Digital Commons Network^™

Vigilance Of Certified Registered Nurse Anesthetists, Timothy Finn

Dissertations

Vigilance of certified registered nurse anesthetists (CRNAs) is an integral component of the care they provide patients under general anesthetic. the practice of CRNas is important as the official seal of the American Association of Nurse Anesthetists (AANA). on the seal, Morpheus, the god of dreams, is shown holding the Lamp of Learning, by the light of which he keeps vigil (Hirter & Van Nest, 1995). as the patients remain unconscious under general anesthesia, CRNas remain the patients' eyes and ears remains responsive to their needs. the CRNa must remain attentive to the patient's needs by continuously monitoring the patient …

Reforming Sensory Disability In Early Modern England, Mary Lutze

Dissertations

Reforming Sensory Disability in Early Modern England traces early modern literary depictions of blindness and deafness during the Reformation. the project proposes an inherently dynamic early modern religious model of disabilities: first characterized by its initial rejection of England's prior faith tradition, then by doctrinal negotiation among reformed dissenters. It analyzes the shift in disability representation in popular literature of the sixteenth and seventeenth century before culminating in an examination of seventeenth-century deaf education. Finally, the project proposes that the seventeenth-century advent of deaf education should be read as a concrete ideological shift in English society's perception of the disabled.

Determining The Genetic And Phenotypic Profile Of Cord Blood Derived T Regulatory Cells And The Effect Of Calcitriol On Immune Suppression, Anya Nikolai-Yogerst

Dissertations

Recent outbreaks in vertically transmitted viruses, such as Zika virus and HIV, have rejuvenated interest in fetal and neonatal immune tolerance. Babies are susceptible to vertically transmitted viruses because fetal and neonatal immune systems are considered to be immune-privileged and will tolerate antigens presented to them by their mother. Thus, understanding the mechanisms of this tolerance is important to design effective treatments for infected mothers to protect their offspring. Here, I define a novel Treg, a type of T cell that mediates tolerance, named bidirectional T cells (BiT), found in human umbilical cord blood (UCB). These cells are induced by …

Early Detection Of Fake News On Social Media, Yang Liu

Dissertations

The ever-increasing popularity and convenience of social media enable the rapid widespread of fake news, which can cause a series of negative impacts both on individuals and society. Early detection of fake news is essential to minimize its social harm. Existing machine learning approaches are incapable of detecting a fake news story soon after it starts to spread, because they require certain amounts of data to reach decent effectiveness which take time to accumulate. To solve this problem, this research first analyzes and finds that, on social media, the user characteristics of fake news spreaders distribute significantly differently from those …

Perivascular Waste Metabolites Clearance In Central Nervous System (Cns), Yiming Cheng

Dissertations

Efficient clearance of interstitial waste metabolites is essential for normal brain homeostasis. Such effective clearance is hampered by the lack of a lymphatic system in the brain, and the cerebrospinal fluid (CSF) is unable to clear large size waste metabolites in the brain. Here, a novel idea that brain arterial endothelium and smooth muscle cells reactivity regulates the clearance of these water-insoluble large size waste metabolites through the perivascular dynamic exchange, and that low dose ethanol promotes this perivascular clearance is proposed.

In Aim 1, the biodistribution of a large size waste metabolite (Amyloid-β protein mimic) in rat perivascular space …

Amyloid Proteins And Fibrils Stability, Farbod Mahmoudinobar

Dissertations

Compared to globular proteins that have a stable native structure, intrinsically disordered peptides (IDP) sample an ensemble of structures without folding into a native conformation.One example of IDP is the amyloid-beta(Abeta) protein which is the main constituent of senile plaques in the brain of Alzheimer's patients.Understanding the process by which IDPs undergo structural changes to form oligomers that eventually aggregate into senile plaques/amyloid fibrils may significantly advance the development of novel therapeutic methods to treat neurodegenerative diseases, for which there is no cure to date. This dissertation has two main objectives. The first one is to investigate and identify structural …

