Digital Commons Network^™

Proactive Text Messaging For Public Health Surveillance During The Covid-19 Pandemic, Daria Kester

Dissertations

Problem

The Department of Public Health (DPH) of a suburban Midwestern county considers surveillance and control of COVID-19 to be sub-optimal, resulting in part from difficulties with completing case and contact interviews.

Methods

To increase the success rate of case investigation, proactive messaging using short message media (SMS) alerts is used in a quality improvement initiative based on the PDSA framework. Participants are sent text message alerts prior to receiving a call from a DPH case investigator. Results are recorded in a statewide database.

Results

Individuals who received text messages prior to receiving a case investigation interview phone call were …

Digital Contact Tracing During The Sars-Cov-2 Pandemic, Erin Katherine Moran

Dissertations

Problem

Manual contact tracing (MCT) is considered an essential public health intervention for infectious disease control. During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, there was insufficient funding or personnel to reduce transmission effectively. Throughout the pandemic, Missouri remained below the recommended contact tracing response rate (CRR) of 50%. One method used globally to aid in pandemic control was digital contact tracing (DCT); however, Missouri was unable to implement digital contact tracing due to barriers faced, which were not unique.

Methods

DCT was selected as subject of a strategic plan (SP) to augment MCT efforts. Other locales’ successes …

Attitudes Toward Sars-Cov-2 In Frontline Healthcare Workers And First Responders, Michelle Tiffany Arrington

Dissertations

Problem: To date, little evidence exists to understand attitudes of SARS-CoV-2 in frontline healthcare workers (HCW) and first responders (FR), related to best practices in mitigating virus spread. The purpose of this project was to assess attitudes toward COVID-19 in young adults, ages 18-44 years old, who are frontline workers related to their adherence to PPE guidelines, social distancing, hand hygiene, community exposures, and vaccinations.

Methods: A descriptive survey design using five-point Likert scale questions and 26 open-ended questions and was implemented one-year after onset of the pandemic. A purposive sample working in a large, urban, Midwest metropolitan area was …

Youth Sports In A Pandemic Age, Robert Bohnert

Dissertations

Abstract

Problem: Youth sporting events is a public health concern as infected youth with coronavirus disease 2019 may unknowingly spread the virus, as many show little to no symptoms (Zimmerman & Nigel, 2020). This project aimed to identify level of adherence to posted Youth Sports Guidelines, which were designed to mitigate the spread of virus at youth sporting events.

Methods: An observational descriptive design was utilized. Two observers tallied guideline violations by participants and spectators at six high-contact (basketball) and six low-contact (swimming) public high school youth sporting events.

Results: A total of 726 youth sport participants and 139 …

What You Speak Shall Come: Examining Spirituality On Retention Of African American Males Attending A Predominantly White Institution Using A Sequential Explanatory Mixed-Methods Design, Carlous Brian Yates

Dissertations

African American males have faced significant challenges at institutions of higher education over the years (Harper, 2013; Griffith et al., 2019). This study aimed to examine the impact of spirituality on the retention of African American males attending a Predominantly White Institution (PWI) through a sequential explanatory mixed-methods design study.

The participants in the study were African American males (N = 47) with age range 18 to 48 years old all attending a mid-sized university located in the mid-western region of the United States during the Fall 2020 and Spring 2021 semesters. The university is considered a Predominantly White Institution …

Methods For Extending Biomedical Reference Ontologies And Interface Terminologies For Ehrr Text Annotation, Vipina Kuttichi Keloth

Dissertations

Biomedical ontologies and terminologies are a cornerstone in various electronic health record systems (EHRs) for encoding information related to diseases, diagnoses, treatments, etc. Ontologies in general represent entities (concepts) and events along with all interdependent properties and relationships in an efficient way to facilitate easy access, retrieval and sharing. With the landscape of medicine rapidly changing, biomedical ontologies and terminologies need to rapidly evolve to support interoperability, medical coding, record keeping, and healthcare activities in general, and to facilitate interdisciplinary research. Extending ontologies by identifying new and missing concepts plays a vital role in the maintenance of ontologies to keep …

The Associations Of Chronic Stress, Social Support, Health Behaviors And Metabolic Syndrome Among Hispanic Women, Edna Esquer

Dissertations

The Associations of Chronic Stress, Social Support, Health Behaviors and Metabolic Syndrome Among Hispanic Women

Background: Metabolic syndrome (MetS) prevalence is 25% among Mexican American women 30 – 49 years of age, compared to 22% among non-Hispanic Whites in the United States. Little is known about the additional contributions of chronic stress, social support and health behaviors to the development of MetS among this population.

