Digital Commons Network^™

Enhancing Organisational Performance Through Patient-Focused Learning Excellence In The Biopharmaceutical Industry, Lori Richter

Dissertations

Drug shortages, quality defects and challenges regarding innovation within the biopharmaceutical industry pose significant risks to patient safety and organisational performance. These problems persist despite the many scientific, technological and economic advances over the past several years in a well-funded, high-revenue industry operated by highly qualified personnel. Evidence suggests that the industry has yet to fully realise the potential for building organisational capabilities to enable learning from mistakes to enhance performance outcomes. This research study explored how biopharmaceutical companies can learn from their mistakes and embrace a culture of learning in order to reduce quality defects and drug shortages by …

“A Real Man . . .”: Deconstructing Machismo Heteronormative Standards With K–12 Latino Male Educators Through Dialogic Spaces, Mario Echeverria

Dissertations

In a K–12 educational landscape where 75% of educators are white women, recruitment of Latino male educators is crucial for diversification, yet these educators represent just 2% of the teaching workforce in the United States (NCES, 2020). These educators grapple with a layered sense of identity as they navigate expectations of hegemonic masculinity and machismo norms that dictate their roles as disciplinarians and saviors, especially for young boys of color (Brockenbrough, 2018; Lara & Fránquiz, 2015; Martino & Kehler, 2006; Mills et al., 2004; Singh, 2021). Unfortunately, Latino male educators leave the profession at twice the rate of their Latina …

The Relationship Between Participation In A Student Success Course And The Retention Rate And Academic Success Of First-Year Freshmen At A Historically Black University, Madeline Martinez

Dissertations

Problem

Amongst the highest at-risk student populations are minority students (students of color), first-generation college students, students from low-socioeconomic status, students experiencing financial challenges, and those who enter college academically underprepared. Furthermore, studies have found a significant gap in the educational achievement of African Americans in comparison to other peer groups. Closing this achievement gap requires educators to take a closer look at the complex concept of student retention and understand the variables and factors associated with students’ successful outcomes from both an individual and institutional perspective. An in-depth examination of the effectiveness of strategies specifically designed for the retention …

Exploring Manifestations Of Pluriform Love In The Leadership Of Christian Early Childhood Communities: A Phenomenological Study 2019-2024 In New Zealand, Sharon Kaye Judge

Dissertations

Problem

This study responds to the need to explore and/or propose models of leadership for Christian early childhood education and care (ECEC) settings in New Zealand (NZ). While previous studies identify love and care as a priority there is a need to define and prioritize Biblical understandings of love that may align with the principles of the national ECE framework. The study represents an alternative narrative to the neo-liberal influences which dominate areas of ECEC leadership through the marketization and standardization of children’s services nationally and globally.

Purpose of Study

Many factors contribute to the purpose of this study which …

Cbct Perceptions Of Radiology Leaders In The Midwest Dental Schools: A Qualitative Study, Tenzin Dadul

Dissertations

Problem

The integration of Cone Beam Computed Tomography (CBCT) in dental education is hindered by a lack of formal training among radiology leaders, insufficient institutional support, and financial constraints. Despite the proven efficacy of CBCT in enhancing diagnostic accuracy and treatment planning, its adoption in pre-doctoral curricula remains limited. This gap in education poses significant challenges for dental graduates, who are increasingly expected to utilize advanced imaging technologies in clinical practice.

