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Understanding The Lived Experience Of Mental Health Following An Alpha-Gal Syndrome Diagnosis: A Phenomenological Study Grounded In Maslow’S Hierarchy Of Needs, Heather L. Hargis Nov 2025

Understanding The Lived Experience Of Mental Health Following An Alpha-Gal Syndrome Diagnosis: A Phenomenological Study Grounded In Maslow’S Hierarchy Of Needs, Heather L. Hargis

Dissertations

Alpha-gal syndrome is a tick-borne food allergy that triggers delayed allergic reactions to mammalian products and profoundly alters daily life. While growing research examines the physiological aspects of alpha-gal syndrome, little is known about its psychological impact. This phenomenological study explored the lived experiences of individuals with alpha-gal syndrome to understand how the condition influences mental health through the lens of Maslow’s Hierarchy of Needs. Data was collected through semi-structured virtual interviews with adults medically diagnosed with alpha-gal syndrome. Thematic analysis revealed significant challenges in meeting Maslow’s lower-tier needs—physiological, safety, and love/belonging—due to dietary restrictions, medical uncertainty, social isolation, and …


Building Bridges: Co-Producing Philanthropic Public-Private Partnerships For The United States National Park System, Jason S. Northern Nov 2025

Building Bridges: Co-Producing Philanthropic Public-Private Partnerships For The United States National Park System, Jason S. Northern

Dissertations

The sustainability of America's National Park System increasingly relies on public–private partnerships that leverage private philanthropy. While the National Park Foundation provides national support, local Park Partner nonprofit organizations, like the Gateway Arch Park Foundation, are key to community-level fundraising and advocacy. This qualitative study of the St. Louis Arch grounds renovation examines how this public–private partnership structure influences donor motivation, trust, and engagement. Guided by Social Exchange Theory and Resource Dependency Theory, this research explores the relational and structural dynamics of this philanthropic co-production including reciprocal donor motivations and interdependence among public, private, and nonprofit partners. Fifteen semi-structured interviews …


The Impact Of Teachers' Mathematics Qualifications On Student Proficiency, Riaz H. Zaidi Nov 2025

The Impact Of Teachers' Mathematics Qualifications On Student Proficiency, Riaz H. Zaidi

Dissertations

Schools across the United States face persistent challenges in strengthening mathematics and science education. The present study investigates the relationship between mathematics teachers’ qualifications and their students’ performance on standardized assessments, using data from a Midwestern urban school district’s ACT mathematics scores. Findings are discussed within the broader context of Science, Technology, Engineering, and Mathematics (STEM) education and national efforts to enhance competitiveness among industrialized nations. Despite the presence of leading universities and colleges, U.S. students continue to rank near the middle internationally in math and science achievement, according to the Pew Research Center. Contributing factors include disparities in teacher …


The Effects Of Learning Environment Resources And Psycap On Student Burnout And Outcomes, Elisandra Rodriguez Moreno Nov 2025

The Effects Of Learning Environment Resources And Psycap On Student Burnout And Outcomes, Elisandra Rodriguez Moreno

Dissertations

This study examined links between learning environmental resources (i.e., social support and feedback environment), burnout, and student outcomes (i.e., satisfaction and academic performance) among 198 graduate healthcare students. The study also investigated whether Psychological Capital (PsyCap) moderated these relationships. Social support and feedback did not predict overall burnout, but both were significantly linked to the burnout dimensions, specifically: emotional exhaustion, depersonalization, and academic efficacy. PsyCap did not moderate most relationships, yet it was consistently associated with lower levels of burnout and higher satisfaction. One exception emerged—for social support and depersonalization, PsyCap served as a compensatory resource, where students with lower …


Assessing The Role Of Social Media As A Complementary Source In Pharmacovigilance: Insights From Faers, X (Formerly Twitter), And Askapatient Data Across Multiple Drug Classes, Nwanneka Okere Nov 2025

Assessing The Role Of Social Media As A Complementary Source In Pharmacovigilance: Insights From Faers, X (Formerly Twitter), And Askapatient Data Across Multiple Drug Classes, Nwanneka Okere

Dissertations

Background: Adverse drug reactions (ADRs) pose significant public health challenges yet remain substantially underreported in traditional pharmacovigilance systems. Social media platforms and patient-reported outcome forums have emerged as potential complementary sources for capturing real-time patient experiences with medications, but their integration with established surveillance systems remains underexplored.

