and photophysical properties of NIR probes play a crucial role in their effectiveness in cell imaging by both conventional and two-photon excitation (2PE) microscopy. In this research, the synthesis, photophysical properties, and two-photon absorption (2PA) …

Bodipy Based Photodynamic Therapy And Potassium Probes, Xiangshan Liu

Dissertations

Boron dipyrromethene (BODIPY) has become more and more popular in photophysical and biological applications. BODIPY based fluorescence compounds have numerous advantage properties including low toxicity, high absorption extinction coefficients, high fluorescence quantum yields, sharp fluorescence emissions, and resistance to photobleaching. All the good properties lead to the wide applications of BODIPY based compounds. In this research, two different kinds of BODIPY are synthesized. Firstly, BDBrC containing carbazole and BODIPY core is synthesized. Cellular uptake research shows BDBrC can target on lysosome and singlet oxygen generation research result indicates that BDBrC can be used in photodynamic therapy. BDBrC also shows pH-sensitive …

Synthesis And Characterization Of Glycosaminoglycan Mimetic Variants For Cartilage Tissue Engineering Applications, Richard David Vincent Jr.

Dissertations

No abstract provided.

The Integration Of Art: A Multiple Case Study Of Science, Technology, Engineering, Art, And Math (Steam) Schools In Three Schools In Southern California, Reyna Esther Smith

Dissertations

Purpose: The purpose of this qualitative multi-case study was to describe and analyze how schools that implement a STEAM program include the arts in their integrated program. The study focused on 3 K-12 schools in Southern California that are located in the Antelope Valley high desert region of the state. This multi-case study analyzed an elementary school, a middle school, and a high school that are in different districts in the area.

Methodology: This multi-case study used qualitative data to analyze the research questions regarding art infusion in STEAM programs and teacher and leader perspectives. Drawing from interviews of teachers …

A Nationally Representative Survey Of Depression Symptoms Among Jordanian Adolescents: Associations With Depression Stigma, Depression Etiological Beliefs, And Likelihood To Seek Help For Depression, Latefa Ali Dardas

Dissertations

Arab adolescents are considered a particularly vulnerable population to depression. The substantial lack of mental health services and the stigma associated with mental illness on the one hand; and poverty, unemployment, and lack of reasonable hopes for a decent future in the context of corruption of regimes and perceived social injustice on the other, call for establishing committed and effective policies to tackle depression and its associated stigma among Arab adolescents at risk for or diagnosed with depression. However, there is a substantial lack of research that can inform the current profile of adolescent depression in the Arab region. We …

The Health-Related Quality Of Life Of Adults With Down Syndrome, Rebecca Jermyn Graves

Dissertations

The purpose of this study was to examine the health-related quality of life (HRQOL) and factors associated with the HRQOL of adults with Down syndrome (DS) as reported by adults with DS and their caregivers. The study was designed to compare measures of HRQOL, health problems, health risks, and health-care utilization of adults with DS based on self-report with those from caregiver-report and to explore associations between HRQOL and health problems, health risks, health-care utilization, adaptive behavior, and demographic characteristics.

Simulated Presence Use For Quality Of Life Maintenance And Reduction Of Symptoms Of Distress In Persons Living With Dementia In Long-Term Care, Erin E. Bush

Dissertations

Nursing home residents with dementia often have an array of neuropsychiatric symptoms, including dementia-related agitation. It is theorized that many of these agitation symptoms occur due to unmet psychosocial needs that could be met by the presence of a caring nursing staff member, family member, or friend.

The purpose of this study was to determine whether live simulated presence improves dementia-related agitation when offered, identify barriers and facilitators to simulated presence between caregivers and residents of long-term care during the COVID-19 pandemic, and to determine if live simulated presence by a caregiver delivered one-on-one improved quality of life in long-term …

Exploring Resilience In Exemplary Rural School Superintendents, Silas Gaussoin-Radcliffe

Dissertations

Purpose: The purpose of this exploratory phenomenological study was to identify and describe the strategies used by exemplary rural superintendents to maintain personal resiliency based on Everly, Strouse, and McCormack’s (2015) five factors of personal resilience (active optimism, decisive action, moral compass, relentless tenacity, and interpersonal support).

