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Hydrodynamic Characterization Of Laboratory And Production Equipment For Pharmaceutical Testing And Manufacturing Using Experimental And Computational Approaches, Chadakarn Sirasitthichoke

Dissertations

The hydrodynamics of process units used in pharmaceutical industry, i.e., the distribution of velocity profiles and shear stresses within the vessel, often controls the process performance, significantly affecting product quality. The hydrodynamics is strongly influenced by several factors such as the vessel shape, stirrer type, presence of internals and baffles, agitation intensity, and liquid properties. Most of these parameters can be varied by the process designers and the operators to achieve the desired process outcomes. The impact of the hydrodynamics on the process outcome can be profound in both large vessels (e.g., reactors) and smaller vessels (e.g., dissolution vessels), involving …

Dependent Censoring In Survival Analysis, Zhongcheng Lin

Dissertations

This dissertation mainly consists of two parts. In the first part, some properties of bivariate Archimedean Copulas formed by two time-to-event random variables are discussed under the setting of left censoring, where these two variables are subject to one left-censored independent variable respectively. Some distributional results for their joint cdf under different censoring patterns are presented. Those results are expected to be useful in both model fitting and checking procedures for Archimedean copula models with bivariate left-censored data. As an application of the theoretical results that are obtained, a moment estimator of the dependence parameter in Archimedean copula models is …

Electric-Field-Driven Processes In Multiphase Fluid Systems, Qian Lei

Dissertations

Advantages of using electric fields in miniaturized apparatuses for a wide range of applications are revealed by numerous experimental and theoretical studies over the last several decades as it offers a simple and efficient method for manipulation of multiphase fluid systems. This approach is considered to be especially beneficial for control of boiling processes and colloidal suspensions considered in the presented work.

Boiling. Today's trends for enhancing boiling heat transfer in terrestrial and space applications focus on removal of bubbles to prevent formation of a vapor layer over the surface at a high overheat. In contrast, this dissertation presents a …

Machine Learning And Computer Vision In Solar Physics, Haodi Jiang

Dissertations

In the recent decades, the difficult task of understanding and predicting violent solar eruptions and their terrestrial impacts has become a strategic national priority, as it affects the life of human beings, including communication, transportation, the power grid, national defense, space travel, and more. This dissertation explores new machine learning and computer vision techniques to tackle this difficult task. Specifically, the dissertation addresses four interrelated problems in solar physics: magnetic flux tracking, fibril tracing, Stokes inversion and vector magnetogram generation.

First, the dissertation presents a new deep learning method, named SolarUnet, to identify and track solar magnetic flux elements in …

The Role Of Microorganisms In Rare Earth Elements Bioaccumulation, Maedeh Soleimanifar

Dissertations

Rare earth elements (REE) are valuable raw materials in our modern life. Extensive REE application from electronic devices to medical instruments and wind turbines, and non-uniform distribution of these resources around the world, make them strategically and economically important for countries. Current REE physical and chemical mining and recycling methods could have negative environmental consequences, and biologically-mediated techniques could be applied to overcome this issue.

In this research, the first objective is to investigate the bioextraction of cerium oxide and neodymium oxide nanoparticles (REE-NP) by a pure culture Methylobacterium extorquens AM1 (ATCC®14718™). Results show that adding up to 1,000 ppm …

Design And Learning-Based Decoding Of Low-Density-Parity-Check Codes For Multiterminal Communication, Salman Habib

Dissertations

The field of information theory was initiated by Claude Shannon in 1948. According to his most notable work, data can be transmitted reliably over a noisy communication channel with high probability, as long as a suitable coding scheme is employed to protect the data from channel noise. Since then, coding theorists have made numerous attempts to design low-complexity error correcting schemes which achieve the Shannon limit.