Purpose: Describe the associations between chronic stress, social support, and health behaviors and the presence of MetS in Hispanic women living in an underserved community.

Methods: A retrospective cohort study design. The Adult Treatment Panel …

Synthesis And Characterization Of Antiviral Drug Candidate Molecules Against The Respiratory Syncytial Virus, Ali Abbas Sabi

Dissertations

Abstract

Pyrrole-imidazole polyamides (PAs) are small molecules that typically develop H-bonds to bind to the minor groove of DNA. PAs are of interest because they can be designed to recognize DNA sequences. PAs have numerous biomedical applications in areas like regulation of gene expression and antimicrobial activity. Specifically, polyamide UMSL1011 (a polyamide synthesized in Dr. Bashkin's lab) inhibits replicating vesicular stomatitis virus (VSV) by binding the viral RNA inside the nucleocapsid, as indicated by research at Professor Ming Luo's lab at Georgia State University. However, some reports have revealed that polyamides have a low affinity for “simple” double-stranded RNA. Nevertheless, …

Date Fruit Fiber Variability In Composition, Tissue Distribution, And Contribution To Hardness Of Date Fruits (Phoenix Dactylifera L.), Navomy George

Dissertations

Date fruit (Phoenix dactylifera L.) is a major desert crop and is an integral part of the United Arab Emirates. This study is on the various aspects of dietary fiber of ten Emirati date varieties. The main objective of this dissertation is to analyze the content and composition of mature date fruits and to study their microstructure. The aspects of biomineralization with particular importance to silica phytoliths and lignification are also studied. Finally, the date fruit dietary composition and microstructure are related to the textural attributes of the fruit. Uppsala method of dietary fiber analysis (AOAC 994.13) is used …

The Lived Experiences Of African American Women Enrolled In Or Graduated From A Doctoral Program And Have Experienced Adverse Childhood Experiences (Aces): A Phenomenological Study, Alicia Williams

Dissertations

Purpose: The purpose of this heuristic phenomenological study is to describe and understand the lived experiences of African American women who are enrolled in or graduated from a doctoral program and have experienced Adverse Childhood Experiences (ACEs) in regards to the supports received and barriers experienced in their life journey toward enrolling in a doctoral program. Methodology: The methodology used for this study was a heuristic phenomenological approach which explored the factors of supports received and barriers experienced during the childhood of African American women who experienced ACEs and still pursued a doctorate degree. The study revealed the commonalities among …

Investigating The Effects Of Tgf-Β On T Cell Activation-Induced Cell Death, Christina Rose Cunha

Dissertations

Achieving immune homeostasis requires the functions and numbers of suppressive regulatory T cells (Tregs) and effector conventional T cells (conv T) to be balanced and precisely controlled. A decrease in Treg numbers is associated with autoimmune diseases such as type I diabetes and multiple sclerosis, while Treg numbers are increased in the tumor microenvironment. Conversely, an increase in conv inflammatory T cells in the tumor microenvironment is associated with better outcomes for cancer patients. Thus, maintaining the appropriate balance between Treg and conventional T cell populations is essential for controlling immune responses against non-self and self-antigens, as well as tumor …

Molecular Determinants Of Fetal Tolerance And The Transition To Adult Immunity, Yi Wei Lim

Dissertations

The perinatal immune system is highly tolerogenic and is phenotypically and functionally distinct from the adult immune system. This tolerogenic nature is a double-edged sword for newborns. While it is beneficial to prevent excessive inflammation against the vast array of foreign antigens encountered after birth, it also causes a lack of immune responses to life-threatening infections. My dissertation research aims to investigate the mechanisms by which perinatal T cells contribute to immune tolerance in infants. A deeper understanding of the nature of the perinatal immune system will provide pivotal knowledge to develop safe and effective strategies to protect infants from …