Mitochondria Imaging And Targeted Cancer Treatment, Tinghan Zhao

Dissertations

Mitochondria are essential organelles as the site of respiration in eukaryotic cells and are involved in many crucial functions in cell life. Dysfunction of mitochondrial metabolism and irregular morphology have been frequently found in human cancers. The capability of imaging mitochondria as well as regulating their microenvironment is important both scientifically and clinically. Mitochondria penetrating peptides (MPPs), certain peptides that are composed of cationic and hydrophobic amino acids, are good candidates for mitochondria targeting. Herein, a novel MPP, D-argine-phenylalanine-D-argine-phenylalanine-D-argine-phenylalanine-NH₂ (rFrFrF), is conjugated with a rhodamine-based fluorescent chromophore (TAMRA). The TAMRA-rFrFrF probe exhibits advantageous properties for long-term mitochondria tracking of …

Cerebro-Vascular Disruption Mediated Initiation And Propagation Of Traumatic Brain Injury In A Fluid Percussion Injury Model, Xiaotang Ma

Dissertations

Traumatic brain injury (TBI) is a major health problem for over 3.17 million people in the US. There is no FDA-approved drug for the treatment because the injury mechanisms have not been clearly identified. The knowledge gap is addressed here by the lateral fluid percussion injury (FPI) rat model, through the understanding of layer-structured mechanisms from physical vascular rupture to acute necrosis, as well as biochemical changes in perivascular space as secondary events.

Firstly, the cerebrovascular hemorrhage and related infarct volume are investigated as the primary events in moderate FPI, which is found to be increased with injury severity in …

Cancer Risk Prediction With Whole Exome Sequencing And Machine Learning, Abdulrhman Fahad M Aljouie

Dissertations

Accurate cancer risk and survival time prediction are important problems in personalized medicine, where disease diagnosis and prognosis are tuned to individuals based on their genetic material. Cancer risk prediction provides an informed decision about making regular screening that helps to detect disease at the early stage and therefore increases the probability of successful treatments. Cancer risk prediction is a challenging problem. Lifestyle, environment, family history, and genetic predisposition are some factors that influence the disease onset. Cancer risk prediction based on predisposing genetic variants has been studied extensively. Most studies have examined the predictive ability of variants in known …

Identifying The Leadership Skills Needed To Develop The Competencies To Lead In A Postcrisis Organization: A Delphi Study, Paul Turgeon

Dissertations

Purpose: Organizational leaders play a pivotal role in postcrisis activities. There is abundant research in the actions of leaders in a crisis; however, there is limited research regarding the leadership competencies required postcrisis, and a gap remains in knowing which leadership skills are needed postcrisis. The purpose of this Delphi study was to identify the leadership skills needed to promote organizational resilience, to act with integrity, and to possess a learning orientation of organizational leaders in the postcrisis phase.

Methodology: This study used a 3-round Delphi technique to identify the leadership skills that support the possession of the competencies needed …

Impact Of Positive Behavioral Interventions And Supports In California High Schools Year Three And Beyond: A Semi-Replicated Mixed-Methods Study, Jolene Mcgarrah

Dissertations

Purpose: The purpose of this mixed-methods study was to determine what differences

existed between pre- and post-PBIS implementation on suspension rates in California high schools. A further purpose of the study was to determine how experienced high school administrators described the impact of PBIS on their school sites. Methodology: This mixed methods study identified 15 California public schools for data collection and five principals for interviews about their perceptions of the impact of PBIS on their campus. The schools and principals were chosen due to proximity to the researcher. The researcher collected quantitative data from the schools and qualitative data …

Educator Knowledge And Usage Of Evidence-Based Interventions For Students With Emotional And Behavioral Disorders In Special Education Programs Across California, Thelmisha Vincent

Dissertations

Purpose: The purpose of this study was to identify the extent to which evidence-based interventions being utilized with students with emotional and behavioral disorders (EBD) by general education teachers, special education teachers, and behavior interventionists working in K-12 special education programs on comprehensive public and non- public school campuses in California.