In the 1960s, Robert Gallager introduced sparse graph-based low-density-parity-check (LDPC) codes which are practically suitable for various coding applications, mainly due to their low encoding and decoding complexity compared to classical codes (e.g., Reed-Muller …

Fluorescence Probes For Bioimaging: Synthesis, Photophysical Properties And Applications, Mehrun Nahar Uddin

Dissertations

Fluorescent probes are a vital tool in the study of cell imaging. There are many types of fluorescent probes ranging from inorganic and organic nanoparticles to organic molecules. When used judiciously, they can help provide essential information on cellular structure and function. The introduction of two-photon microscopy has expanded the need for new probes, in particular near-infrared (NIR) absorbing and emitting fluorescent probes. The photochemical and photophysical properties of NIR probes play a crucial role in their effectiveness in cell imaging by both conventional and two-photon excitation (2PE) microscopy. In this research, the synthesis, photophysical properties, and two-photon absorption (2PA) …

Bodipy Based Photodynamic Therapy And Potassium Probes, Xiangshan Liu

Dissertations

Boron dipyrromethene (BODIPY) has become more and more popular in photophysical and biological applications. BODIPY based fluorescence compounds have numerous advantage properties including low toxicity, high absorption extinction coefficients, high fluorescence quantum yields, sharp fluorescence emissions, and resistance to photobleaching. All the good properties lead to the wide applications of BODIPY based compounds. In this research, two different kinds of BODIPY are synthesized. Firstly, BDBrC containing carbazole and BODIPY core is synthesized. Cellular uptake research shows BDBrC can target on lysosome and singlet oxygen generation research result indicates that BDBrC can be used in photodynamic therapy. BDBrC also shows pH-sensitive …

The Integration Of Art: A Multiple Case Study Of Science, Technology, Engineering, Art, And Math (Steam) Schools In Three Schools In Southern California, Reyna Esther Smith

Dissertations

Purpose: The purpose of this qualitative multi-case study was to describe and analyze how schools that implement a STEAM program include the arts in their integrated program. The study focused on 3 K-12 schools in Southern California that are located in the Antelope Valley high desert region of the state. This multi-case study analyzed an elementary school, a middle school, and a high school that are in different districts in the area.

Methodology: This multi-case study used qualitative data to analyze the research questions regarding art infusion in STEAM programs and teacher and leader perspectives. Drawing from interviews of teachers …

Effects Of Extra-Curricular Project-Based Learning Experiences On Self-Efficacy And Interest In Stem Fields In High School, Taihao Kevin Wan

Dissertations

As our society and systems become more technologically advanced, increasing opportunities exist for students interested to pursue careers in Science, Technology, Engineering, and Mathematics (STEM) fields. However, pervasive inequities have led to differences in the extent to which women and underrepresented racial/ethnic groups choose to pursue study and career pathways in STEM. Project-Based Learning (PBL) is among the most widely researched strategies suggested to support student learning and motivation and has more recently been applied to school-based efforts to increase student interest in STEM related fields. Rooted in Social Cognitive Career Theory, this study examined changes in students’ self-reported general …

Empathy As A Moderator Of Preservice Teachers’ Culturally Responsive Teaching Self-Efficacy And Outcome Expectancy Beliefs, Juta Tammachart

Dissertations

The main purpose of this research was to examine the relationship model between culturally responsive teaching self-efficacy (CRTSE) and culturally responsive teaching outcome expectancy beliefs (CRTOE) in Thailand. There were two research questions outlined in the study: what is the relationship between preservice teachers’ CRTSE and CRTOE? Also, does the culturally responsive teaching teacher empathy (CRTTE) moderate the relationship of preservice teachers’ CRTSE and CRTOE?

Based on the CRT standards by Siwatu (2005), there were three measures applied in the study: CRTSE, CRTOE, and CRTTE scales. These instruments were piloted with 536 preservice teachers in the Faculty of Education, Prince …

Vigilance Experiences: Cancer Patients, Families, And Nurses, Wendy C. Kooken

Dissertations

Cancer disease, treatment, and errors in health care put patients at increased risk for poor outcomes. To improve outcomes and protect patients, researchers recommend increased vigilance; yet, research on vigilance in health care is minimal. There are even fewer studies on patients, family members, and nurses' experiences of vigilance, although such studies could contribute to understanding mechanisms that foster vigilance within and across groups.