Methodology: This exploratory phenomenological study used purposeful criterion sampling and recommendations from the county superintendents in the identified geographic area. Each of the 8 identified exemplary rural superintendents was interviewed using an instrument aligned to the five factors of personal resilience and their definitions. The researcher collected rich qualitative interview data, that were …

Effects Of Extra-Curricular Project-Based Learning Experiences On Self-Efficacy And Interest In Stem Fields In High School, Taihao Kevin Wan

Dissertations

As our society and systems become more technologically advanced, increasing opportunities exist for students interested to pursue careers in Science, Technology, Engineering, and Mathematics (STEM) fields. However, pervasive inequities have led to differences in the extent to which women and underrepresented racial/ethnic groups choose to pursue study and career pathways in STEM. Project-Based Learning (PBL) is among the most widely researched strategies suggested to support student learning and motivation and has more recently been applied to school-based efforts to increase student interest in STEM related fields. Rooted in Social Cognitive Career Theory, this study examined changes in students’ self-reported general …

Empathy As A Moderator Of Preservice Teachers’ Culturally Responsive Teaching Self-Efficacy And Outcome Expectancy Beliefs, Juta Tammachart

Dissertations

The main purpose of this research was to examine the relationship model between culturally responsive teaching self-efficacy (CRTSE) and culturally responsive teaching outcome expectancy beliefs (CRTOE) in Thailand. There were two research questions outlined in the study: what is the relationship between preservice teachers’ CRTSE and CRTOE? Also, does the culturally responsive teaching teacher empathy (CRTTE) moderate the relationship of preservice teachers’ CRTSE and CRTOE?

Based on the CRT standards by Siwatu (2005), there were three measures applied in the study: CRTSE, CRTOE, and CRTTE scales. These instruments were piloted with 536 preservice teachers in the Faculty of Education, Prince …

"All For The Family:" A Case Study On The Migration Of Philippine Educated Nurses To Ontario Through The Live-In Caregiver Program, Oluwabukola Oladunni Salami

Dissertations

Despite evidence that suggests that nurses migrate to Ontario through the Live-in Caregiver Program, no research has been conducted on this group of nurses in Ontario. This study addresses that gap utilizing the transnational feminist concept of "global care chains" in a single holistic case study design to explore the experience of nurses who migrate to Ontario through the Live-in Caregiver Program (2001-2011), and examine the diverse perspectives of stakeholders on issues of rights and obligations of these nurses. Fifteen live-in caregivers and nine policy stakeholders were interviewed, and an analysis undertaken of immigration and nursing policy documents. Findings indicate …

What Does Masculinity Have To Do With It? The Roles Of Fathers In The Socialization Of Children’S Emotions And Emotion Regulation, Kathryn Cherry

Dissertations

Emotion regulation skills are important in a variety of domains throughout the lifespan, including psychological, social, academic, and occupational functioning. Research on children’s emotion regulation skill development often examines the family, exploring caregiver approaches to emotion socialization. However, this research has predominantly been conducted with mothers. Fathering is of particular interest to children’s emotional development for a variety of reasons, including the role of traditional Western masculine norms in gendered differences in emotion expression and regulation techniques. Fathers’ conformity with masculine norms and difficulty with emotion regulation have potential to impact their emotion socialization practices, and therefore relate to their …

Distribution, Abundance, And Population Genetics Of The Alligator Snapping Turtle (Macrochelys Temminckii) In Mississippi, Luke Pearson

Dissertations

The southeastern United States is a freshwater turtle biodiversity hotspot, second only to southeastern Asia, and this region is inhabited by one of the largest freshwater turtles in the world: the alligator snapping turtle (Macrochelys temminckii). This species was heavily harvested from the 1960’s to the 1980’s for the turtle soup industry, apparently contributing to substantial, range-wide population declines. These declines, coupled with anthropogenic impacts on riverine and floodplain habitats, have led to M. temminckii being petitioned for federal listing under the U.S. Endangered Species Act; it is currently under review by the U.S. Fish and Wildlife Service …

Exploring Emotional Labor, Emotional Dissonance, And Job Satisfaction Among African American Student Affairs Professionals At Predominately White Institutions, Vashae Dixon

Dissertations

Turnover in higher education is excessive compared to other education fields (Wilson et al., 2016). Up to 60% of student affairs professionals leave the field within the first five years of their professional career (Fried, 2014; Naifeh & Kearney, 2020), resulting in a loss of money, efficiency, and productivity (Allen et al., 2010). Previous research shows the link between turnover and job satisfaction for student affairs professionals (Fried, 2014) and the relationship between job satisfaction, emotional labor, and emotional dissonance (Parajon, 2011). Existing research lacks specific information about African Americans, undermining organizational efforts to retain employees of all identities. This …

The Understanding Of Digital And Multimedia Evidence (Dme) By Attorneys And Digital Forensic Examiners (Dfe) Within The United States Criminal Justice System, Joseph Levi White

