Digital Commons Network^™

Trustworthy Machine Learning Through The Lens Of Privacy And Security, Thi Kim Phung Lai

Dissertations

Nowadays, machine learning (ML) becomes ubiquitous and it is transforming society. However, there are still many incidents caused by ML-based systems when ML is deployed in real-world scenarios. Therefore, to allow wide adoption of ML in the real world, especially in critical applications such as healthcare, finance, etc., it is crucial to develop ML models that are not only accurate but also trustworthy (e.g., explainable, privacy-preserving, secure, and robust). Achieving trustworthy ML with different machine learning paradigms (e.g., deep learning, centralized learning, federated learning, etc.), and application domains (e.g., computer vision, natural language, human study, malware systems, etc.) is challenging, …

Ai Approaches To Understand Human Deceptions, Perceptions, And Perspectives In Social Media, Chih-Yuan Li

Dissertations

Social media platforms have created virtual space for sharing user generated information, connecting, and interacting among users. However, there are research and societal challenges: 1) The users are generating and sharing the disinformation 2) It is difficult to understand citizens' perceptions or opinions expressed on wide variety of topics; and 3) There are overloaded information and echo chamber problems without overall understanding of the different perspectives taken by different people or groups.

This dissertation addresses these three research challenges with advanced AI and Machine Learning approaches. To address the fake news, as deceptions on the facts, this dissertation presents Machine …

Influence Of Material Properties On Granules Prepared By Dry Co-Rotating Twin Screw Extrusion And Counterrotating Batch Mixing, Afstathios Steve Pafiakis

Dissertations

Recently, the pharmaceutical industry has shown interest in continuous granulating technology because of the flexibility it offers as an option that bypasses the costly scale-up process associated with batch manufacturing. However, the granulation mechanism(s) using twin screw co-rotating hot melt extrusion (HME) has not been fully explored, and it is not yet well understood. This leads to costly experiments during development and process reliability problem in commercial manufacturing. The main objective of this dissertation is to increase the mechanistic understanding of the twin screw granulation process of systems containing an active pharmaceutical ingredient (API) and a polymer excipient. This is …

V-Shaped Temperature Dependences And Pressure Dependence Of Elementary Reactions Of Hydroxyl Radicals With Several Organophosphorus Compounds, Xiaokai Zhang

Dissertations

Organophosphorus compounds have brought increasing attention since they are widely used as flame-retardants, which can take effect in combustion via reactions with reactive radicals. These reactions are influenced by variables such as temperature and pressure, resulting in a temperature and pressure dependent rate constant. Studying this reaction kinetics has great importance in both combustion reaction and atmospheric environment.

This study is focused on kinetics of several elementary reactions of combustion importance. The kinetics of hydroxyl radicals were studied using pulsed laser photolysis coupled to transient UV-vis absorption spectroscopy over the 295 - 837 K temperature range and the 1 - …

Development Of Non-Viral Nano-Carriers For Gene Delivery And Covid-19 Vaccines, Zhongyu Li

Dissertations

Gene therapy is one of the most promising medical fields with the potential to effectively advance the treatment of difficult diseases by producing therapeutic proteins or repairing defective gene sequences. However, gene therapy presents severe challenges in delivery including renal clearance, phagocytosis, enzymatic degradation, protein absorption, and cellular internalization barriers, which have been barriers for translation into the clinic. Naked nucleic acids, with their intrinsic negative charge, electrostatically repulse the anionic cell membrane, preventing cellular uptake. Also, they are considered foreign genetic material when introduced into the body and are rapidly cleared by the reticuloendothelial system or degraded by nucleases, …

Development Of Novel Nanocarbon Based Materials And Membranes With Enhanced Biocidal Capabilities For Clean Water Generation, Indrani Gupta

