Digital Commons Network^™

Unius Regulae Ac Unius Patriae: A Standardizing Process In Anglo-Saxon England, Daniel Matteuzzi O'Gorman

Dissertations

My dissertation investigates the value of `standards' and `standardization' as tools for historians to interpret social and political dynamics in the Middle Ages. To date, medieval scholarship has utilized these concepts in a relatively unsophisticated manner; standardization has been taken to simply mean the imposition of uniformity. My dissertation uses the work of contemporary engineers and sociologists to problematize this understanding of standardization. I argue that the term, properly employed, signifies a process of consensus, of horizontal rather than hierarchical relationships and of ongoing revision. Further, I contend that standardization is a means and not an end, and that those …

Signaling Between Two Sensor Kinases Controls Biofilms And Host Colonization In A Bacterial Symbiont, Allison N. Norsworthy

Dissertations

Organisms within all domains of life must acclimate to fluctuating environments to survive. To do this, cells utilize sensory circuits, which function to connect environmental stimuli to an intracellular response. One common sensory pathway utilized by bacteria is two-component signaling (TCS), composed of an environmental sensor (the sensor kinase, SK) and a cognate, intracellular effector (the response regulator, RR). The marine bacterium Vibrio fischeri uses an elaborate TCS phosphorelay containing a hybrid SK, RscS, and two RRs, SypE and SypG, to colonize its natural squid host, Euprymna scolopes. This TCS pathway regulates V. fischeri's ability to form a biofilm, or …

Extended Treatment Window Exists For Improving Sensorimotor Recovery Using Anti-Nogo A Immunotherapy In Adult Rats With Chronic Stroke Deficits, Katherine Marie Podraza

Dissertations

Stroke related death ranks as the fourth most common cause of mortality in the United States. Current therapeutic options following stroke are limited. One potential therapy involves the use of anti-Nogo-A immunotherapy post-stroke. Our laboratory has shown that the administration of this novel treatment results in sensorimotor recovery in adult and aged rats. This therapy has been shown to be efficacious when applied immediately, 24 hours, and 1 week post-stroke in rats with mild to moderate sensorimotor deficits. In addition, recent results suggest that administration of anti-Nogo-A immunotherapy up to 9 weeks after stroke still induces functional recovery and neuroanatomical …

Participant Engagement In Home Visits: A Missing Piece In The Puzzle Of Evidence Based Programs And Implementation Science?, Mariel Sparr

Dissertations

Within the social services field, researchers, policy makers, and practitioners are paying increasing attention to the concept of `evidence based' home visiting program models. However, a singular focus on evidence based programs continues a tradition of limited and vague understandings of how programs are actually implemented.

The field of implementation science offers a framework for expanding this focus to more fully understand how home visiting programs are implemented. A key dimension of implementation is participant responsiveness. The field of home visiting lacks a coherent and standard conceptualization of participant responsiveness. As one might expect, it also lacks standard measurement of …

Eliminating Acute Myeloid Leukemia Stem Cells By Targeting The Niche Microenviromnent: Co-Inhibition Of Tnf/Il1- Jnk And Nf-Κb, Andrew Volk

Dissertations

Leukemia Stem Cells (LSCs) from Acute Myeloid Leukemia (AML) require the activity of the transcription factor NF-kB to maintain stemness and drive tumor formation. Blocking NF-kB can preferentially eliminate LSCs in vitro with minimal effects on healthy Hematopoietic Stem and Progenitor Cells (HSPCs), making NF-kB a compelling target for anti-leukemia therapies. However, blocking NF-kB in vivo can only extend survival for a short period of time before transplanted mice succumb to the disease. I propose this is due to components of the in vivo niche supporting LSC survival and compensating for the inhibition of NF-kB.