Methodology: This mixed method study identified commonly used instructional strategies for students with (EBD) in public and non-public school settings. Respondents were purposefully chosen from general education teachers, special education teachers, and behavior interventionists across California. The data from online survey and interviews were analyzed through factorial ANOVA, descriptive …

The Effects Of Health Beliefs, Acculturation, And A Culturally Appropriate Teaching Intervention On Parents' Knowledge Of And Compliance With Tuberculosis Treatment In A Mexican-American Population: A Preliminary Analysis, Renee P. Mcleod

Dissertations

The primary purpose of this research study, using a correlational and comparative descriptive design, was to examine the effects of health beliefs, acculturation, and a culturally appropriate Spanish-language audiotaped novena on knowledge of Tuberculosis (TB), and compliance with treatment and medications in Mexican-American parents' of a child with TB infection. Due to the limited number of subjects obtained (N = 31), the research data and analyses are presented as preliminary findings since meaningful hypothesis testing would be premature at this time.

Character And Ethical Behavior Of Nurses, Nelda S. Godfrey

Dissertations

The purpose of this study was to examine relationships among personal normative characteristics, personal descriptive characteristics, and ethical behavior of nurses in practice. Little is known about the place of virtue theory in nursing practice and the factors that influence the nurse as moral agent. One hundred thirty-one registered nurses with at least six months' experience working in direct cam positions in one of three hospital practice settings—urban, suburban, and rural—participated in the study. Three instruments were used with the randomized sample: (a) Demographic Data Form, (b) The INSURE Survey™, an instrument used to measure attitudes of potential employees, and …

Exemplary Chief Nurse Executives Leading Through Storytelling, Tricia Kassab

Dissertations

Purpose: The purpose of this phenomenological study was to understand and describe how exemplary human resources administrators use storytelling to lead organizations using Denning’s (2011) model. In addition, it was the purpose to understand how they use storytelling to create transformational change. Denning’s The Leader’s Guide to Storytelling highlights eight storytelling narrative patterns: to ignite action, to communicate who you are, to build your brand, to transmit values, to foster collaboration, to share knowledge, to tame the grapevine, and to share vision.

Methodology: This phenomenological qualitative study described the lived experiences of exemplary elementary chief nurse executives in California. The …

Leadership Storytelling: How Elementary School Principals Use Storytelling To Lead And Make Transformational Change, Nicholas Damico

Dissertations

Purpose: The purpose of this phenomenological study was to understand and describe

how exemplary elementary school principals use storytelling to lead organizations

using Denning’s (2011) model. In addition, it was the purpose to understand how

exemplary elementary school principals use storytelling to create transformational

change in organizations. Denning’s The Leader’s Guide to Storytelling highlights eight storytelling narrative patterns:

• Storytelling to ignite action and implement new ideas
• Storytelling to build trust
• Storytelling to build brand
• Storytelling to transmit organizational values
• Storytelling to foster collaboration
• Storytelling to share knowledge
• Storytelling to neutralize rumor
• Storytelling to share your vision

Methodology: This …

Stress And Coping Of Caregivers To Individuals With Dementia, Karen Annette Jensen

Dissertations

Considerable literature exists on the presence of burden among caregivers, however, it has also been discovered that individuals psychologically adapt to situations in which they are involved. The purpose of this study is, utilizing an adaptation paradigm, to examine the interrelationship of factors in the caregiver's environment and the mediating role of coping mechanisms on appraisal of caregiving. The theoretical framework to guide this study was based on Roy's Adaptation model in conjunction with Lazarus and Folkman's cognitively-based theory of stress and coping.