Purpose: This study examined ADR reporting patterns across FDA Adverse Event Reporting System (FAERS), X (formerly Twitter), and Askapatient to evaluate whether patient-generated digital data can complement traditional pharmacovigilance systems for enhanced drug safety monitoring.

Methods: An explanatory sequential mixed-methods design analyzed 107,753 reports representing 289,740 individual ADR occurrences for …


Virtual Reality In Esl Teaching And Learning In A Hybrid Learning Environment In The United Arab Emirates, Basma Abdulla Abri Nov 2025

Virtual Reality In Esl Teaching And Learning In A Hybrid Learning Environment In The United Arab Emirates, Basma Abdulla Abri

Dissertations

This study examines the impact of Virtual Reality (VR) on the oral proficiency of EFL learners in the UAE context, with exploring the instructors and students’ perspectives on using VR as a language learning tool. The study involved 44 Emirati higher education students enrolled in an English Communications Program divided into a control group using traditional methods, and an experimental group using VR tools for communicative activities. Data collection employed mixed-methods research through questionnaire surveys involving college students and interviews with EFL instructors over a ten-week period. According to the findings, the experimental group demonstrated higher oral proficiency than the …


How Do Emirati University Students Develop Their Academic Biliteracy? A Mixed-Method Study, Eman Kamel Rababa Nov 2025

How Do Emirati University Students Develop Their Academic Biliteracy? A Mixed-Method Study, Eman Kamel Rababa

Dissertations

Framed by Hornberger’s continua of biliteracy model, this study investigated the developmental dynamics of academic biliteracy among Emirati university students. The research employed a sequential mixed-methods design, conducted across three public universities in the UAE. In the initial qualitative phase, interview data were collected from 30 students. Informed by these findings and the extant literature, a quantitative survey was then developed and administered to a sample of 299 students from various disciplines. The qualitative data were analyzed using reflexive thematic analysis, while the quantitative data were examined using advanced statistical analyses, including structural equation modeling. Three primary themes emerged from …


Domestic Inter-Sectorial Network Topological Evolution And Industrial Policy: A Comprehensive Network Analysis, Mahanad Ali Al Sabahi Nov 2025

Domestic Inter-Sectorial Network Topological Evolution And Industrial Policy: A Comprehensive Network Analysis, Mahanad Ali Al Sabahi

Dissertations

While controversial, industrial policy propose a compelling argument for the government role in stimulating economic growth. The “new industrial policy” approach proposes a shift from a “Why” to “How” should industrial policy be implemented. Building upon this, in line with the increased utilization of network theory in economic research, this research examines network analysis as an econometric diagnostic tool asking, “How network analysis could be utilized in understanding the domestic economy and designing industrial policy?”. The study utilizes country input-output tables to calculate centrality measures corresponding to different connectivity concepts, and explore the dependency between domestic industries. The research demonstrated …


Institutional Belonging And College Success In A Neoliberal Environment, Alicia C. Figueroa Oct 2025

Institutional Belonging And College Success In A Neoliberal Environment, Alicia C. Figueroa

Dissertations

As higher education evolves in response to various pressures, adult learner graduate students, particularly women who are mothers, find themselves navigating a complex landscape shaped by neoliberal ideals of belonging. This research aimed to explore the multifaceted notions of belonging within a neoliberal environment and provide insight into a growing sector of this college student population. The project sought to illuminate the unique experiences of female adult learner graduate students, especially mothers, as they increasingly return to college post-COVID-19. Employing a qualitative phenomenological research design, this study gathered diverse narratives from this sub-population. The methodology utilized purposeful sampling for semi-structured …


Client And Clinician Priorities For Same-Day Prep And Doxy-Pep Awareness, Uptake, And Persistence In Primary Care, Nathaniel Albright Oct 2025

Client And Clinician Priorities For Same-Day Prep And Doxy-Pep Awareness, Uptake, And Persistence In Primary Care, Nathaniel Albright

Dissertations

Approximately 70% of all new human immunodeficiency virus (HIV) infections are among populations of sexual and gender minorities (SGM) and are primarily attributable to sexual contact. Currently, only 26% of the U.S. population who would benefit from HIV preexposure prophylaxis (PrEP) are prescribed this effective biomedical HIV prevention strategy. Biomedical prevention strategies for bacterial sexually transmitted infections (STI) like doxycycline postexposure prophylaxis (doxy-PEP), are a vital component to the successes of ending the HIV epidemic given the well-known association between STIs and risk for HIV infection. In this multiple methods study, we leveraged group concept mapping and conducted focus groups …