I observed patients with partially …

Profiles Of Protective Factors In Urban African American Youth Exposed To Community Violence: A Prospective Study Of Resilience, Devin Colleen Carey

Dissertations

The broad purpose of the study was to investigate the relationship between exposure to community violence and adjustment in an urban sample of African American youth living in Chicago. After years of research on community violence, there has been a call to understand the influences of all levels and systems on child adjustment, as well as to use research to promote positive outcomes and prevention of future violence (Aisenberg & Herrenkohl, 2008). With this in mind, this project used latent profile analysis to create profiles of protection based on individual, family, peer, and community factors, as well as evaluate the …

The Gut-Liver Axis Regulates Pulmonary Inflammation After Intoxication And Burn Injury, Michael M. Chen

Dissertations

The increasing prevalence of binge drinking and its high association with traumatic injury warrant further investigation into the mechanisms underlying the worsened clinical outcomes associated with this combined injury. Existing literature suggests the liver is at the center of the postburn systemic response with crosstalk between the intestinal microbiome and the liver playing an important role after injury. There is a paucity in the literature, however, regarding the role of the gut-liver axis in the common clinical scenario of burns preceded by alcohol intoxication. Previous studies in our laboratory demonstrated intoxication potentiates postburn hepatic damage and IL-6 production in a …

Exploring The Impact Of Mindfulness On Adolescents: A Mixed Methods Approach, Poonam Desai

Dissertations

As social emotional learning gains greater focus, identifying effective interventions for high-risk students, such as students with Emotional/ Behavioral Disorder (EBD), becomes a priority. Mindfulness, as an intervention, offers a unique set of skills to increase emotional awareness and regulation, while also teaching key social emotional skills (Singh et al, 2007). Mindfulness, or the nonjudgmental observation of one's thoughts, feelings, and emotions, has roots in Buddhist philosophy, but is used secularly in the fields of psychology, medicine, and education (Baer, 2003). In this mixed methods study, the researcher aims to examine the experiences of adolescents who have EBD at an …

Negotiating Diabetes: Professional Diabetes Care Work In The U.S., Melissa Marie Gesbeck

Dissertations

The rising incidence of diabetes mellitus (types 1 and 2) transcends national borders, creating a global pandemic. The U.S. leads the world in diabetes prevalence, despite its wealth and access to sophisticated medical technologies. Within health care, there is an increasing focus on lifestyle and behavioral interventions that research suggests may be the key to reversing this trend, but thus far their effectiveness in practice is uneven at best. In order to gain a better understanding of the other factors involved in professional diabetes care work that might support or inhibit effective diabetes management, this research treats diabetes as a …

Juvenile Delinquent Strengths Assessment: Evaluating The Gap Between Research And Practice, Michael David Knoll

Dissertations

Juvenile delinquency remains a significant problem in the United States, not only for society but also for adolescents who become involved in the criminal justice system. Psychologists working within juvenile justice settings are often tasked with providing valuable information to the courts in the service of this vulnerable population. Such evaluation practices have consistently focused on identifying risk factors for recidivism, while largely neglecting the importance of strengths factors in predicting of positive outcomes for juvenile delinquents. There is a clear need to bridge the gap between the strengths-based variables identified by the literature and the actual assessment practices commonly …

Incapacitated Fatherhood: The Impact Of Incarceration On African American Fathers, Dara Lewis

Dissertations

This project examines the ways that incarceration can shape the meaning and performance of fatherhood. Using 109 surveys and 30 in-depth interviews, three dominant themes emerged that constitute a model father identity standard: 1) being there for their children; 2) being an example for their children; and 3) providing their children with love, basic needs, and protection. The findings indicate that prison environment and post-incarceration restrictions do not support fathers’ ability to perform their roles as fathers, or the maintenance of healthy relationships between fathers and their children. Specifically, it disrupts the father identity confirmation process. As a result, relational …

Backlash Against Working Mothers, Kala Jean Melchiori

Dissertations

Research by Rudman and colleagues (2012) has detailed how people who defy social stereotypes (called vanguards) experience discriminatory backlash for acting counter-stereotypically. In the present research, I took Rudman's Backlash and Stereotype Maintenance Model (BSMM) and applied it to working women and working mothers. Due to the different content of the stereotypes of working women versus working mothers, I predicted that the process through which perceivers engage in backlash against the two groups is different. I used the theory of Ambivalent Sexism to shape my predictions for how working mothers are vulnerable to different forms of backlash than working women …