Dissertations

Water scarcity is one of the major challenges facing humanity today, driven by population growth, economic development, and dietary shifts towards more water-intensive animal products. To address this issue, efficient water resource management and recycling of wastewater are essential. However, around 80% of wastewater globally is discharged into water bodies without treatment, posing a risk to ecosystems and human health. Pathogens, or harmful microorganisms, are a primary cause of water impairment and the transmission of waterborne diseases, leading to increased mortality rates. Traditional methods of treating pathogens involve the use of radiation or chemical disinfectants. Nonetheless, these methods have drawbacks, …

Design, Synthesis, Biological And Computational Studies Of Flavonoid Acetamide Derivatives, Daniel Kasungi Isika

Dissertations

Flavonoid compounds (FC) have extensive biological applications through potent antimicrobial, anti-inflammatory, anticancer, antidiabetic, and antioxidant properties. These applications are nevertheless limited by low bioavailability, poor aqueous solubility, enzymatic degradation, rapid metabolism, and fast body clearance. FC show unique structure-activity relationships (SARs) essential in assessing and mitigating the prevalent challenges impeding their applications. These challenges can be addressed by structural modification of the FC through functionalization of the phenolic rings, modification of the ketone group, and modification of the phenolic hydroxyl groups with bioisosteres.

The objectives of this work are to (i) design and synthesize novel flavonoid acetamide derivatives (FADs) and …

Topics On Asymmetric Classification, Subhrasish Chakraborty

Dissertations

Asymmetric classification refers to a situation where the cost of misclassifying one class is significantly higher than the cost of misclassifying the other class. This problem is common in many real-world scenarios, such as medical diagnosis or fraud detection. In this dissertation two of the common types of asymmetric classification problems have been dealt with — imbalanced classification and ordinal classification. An example of imbalanced classification is to detect fraudulent credit card transactions where the distribution of the normal and fraud transactions are extremely skewed. On the other hand, ordinal classification, also known as ordinal regression, is widely used in …

Improving Recognition Of Depression Among The Adult Patients In Psychiatric Settings, Jane A. Ferraris

Dissertations

Depression rating scales may improve depressive symptom identification. At the project site, there was no consistent process for determining patients' depressive symptoms, so an evidence-based solution was sought. The purpose of this quality improvement project was to determine if the translation of Dunlop et al.'s research utilizing the Hamilton Depression Rating Scale-6 (HAMD-6) would impact the rate of identification of depressive symptoms and referrals to psychology for Cognitive Behavioral Therapy (CBT) among adult patients.

Treatment Outcome From Cognitive Processing Therapy Examined Three Ways, Sophie Haven

Dissertations

Cognitive Processing Therapy (CPT), a Cognitive Behavioral Therapy for treating Post Traumatic Stress Disorder (PTSD), is an evidence-based treatment that has been demonstrated to be effective in treating PTSD. Nonetheless, CPT can have a high rate of treatment non-completion. Attrition from therapy has been operationally defined using multiple contrasting methods. Understanding attrition using a definition with the most clinical utility is essential to improving outcomes from efficacious treatments. Two clinically relevant definitions for attrition, session attendance and symptom improvement, are critical to understanding attrition. Combining information from both definitions, to create four separate groups, will provide more accurate information about …

Male Nursing Students In The Community College And The Struggle To Completion, Geri Brewer

Dissertations

Despite significant contributions to healthcare made by male nurses throughout the centuries, nursing is a female-dominated profession, creating challenges for male nursing students. The problem addressed in this study was that male nursing students experience challenges that impede their success toward completing their urban Midwest community college nursing program. Guided by the nursing undergraduate retention and success model, the purpose of this basic qualitative study was to explore male nursing students' perceptions of the challenges they face that impede their success and their recommendations for the supports they need to overcome these challenges within two urban Midwest community college nursing …

Mantram For Mamas: A Pilot Study For Postpartum Women, Ritamarie Smedile

Dissertations

Objective: This pilot study launched an online Mantram Repetition Program (oMRP) using a virtual health portal that aimed to explore online portal accessibility, oMRP acceptance, and overall interface satisfaction among a sample of postpartum women.

