Digital Commons Network^™

The Role Of Microrna In Cardioprotection: Ischemic Preconditioning And Mesenchymal Stem Cell Paracrine Effects, Kristin Luther

Dissertations

Changes in gene expression and protein levels are an important aspect of cardioprotection in which short non-coding RNA known as miRNA may play a key regulatory role. We investigated the functions of several miRNAs in the context of two cardioprotective stimuli, ischemic preconditioning (IPC) and mesenchymal stem cell (MSC) paracrine effects. We hypothesized that downregulation of a set of miRNAs (miR-148a/b, miR-30b, and let-7a*) augments expression of protective heat shock proteins during IPC, and that MSC exosomes transfer miR-21 to cardiomyocytes, resulting in downregulation of pro-apoptotic genes and reduction of infarct size.

IPC increased the level of Hsp70, Hsp90, and …

The Utilization Of Liquid Chromatography Tandem Mass Spectrometry And Related Techniques For The Analysis And Identification Of Emerging Contaminants In Aqueous Matrices, Matthew Reichert

Dissertations

Environmental pollutants can be found in many ecosystems and cover many different compound classes. The Environmental Protection Agency is responsible for monitoring and regulating several of these classes of compounds which daily enter the environment. However, there are still hundreds, if not thousands, of compounds present in the environment which have yet to be regulated or even identified. The discovery and identification of these unknown emerging pollutants is crucial for the prevention of potential human health risks and irreversible ecological damage.

The research presented is divided into two projects. The first part of this research investigates the disinfectant 3-Bromo-1-chloro-5,5-dimethylhydantoin, which …

Habermas And Public Reason In The Digital Age: Technology And Deliberative Democracy, Asaf Bar-Tura

Dissertations

Scholars defending the deliberative model of democracy have focused much of their attention on argumentation and criteria for offering public reasons in deliberative processes, but have paid little attention to the ways in which digital technologies mediate such deliberations. Conversely, critical theorists of technology have emphasized the socially determined nature of technology, but have lacked a theory of democracy through which to normatively assess technologies that mediate public discourse. Through a reworking of Jürgen Habermas’s discourse-based theory of democracy, my research provides a new understanding of the flows of political communication and power in the democratic public sphere and the …

The Chilean Student Movement: A Family Matter. The Intimate And Conflicting Construction Of Revolution In A Post Dictatorial Country, Leslie Parraguez Sanchez

Dissertations

In 2011, thousands of students filled the main streets and occupied most educational establishments of Chile to demand a profound transformation of the educational system – one of the main reforms of Pinochet’s government. Like students in many other countries, the Chilean Student Movement has been struggling against the pervasive effects of neoliberalism on the higher educational system, aiming to recover the public sense of education. Students from all over the country began to organize to struggle against profits in the higher education system. In doing so, students denied the very core of the neoliberal economic system and deeply (re)politicized …

The Impact Of Altered T Cell Receptor—Peptide-Major Histocompatibility Complex Interactions On Antigen Recognition And T Cell Function, Timothy T. Spear

Dissertations

Adoptive cell transfer (ACT) using T cell receptor (TCR) gene-modified T cells is an exciting and rapidly evolving field. Numerous basic science and clinical studies have demonstrated various levels of feasibility, safety, and efficacy using TCR-engineered T cells to treat cancer and viral infections. Genomic instability of targeted diseases, however, requires effective and safe TCRs to cross-recognize mutated antigens while minimizing on- or off-target toxicities. Thus, improvements to T cell-based therapeutics mandate a broader understanding of the principles governing antigen recognition. This dissertation addresses critical biologic questions evaluating which parameters are most important in facilitating antigen recognition, and how alterations …

Electroosmotic Microfluidic Oligonucleotide Synthesis Reactor, William R. Gaillard