The purpose of this study was twofold: Aim 1 was to describe the experiences of vigilance as perceived at the individual levels of patients receiving treatment for cancer, family members of a patient with cancer, and …

The Impact Of Mississippi’S K-3 Literacy Initiative Professional Development, Billie Fick

Dissertations

This quantitative survey study explored the statistical significance of participation in the training Language Essentials for Teachers of Reading and Spelling (LETRS) by early childhood educators in Mississippi, specifically K-3. The three outcome measures were teachers’ beliefs related to Mississippi’s K-3 Literacy Initiative: instructional practices, student learning outcomes, and barriers of technology use in literacy instruction. A total of 78 people completed the LETRS Survey, which consisted of a five-point scale. Demographic data included: grade range, teaching experience, number of students taught weekly, highest degree earned, teaching a tested subject/grade, mode of instructional delivery, technological barriers, and parental support for …

The Understanding Of Digital And Multimedia Evidence (Dme) By Attorneys And Digital Forensic Examiners (Dfe) Within The United States Criminal Justice System, Joseph Levi White

Dissertations

One goal of this research was to determine potential themes that may influence the understanding of Digital and Multimedia Evidence (DME) by attorneys and Digital Forensic Examiners (DFE) within the United States Criminal Justice System. Qualitative semi-structured interviews were conducted to gather information from experienced criminal attorneys and DFEs regarding potential influences on their understanding of DME. The results of these interviews were transcribed, and the data coded to allow for qualitative analysis. Five themes were developed from this data and are thought to play a role in understanding of DME by attorneys and DFEs: motivation for involvement in the …

Granulins In Norm And Neurodegenerative Pathologies, Anukool Bhopatkar

Dissertations

Granulins (GRNs) are small, cysteine-rich modules produced from the proteolytic cleavage of the precursor protein called progranulin (PGRN). GRNs are present in the form of seven tandem repeats within the precursor and are known to be produced in the extracellular and in lysosomal environments. In physiology, PGRN and GRNs plays pleiotropic roles such as neuronal growth and differentiation, immunomodulation, wound healing. Recent studies have implicated pathological role for PGRN in Alzheimer disease (AD) and frontotemporal dementia (FTD) but specific mechanism(s) remains unclear. However, potential interactions between GRNs and Ab42 and TDP-43 seem like a plausible underlying mechanism. Studies presented here …

Dicer Represses Antiviral Innate Immunity Pathways In Mouse Embryonic Stem Cells, Chandan Gurung

Dissertations

Recent studies have demonstrated that embryonic stem cells (ESCs) are deficient in expressing type I interferons (IFN), the cytokines that play key roles in antiviral responses. However, the underlying molecular mechanisms and biological implications of this finding are poorly understood. In this study, I used a synthetic RNA-based assay that can simultaneously assess multiple forms of antiviral responses in ESCs. Dicer is an enzyme essential for RNA interference (RNAi), which is used as a major antiviral mechanism in invertebrates but not clear in vertebrates. RNAi activity is detected in wild-type ESCs but is abolished in Dicer knockout ESCs (D−/−ESCs) as …

The Relationship Between Shared Decision-Making And School Climate, Sara Bardwell

Dissertations

The focus of this study was to determine the extent of the relationship between shared decision-making and school climate. In order to explore these constructs, a quantitative survey included SEDS-R, OCI, and demographic items. The 109-item survey questionnaire was made available to K-6 elementary teachers in Mississippi.

Two hundred twenty-nine teachers responded to the questionnaire using Qualtrics. Survey results from SEDS-R and OCI were downloaded into Excel and cleaned of incomplete data sets and participants who did not meet the specifications set by the researcher. SPSS was then used to average the results from SEDS-R and OCI. Demographic information gathered …

Analyzing And Detecting Android Malware And Deepfake, Md Shohel Rana

Dissertations

Rapid advances in artificial intelligence (AI), machine learning (ML), and deep learning (DL) over the past several decades have produced a variety of technologies and tools that, among numerous cybersecurity issues, have enticed cybercriminals and hackers to design malware for the Android operating systems and/or manipulate multimedia. For example, high-quality and realistic fake videos, images, or audios have been created to spread misinformation and propaganda, foment political discord and hate, or even harass and blackmail people; these manipulated, high-quality and realistic videos became known recently as Deepfake. There has been much work done in recent years on malware analysis and …