Research And Reality: Towards Responsible Medical Research For Catholic Universities, Michael Patrick Mccarthy

Dissertations

It is frequently noted that 90% of medical research stands to benefit only 10% of the population. While others dispute the numbers, there is little doubt that disparities exist in the global agenda for medical research. One needs no clearer example of research—not to mention public health and health care delivery—disparities than the Ebola outbreak that plagues West Africa. Despite these disparities, Catholic universities continue to engage in the social practice of medical research that deviates very little from the national funding priorities established through the National Institute for Health.

This dissertation argues that these unjust disparities are perpetuated by …

Characterization Of The Effect Of Anti-Nogo-A Antibody Treatment On Sensorimotor Recovery After Traumatic Brain Injury, Stephen Nawara

Dissertations

Estimates indicate that over 5 million Americans are currently living with Traumatic Brain Injury (TBI) related disability. Much effort has been put into enhancing functional recovery with physical therapy and other rehabilitative approaches. These strategies are thought to function by facilitating the brain’s innate capacity for neuroregeneration and neuroplasticity. However, the success of these strategies may be limited due the presence of growth- and plasticity- inhibiting factors expressed in the adult brain.

The presence of the membrane protein Nogo-A has been associated with reduced neurite outgrowth in vitro, identifying it as one such molecule. In addition, rodents treated with antibodies …

Gender-Homogenous Mentoring, Spiritual Wellbeing, And Self-Efficacy Beliefs In African American Male Adolescents: A Test Of Three Models, Toussaint David Whetstone

Dissertations

Many African American male adolescents mature without the influence of an adequate social model, or a positive, same sex (or gender-homogenous) mentor. Thus, it may be difficult for African American male adolescents to reach adulthood having developed the perceived capability to be successful within specific domains that American society commonly associates with a healthy life course trajectory. A large body of research has suggested that vicarious experience or role modeling is a primary source of efficacy information in a variety of life domains. Research has also suggested that modeling effects are enhanced if the subject and model are similar, especially …

Knowledge Spaces : A Context-Driven Concept System Framework For Data Integration, William T. Sabados

Dissertations

This dissertation examines the role of context in data integration. Traditionally, data integration solutions attempt to find semantic correlations between data sources and determine which elements match. These traditional solutions do not ask in what context the candidate data elements match, nor do they make an attempt capture it. Instead, they assume a single implicit "correct" context. This is odd considering how strong an effect context has in how people perceive, process, and make decisions based on the information available to them. The knowledge space framework introduced in this work remedies this shortcoming by introducing a formal way to capture …

Adaptive Control For Autonomous Navigation Of Mobile Robots Considering Time Delay And Uncertainty, Stephen Kofi Armah

Dissertations

Autonomous control of mobile robots has attracted considerable attention of researchers in the areas of robotics and autonomous systems during the past decades. One of the goals in the field of mobile robotics is development of platforms that robustly operate in given, partially unknown, or unpredictable environments and offer desired services to humans. Autonomous mobile robots need to be equipped with effective, robust and/or adaptive, navigation control systems. In spite of enormous reported work on autonomous navigation control systems for mobile robots, achieving the goal above is still an open problem. Robustness and reliability of the controlled system can always …

Contributors To Infant Sleep: Factors Influencing Sleep Consolidation In Five- To Seven-Month Olds, Amber Leigh Evenson

Dissertations

Sleep is a universal construct that receives much attention in media and science, at least partially due to its importance as an essential component in development, health, and wellbeing. While undeniably vital, infant sleep is often variable and relatedly perplexing to parents. Around five-to-seven months of age, infants enter a time of quantifiable developmental change, impacting relational, cognitive, motoric, communicative and sleep behaviors. Because adequate sleep is considered one of the most indispensable precursors for developmental gains, factors that impact the progression of sleep are of interest. The current study utilized Ecological Theory to examine what variables impact sleep consolidation, …