Dissertations

The principle objective of this dissertation is the development of a microfluidic oligonucleotide (oligo) synthesis reactor that sequences oligos with equal quality to commercial synthesizers and with equal waste reduction to previously published microfluidic synthesizers. The microfluidic approach to oligo synthesis increases throughput due to parallelization, provides simplification by integration of multiple functions into one platform, and decreases cost due to miniaturization and waste reduction. Microfluidic oligo synthesizers demonstrate these advantages over industrial synthesizers but have error rates that are too high for commercialization. The microfluidic synthesizer design investigated in this dissertation incorporates several innovations to reduce the error rates …

Transverse Stratified Structure For Tunable Beaming And Filtering At Terahertz Frequencies, Daniele Lo Forti

Dissertations

The terahertz field is rapidly expanding due to technological progress over the last few years. While source and detectors are available in this frequency range, there is still no firmly established technology for tunable filters and modulators. In this work a number of transverse stratified configurations of metal and dielectric layers are studied for modulating Terahertz radiation in amplitude and phase. The first configuration analyzed is a set of metal plates placed on top of each other and separated by a thin layer of Liquid Crystal (LC). The period of the grating is such that the only propagating order is …

Robust Support Media For High Throughput Chromatographic Separations, Javier Sanchez Santiago

Dissertations

Affinity chromatography is used to separate biomolecules based on highly specific interactions, such as receptor and ligand, enzyme and substrate or antigen and antibody. Traditional chromatographic separation systems have the disadvantages of low flowrates, high pressure drop across the column, low capacity and poor reusability. Ceramic monoliths have been previously used as active support for affinity chromatographic columns due to their compact geometry and outstanding mechanical properties. In addition, mathematical models have been developed in order to determine the adsorption and elution times depending on the monolith geometry. The reversible interaction between L-asparagine and L-asparaginase has been exploited, using a …

The Digital Divide Through The Lens Of Critical Race Theory: The Digitally Denied, Stacy Gee Hollins

Dissertations

The purpose of this qualitative research study was to examine African American community college students’ availability to technological resources and how that availability affects their success. In this study, technological resources include access to the internet, software, hardware, technology training, technology support, and community resources. This study included six community college professors and six African American community college students enrolled in a Midwest community college. A major tenet of Critical Race Theory, storytelling, was used to give voice to students who lack sufficient access to technological resources referred to as the digitally denied. Data from this study can create an …

Hidden Voices: The Missing Narratives Of Voluntary Interdistrict Choice Participants From 2000 To 2004 And Student Transfer Participants From 2013 To 2014, Miranda Temecka Ming

Dissertations

This study explored the perspectives of students participating in the Voluntary Inter-district Choice program from 2000-2004 and the experiences of participants in the Student Transfer Program attending the same suburban district due to the lack of accreditation in their neighboring schools during 2013-2014. The study uncovered the voices of participants in the VICC and student transfer program and to provided their voices in hope that it may be used as an instrument of change. This subjective, phenomenological qualitative study explored the lived experiences of high school students transferring to suburban districts and provides an in-depth analysis of their social, emotional, …

Arthur L. Washington, Twentieth Century Educator And Change Agent At Sumner High School, Herman Leo Harris

Dissertations

In the history of the United States, the Midwest, in general, and Missouri, in particular, has had a complex role concerning issues of race. For example, St. Louis was the site for the 1857 Dred Scott Case, which determined those of African ancestry could never become citizens. Fast forward to the 1940s and ‘50s and Missouri, as well as the rest of the United States, is still divided by race and largely segregated. As an African American man, Arthur L. Washington, would not be satisfied with the culture of the day. Born December 14, 1917, Washington envisioned the world with …

Women, Sex, And God: Women's Sexuality And The Internalization Of Religious Messages, Petra Sterling Blum