Background: Postpartum depression remains one of the most common and severe childbirth complications, affecting more than 13% of women during the first three months after childbirth. Cognitive or behavioral talk therapy sessions and medication are the most frequently recommended treatments to alleviate symptoms. Although effective, women tend not to enroll or adhere to these modalities, suggesting they need alternative treatment plans. A possible alternative, mirroring …

The Lived Experience Of Patients With Clostridioides Difficile, Andrea Scherschel

Dissertations

Background: Clostridioides difficile (C. difficile) is the most common healthcare-acquired gastrointestinal infection in the United States. While there is a plethora of information on the treatment and diagnosis of C. difficile infection (CDI) in the literature, there is a paucity of research findings describing the lived experience of a person with the disease.

Objective: This study described the lived experience of patients who have had one or more CDIs.

Lines of Inquiry: There were two lines of inquiry for this study: (1) Describe the lived experience of having a CDI, and (2) determine if photo-elicitation as a research modality enhanced …

Anxiety And Agitation In Adult Patients Admitted To An Emergency Room During The Covid-19 Pandemic, Doris L. Asombrado

Dissertations

Purpose: The purpose of this retrospective correlational study was to identify the relationship between COVID-19 status and the prevalence of anxiety-agitation with select sociodemographic and clinical characteristics in adults admitted to the ED during the pandemic (03/01/2020 through 12/31/2020).

Background: COVID-19 infections combined with the WHO and CDC recommendations to mitigate spread have had deleterious psychosocial and economic outcomes with the risk of subsequent COVID-19 related mental illness. Studies indicate one in three adults experience anxiety or depression.

Methods: This retrospective correlational study reviewed 2,572 psychiatric admissions from a Southern California ED during the pandemic from March 1, 2020 through …

Nurse Practitioner's Perspectives On Human Trafficking In The Emergency Department; A Narrative Inquiry, Ann Gerhart

Dissertations

Background: Human trafficking (HT) is a global and domestic concern that impacts individuals, families, and communities. Over the last ten years, HT has become a significant public health concern intersecting with the health care community in various settings. HT abuse and oppression have both short- and long-term health consequences. Approximately 50 to 88% of trafficked individuals visit a health care provider, and 63% of those visits are evaluated in the emergency department (ED). Nurse practitioners (NPs) working in the ED interact with HT individuals but have not been represented in recent research scholarship.

Purpose: The purpose of this qualitative …

Social Determinants Of Health And Health Confidence, Laura Truman

Dissertations

Purpose/Aims: The purpose of this study was to investigate the relationship among social determinants of health (SDOH), select sociodemographics, and health confidence level in adults receiving care at an urgent care center.

Background/Rationale: To improve overall health and reduce health inequities during a global pandemic and unprecedented rates of inflation, the relevancy and urgency of identifying how patient-level SDOH impact health confidence level are even greater. Extant research indicates a relationship between the number of unmet social needs and low health confidence. Low health confidence predicts poor involvement in self-care and is associated with an increased use of costly health …

Academic Nursing Administrators' Experiences With Social Distancing During Covid-19: A Qualitative Study, Vineta Mitchell

Dissertations

The COVID-19 pandemic brought about many unpredictable challenges requiring flexible and adaptable solutions for higher education, especially in nursing academia. The COVID-19 pandemic challenged nursing academia, including academic nursing administrators (ANAs), to keep staff and students safe while mitigating the spread of the disease. The ongoing outbreak of COVID-19 and the global healthcare crisis of this generation led to the need for social distancing. As the number of deaths increased from the coronavirus, radical changes were adopted in the United States, including social distancing. The COVID-19 pandemic complicated the practical aspects of the practicum in nursing education as they questioned …

Relationship Between Social Support And Stress In Accelerated Nursing Students, Karen L. Bravo

Dissertations

Nursing program attrition rates and retention rates in the first year of professional practice are excessive due to stress. Investigating through this quantitative, correlative research study is due to the lack of information related to accelerated students and stress. Theories framing this study, the Transactional Model of Stress and Coping, and Triadic Reciprocal Determinism Theory, posit that the environment, whether internal or external, affects stress reactions. The research questions included relationships of Significant Other Support, Family Support, and Friend Support to Perceived Stress Score in a two-part online survey of 116 United States participants.