Exploring The Experience Of Nursing Students During Their Community Health Nursing Clinical Placement At Schools, Lina Ghosn Nouwayhed Oct 2025

Exploring The Experience Of Nursing Students During Their Community Health Nursing Clinical Placement At Schools, Lina Ghosn Nouwayhed

Dissertations

Community health nursing is an exciting, challenging, and evolving field that creatively integrates various areas of nursing practice with public health knowledge (Stanhope & Lancaster, 2016). Learning in practical settings is invaluable for student nurses; that is why clinical placements account for 50% of nursing curriculum requirements (Henderson, 2011). At Makassed University of Beirut, the community nursing practicum takes place in schools, with school nurses serving as mentors during these placements.

This research study aims to:

  • Explore the experiences of student nurses during community clinical practice.
  • Develop guidelines to enhance learning during community clinical practice.

The study sample consisted of …


Exploring The Relationships Between Childhood Emotional Neglect, Attachment, Perfectionism, And Adult Mental Health Struggles Across The Socioeconomic Spectrum, Jordan Biedrzycki Oct 2025

Exploring The Relationships Between Childhood Emotional Neglect, Attachment, Perfectionism, And Adult Mental Health Struggles Across The Socioeconomic Spectrum, Jordan Biedrzycki

Dissertations

This mixed-methods, cross-sectional study investigated the associations between childhood emotional neglect, perfectionism, attachment insecurity, and internalizing symptoms (depression and anxiety) among adults from varying socioeconomic (SES) backgrounds. Participants (N = 210) aged 18 years or older completed five validated self-report instruments for the quantitative analyses and answered two optional open-ended questions that yielded qualitative data. Data from the self-report measures were analyzed using independent samples t-tests, linear regressions, and moderation analyses conducted with the PROCESS macro. Three hypotheses were tested in this study. First, participants from high-SES backgrounds reported experiencing emotional neglect more frequently than other maltreatment subtypes (t = …


Jet Impingement And Vortex/Swirl Cooling Of Different Inlet And Outlet Geometrical Configurations For Turbine Blade Leading Edge Cooling, Irfan Ahmad Sheikh Oct 2025

Jet Impingement And Vortex/Swirl Cooling Of Different Inlet And Outlet Geometrical Configurations For Turbine Blade Leading Edge Cooling, Irfan Ahmad Sheikh

Dissertations

Gas turbine blades operate in extreme environments, exposed directly to high-temperature combustion gases that cause severe thermal stresses, weaken material integrity, and may lead to structural failure. Proper cooling is crucial to lower blade temperatures, reduce thermal stresses, prevent failure, and improve overall engine efficiency. This work presents a detailed numerical study of various cooling configurations by applying two advanced leading-edge cooling methods, jet impingement and swirl cooling, across different inlet mass flow rates and jet Reynolds numbers (Rej) ranging from 1,000 to 20,000 to evaluate their cooling performance.

Several advanced leading-edge cooling configurations are proposed and compared with the …


Experiences With Social Media Social Comparison In Women Ages 18-28: A Qualitative Study, Olivia Oakley Dr. Sep 2025

Experiences With Social Media Social Comparison In Women Ages 18-28: A Qualitative Study, Olivia Oakley Dr.

Dissertations

This qualitative study aimed to understand young women’s experience using social media and their reported mental health connections, such as self-esteem and comparison. As inferred in recent research, a wide range of social media content is being produced and consumed, from promoting the “thin ideal” to newer campaigns advocating for body positivity (Cohen et al., 2019, Grabe et al., 2008; Groesz et al., 2002). In a time where there is so much online content to consume, it is important to continue to evaluate the lived experiences of those using social media. This phenomenological qualitative research captured the lived experiences of …


Understanding Middle Managers In Community Colleges, Mason Salazar Sep 2025

Understanding Middle Managers In Community Colleges, Mason Salazar

Dissertations

This dissertation explores the lived workplace experiences of non academic middle managers at community colleges, a group often overlooked in higher education research. Using a phenomenological approach, this study draws on semi-structured interviews with eleven directors and managers to highlight how these professionals navigate their campus environments, operational demands, and student needs. Framed by Max Weber’s theory of bureaucracy, the findings underscore the dual roles middle managers play, as organizational lynchpins and leaders and as advocates for students, all while operating within constrained organizational structures. Key themes include varied levels of institutional knowledge, differential access to professional development, and constrained …