Dissertations

Grounded theory methodology was used to explore women’s internalization of religious messages regarding their sexuality. Two research questions served as the guide for this study: how are women’s sexual self-views informed by their religious teaching, and how are these messages, along with their experiences, lived in them sexually, psychologically, and spiritually? Eleven women (ages 30-74) were chosen who had been raised in a Western Christian tradition in the US (8 Protestant, 3 Catholic). Participants were interviewed through an in-depth three-interview process to gain an understanding of their experiences and how they resolved their concerns with sex and spirit. The findings …

Comparison Of Beginning Teachers' And Experienced Teachers' Readiness To Integratetechnology As Measured By Tpack Scores, Heather S. Fontanilla

Dissertations

Despite a growing awareness of the importance of technology in education, increased investment and attention to preparing teachers to integrate technology into the classroom, research shows that technology continues to fail to live up to its potential for transforming education. As schools move from standards based testing to implementation of the Common Core State Standards (CCSS), an expectation exists that teachers will be using technology to transform their teaching practices. There is also an expectation that schools are providing students with 21st century skills, including the use of technology. In exploring the reasons teachers are not using technology effectively, much …

Behind Closed Doors: The Mask Of Antiracism In Presentation And Practice, Kevin Murray

Dissertations

School districts have recognized the challenges that teachers face in building relationships with the students they teach. This can be especially true when the teacher is White and the students are people of color. This study is a follow-up to an intense, year-long professional development that a group of teachers experienced in 2012. Through interviews, six such participants were asked about their experiences in the classroom, the ways in which they felt they had grown because of the professional development, and ways that they had implemented what they learned in their classrooms. While the teachers had positive things to say …

How Did The Students Cross The Stage? The Relationship Of Demographic Factors On Early Selection Of College Major, Christy Riddle

Dissertations

Student retention is a highly researched topic studied for many decades, but low retention of college students still exists today. As more states move to success-based funding formulas, it is more important than ever for higher education institutions to increase retention efforts (Swecker, 2011). Colleges and universities launch programs trying to combat and improve retention deficits. Research reveals that student engagement, academic advising, demographics, socioeconomic factors, and early selection of major within the first academic year play a role in retention.

The purpose of this study is to determine if early selection of major relates to the demographic factors of …

Analysis Of Bloggers’ Usage Of The Web Space In Kyrgyzstan To Engage Civically And Politically, Bahtiyar Kurambayev

Dissertations

This dissertation work seeks to assess the implications of the internet (blogging) in non-democratic Kyrgyz Republic for engaging civically and politically. Existing literature offers contradictory findings about the role of internet in non-democratic countries and Kyrgyz Republic is one of those non-western countries that have been overlooked. To understand how the internet may relate to engagement civically and politically, the author applies survey approach and in-depth interviews to examine the relationship between the internet and engagement by specifically looking at how Kyrgyz bloggers use the web space.

The sample is drawn from student population. The author collected online 132 responses …

Enterprise Risk Management (Erm) At U.S. Colleges And Universities: Administration Processes Regarding The Adoption, Implementation, And Integration Of Erm, Anne E. Lundquist

Dissertations

The variety, type and volume of risks affecting higher education are numerous and the consequences for unmanaged risks and missed opportunities are more significant than ever before. In response, many institutions of higher education are adopting an Enterprise Risk Management (ERM) approach. External factors, as well as institutional culture, play a role in the decision to adopt ERM, as well as the path of implementation. Because higher education has unique characteristics that differentiate it from other organizations, particularly a shared governance structure, the adoption and implementation decisions, and resulting ERM frameworks, have aspects that make them unique to the higher …

College Student Leadership Development Participation And Emotional Intelligence, Nicole Renae Portell Brown

Dissertations

Leadership development has been identified as a key college outcome (Komives, Dugan, Owen, Slack, & Wagner, 2011). Emotional intelligence as a leadership development framework has shown promise in many applications (Petrides, 2011). Able to be augmented through purposeful training and practice, high levels of emotional intelligence have been linked to job performance, healthy relationships, and emotional well-being (Joseph, Jin, Newman, & O’Boyle, 2014). This study focused on changes in emotional intelligence as a metric for personal and professional development through a state university’s leadership program. Students’ self-reported change in global and factor emotional intelligence were measured utilizing the Trait Emotional …