An Exploration Of Black Church Leaders' Intentions To Develop Critical Consciousness Among African-American Students, Taheesha Quarells

Dissertations

African-American students experience human capital opportunity and achievement gaps. Researchers have called for culturally relevant strategies to help close the gaps. The historic Black Church, a part of many African-American students’ culture and community, is a historic and current source of social capital for positive human capital development outcomes. Critical consciousness develops positive human capital outcomes, such as academic achievement, in African-American and other minority students. Much of the literature on critical consciousness is quantitative in nature and therefore does not include the intentions or the willingness of organizations to develop critical consciousness. Therefore, there is a need to understand …

The Impact Of Organizational Citizenship And School Culture And Climate Behaviors Of Small Elementary School Principals, Teresa Cowan-Fayter

Dissertations

Purpose: The purpose of this mixed methods study was to determine whether there was a relationship between the small school elementary principal organizational citizenship behaviors (OCBs) as measured by the Principal School OCB Survey and the student academic achievement on the California Assessment of Student Performance and Progress (CAASPP) in California small school districts. An additional purpose was to determine how small school elementary principals identify and describe the impact of their personal behaviors on school culture and climate.

Methodology: This is a mixed methods study. Archival data were collected from the California Department of Education (CDE) Dashboard, and additional …

Synthesis Of Molecular Probes For The Detection Of Toxic Analytes, Rashid Mia

Dissertations

Two different types of molecular probes have been synthesized. The first family of probes is the coumarin class of compounds. These chemodosimters are referred to as Low Molecular Weight Fluorescent probes (LMFP). The other type of molecular probe is a macrocycle known as a pillar[5]arene receptor.

The chemodosimters (2.12a-c and 3.12a) were synthesized in four to five steps. The photophysical properties were extensively studied in various solvent systems (DMSO, CH₃CN, DMF, MeOH, EtOH, Me₂CO, MeCO₂Et, CHCl₃, C₆H₅Me, and C₆H₆). Dimethyl sulfoxide (DMSO) …

Is Testing A Laughing Matter? Achievement Effects Via Working Memory And Humor Relevance, Ivan Jay Wayne

Dissertations

The relevant literature concerning the relationship between humorous intervention and academic performance features conflicting evidence. Authors present evidence that humor is able to directly benefit student academic performance (Ford et al., 2012), while other authors suggest humorous distraction may actually worsen performance (Bieg et al., 2015). Among the issues contributing to these contradictory findings are two particularly important considerations: the mechanism by which humor may impact performance and the content of humor used in interventions. One mechanism by which humor could impact subsequent academic performance is working memory (Strick et al., 2009). The first study (n = 31) investigated if …

Informing Cognitive Screening In The Young Adult Population, Samantha L. Mcdaniel

Dissertations

The clock drawing test (CDT) is a cognitive screening measure with sound psychometric properties which has been well researched over the past century. The CDT is a popular tool for many healthcare professionals to administer independently or as part of a more thorough cognitive evaluation. Given the drastic technological and social developments over the years since the CDT was developed as well as the persistent research focus on older adult populations, a gap in the CDT literature presented for young adults, who may have difficulty drawing an analog clock. Identifying cognitive impairment can improve health outcomes. The young adult population …

In An Era Of Soft Skills: Investigating Teamwork Skills In The Geosciences, Samuel Cornelius Nyarko

Dissertations

Geoscience employers have increasingly called for student competency in three sets of skills – technical, field and soft skills. One major soft skill identified by employers is teamwork, which is critical in laboratory and field-based activities. At the same time, educators seek to inculcate in students a stronger focus on the development of teamwork skills as they are useful for knowledge sharing and problem solving. This interconnected value of teamwork in both the workforce and academia means students’ preparation should include learning teamwork in the geoscience. However, before educators can design strategies that help students learn critical teamwork skills, we …

Essays On Bitcoin And Cryptocurrencies, Jiasong Wu

Dissertations

Bitcoin and cryptocurrencies, invented as potential digital international currencies, have gradually drawn more and more attention since their birth. The growing popularity of cryptocurrencies in the past decade and the recent acceptance of Bitcoin as legal tender in El Salvador suggests that there is growing acceptance of these instruments and that cryptocurrencies are here to stay. Among these cryptocurrencies, Bitcoin has a unique place being the first and most well-known cryptocurrency in terms of price, market capitalization, and trading volume.

