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Mutual Regulation Of Crp And N(Epsilon)-Lysine Acetylation In Escherichia Coli, Robert James Davis

Dissertations

Post-translational modifications, such as N(epsilon)-lysine acetylation, are known to alter the behavior of transcriptional regulators in eukaryotes, but very little is known about the consequences of acetylation on transcriptional regulation in bacteria. Here, I provide evidence that a global transcriptional regulator of carbon metabolism, cAMP Receptor Protein (CRP), promotes both enzymatic and non-enzymatic lysine acetylation in E. coli. Non-enzymatic lysine acetylation occurs when cells ferment acetate, such as during growth on high concentrations of glucose. Intriguingly, CRP can be non-enzymatically acetylated on several lysines, including lysine 100 (K100). I provide evidence that neutralization of the K100 positive charge, as would …

Cruzando Fronteras: The Immigration Experiences Of Central American Women, Cecelia Quinn

Dissertations

The present study explores the immigration experiences of Central American women. As violence and poverty mounts in the Northern Triangle; Guatemala, El Salvador, and Honduras, immigrants continue to migrate north. Immigrant women risk their lives seeking safety, opportunity, and reunions with loved ones. Central American women's immigration journeys are unique and they face the added dangers of gender-based violence. This exploratory, qualitative study guided by feminist standpoint theory allowed the women to tell their stories in their own language, as they saw fit. Twelve Central American Latinas shared their immigration experiences, responding to semi-structured interviews. Through interpretive phenomenological analysis and …

Forgetting How To Hate: The Evolution Of White Responses To Integration In Chicago, 1946-1987, Chris Ramsey

Dissertations

After the Supreme Court made restrictive covenants illegal in 1948, violence became the default response for numerous white communities across the South Side of Chicago when African Americans moved into €“ or just passed through €“ their neighborhoods. The civil rights movement's high-profile successes in the first half of the 1960s and the media attention Dr. Martin Luther King Jr.'s open housing marches on the Southwest Side of Chicago brought to segregation in the urban North made brute force unacceptable to the public at-large. White ethnic residents on Chicago's Southwest Side realized they could no longer resort to violent means …

Centering The Margins: Elevating The Voices Of Women Of Color To Critically Examine College Student Leadership, Natasha T. Turman

Dissertations

The leadership viewpoints of Women of Color (WOC), in general, and WOC collegians specifically, are not widely available or recognized. This exclusion and oversight is a disservice to all. The inadequate inclusion of WOC's perspective in leadership literature is due to the assumptions of race and gender neutrality in leadership studies. Viewing leadership as a set of universal constructs, garnered from a select few and generalized to a great many, is not adequate to understanding the leadership experiences of WOC within dominant-culture environments. To address these deficits, critical leadership scholars have proposed that leadership be (re)conceptualized from a multicultural perspective, …

Mild Hydrofunctionalizations Of Olefins Using More Cost-Effective Metal Catalysts, Alexander James Villani-Gale

Dissertations

The focus of this dissertation is the study of alkene hydroaylation reactions. In the first chapter, a review of the relevant literature concerning zinc- and iron-catalyzed hydroarylation of unsaturated bonds is presented. In chapter two, the development of a zinc-catalyzed hydroarylation of alkenes is presented, which is quickly followed by a detailed investigation into the probable mechanism. Chapter three discusses the development of an iron/silver-catalyzed arene prenylation reaction, followed by the development of an iron/zinc-catalyzed arene prenylation reaction. The final section of chapter three discusses the adaptation of the iron/zinc-catalyzed arene prenylation into an undergraduate organic teaching laboratory.

The Female Urogynecological Microbiome: Determining Niche Specificity, Krystal Thomas-White

Dissertations

Contrary to dogma, urine is not sterile. Recent discoveries show that the female urinary bladder contains a unique microbiome,with differences in healthy and disease states. This female urinary microbiome (FUM) is distinguishable from vulvo-vaginal contamination; yet, only the few centimeters of the urethra separate these two niches. Recent studies show that the most common bladder organisms are Lactobacillus, Gardnerella, Streptococcus, Corynebacterium, and a diverse group of anaerobes, the same genera commonly found in the vagina. Thus, we asked if the bladder and vaginal microbiomes are interconnected.