Purpose of Study

This qualitative study aimed to explore the perceptions of radiology leaders in Midwest dental schools regarding the integration of CBCT education into pre-doctoral curricula. The objectives …

Employees' Perception Of The Management Of The Covid-19 Crisis At Najran University, Saudi Arabia, Noora Nasser Alsuhaibani

Dissertations

Problem

During the COVID-19 crisis, particularly in the context of Saudi education, the ability to physically attend schools and colleges was greatly hindered due to the widespread transmission of the virus and the resulting obstacles. The issues necessitated the use of crisis management strategies. Some Saudi universities are capable of implementing an organized plan both before to and during crisis management, whereas others lack this competence. This is a substantial problem. Several universities in Saudi Arabia effectively managed the COVID-19 epidemic, whereas others did not. Furthermore, prior studies on crisis management indicate that administrators exhibit diverse responses. By participating in …

Understanding Emerging Adult Mental Health And Attachment: The Roles Of Parental Factors In Childhood, Trauma, And Gender, Christiana A. Howell

Dissertations

Problem

The experience of the parental environment growing up, parental psychopathology in childhood, exposure to trauma throughout the lifespan, insecure adult attachment, and social support have been established as factors that influence mental health in adulthood. These factors have not yet been studied together as a complex model of emerging adult mental health and attachment. The purpose of this study was to develop a theoretically and empirically supported model of these factors to understand how these factors interact to influence mental health in emerging adulthood. Additionally, the purpose was to understand if these factors interact differently based on gender.

Method …

Reporting And Addressing Sexual Harassment At Four Institutions Of Higher Learning In Zambia: A Quantitative Study Of Related Attitudes And Perceptions, Earlymay Chibende

Dissertations

Problem

Sexual harassment is a social ill that exists across nations, socio-economic backgrounds, races, nationality, ethnicity, age groups, and sex. Although both male and female members of society experience sexual harassment, research shows that a greater percentage of sexual harassment victims are women (Whitley & Page, 2015; CharterJee, 2018). A comparison of the prevalence of sexual harassment at workplaces and educational institutions shows that sexual harassment is more widespread at institutions of learning than at workplaces. Research on the prevalence of attitudes and or perceptions toward sexual harassment in institutions of higher learning shows that between 10%- 68% of female …

The Impact Of Hybrid Working On Employee Way Of Life And The Need To Reshape The Employee Value Proposition, Kanishka Chandanamali Athalage

Dissertations

This dissertation details a post-pandemic qualitative investigation conducted to understand the impact of hybrid working solutions on reshaping the employee value proposition (EVP) in the health insurance industry of the UAE. The research aims to evaluate how the introduction of modern hybrid working solutions impacts employees in a post-pandemic environment and, in turn, whether this creates a demand for human resources to refocus drivers of the EVP. Traditionally, EVP is referred to as the overall give-and-get in an employment deal; however, the pandemic was an eye-opener for organizations to redefine what it entails. Since hybrid working has become the new …

The Role Of Semaphorins In Response To Injury In C. Elegans Neurons, Maria Belen Harreguy Alfonso

Dissertations

When neural tissue is injured by trauma, delicate neuronal processes such as axons and dendrites are prone to lesion damage and often disconnect. The molecular, cellular, and circuit mechanisms that underlie the regrowth and reconnection of these processes and the recovery of behavior are major challenges in the fields of neuroscience, regeneration, and resilience. At the molecular and cellular levels, signaling pathways that mediate neuronal growth cone guidance during development can play a role in neuronal regeneration and recovery from injury. One family of signaling proteins involved in this process comprises the highly conserved semaphorins and their receptors, the plexins. …

Model-Based Deep Autoencoders For Clustering Single-Cell Rna Sequencing Data With Side Information, Xiang Lin

Dissertations

Clustering analysis has been conducted extensively in single-cell RNA sequencing (scRNA-seq) studies. scRNA-seq can profile tens of thousands of genes' activities within a single cell. Thousands or tens of thousands of cells can be captured simultaneously in a typical scRNA-seq experiment. Biologists would like to cluster these cells for exploring and elucidating cell types or subtypes. Numerous methods have been designed for clustering scRNA-seq data. Yet, single-cell technologies develop so fast in the past few years that those existing methods do not catch up with these rapid changes and fail to fully fulfil their potential. For instance, besides profiling transcription …

Novel Photobase Generators For Photoinduced Polymerization And Ph Regulation, Shupei Yu