The first two essays of this dissertation focus on Bitcoin and the third essay focuses on the cryptocurrency market in …

Connected And Automated Vehicles: Their Implication On Capacity Of A Basic Freeway Section And Impacts On Walkway Safety, Sia Macmillan Lyimo

Dissertations

Autonomous vehicles have recently gained the attention of researchers due to their expected potential benefits on highway traffic streams, such as improving roadway capacity, among others. It is imperative to investigate how these expected benefits can be leveraged in the transportation sector. Understanding the safety and operational benefits helps the concerned transportation agencies and other key stakeholders to make necessary infrastructural and policy adjustments to accommodate such future traffic operation changes. The main goal of this dissertation is to study the impact of connected and automated vehicles on freeway capacity. The simulated environment was created to emulate autonomous vehicle behaviors, …

Mechanisms And Applications Of Improved Protein Analysis By Desorption Electrospray Ionization Mass Spectrometry (Desi-Ms), Roshan Javanshad

Dissertations

Electrospray ionization mass spectrometry (ESI-MS) is a soft ionization technique that allows detection of macromolecules, such as intact proteins, by the formation of multiply charged ions from solutions. Desorption electrospray ionization mass spectrometry (DESI-MS) is an ambient ionization technique that directly samples analyte from a surface during ESI-MS analysis. Although DESI-MS is highly accomplished at the analyses of metabolites, lipids, and other small molecules, it is far more limited when it comes to protein analysis. While most of the field in ambient ionization MS has moved towards primarily applications, our approach has been to explore the use of DESI-MS and …

Advanced Risk Models To Predict Surgical Site Infections Using Machine Learning Approaches And Risk-Adjusted Control Charts, Rabia Emhamed Al Mamlook

Dissertations

Even though most infections are treatable with antibiotics, Surgical Site Infections (SSIs) remain a significant healthcare problem as they increase hospital stays, require additional treatments, reduce a patient’s quality of life, and increase morbidity and mortality. To reduce the risks and to encourage the highest quality healthcare, it is important to measure, predict, and monitor the risk of SSIs. Preoperative prediction of SSIs is essential to facilitate the implementation of preventative strategies for high-risk patients. The overarching goal of this dissertation is to investigate new opportunities of using machine-learning (ML) to improve the accuracy and use of pre-operative prediction models …

New Experience: An Ethnographic Study Of Students Who Transfer From A Low-Performing Public School District To A Better-Performing Public School District In Missouri, Yolanda J. Campbell

Dissertations

School districts in Missouri are responsible for public K-12 education and must be accredited to educate children. As a result, there is an evoking interest, demanding attention in Missouri public schools' quality and the students who transfer from unaccredited, critically low-performing schools to accredited, significantly betterperforming schools. These students have a higher risk of failing academically or dropping out of school and transitioning successfully into adulthood. Therefore, through this study, students, parents/guardians, and teachers tell their stories to empower the public to work together to raise all students' achievement in school, close the poverty and opportunity gap in education, and …

An Investigation Of A Teacher Education Program And The Hiring Of Newly Certified Teachers In At-Risk And Non-At-Risk Schools, William Lancaster

Dissertations

Research has shown teachers are the most important factor when determining student success, even with the field of education in a constant state of uncertainty. Schools all over the nation are struggling to acquire quality teachers into their buildings, and teacher preparation programs are having a difficult time producing enough teacher candidates. This study investigated what initial jobs students choose to take in their first year after completing an educational degree from one study university’s teacher preparation program, through numerous secondary data points and a participant survey. The quantitative data suggests that recent graduates are just as likely to go …