A Study Of The Regular Educators’ Preparedness To Educate Students With Autism Spectrum Disorder, Tammy Rhodes

Dissertations

This study’s focus was on determining the level of knowledge K-5 educators have in one district regarding evidence-based practices that address the specific needs of students with Autism Spectrum Disorder [ASD]. The study also focused on determining what kind of inclusion task force had been established in the district, if any. Based on the findings of this study, all of the participating K-5 regular educators reported they have established a supportive culture/climate, have organized and defined work areas, use routines, regularly collect data, are flexible with curriculum, and group students based on needs. This study also revealed slightly over half …

Active Learning Strategies And Vocabulary Achievement, John Robert Griffith

Dissertations

Using a quantitative method of data collection, this research explored the question: Do active learning strategies used in grades 5 and 6 affect student vocabulary achievement in a positive or negative direction? In their research, Wolfe (2001), Headley, et al., (1995), Freiberg, et al., (1992), and Brunner (2009) emphasize the importance of understanding how children learn through active learning processes such as hands-on opportunities, cooperative learning, and technology-based instruction. Other researchers such as Baker, et al., (2000), Nagy, et al., (1987) and Searfoss, et al., (2001) stress the importance of meaningful vocabulary instruction when teaching reading. This study supports their …

Exploring Strategies For Effective Advocacy: The Lived Experience Of Leaders Of Pakistani Non-Governmental Organizations, Rubina F. Bhatti

Dissertations

Non-governmental Organizations (NGOs) have increasingly been recognized as influential players in world politics and international development. Despite limited financial resources and having to rely on volunteers who often lack formal training, NGOs’ advocacy work has often been highly effective. Since the beginning of the 1990s, it has resulted in both the formulation of new policies and the cancellation or modification of existing ones.

Advocacy work by NGOs is especially important in countries like Pakistan because deep-rooted injustices and discrimination are unlikely to change without pressure from NGOs. This study investigated the strategies used by five NGO leaders for effective advocacy …

Exploring Unintended Pregnancy In The United States Military: A Phenomenological Approach, Mary Kathryn Phillips

Dissertations

Nearly half of the 6.7 million pregnancies in the United States each year are unintended. The U.S. unintended pregnancy rate is significantly higher than the rate in many other developed countries. By age 45, more than half of all American women will have experienced an unintended pregnancy, and three in ten will have had an abortion. Previous empirical research aimed to fix the rate of unintended pregnancy before it was adequately explored. The rationale for this study emanated from the belief that interventions intended to reduce the rate of unintended pregnancy will be more successful if the essence of unintended …

The Tale Of Two Middle School Literacy Coaches: Implications For Building Coaching Capacity, Tina Edwards

Dissertations

This study examines the day to day practices of two middle school literacy coaches. My intention is to capture how coaches continue to build their capacity. Data were gathered through multiple sources, in the form of interviews, observations, a focus group, field notes, reflection journal and artifacts. I then analyzed the data to look for themes. Three major themes emerged through this research and several implications are made for literacy coaches, principals, district leadership, professional development providers, university programs and school systems.

Increasing Student Achievement Through Supporting English Language Learners, Michelle George

Dissertations

The purpose of this advocacy document is to demonstrate the need for a policy to implement a two-way immersion program in Spanish and English. The intent of this policy is to provide opportunities for students to be successful in a global society, acquire a second language, and develop a strong global awareness. This advocacy document includes an analysis of the educational, economic, social, political, moral, and ethical need for the policy change. The primary needs addressed through research are the ability to implement strong instructional practices of language development for English as a Second Language (ESL) student and to develop …

Creating A Framework For Success For High School African American Males: A Policy Advocacy Document, Ilandus Hampton Sr.