Give People Money: The Effect Of Perceived Inequality In Everyday Life And Previous Cash-Transfer Programs On Support For Universal Basic Income, David Thomas Igliozzi Sep 2025

Give People Money: The Effect Of Perceived Inequality In Everyday Life And Previous Cash-Transfer Programs On Support For Universal Basic Income, David Thomas Igliozzi

Dissertations

Economic inequality is a global concern with many adverse consequences for people across class divides. These consequences vary in scope—from negative effects on individual’s physical, mental, and social health to large-scale economic shifts which result from climate change (Galbraith & Hale, 2008; Hiesh & Pugh, 1993; Kaplan et al., 1996; La Ferrara & Alesina, 2000; Solt, 2008; Vilhjalmsdottir et al., 2016; Wilkinson & Pickett, 2007). Policy solutions meant to address the negative effects of economic inequality include government redistribution of wealth. Universal Basic Income (UBI), a specific and actionable policy of government redistribution, is a promising method of economic inequality …


The Social Aesthetics Of Recognition, Italo Alves Sep 2025

The Social Aesthetics Of Recognition, Italo Alves

Dissertations

The history of social philosophy is a history of suspicion toward the aesthetic (1). However, since we apprehend social reality fundamentally through its aesthetic appearances, an account is needed of how “the aesthetic” must enter the social-philosophical discourse, particularly in reconstructive models of social critique. I call this account “social aesthetics.” Social aesthetics illuminates how certain social experiences generate normative claims even in the lack of discursive articulation. (2) I argue that the philosophy of recognition, concerned with this relationship between social experience and normative claim-making, contains an unacknowledged aesthetic dimension, which I uncover through a critical reading of Axel …


Examining The Impact Of Technology-Enhanced Peer Mentorship On First-Year University Students’ Mental Health And Academic Success, Maya Hareli Sep 2025

Examining The Impact Of Technology-Enhanced Peer Mentorship On First-Year University Students’ Mental Health And Academic Success, Maya Hareli

Dissertations

Poor mental health among first-year college students has been associated with a plethora of unfavorable outcomes including worsening mental health problems later in college as well as declines in academic performance, rates of college retention, and postgraduate employment and income potential. While demand for mental health services on college campuses is high, there are various barriers to accessing these services. Peer mentoring is a resource-efficient solution for curbing college student mental health and academic challenges; however, the effects of past mentoring programs are inconsistent. Additionally, technology-delivered interventions (TDIs) have been shown to yield positive outcomes for young adults along various …


More Than Trauma: The Story Of Intergenerational Survival, Tiffany Fang Sep 2025

More Than Trauma: The Story Of Intergenerational Survival, Tiffany Fang

Dissertations

Parental trauma can have a profound effect on children. The process of passing along traumatic experiences, known as the intergenerational transmission of trauma (IGT) and the process of passing along adaptations to these adverse circumstances, known as the intergenerational transmission of resilience (IGR), have been explored in populations such as survivors of the Holocaust and war refugees (Danieli et al., 2017; Kellermann, 2001; Sangalang & Vang, 2017). This study sought to extend findings to Chinese American immigrant families, many of whom experienced trauma in the form of war, sociopolitical violence, and poverty in 20th-century China. Despite the presence of these …


Adolescent Social Media Use And Complete Mental Health: Examining The Intersections Of Identity, Social-Emotional Skills, And Social Support, Reese Hyzer Sep 2025

Adolescent Social Media Use And Complete Mental Health: Examining The Intersections Of Identity, Social-Emotional Skills, And Social Support, Reese Hyzer

Dissertations

Social media and technology use have become ubiquitous for today’s adolescents. With the rise in technology use, mental health disorder diagnoses have also increased. Despite the increase in concern for both adolescent social media use and mental health, many schools, parents, and youth service clinicians do not have the knowledge or resources to intervene effectively. The current study explores two research questions. The first is to evaluate the moderating effect of social-emotional skills and social support on the relationship between social media use and mental health through structural equation modeling (SEM). The second research question is to explore whether this …