Caregivers' Psychological Factors Underlying Sugar-Sweetened Beverage Intake Among Non-Hispanic Black Preschoolers, Julia A. Franson Tipton

Dissertations

Non-Hispanic black children consume greater amounts of sugar-sweetened beverages (SSBs) and are at disproportionately high risk for obesity and other SSB-related health problems. The purpose of this study was to determine the relationships between caregivers' beliefs, attitude, subjective norm, perceived behavioral control, past behavior, and intention to serve SSBs to non- Hispanic black preschoolers. The researcher conducted a cross-sectional, correlational study using multiple regression with path analysis using the Expanded Theory of Planned Behavior as the theoretical framework.

Exemplary Human Resources Administrators Leading Through Storytelling, Colleen Slattery

Dissertations

Purpose: The purpose of this phenomenological study was to understand and describe how exemplary human resources administrators use storytelling to lead organizations using Denning’s (2011) model. In addition, it was the purpose to understand how they use storytelling to create transformational change. Denning’s The Leader’s Guide to Storytelling highlights eight storytelling narrative patterns: to ignite action and implement new ideas, build trust, build your organizations’ brand, transmit organizational values, foster collaboration, share knowledge, neutralize rumor, and create and share vision.

Methodology: This phenomenological qualitative study described the lived experiences of exemplary human resources administrators in Northern California. The researcher was …

Strategies Exemplary High School District Superintendents Use To Work With The Political Styles Of School Board Members, Jeffrey Tooker

Dissertations

Purpose: The purpose of this mixed methods study was to understand the political styles of high school district superintendents and school board members as perceived by superintendents. In addition, it was the purpose of this study to identify the political strategies high school district superintendents use to work with the different political styles of board members. Methodology: Through an explanatory sequential mixed-methods study design, an electronic survey was utilized to collect quantitative data. Following quantitative data collection, in-depth qualitative data was collected through one-on-one interviews with exemplary high school district superintendents in California. The results of the quantitative survey data …

Pain And Postoperative Health-Related Quality Of Life In Inguinal Hernia Patients, Cheryl B. Rowder

Dissertations

The purpose of this study was to explore the relationship between selected variables (i.e., pain issues, hernia characteristics, and personal attributes) and postoperative health-related quality of life in inguinal hernia patients. This study identified preoperative variables predictive of lower postoperative health-related quality of life. The study entailed non-experimental retrospective analyses of variables generated during an ongoing longitudinal cooperative clinical study to examine patient outcomes after inguinal hernia repair. Fourteen Veterans Affairs Medical Centers in the continental United States participated in the study. Data were collected from eligible participants upon entry into the project and at 3 months post-surgery. The sample …

Marital Reciprocal Support In The Context Of Cancer, Lillian G. Douglass

Dissertations

The purpose of this study was to examine the relationship between mutual spouse support and the psychological status of spouses whose mates were being treated for cancer. The conceptual framework was developed from a literature review in which empirical studies and interpersonal theories suggested the importance of social support to health promotion and maintenance in stressful life situations. A descriptive cross-sectional correlational design was used.

Nurses' Negotiation Processes In Facilitating Ethical Decision-Making In Patient Care, Teresa A. Savage

Dissertations

The literature on ethical decision-making by nurses presents both prescriptive and descriptive decision-making models. The processes nurses use to move through the step-wise models has not been described. An atheoretical approach was taken using naturalistic inquiry methodology to explore the processes further. Eighteen nurses working in a Midwest, urban academic medical center were interviewed. The major themes focused on the moral agency of nurses and the processes by which nurses accomplish their objectives for their patients. Physician-nurse relationships and their interactions were critical in the expression of moral agency of the nurses. The main finding in the study was that …

The Challenges Navy And Marine Corps Veterans Face While Seeking Civilian Employment In San Diego County, California, Absalom Morris

Dissertations

Purpose: The purpose of this phenomenological study was to explore the lived experiences of Navy and Marine Corps veterans who have transitioned to the civilian workforce in San Diego County, California since the 2011 draw-down of Operation Iraqi Freedom and Operation Enduring Freedom with respect to personal, mental health, cultural/societal, and organizational support and barriers.