The Influence Of Childhood Familial Dysfunction On Emotional Well-Being And Substance Use Behaviors In Young Adults, Margaret Bullerjahn

Dissertations

Problematic substance use in young adulthood can lead to a variety of societal and individual consequences; therefore, it is important to understand risk factors contributing to its development. Although several individual and environmental factors can contribute to the development of substance misuse, the relationship between family dysfunction and emotional functioning in the prediction of substance use has been relatively understudied within this developmental period. The current study aimed to further understand how childhood family dysfunction, emotion regulation, and emotion reactivity aid in the development of young adult substance misuse. 405 young adults were surveyed about their childhood family experiences, current …

Nursing Students' Intention To Work With The Elderly After Graduation: A Qualitative Study, Terri Murabito

Dissertations

America's population is aging. More than one in five Americans will be over 65 by 2030. These numbers are expected to challenge existing healthcare systems. The recruitment and retention of qualified, competent registered nurses (RNs) to care for this vulnerable population have become urgent. However, undergraduate baccalaureate nurses consistently report geriatric nursing as the least preferred clinical area to in work after graduation. To understand how graduating nurses discern their career intentions, a basic qualitative study was undertaken using Ajzen's theory of planned behavior as an underlying theoretical framework. The purpose of the study was to understand and interpret nursing …

Simulation And Improving Clinical Judgment In Prelicensure Nursing Students: A Mixed Method Approach, Lizabeth J. Reents

Dissertations

Simulation has been considered a valid pedagogy for health professionals in education and actual practice. Its proper execution is vital for proper assimilation of knowledge, skills, and attitudes within the pre-licensure students throughout their curricular journey. High fidelity and multi-patient simulation scenarios were employed for beginner fundamental and advanced senior level nursing students with significant quantitative increases in clinical judgment found between groups using an independent t test and the Lasater Clinical Judgment Rubric (LCJR). The LCJR is based upon the Tanner's clinical judgment model and has been extensively used throughout the world demonstrating solid reliability and validity. Qualitative responses …

The Experience Of "Doing Well" In Older Nursing Home Residents: Bringing The Past To The Present, Ronald J. Walent

Dissertations

Though discussions of well-being and quality of life for older adults in American nursing homes have flourished over the past decade, relatively few studies have explored these notions from the perspective of older residents themselves. The purpose of this research is to understand experiences and perceptions of "doing well" in older nursing home residents.

Improving The Use Of Advance Care Planning In Assisted Living Facilities, Johnpaul King

Dissertations

Ensuring patients receive care in the fashion they so choose at the end of life should be considered and addressed upon any admission process. The project site noted many unnecessary, repeated emergency room (ER) visits for residents so an evidence-based solution was sought. The purpose of this quantitative, quality improvement project was to determine if the implementation of the Carolina Caring Hospice Agency ACP (CCHAACP) toolkit would impact ACP implementation and reduce ER visits among residents in an assisted living facility (ALF) in Western North Carolina over four weeks. Orem's selfcare theory was the framework of the project. Data was …

Diabetes-Related Distress Experienced By Saudi Adults With Type Two Diabetes Mellitus, Ibtesam Alqahtani

Dissertations

Living with a chronic condition such as diabetes mellitus (DM) and adhering to its complex treatment regimen strongly affect patients' psychological well-being as well as their physical health. Diabetes-related distress (DRD) is a common issue, affecting 40% of DM cases, but it often goes unnoticed and untreated. Despite the high prevalence of DM in the Saudi population, DRD has received little research attention.

This study explored the lived experience of DRD among Saudi adults with type 2 diabetes mellitus (T2DM) in the Kingdom of Saudi Arabia.