Perverse Convergences: Aelred Of Rievaulx And The Queerness Of Waiting, Zaccary A. Haney Sep 2025

Perverse Convergences: Aelred Of Rievaulx And The Queerness Of Waiting, Zaccary A. Haney

Dissertations

ABSTRACT Using Aelred of Rievaulx’s (1110-1167) treatise Spiritual Friendship and his fundamental insight, “God is friendship,” this dissertation seeks to understand how the divine arrives woven into the dynamics of human relationships. I bring together social media research, critical theories of language, queer phenomenology, queer temporalities, and liberation theologies into a cross-temporal erotic narrative between Aelred and me. The first part establishes the imaginative distemporal space of Sodom, based on a shared homosexual identity. It critiques historical and theological disciplines as familiarizing discourses that compel arrivals of the other through structures authentication and the social magic of professionalization. In the …


Investigating Queer Asians' Accultrative Resilience And Wellbeing, Yiyu Cheng Sep 2025

Investigating Queer Asians' Accultrative Resilience And Wellbeing, Yiyu Cheng

Dissertations

This dissertation examines the role of resilience factors in moderating the effects of acculturative stress on the well-being of queer Asian Americans. A total of 181 survey responses were collected from queer-identified Asian Americans over the age of 18 residing in the United States. Using hierarchical multiple regression analysis, this study explores three models incorporating two identity resilience factors (ethnic identity salience and queer identity salience), two community resilience factors (ethnic community support and queer community support), and two intersectional resilience factors (queer Asian identity salience and queer Asian community support). Well-being was assessed through life satisfaction, negative affect, and …


Drawing The Curtain: A Grounded Theory Analysis Of The Conceptualizations Of Culture, Ethnicity And Race In Professional Training Materials For Child Life Certification, Kia Lee Ferrer Sep 2025

Drawing The Curtain: A Grounded Theory Analysis Of The Conceptualizations Of Culture, Ethnicity And Race In Professional Training Materials For Child Life Certification, Kia Lee Ferrer

Dissertations

Objectives: Certified Child Life Specialists (CCLS) are pediatric healthcare professionals primarily working in hospital settings to support children and families in navigating the developmental challenges of hospitalization, illness, and enduring medical treatment. Recognizing the presence of racial and ethnic health disparities, coupled with the field’s notable lack of diversity (98% White female), the child life workforce is increasingly acknowledging the undeniable evidence that discriminatory behaviors adversely affect a child’s life and well-being. As advances in the social sciences increasingly reveal that discrimination functions as a "socially transmitted disease" in a child's life, I predict that the failure of child life …


The Beloved Disciple In Performance, Eric Christian Zito Sep 2025

The Beloved Disciple In Performance, Eric Christian Zito

Dissertations

This project aims to reconsider the Fourth Gospel’s Beloved Disciple from the standpoint of biblical performance criticism, an approach that takes seriously the likelihood that most first-century audiences would have encountered the Fourth Gospel by means of performance rather than private reading. The dissertation considers: 1) what difference the medium makes in a first-century reception of John’s Gospel, and 2) how early audiences would have been shaped by the discipleship model portrayed by the unnamed Beloved Disciple in a performance setting. Against the current of mainstream scholarship, I argue that the Beloved Disciple is a developing character who epitomizes Johannine …


Forgive As We Are Forgiven: Reframing A Trinitarian Model Of Forgiveness In A Post-Genocide Rwanda, Deogratias Mbonyumugenzi Sep 2025

Forgive As We Are Forgiven: Reframing A Trinitarian Model Of Forgiveness In A Post-Genocide Rwanda, Deogratias Mbonyumugenzi

Dissertations

This dissertation seeks to develop a theological model of forgiveness rooted in a relational conception of the Trinity. The central argument of this dissertation is that the model of forgiveness practiced in post-genocide Rwanda and the forgiveness modeled by Jesus, and testified to in the New Testament and developed in the Christian tradition, are good, but not sufficient to address the kind of trauma and human disrepair, as well as the devastation of communities, inflicted by genocide. Rather, a theology of forgiveness modeled on a relational conception of the Trinity and its practical implications for a Trinitarian ecclesiology and anthropology …


Effectiveness Of A Classroom-Based Stress Awareness And Coping Skills Program Among Adolescents From Diverse Backgrounds, Adriane Van Zwoll Sep 2025