Previous work suggests a link between these two niches. The vaginal tract of reproductive …

Childhood Obesity Programming In Schools: A Mixed Method Program Evaluation Of The Cope Healthy Lifestyles Teen Intervention, Lindsay Viellieu

Dissertations

The current study was designed to evaluate the effectiveness of the COPE Healthy Lifestyles TEEN program with adolescent females within a suburban high school setting. The program assessed changes in Body Mass Index, knowledge and behaviors relating to nutrition and physical activity and self-concept. The study also focused on participants' perspectives on program components and how those components facilitate change. The results of this study indicate the program increased knowledge relating to nutrition and physical activity; behaviors relating to physical activity; and self-concept. Given the on-going nature of the childhood obesity epidemic worldwide and the relationship between mental health and …

Examining The Effects Of Adolescent Binge Alcohol Exposure On The Negative Feedback Of The Hpa Axis And Adult Responses To Psychological Stress, Audrey Rose Torcaso

Dissertations

Binge drinking during adolescence is a common occurrence which is associated with increased risk of developing alcohol dependence and other mental health disorders. Hypothalamo-pituitary-adrenal (HPA) axis dysfunction is one characteristic commonly observed in many affective disorders, including anxiety and depression. Our laboratory has previously demonstrated that adolescent binge-pattern alcohol exposure results in long-term dysfunction of the HPA axis in a Wistar rat model, characterized by deficient glucocorticoid feedback inhibition. The current study aimed to characterize the behavioral phenotype of these rats in response to psychological stress during adulthood, and furthermore sought to understand the molecular mechanisms by which adolescent binge …

Patriots And Practical Men: British Educational Policy And The Responses Of Colonial Subjects In India, 1880-1890, David Thomas Boven

Dissertations

This dissertation focuses on the interplay between educational policy implemented by the British colonial authorities in India and the religious and ethnic communities impacted by these policies. It first considers educational policies promulgated from the earliest days of rule by the British East India Company until the Hunter Commission of 1882. Following this survey, the dissertation considers Indian reactions to these systems and colonial structures of education between 1880 and 1890. Those colonizing India had planned to use education as a means of stabilizing and strengthening their own rule on the subcontinent. As the British colonizers steadily overran the subcontinent, …

Role Of The Interleukin-22 And Stat3 Signaling Pathway In Gut Barrier Maintenance Following Intoxication And Burn Injury, Adam M. Hammer

Dissertations

More than half of patients admitted to burn centers for treatment have measurable alcohol levels in their blood. Intoxication that precedes a traumatic burn injury leads to worsened patient outcomes, including higher rates of infection and sepsis. The intestines harbor the largest concentration of bacteria in the human host. Any disruption of the intestinal barrier as a result of intoxication and burn injury could contribute to infection and/or sepsis from gut-derived microbes. Previous work has demonstrated that the intestinal barrier becomes leaky, and that administration of interleukin-22 (IL-22) significantly reduces gut barrier leakiness following alcohol and burn injury. However, the …

Endocytic Vesicle Rupture In The Pathogenesis And Propagation Of Neurodegenerative Proteinopathies, William P. Flavin

Dissertations

Numerous pathological amyloid proteins spread from cell-to-cell during neurodegenerative disease, facilitating the propagation of cellular pathology and disease progression. Understanding the mechanism by which disease-associated amyloid protein assemblies enter target cells and induce cellular dysfunction is therefore key to understanding the progressive nature of such neurodegenerative proteinopathies. In this study, we utilized an imaging-based assay to monitor the ability of disease-associated amyloid assemblies to induce the rupture of intracellular vesicles following endocytosis, as well as to elucidate the cellular consequences of this damaging mechanism of invasion. We observed that the ability to induce vesicle rupture is a conserved feature of …

Applying A Cognitive-Behavioral Model To Conceptualize Burnout And Coping For Teachers In Urban Schools, Daniel Camacho