Herbert Spencer And His American Audience, Joel F. Yoder

Dissertations

The philosopher Herbert Spencer (1820-1903) is little remembered today, but in the late nineteenth century he was a world-renowned figure and widely read. Spencer was popular in his native England, but even more highly regarded in America. Modern scholars generally understand this popularity as stemming from Spencer’s social Darwinism—that is, his belief that natural selection does and should operate on humans to improve mankind. On the other hand, many of those who have studied Spencer’s work claim that he was not a social Darwinist at all. It is my contention that Spencer was a social Darwinist, but that other aspects …

Synchrophasor Assisted Efficient Fault Location Techniques In An Active Distribution Network, Anil Khanal

Dissertations

Reliability of an electrical system can be improved by an efficient fault location identification for the fast repair and remedial actions. This scenario changes when there are large penetrations of distributed generation (DG) which makes the distribution system an active distribution system. An efficient use of synchrophasors in the distribution network is studied with bidirectional power flow, harmonics and low angle difference consideration which are not prevalent in a transmission network. A synchrophasor estimation algorithm for the P class PMU is developed and applied to identify efficient fault location. A fault location technique using two ended synchronized measurement is derived …

Military Millennials As Next Generation Leaders: Do Leadership Traits Matter?, Phillip Michael Green

Dissertations

Employers are constantly evaluating individuals to fill leadership roles within their organizations to extract the highest return from their resources and investments. Millennials, born between 1982 and 2000 (Howe and Strauss, 2000), represent the youngest and newest generation entering the workforce. A sub-population of this generation consists of military veterans returning to the United States after the wars in Iraq and Afghanistan. This quantitative study examines the leadership traits of the military Millennials that have transitioned to civilian life and compares this population segment with Millennials without a military background. To compare the two groups of the generational cohort, a …

A Case Study On Ethical Decision Making By Legislative Leaders And Their Motion To Approve The North Carolina Charter School Bill Of 2011, Moses Fox Iii

Dissertations

The purpose of this study was to explore the role that equity and ethics played in decision making by examining the perspectives of elected leaders in a case where members of the North Carolina legislature decided to lift the cap on charter schools by enacting the 2011 North Carolina Charter School Bill. The analysis was based on triangulated qualitative data from historical documents, written documents from the state’s legislative library, and interviews from consenting legislative leaders of North Carolina. The researcher used Colaizzi’s (1978) phenomenological data analysis protocol to explore and understand the participants’ lived experiences. Finally, a pattern matching …

A Novel Approach For Identifying Cloud Clusters Developing Into Tropical Cyclones, Chaunte' W. Lacewell

Dissertations

Providing advance notice of rare events, such as a cloud cluster (CC) developing into a tropical cyclone (TC), is of great importance. Having advance warning of such rare events possibly can help avoid or reduce the risk of damages and allow emergency responders and the affected community enough time to respond appropriately. Considering this, forecasters need better data mining and data driven techniques to identify developing CCs. Prior studies have attempted to predict the formation of TCs using numerical weather prediction models as well as satellite and radar data. However, refined observational data and forecasting techniques are not always available …

The Leadership Efficacy Of Graduates Of North Carolina School Of Science And Mathematics: A Mixed-Methods Analysis, Renee Mason Letita

Dissertations

This study examines the leadership efficacy amongst graduates of NCSSM from the classes of 2000–07 as the unit of analysis. How do NCSSM graduates’ perceptions of their leadership efficacy align with research on non-cognitive variables as indicators of academic performance using the unit of analysis as a performance outcome? This study is based on the theoretical construct that non-cognitive psychological (also called motivational) factors are core components of leadership self-efficacy, indicative of NCSSM graduates (who had high academic performance and attained STEM degrees). It holds promise for increasing both student interest and diversity in the race to strengthen the STEM …

Academic And Non-Academic Variables As Predictors Of Nclex-Rn Success Among Traditional Associate Degree Students At Southern Adventist University, Christine Moniyung

Dissertations

Problem

The School of Nursing at Southern Adventist University offers both Associate of Science and Bachelor of Science in nursing degrees. A majority of the students who sit for the NCLEX-RN are associate of science in nursing graduates. The pass rate dropped from 94.9% in 2010 to 88.8% in 2011. The pass rate went up to 93.3% in 2012, but dropped again by almost 5% in the following year, and to an all-time low of 76.5% in 2014.