Healthcare Leadership In The Context Of Cognitive Diseases Of Aging: A Community-Based Participatory Research Model, Dean Sherzai

Dissertations

The Problem

The world is facing a tsunami of chronic diseases of the brain such as dementia, Parkinson's, and stroke. But all populations are not affected equally. Though we are all at greater risk of developing these diseases, minority communities such as the Black and Hispanic populations are at much greater risk of succumbing to these conditions. To date we have spent billions of dollars on research and public health measures that have repeatedly failed, but over the last decade it has become evident that much of these diseases can simply be averted through effective public health and community-based measures …

Analysis Of Regulatory Mechanisms For T Cell Activation, Aleksandra Vuchkovska

Dissertations

The primary function of the immune system is to seek and eliminate altered or unhealthy cells. T cells are a major component of the immune response and mediate their functions by recognizing specific antigens that allow elimination of infected or neoplastic cells. To avoid inappropriate activation and subsequent immune injuries, T cells have evolved strategies to discriminate self from non-self, or healthy from altered and infected. These strategies rely on the activation of receptors that restrict the T cell response. CD33rSiglecs are a family of mostly inhibitory receptors that bind to sialic acids. Siglecs respond to specific sialic acid patterns …

High-Speed Rail Safety Analysis Based On Dual-Weighted Complex Network, Liu Lv

Dissertations

This study uses a complex network model to analyze the causes of accidents in high-speed railway operations. By identifying the key factors that led to high-speed railway accidents, hidden safety hazards were discovered. This will help improve the operational safety of the U.S. high-speed rail line under construction.

The analysis uses the regional high-speed railway network in Guangzhou, China as a case study, including the railway (including high-speed railway) accidents that occurred in the company's jurisdiction from 2013 to 2017. With comparative analysis between general railways and high-speed railways, the changes of high-speed railway safety factors are explored. Data analysis …

Countering Internet Packet Classifiers To Improve User Online Privacy, Sina Fathi-Kazerooni

Dissertations

Internet traffic classification or packet classification is the act of classifying packets using the extracted statistical data from the transmitted packets on a computer network. Internet traffic classification is an essential tool for Internet service providers to manage network traffic, provide users with the intended quality of service (QoS), and perform surveillance. QoS measures prioritize a network's traffic type over other traffic based on preset criteria; for instance, it gives higher priority or bandwidth to video traffic over website browsing traffic. Internet packet classification methods are also used for automated intrusion detection. They analyze incoming traffic patterns and identify malicious …

The Experience Of Living With Hypertension: Lessons From A Cohort Of Older Men, Junjira Seesawang

Dissertations

Poor adherence to treatment and poorly controlled hypertension are common in older men, especially in rural areas. Knowledge about the experience of living with hypertension among older men is important for developing nursing practices to enhance treatment adherence. However, little is known about the personal experiences of older men with hypertension. This dissertation includes three papers that address the following: (1) the experiences of men with hypertension, based on a review of literature, (2) factors influencing the ability to self-manage hypertension among older adults in Asian countries, based on a review of qualitative studies, and (3) grounded theory study exploring …

Providing Head Start Services Amid A Global Pandemic: A Mixed Methods Explanatory Study Of Capacity, Resources, And Support, Kelly L. Vigants

Dissertations

The COVID-19 pandemic altered education in dramatic ways including immediate building closures and the implementation of virtual instruction. In March of 2020, Michigan faced a statewide shutdown on all non-essential travel as Michiganders were ordered to “Stay Home. Stay Safe.” Head Start began to provide remote services to families and students. Head Start lead teachers were charged with using virtual methods to teach their students. With little direction in the beginning and many unknowns, Head Start lead teachers used innovative methods to promote family engagement.