Dissertations

Teachers in urban schools, facing a myriad of daily stressors and oftentimes without sufficient knowledge and skills to manage the social and emotional needs of their students and themselves, experience stress and burnout at levels that cause them to leave the teaching profession at alarming rates. Research pertaining to teaching stress, burnout, and coping has largely been devoted to enumerating the stressors that teachers experience, the impact of burnout on teachers and their students, and relating type of coping strategies that teachers employ. This body of literature falls short of illuminating what makes the teaching profession so inherently stressful, the …

My Leadership Experiences With Peace Circles As A Restorative Practice, El-Roy Estes

Dissertations

Restorative practices emerged on the scene within the Chicago Public Schools (CPS) as of recent. In 2006, CPS revamped their Student Code of Misconduct handbook from a strict and stern "zero-tolerance" voice to a more sensitive and subtle "restorative talk" approach. With this transition in effect, the school's culture and climate are expected to positively improve and at the same time support the social and emotional and academic performance of the students. Peace Circles is one of the alternate solutions to address these issues by decreasing out-of-school suspensions and improving social and emotional and academic learning. This capstone self-study will …

Love And Loyal Actions': Ritual Affect And Royal Authority, 1688-1760, Amy Oberlin

Dissertations

This project examines the changing emotional relationship between the English royal court and the public during the reigns of the last Stuarts (1688 - 1714) and the early Hanoverians (1714-1760), when the court was forced to abandon traditional representations of divine right. During this period, the rise of print, the growth of representative institutions and changing cultural attitudes to emotion created a new style of monarchy, one more emotionally accessible to its subjects. These changes signaled the death of rule by divine right and the birth of a modern monarchy. In essence, the monarch moved from heaven to earth, becoming …

Exploring The Lived Experiences Of Exemplary National Blue Ribbon Elementary School Principals In Improving Student Learning Through Effective Coaching Conversations With Their Teachers: A Phenomenological Study, Colleen Flavin

Dissertations

Purpose: The purpose of this study was to discover and describe how exemplary National Blue Ribbon elementary school principals improve student learning through effective coaching conversations with their teachers. A second purpose was to explore the barriers they encountered to holding these conversations and the actions to overcome these barriers.

Methodology: This study utilized a phenomenological design. The primary source of data collection was a standardized open-ended interviews. Using inductive analysis, the data were coded and themes were identified that aligned to the research questions.

Findings: Data analysis revealed that exemplary National Blue Ribbon elementary school principals used coaching conversations …

Exploring The Lived Experiences Of Exemplary National Blue Ribbon Elementary School Teachers In Improving Student Learning Through Effective Coaching Conversations With Their Principals: A Phenomenological Study, Kristin Watson

Dissertations

Purpose: The purpose of this study was to discover and describe how exemplary National Blue Ribbon Elementary School teachers improve student learning through effective coaching conversations with their principals. A second purpose was to explore the barriers they encountered to holding these conversations and actions they took to overcome barriers. The theoretical framework for this study was grounded in Lev Vygotsky’s sociohistorical viewpoints of development which relies on social interaction as an ingredient in the process of learning.

Methodology: This study employed a qualitative methodology utilizing in-depth and semi-structured interviews of 12 participants. Participants were identified in collaboration with the …

A Mixed-Methods Study Examining Effective Practices For Increasing Secondary Student Enrollment In Career And Technology Education Courses, Richard E. Radcliffe Jr

Dissertations

ABSTRACT

A Mixed-Methods Study Examining Effective Practices for Increasing Secondary Student Enrollment in Career and Technology Education Courses

by Richard Radcliffe

The purpose of this exploratory mixed-methods study was to discover and explore the factors that encouraged and discouraged enrollment in Career and Technical Education (CTE) pathways at California comprehensive high schools. In addition, this study examined the recruitment methods used by CTE pathways and sought to determine which ones were most beneficial. A sample of district CTE administrators from Riverside, San Bernardino, and San Diego counties were interviewed to develop the initial findings of this study, and then upon …

The Role Of The Secondary Principal As A Transformational Leader In High Performing, Project Based Learning Schools In California, Daniel P. Ching