Effectiveness Of A Classroom-Based Stress Awareness And Coping Skills Program Among Adolescents From Diverse Backgrounds, Adriane Van Zwoll

Dissertations

The ongoing youth mental health crisis in the United States, worsened by the COVID-19 pandemic, has highlighted the urgent need for accessible and effective school-based interventions. This dissertation evaluates the effectiveness of Stress Less: Resilience for Success™, a single-session, classroom-based stress awareness and coping skills program implemented by NAMI Metro Suburban in diverse middle and high schools in the western suburbs of Chicago from 2018 to 2024. Using the CDC’s Framework for Program Evaluation, this study analyzes secondary data from 7,225 pre-test and post-test surveys and is complemented by qualitative informational interviews with current and former NAMI staff and volunteers …


Challenges In Providing Equitable Education For Primary School Students With Learning Disabilities In Zimbabwe: Teachers’ Experiences., Joyce Madzinga Sep 2025

Challenges In Providing Equitable Education For Primary School Students With Learning Disabilities In Zimbabwe: Teachers’ Experiences., Joyce Madzinga

Dissertations

This study examines the challenges primary school teachers in Zimbabwe face when supporting students with learning disabilities (LDs). Many learners with LDs are excluded from adequate classroom support due to systemic, cultural, and resource limitations. Learning disabilities are often under-recognized as compared to other disabilities because they are invisible. Raising awareness and empowering educators are crucial steps toward addressing these hidden needs and ensuring they are recognized and met. Six teachers were interviewed using a qualitative ethnographic approach. Findings reveal obstacles, including insufficient training in special education, limited teaching resources, high pupil-teacher ratios, negative societal attitudes, and poverty-related constraints. Additional …


Robust Ai Solutions For Financial Markets Through Generative Modeling, Dynamic Graph Learning, And Reinforcement-Based Portfolio Optimization, Jingyi Gu Aug 2025

Robust Ai Solutions For Financial Markets Through Generative Modeling, Dynamic Graph Learning, And Reinforcement-Based Portfolio Optimization, Jingyi Gu

Dissertations

Financial markets are inherently uncertain and dynamic, driven by complex factors such as macroeconomic signals, investor sentiment, and evolving inter-asset relationships. While machine learning has advanced financial modeling, existing approaches often fall short in addressing the real-world intricacies of finance. This dissertation confronts two critical challenges, human-driven stochasticity and risk-intensive decision-making under real-world trading constraints, while seizing a pivotal opportunity, the structural dynamics of evolving financial systems. These elements are foundational to advancing robust and practical financial intelligence.

To this end, this dissertation develops a unified framework for robust financial modeling and decision-making. The framework is architected as a progressive, …


Large-Scale Graph Algorithms And Applications With An Emphasis On Fintech Data, Fuhuan Li Aug 2025

Large-Scale Graph Algorithms And Applications With An Emphasis On Fintech Data, Fuhuan Li

Dissertations

Graph algorithms are essential analytical tools with applications spanning cybersecurity, biology, social media, and increasingly, financial technology (FinTech). The complex and interconnected nature of financial data, particularly in cryptocurrency networks, presents unique opportunities for graph-based analysis in fraud detection and anomaly identification.

This dissertation presents the design and implementation of scalable graph algorithms tailored for large-scale networks, with particular emphasis on FinTech applications. The primary contributions include: (1) novel cover-edge based triangle counting algorithms that significantly reduce computational overhead through breadth-first search preprocessing, achieving substantial speedups over traditional methods and dramatic communication reduction in distributed settings, (2) optimized parallel implementations …


Development And Implementation Of Novel Mass Spectrometric Methods For Metabolism Studies In Drug Discoveries, Huifang Yao Aug 2025

Development And Implementation Of Novel Mass Spectrometric Methods For Metabolism Studies In Drug Discoveries, Huifang Yao

Dissertations

The field of drug discovery has evolved significantly over the past few decades, with a growing emphasis on understanding the metabolic pathways and biotransformation processes that influence the pharmacokinetics and pharmacodynamics of drug candidates. Novel mass spectrometric methods have emerged as powerful tools in this domain, facilitating the comprehensive analysis of metabolic profiles and enabling the identification of metabolites with implications for safety, efficacy, and overall drug development. However, challenges remain in quantifying metabolic flux—an essential aspect of understanding drug action—particularly due to the limitations of traditional isotope kinetic assays, which often involve lengthy sample preparation and the use of …