This study used a mixed method, explanatory sequential design to evaluate the most effective methods …

Cardiac Electrophysiology: Exploring Racial And Gender Outcomes Of Treatment Of Paroxysmal And Persistent Atrial Fibrillation Using Sotalol And Dofetilide, Nicole Lanette Bradford-Love

Dissertations

Purpose

The purpose of this study is to explore the association between gender and racial lines in the conversion and sustainment of normal sinus rhythm (NSR) from paroxysmal atrial fibrillation (PAF) and persistent atrial fibrillation using the anti-arrhythmic drugs (AADs) sotalol and dofetilide.

Methods

A secondary data analysis was performed to assess the relationships of the independent and dependent variables listed above. Using SPSS v. 24 descriptive statistics were obtained and initially evaluated for accuracy with histograms. A cross-tabulation frequency table was produced to determine the number of variables that fell into each dependent category. Following this, the frequencies were …

Comorbidity And Quality Of Life Of Hiv-Positive Adults Living In Supportive Housing, Rose Sharp

Dissertations

Problem: Life expectancy for people living with HIV significantly increased with widespread use of antiretroviral therapy, resulting in population increases in comorbidity prevalence. The increased burden of living with both HIV and comorbidities lowers health-related quality of life (HRQoL).

Methods: Using a descriptive, correlational, cross-sectional design, a convenience sample of HIV-positive adults was selected from seven supportive housing communities. Comorbidities were assessed using a modified Self-Administered Comorbidity Questionnaire, and HRQoL using the Patient-Reported Outcome Measurement Information System Scale v1.2 – Global Health.

Results: A sample of 17 (N = 17) adults reported a mean of 4.2 (SD = …

Evaluation Of The Genetic And Structural Variations Of Camel Hemoglobin, Amanat Ali

Dissertations

The single-humped Arabian camel (Camelus dromedarius) thrives in the hot arid Arabian desert. Many unique adaptations permit it to accomplish this. Camel erythrocytes or red blood cells (RBCs) have a peculiar elliptical shape and are amenable to large variations in physical conditions resulting from dehydration and rehydration cycles. The oxygen transport protein hemoglobin is found abundantly in RBCs and is also believed to behave differently in camels. While several physiological and biochemical studies have been performed on camel hemoglobin, very little is known about genetic and structural adaptions in this protein. The camel genome harbors several unique variations …

Stochastic Delay Differential Equations With Applications In Ecology And Epidemics, Hebatallah Jamil Alsakaji

Dissertations

Mathematical modeling with delay differential equations (DDEs) is widely used for analysis and predictions in various areas of life sciences, such as population dynamics, epidemiology, immunology, physiology, and neural networks. The memory or time-delays, in these models, are related to the duration of certain hidden processes like the stages of the life cycle, the time between infection of a cell and the production of new viruses, the duration of the infectious period, the immune period, and so on. In ordinary differential equations (ODEs), the unknown state and its derivatives are evaluated at the same time instant. In DDEs, however, the …

The Relationship Among Perfectionism, Perceived Stress, And Coping In Baccalaureate Nursing Students, Amanda Finley

Dissertations

Perfectionism in nursing students is an understudied problem that may affect student and workforce success. Perfectionism has been linked to increased stress and less effective coping styles, as well as depression, anxiety and other psychological alterations. However, it has rarely been studied in nursing students. Studying perfectionism in this population is important because it may increase the likelihood that new nurses will struggle with the stress of practice and it could be a significant factor in early career attrition. The purpose of this descriptive, correlational study was to gain a better understanding of the incidence of perfectionism in a nursing …

Synthesis Of Biologically Active Phosphorus Heterocycles, Giri Gnawali

Dissertations

This dissertation work is divided into two parts. The first part is focused in the development of methodology for the synthesis of phostones and phosphonosugars and advancement thereof. The second part is focused in the development of affinity probes based on analogs of natural products cyclophostin and the cyclipostins.