Dissertations

ABSTRACT

The Role of the Secondary Principal as a Transformational Leader in High Performing, Project Based Learning Schools in California

by Daniel Ching

Purpose: California (CA) schools are facing increased pressure to implement new content standards and perform well on the California Assessment of Student Performance and Progress (CAASPP). The new standards focus on higher level thinking skills, technology, and skills that cross multiple content areas. These expectations are aligned with project based learning (PBL) as an instructional model. However, there are very few models for PBL schools that are considered high performing. To implement PBL in high schools requires …

Afrocentric Curriculum: A Paradigm For Healing And Education, Ameer Akinwale Ali

Dissertations

As a result of the plight of some African-American men, changes are needed to improve the US mental health system’s curriculum and practices in order to produce sustainable positive outcomes culturally-relevant therapy is key to addressing the needs of this under serviced population. Afrocentric psychotherapy provides one promising culturally relevant framework to address the needs of African-American men clinically. The purpose of this study was to explore and observe a culturally-relevant curriculum in action and, more specifically, to document perceived affects derived from using an Afrocentric curriculum with African-American men in therapy through a series of in-depth interviews and observations. …

Bullying Experiences And Resilience In Lgbtq Youth, Melinda Mccormick

Dissertations

Many young LGBTQ people are experiencing bullying which can lead to increased risk of suicide, drug abuse, and depression, as well as an increased risk of out-of-home placements in either foster care or homeless shelters. As a result of this, LGBTQ young adults are often framed as being at risk. Although this has been helpful in the past in order to raise awareness of the challenges experienced by LGBTQ young people, there is also evidence that they show resilience in response to those challenges. In order to advance the social work value of being strengths-based, this research looked for examples …

Integrating Digital Literacy And Traditional Print Text: A Focus On Struggling Readers During Guided Reading, Andrea Heckman-Hughes

Dissertations

This action research examines how digital literacies can be integrated into guided reading groups with struggling readers. It looks closely at the way a well-planned text set, both digital and print, can support struggling readers in their literacy learning. Using critical discourse analysis (CDA) and multimodal analysis, I analyzed observations, interviews, and documents to understand how struggling readers engaged with both digital and print texts, transliteracy skills, as well as with each other. Findings revealed that the support of a text set, both teacher and student driven, supported student engagement, comprehension, and development of transliteracy skills. With teacher support, students …

The Writing Development Of Multilingual Youth In A Spanish Immersion School, Angela Billur Layton

Dissertations

Language immersion schools offer students from diverse backgrounds with an opportunity for language enrichment education. Yet few studies attend to students’ perspectives on writing and multilingualism in immersion schools. The purpose of this study was to explore how four students from different linguistic and cultural backgrounds were developing writing and multilingual competencies at their Spanish Immersion Elementary School (SIES). This research investigated children’s emerging theories of writing and how school policies afforded and constrained practice. Further, this study examined the developmental trajectory of one trilingual student’s writing over time. This qualitative inquiry drew from two research traditions: ethnographic case study …

Up In Smoke: Using In-School Tobacco Education And Media Literacy To Reduce Smoking Initation Among 7th Grade Students In A Suburban Setting, Cynthia Ford Pulley

Dissertations

ABSTRACT Purpose The uptake of smoking by youth under the age of 18 increases the likelihood that they will become lifetime smokers. The CDC recommends best practices regarding tobacco prevention. Among them are Community Policies for tobacco-free zones, community initiatives, anti-tobacco media campaigns, and access to quit-smoking resources. The last of these best practices is a recommendation to provide education in the schools. The subject of this research was the implementation of an in-school tobacco curriculum based on Media Literacy, which provides youth the ability to critically evaluate media messages that equate the “cool” smoking habit with beauty, confidence and …

The Experiences Of International And Foreign-Born Students In An Accelerated Nursing Program, Myrna L. True

Dissertations

More international and foreign-born people are choosing to live in America than ever before, many permanently. During the past decade, both education and healthcare have been acutely affected by this change in the national population. To address the need to provide effective healthcare to all ages of a diverse population as well as provide quality educational experiences for international and foreign-born students who enroll in American nursing programs, professional nursing has consistently revised and updated healthcare delivery practices and nursing program curricula. Research consistently addresses the provision of healthcare delivery to a diverse population, but in comparison little has been …