Methodology: This phenomenological, qualitative study identified and interviewed six U.S. Navy veterans and six U.S. Marine Corps veterans who have transitioned from active duty military service to the civilian workforce. The participants were purposefully and conveniently selected based on specific criteria.

Findings: After the analyzing, …

Effects Of Self-Esteem, Threat Appraisal, And Coping Responses On The Somatic Components Of Illness: A Test Of A Proposed Causal Model With Professional Women, Linda Langley Moneyham

Dissertations

The study was designed to test a causal model of theoretical relationships among self-esteem, threat appraisal, coping responses, and the somatic components of illness with a population of professional women. The proposed causal model was derived from Lazarus's cognitively oriented theory of psychological stress and coping. Development of a valid model of interrelations among the variables of interest would assist in the formulation of nursing interventions aimed at decreasing vulnerability to stress and stress-related illness. A correlational field investigation was conducted to test the hypothesized causal model.

Ethical Dilemmas Of Nurse Executives: A Descriptive Study, Caroline Camunas

Dissertations

This research was designed to describe the ethical dilemmas and to identify the facilitating and inhibiting factors perceived by nurse executives when making decisions that have ethical implications. As there has been little research in this area the study was a descriptive study one.

The Relationship Among Health Locus-Of-Control, Value Of Health, And Health Behavior In Adolescents, Phyllis K. More

Dissertations

This study explores selected personality factors which may explain part of the variance in health behavior in adolescents. Theoretical and empirical evidence suggested that internal health expectancy and high value of health should be related to adolescents' choices of health behavior. Health expectancy was measured by the Multidimensional Health Locus of Control Scales (Wallston, Wallston & DeVellis, 1978), value of health by the Value Survey (Wallston, Maides & Wallston, 1976), and adolescent health behavior by the Student Lifestyle Survey (McKillip & Taylor, 1979). The Student Lifestyle Survey measures ten components of health behavior as follows: (1) alcohol use, (2) smoking, …

Using Machine Learning Classification Methods To Detect The Presence Of Heart Disease, Nestor Pereira

Dissertations

Cardiovascular disease (CVD) is the most common cause of death in Ireland, and probably, worldwide. According to the Health Service Executive (HSE) cardiovascular disease accounting for 36% of all deaths, and one important fact, 22% of premature deaths (under age 65) are from CVD.

Using data from the Heart Disease UCI Data Set (UCI Machine Learning), we use machine learning techniques to detect the presence or absence of heart disease in the patient according to 14 features provide for this dataset. The different results are compared based on accuracy performance, confusion matrix and area under the Receiver Operating Characteristics (ROC) …

Assessment Of Validity And Reliability Of A Neurophysiologic Evoked Potential Instrument, Wanda O. Wilson

Dissertations

The purpose of this study was to determine the validity of a step by step non-simultaneous method for measuring somatosensory evoked potentials (SSEPs) and to determine reliability of a neurophysiologic evoked potential instrument, Bio-logic Evoked Potential System, on healthy, adult volunteers in a controlled environment. The neurophysiologic monitoring during anesthesia and surgery is used to optimize surgical outcomes and minimize neurologic morbidity. During surgery, the anesthetic regimen and subject variables can affect the electrical signals of neurophysiologic monitoring. The neurophysiologic instrument has an important role in the successful monitoring of the central nervous system. The research questions were: (1) What …

Critical Care Performance In A Simulated Military Aircraft Cabin Environment, Margaret Mcneill

Dissertations

Since the start of Operation Enduring Freedom in 2001, over 42,063 patients have been transported by the United States Air Force aeromedical evacuation system. Critical Care Air Transport Teams (CCATTs) provide care for 5-10% of the injured and ill warriors that are transported on military cargo aircraft to definitive treatment facilities. The purposes of this study were to determine the effect of two stressors of flight, altitude-induced hypoxia and aircraft noise, and to examine the contributions of fatigue and clinical experience on cognitive and physiological performance of CCATT providers. This repeated measures 2 x 2 x 4 factorial study included …