Phostone (3) and phosphonosugars are cyclic phosphonates. The anomeric carbon of sugar is replaced by a phosphorus atom. The synthesis of phostones has been achieved starting form the key intermediate, γ,δ-epoxy vinyl phosphonate (1). The palladium catalyzed ring opening of γ,δ-epoxy vinyl phosphonates by a nucleophile results …

Enrichment Of Ontologies Using Machine Learning And Summarization, Hao Liu

Dissertations

Biomedical ontologies are structured knowledge systems in biomedicine. They play a major role in enabling precise communications in support of healthcare applications, e.g., Electronic Healthcare Records (EHR) systems. Biomedical ontologies are used in many different contexts to facilitate information and knowledge management. The most widely used clinical ontology is the SNOMED CT. Placing a new concept into its proper position in an ontology is a fundamental task in its lifecycle of curation and enrichment.

A large biomedical ontology, which typically consists of many tens of thousands of concepts and relationships, can be viewed as a complex network with concepts as …

Increasing Provider Awareness To Detect, Treat, And Reduce Sexually Transmitted Infections In Male Service Members, Vincent E. Krause

Dissertations

The incidence of sexually transmitted infections within the military continues to rise at rates higher than that of the civilian population. The project was developed to improve provider perception related to the male patient's sexual history, practices, and attitudes and focus on adherence to the recommended guidelines related to screening for sexually transmitted infections (STIs), specifically Chlamydia trachomatis and Neisseria gonorrhoeae. Education was provided regarding recommended screening criteria, screening protocols, interview techniques, screening options available, and statistical data. The goal was to increase provider awareness and laboratory diagnosis of STI screenings among the male population, reducing chlamydia and gonorrhea infections …

Inverse Problems For Polynomial And Rational Matrices, Richard Allen Hollister

Dissertations

Inverse problems have long been studied in mathematics not only because there are many applications in science and engineering, but also because they yield new insight into the beauty of mathematics. Central to the subject of linear algebra is the eigenvalue problem: given a matrix, and its eigenvalues (numerical invariants). Eigenvalue problems play a key role in almost every field of scientific endeavor from calculating the vibrational modes of a molecule to modeling the spread of an infectious disease, and so have been studied extensively since the time of Euler in the 18th century.

If a typical matrix eigenvalue problem …

Bridging The Gap In Primary Care Of Inflammatory Bowel Disease (Ibd) Patients, Deanna Dial

Dissertations

Abstract

Problem. Patients in rural or medically underserved areas (MUAs) with inflammatory bowel disease (IBD) have limited access to primary care preventative services, making them even less likely to obtain preventative care, placing them at even greater risk for adverse health outcomes.

Methods. A two-phase retrospective chart review utilizing a convenience sample of patients diagnosed with IBD from a privately-owned gastroenterology office to evaluate the effectiveness of increasing preventative screenings for IBD patients. The first review included 53 patients seen from January to April 2019. A preventative screening

evaluation tool (PSET) was developed based on literature recommendations, including the American …

Evaluation Of Mcgeer Criteria For Uti Determination In A Nursing Home, Julie Rehagen

Dissertations

Problem: Urinary tract infection (UTI) is one of the most complex and challenging medical diagnoses to make in the long-term care (LTC) population. The unnecessary treatment of a UTI can increase cost of care and the likelihood of multi-drug resistant organisms.

Methods: The McGeer criteria which focuses on UTI in the LTC population was utilized to complete a quality improvement initiative. A descriptive cohort project utilizing retrospective and prospective data was completed to determine if an implemented McGeer criteria protocol improved the avoidable treatment of asymptomatic bacteriuria (ASB).

Results: Before implementation of the protocol, 62.5% of residents were unnecessarily treated …

Knowledge And Health Beliefs About Breast Cancer Screening Among Rural Palestinian Women: Pilot Study, Hanan Saca-Hazboun

Dissertations

Breast cancer is the most frequent type of cancer among women and the risk increases with age, with an estimated 1.67 million new cases in 2012 and a 25% incidence of all cancers in women in both developed and developing countries. It is the most frequent cause of cancer death in women in less developed regions (324,000 deaths, 14.3% of total), (Ferlay, Soerjomataram, Dikshit, Eser, Mathers, Rebelo, et al., 2015). Breast cancer is diagnosed at advanced stages of the disease in women who reside in the developing countries of the Eastern Mediterranean region (Jemal, Bray, Center, Ferlay, Ward, & Forman, …