Dissertations

One goal of this research was to determine potential themes that may influence the understanding of Digital and Multimedia Evidence (DME) by attorneys and Digital Forensic Examiners (DFE) within the United States Criminal Justice System. Qualitative semi-structured interviews were conducted to gather information from experienced criminal attorneys and DFEs regarding potential influences on their understanding of DME. The results of these interviews were transcribed, and the data coded to allow for qualitative analysis. Five themes were developed from this data and are thought to play a role in understanding of DME by attorneys and DFEs: motivation for involvement in the …

Granulins In Norm And Neurodegenerative Pathologies, Anukool Bhopatkar

Dissertations

Granulins (GRNs) are small, cysteine-rich modules produced from the proteolytic cleavage of the precursor protein called progranulin (PGRN). GRNs are present in the form of seven tandem repeats within the precursor and are known to be produced in the extracellular and in lysosomal environments. In physiology, PGRN and GRNs plays pleiotropic roles such as neuronal growth and differentiation, immunomodulation, wound healing. Recent studies have implicated pathological role for PGRN in Alzheimer disease (AD) and frontotemporal dementia (FTD) but specific mechanism(s) remains unclear. However, potential interactions between GRNs and Ab42 and TDP-43 seem like a plausible underlying mechanism. Studies presented here …

Dicer Represses Antiviral Innate Immunity Pathways In Mouse Embryonic Stem Cells, Chandan Gurung

Dissertations

Recent studies have demonstrated that embryonic stem cells (ESCs) are deficient in expressing type I interferons (IFN), the cytokines that play key roles in antiviral responses. However, the underlying molecular mechanisms and biological implications of this finding are poorly understood. In this study, I used a synthetic RNA-based assay that can simultaneously assess multiple forms of antiviral responses in ESCs. Dicer is an enzyme essential for RNA interference (RNAi), which is used as a major antiviral mechanism in invertebrates but not clear in vertebrates. RNAi activity is detected in wild-type ESCs but is abolished in Dicer knockout ESCs (D−/−ESCs) as …

Sustainable Development Among Four–Year Higher Education Institutions In The United States: A Geographic And Anthropological Perspective, Kori Nadine Armstrong

Dissertations

This dissertation investigates the factors that contribute to the cultural characteristics of sustainability among higher education institutions (HEIs) in the United States to shed light on how they represent themselves as sustainable. It documents four-year HEIs in the United States that self-identify as sustainable; evaluates how these institutions portray themselves to society as sustainable; and documents who is leading sustainability on U.S. college campuses. This dissertation fills an important gap in the literature on sustainable development in higher education that Holm and others (2016) have identified. Although education for sustainable development (ESD) has been recognized as an important topic, and …

Approaches To Studying And Study Tactics Of Baccalaureate Nursing Students, Lisa D. Brodersen

Dissertations

This research was designed to describe study approaches and study tactics used by baccalaureate nursing students. Previous inquiry indicates that students will take a Deep, Strategic, or Surface approach to studying and will use specific study tactics to meet the demands of their learning contexts.

Rheological Properties Of Recyclable Polymer Matrices For Advanced Composite Applications, Rahul Shankar

Dissertations

This dissertation focuses on evaluating the rheological characteristics of a variety of recyclable polymer matrices, which can compete with thermosets in a wide range of specialized applications. Studying the fundamental solid and melt-state viscoelastic properties and establishing structure-property-processing relationships is critical for the widespread adoption of these novel recyclable polymers in commercial applications. The first chapter provides an introductory overview of the different recyclable polymer matrices and their applications including high performance thermoplastics as thermoset replacements in high energy composite manufacture, multifunctional specialty thermoplastics for additive manufacturing and next generation, reprocessable covalent adaptable networks for self-healing applications. Furthermore, the important …

Synthesis Of Molecular Probes For The Detection Of Toxic Analytes, Rashid Mia

Dissertations

Two different types of molecular probes have been synthesized. The first family of probes is the coumarin class of compounds. These chemodosimters are referred to as Low Molecular Weight Fluorescent probes (LMFP). The other type of molecular probe is a macrocycle known as a pillar[5]arene receptor.

The chemodosimters (2.12a-c and 3.12a) were synthesized in four to five steps. The photophysical properties were extensively studied in various solvent systems (DMSO, CH₃CN, DMF, MeOH, EtOH, Me₂CO, MeCO₂Et, CHCl₃, C₆H₅Me, and C₆H₆). Dimethyl sulfoxide (DMSO) …