Saudi Adults In Vaso-Occlusive Crisis Accessing Healthcare For Pain Management: A Phenomenological Inquiry, Jawhrah Alqahtani

Dissertations

Vaso-occlusive crises (VOCs) require frequent utilization of healthcare services by adults with sickle cell disease (SCD). This increases the likelihood of poor care and healthcare disparities. The experiences of SCD patients attempting to access pain management have rarely been examined. An evaluation of these experiences may ease the lifelong suffering of Saudi Arabians affected by SCD.

This study explored the lived experience of Saudi Arabian adults when accessing the healthcare system for pain management in VOC.

Mixed Method - How Do Medical-Surgical Nurses Provide Compassionate Care To Patients In The Face Of Adversity?, Diane D. Kret

Dissertations

Compassion is a quality that is the very essence of nursing. Nurses, as professionals, seek to alleviate suffering. It is through providing compassionate, connected care that nurses can relieve their patients' suffering. In the midst of adversity such as taking care of ill and dying patients, especially in the Covid-19 pandemic, nurses have been challenged with providing compassionate care despite the increased toll that this may have on them. There is evidence that exposure to these events can cause compassion fatigue and burnout. When these signs of compassion fatigue or compassion burnout are not addressed, nurses have decreased job satisfaction …

Utilizing New Technologies To Measure Therapy Effectiveness For Mental And Physical Health, Jonathan Ossie

Dissertations

Mental health is quickly becoming a major policy concern, with recent data reporting increasing and disproportionately worse mental health outcomes, including anxiety, depression, increased substance abuse, and elevated suicidal ideation. One specific population that is especially high risk for these issues is the military community because military conflict, deployment stressors, and combat exposure contribute to the risk of mental health problems.

Although several pharmacological approaches have been employed to combat this epidemic, their efficacy is mixed at best, which has led to novel nonpharmacological approaches. One such approach is Operation Surf, a nonprofit that provides nature-based programs advocating the restorative …

Audacious Corazón: A Nuanced Art Of Care, Dianne Bermudez Torres

Dissertations

Historically, the concept of care in higher education has focused on academic achievements, neglecting the significance of building meaningful relationships between faculty and students that engage both affective and cognitive dimensions (Noddings, 1994). Teaching with the heart, or corazón, embodies care in teaching. Employed in this study was a mixed-methods, exploratory case study approach that explored the intricate art of care and how faculty foster bilingual authorization credential teacher candidates to evolve into culturally responsive educators. Pearson et al.’s (2021) cariño pedagogy serves as a model that empowers faculty’s humanizing agency. Additionally, the study also reflected on the concept of …

Resistencia Indocumentada: Exploring The Lived Experiences Of Higher Education Undocumented Students In The San Diego-Tijuana Border Region, Adan Escobedo Sanchez

Dissertations

Undocumented students face myriad obstacles while attending higher education institutions that would deter them from completing their academic journeys. Furthermore, they are placed with a dual narrative that labels them as either dangerous or exceptional. This study explored the lived experiences of undocumented students in college in the San Diego-Tijuana border region to consider what factors have led to resilience and resistance in their academic journey. By understanding these factors, the research aimed to tackle the dual narrative that burdens undocumented students from the illegality as a master status they possess.

This study used narrative inquiry and a literature review …

Racism Without Race: The Racialization Of Middle Eastern And North African Students At U.S. Colleges, Hannah Mesouani

Dissertations

Although a growing body of literature covers the experiences of international students at U.S. colleges, the stories of those who do not fit into the U.S. racial schema remain untold. This study examined how Middle Eastern and North African (MENA) students understood their racial identities given the United States’ tense history with Islam and the MENA world. Using foundational texts on critical race theory, current scholarship on Arab Americans and foreign-born students, and facets of the Ethnic Identity Scale (EIS), this study examined the experiences of MENA students who study amid a national backdrop of xenophobia and racialized Islamophobia. This …