Impact Of A Growth Mindset Intervention On Academic Performance Of Students At Two Urban High Schools, Lisa Brougham

Dissertations

Urban high school students have greater challenges with respect to retention and graduation rates than their non-urban peers (Farrington et al., 2012). Many academic initiatives have attempted to resolve the problems of retention and poor academic performance with little sustained success. For this study, the empirical literature was reviewed to identify a remedy for poor academic performance that may be implemented by school counselors. Focusing on non-cognitive skills, specifically developing a growth mindset, has shown promising results (Aronson, Fried, & Good, 2002; Blackwell, Trzesniewski, & Dweck, 2007; Yeager & Dweck, 2012). The underlying theoretical framework for this study is Dweck’s …

Development Of An Hplc-Based Oligosaccharide Synthesizer, Salvatore Pistorio

Dissertations

Carbohydrates are the most abundant molecules on Earth. They are involved in a wide range of fundamental biological processes: anti-inflammation, immune response, joint lubrication, cell growth, antigenic determination. Carbohydrates are also held responsible for many damaging cellular processes, such as bacterial and viral infections, development of tumors, etc.. Therefore, the development of effective methods for the synthesis of complex carbohydrates has become a critical area of glycosciences. One challenge that stands out is the stereocontrol in the synthesis of glycosidic bonds, the linkage that serves as the only means to connect simple monosaccharides into complex oligomeric networks. Beyond this, the …

Transforming To 21st Century Learning Environments: Best Practices Revealed Through A Study Of Exemplar Schools, Kelly S. Wilbert

Dissertations

ABSTRACT

Transforming to 21st Century Learning Environments: Best Practices Revealed through a Study of Exemplar Schools

by Kelly Wilbert

As the world’s economy shifted from the Industrial age to the Knowledge age, the prerequisites of current and future careers also transformed. Trends revealed that students in school now are preparing for jobs that do not currently exist. Investigating strategies to meet the challenge of transforming instructional practices was a focus of this research. The purpose of this phenomenological qualitative study was to identify and describe best practices used at elementary schools in California recognized as exemplary by the Partnership for …

Learning Language With Technology In A Hybrid University Eap Course, Jerol Brent Enoch

Dissertations

Today’s college campuses are offering increased alternatives to the traditional face-to-face classroom, including hybrid or blended courses that combine online and face-to-face elements. Language learning is no exception. This instrumental case study examines the affordances and constraints of integrating technology into a hybrid language classroom, following one teacher’s construction of an undergraduate, hybrid English for Academic Purpose (EAP) grammar class for ten international students in their first year of study at an American university. Drawing on data from this single classroom case, findings address both the instructor’s and students’ perceptions of course content and delivery, knowledge expression activities, and classroom …

Doctrinal Dialogues: Factors Influencing Client Willingness To Discuss Religious Beliefs, Katherine A. Judd

Dissertations

Religious beliefs are an important part of daily life for many individuals; however, these beliefs are often not discussed in therapy settings. As a result, clients and clinicians may encounter barriers to treatment and be unable to harness potentially beneficial aspects of the religious belief system. The current study investigated factors influencing client willingness to discuss religious beliefs with a therapist, with the factors of interest being perceived clinician cultural humility (PCH), religious outlier status (ROS), and religious commitment (RC). Participants in the current study (N = 535) completed measures assessing RC and ROS and viewed a five-minute clip depicting …

Implications Of Diverse Peer Interactions On Body Image Satisfaction And Cosmetic Surgery Acceptance Among College Students, Shamekia Labrittney Woods

Dissertations

Whereas body image satisfaction and cosmetic surgery acceptance has been widely studied over the last 30 years, these topics as they pertain to college students have not been examined extensively—most notably, the implications that diverse peer interactions have on students’ body image satisfaction and their acceptance of cosmetic surgery as a means of improving body image. Diverse peer interactions refer to interactions among peers of different racial and/or cultural backgrounds. For many college students, college provides the first opportunity whereby students may interact and engage to a great extent with students from racial and cultural backgrounds different from their own. …