Unlike most AS nursing program student populations in the nation, the majority of SAU students are young and considered traditional-age college students. …

The Relationship Between Episodes Of Dissociative Amnesia, Symptomology Of Post-Traumatic Stress Disorder, And Childhood Sexual Abuse, Jennifer E. Perkins

Dissertations

Problem. Identifying the possibility of a significant relationship between childhood sexual abuse, symptoms of Post-Traumatic Stress Disorder (PTSD), and episodes of dissociative amnesia is both relevant and useful in the therapeutic setting. Identifying indicative factors for a history of childhood sexual abuse and including them in a standardized therapeutic assessment will assist therapists in planning future treatment. This study used secondary data to examine the relationship between childhood sexual abuse, symptomology of PTSD, episodes of dissociative amnesia, and selected demographic characteristics.

Method. This quantitative study used a therapist-completed data collection tool which compiled brief client demographics, episodes of dissociative amnesia, …

Testing The Technology Acceptance Model 3 (Tam 3) With The Inclusion Of Change Fatigue And Overload, In The Context Of Faculty From Seventh-Day Adventist Universities: A Revised Model, David Andrew Jeffrey

Dissertations

Problem.

In recent years, the use of technology in institutions of higher learning has grown significantly. The use of Learning Management Systems (LMSs) is central to this growth. LMSs assist in the ease, consistency, and effectiveness of delivering instruction to students. The challenges involved in implementing an LMS, and the time pressures placed on faculty make decisions concerning LMSs particularly crucial. Since the goal of administration is to encourage adoption and optimal usage of the LMS by as many faculty members as possible, the focus of this study is the dynamic of factors that predict usage of Learning Management Systems. …

Educator's Implementation Of The Connecticut Guidelines For The Identification And Education Of Children And Youth With Autism, Linda K. Grimm

Dissertations

The Problem

As the number of children with autism needing educational support continues to increase, combined with the limited availability of resources, this study aims to examine how educators responsible for teaching children with autism have experienced implementation of the Connecticut Guidelines for the Identification and Education of Children and Youth with Autism (2005), (Guidelines). At this time there have been no studies done in the State of Connecticut to assess the implementation of the components for effective education of children with autism, as set forth in the Connecticut Guidelines.

Method

The Connecticut Autism Needs Survey, an on-line self-report survey …

Diversity And Student Engagement In A Small Multi-Ethnic Liberal Arts University In California, Yamileth Bazan

Dissertations

Problem

As the general population of minorities continues to increase nationwide, so has the number of underrepresented racial/ethnic groups qualified to enter higher education. While some public universities are responding to various diversity initiatives and changes, a number of institutions, especially small liberal arts colleges, have been less responsive to these changes in demographics. As liberal arts colleges begin to plan more effectively to respond to a more pluralistic student body, more understanding is needed about the student engagement patterns of these underrepresented groups. This study looks at the engagement patterns of a small liberal arts research university in Southern …

L30a Mutation Of Phospholemman Mimics Effects Of Cardiac Glycosides On Isolated Cardiomyocytes, Ryan David Himes

Dissertations

In order to determine if mutations made to phospholemman (PLM) could increase PLM binding to the Na/K-ATPase (NKA) and cause positive inotropy we performed scanning mutagenesis of the transmembrane domain of PLM and measured FRET between each mutant and NKA. We observed increased binding to NKA for several PLM mutants compared to WT, including L27A, L30A, and I32A. In isolated cardiomyocytes, overexpression of WT PLM increased the amplitude of the Ca2+ transient compared to GFP control. Ca2+ transient amplitude was further increased by L30A PLM overexpression. L30A mutation also delayed Ca2+ extrusion and increased the duration of the cardiomyocyte contraction. …