Dissertations

The policy advocacy document is an alternative to the traditional doctoral dissertation. This approach arose from the educational administration preparation reform agenda which calls for more thoughtful approaches to educational policy development, a concern that educational leadership express itself in a moral context, and a desire to develop reflective practices in administration. (Browder, 1995). This document attempts to ensure public schools, high schools in particular, are providing African American males with the skills and knowledge necessary to be academically successful so that they are given the opportunity and support necessary to achieve economic and social advancements throughout life. The policy …

Using Frequent, Unannounced, Focused, And Short Classroom Observations To Support Classroom Instruction, Lawrence T. Cook

Dissertations

This paper examines the need to do more frequent, short (10- to 15-minute), unannounced, and focused classroom observations to support classroom instruction. Currently, the state requires at least one to three classroom observations per teacher; the number of observations is based on tenured and rating status. Classroom observations consist of at least a 15- to 30-minute pre-observation, a 30- to 60-minute observation, and a 30- to 45-minute postobservation. The diagnostic framework of Wagner, Kegan, Lahey, Lemons, Garnier, Helsing, Howell, and Rasmussen’s (2006) systemic change plan was used. The process looked at current (As-Is) and future (To-Be) status of an organization …

Impact Of Single Gender Programs On Achievement, Attendance, Discipline, And Character: A Program Evaluation Project, Carla L. Sparks Dr.

Dissertations

The instance of single gender education in American public schools has risen since the 2006 amendments to Title IX permitting public schools to separate boys and girls for academic purposes. The purpose of this study is to determine the efficacy of single gender education to promote gains in student academic achievement, increase attendance levels, support character development, and decrease student discipline problems. The context of this inquiry is a large public school district that incorporates single gender education applications across the district. My study is focused on an all-girls middle school and an all-boys middle school, and it demonstrates outcomes …

Model Minority Mismatch: Exploring The Community College Experience And Persistence Of Southeast Asian American Students, Genda Vann Ed.D

Dissertations

This study aimed to investigate the relationship of Southeast Asian American student involvement and persistence in urban community colleges of Illinois. There are large gaps in research regarding the academic struggles of Southeast Asian American students because most data concerning Asian Americans is aggregate, consolidating all experiences rather than considering each sub-group independently. The existing data revealed that Asian Americans are performing exceptionally well in academics, especially when compared to other minority groups, such as African American and Latinos, resulting in Asian Americans being stereotyped as the “model minority” (CARE, 2008). However, a closer assessment of the data shows that …

Assessment And Comparison Of The Electronic Properties Of Group 10 Bimetallic Nanoparticles Relative To Their Monometallic Counterparts, Ali Bolandi

Dissertations

Group 10 transition metals with nanoscale dimensions offer significant advantages over their bulk counterparts. Significant work has been devoted toward studying the benefits of their catalytic efficiencies, however, less has been dedicated toward understanding their electronic properties and how such changes influence charge storage and sensor efficiency. The dissertation work focuses on designing metallic and bimetallic nanoparticles consisting of nanoscale Group 10 transition metals with welldefined structures, prepared using a facile synthetic procedure. The nanoparticles were characterized by electron microscopy, spectroscopic and x-ray techniques. The efficiency of monometallic and bimetallic nanoparticles toward electron storage was investigated electrochemically and by optical …

Novel Software Defined Radio Architecture With Graphics Processor Acceleration, Lalith Narasimhan

Dissertations

Wireless has become one of the most pervasive core technologies in the modern world. Demand for faster data rates, improved spectrum efficiency, higher system access capacity, seamless protocol integration, improved security and robustness under varying channel environments has led to the resurgence of programmable software defined radio (SDR) as an alternative to traditional ASIC based radios. Future SDR implementations will need support for multiple standards on platforms with multi-Gb/s connectivity, parallel processing and spectrum sensing capabilities. This dissertation implemented key technologies of importance in addressing these issues namely development of cost effective multi-mode reconfigurable SDR and providing a framework to …