Dissertations

Photochemistry encompasses the investigation of chemical processes instigated by light absorption. As important branches of photochemistry, photosensitive and optical materials have attracted extensive research interests in both academia and industry. Photosensitive and optical materials are composed of polymers / small molecules with photo-responsive properties. These materials not only can absorb light in the desired energy spectrum, but also exhibit chemical / physical reactions, which can be applied to different fields such as photoredox, photo-heat, phototherapy, solar cells, diodes, etc. Among them, photobase generators (PBGs) are a series of photosensitive compounds, which absorb the incident light, then release the basic species …

Assessing The Feasibility And Mechanism Of Destructive Removal Of Per- And Polyfluoroalkyl Substances (Pfas) From Water, Kaushik Vinaykumar Londhe

Dissertations

One of the most pertinent challenges faced by the drinking water community is the widespread contamination of per- and polyfluoroalkyl substances (PFAS). These anthropogenic chemicals have been ubiquitously used in everyday products such as carpets, stain repellents, dyes, shampoos, non-stick cookware as well as in aqueous firefighting foams. PFAS are linked with adverse health effects in humans such as thyroid disease, obesity, immunological and reproductive disorders and linked to cancer in adults and low birth weight and developmental defects in infants.

Conventional water treatment technologies have proven to be largely ineffective in PFAS remediation, due to their extreme stability and …

Development Of Novel Protein Digestion And Quantitation Methods For Mass Spectrometic Analysis, Yongling Ai

Dissertations

Proteins are the workhorses of biology, playing multifaceted roles in maintaining cellular function, signaling, and response to environmental cues. Understanding their abundance and dynamics is pivotal for unraveling the complexities of biological processes, which underpins the foundations of molecular and cellular biology. Accurate measurement of protein quantities provides insights into cellular homeostasis, facilitates the discovery of biomarkers, and sheds light on the molecular mechanisms of diseases, bridging the gap between the molecular intricacies of proteins and their functional consequences in health and disease. The evolution of protein quantitation methodologies, from classical colorimetric assays to sophisticated mass spectrometry-based approaches, has expanded …

Homeless Barriers: A Phenomenological Study Of Service Providers In Thurston County, Washington State, Michael Meredith

Dissertations

Purpose: This qualitative phenomenological study aims to describe the perceptions of homeless service providers in Thurston County, Washington State, and describe barriers to the homeless seeking assistance. This study interviewed ten Thurston County service providers about their perception of the barriers preventing the unsheltered homeless from using available services. Identifying barriers and developing strategies to reduce or remove them is expected to reduce or eliminate homelessness.

Methodology: This qualitative phenomenological study describes the homeless service providers' perceptions of the homeless and the barriers to the homeless seeking assistance. The researcher conducted interviews with a sample of ten service providers to …

Value And Impact Of Nurse Innovators Working In Academic, Industry, And Government Settings: A Qualitative Study, Olivia A. Lemberger

Dissertations

This dissertation explores the value and impact of nurse innovators working in academic, industry, and government settings. A qualitative descriptive study was chosen to understand the contributions of nurse innovators and the outcomes associated with their innovative endeavors. The purpose of this study is to better understand the contributions of nurse innovators by answering the following research questions: 1) How do nurses perceive that nursing innovation adds value to and/or impacts patients or the United States health care system? 2) What metrics/outcome measures do nurse innovators identify as relevant or useful to evaluate innovation success? And 3) What methods/resources do …

Supports And Barriers Of The Lived Experience Of Hmong Women K-12 Administrators Seeking Advancement In Leadership Positions, May Moua

Dissertations

Purpose: The purpose of this qualitative phenomenological study was to examine the supports of cultural, family, community, professional career, and mentorship Hmong women administrators experienced in their career path toward a high-ranking educational administrative position. Additionally, the purpose of this study was to examine the cultural, family, community, professional career, and mentorship barriers Hmong women administrators experienced as they ascended to high-ranking educational administrative positions.

Methodology: This study was conducted using qualitative research methods. The researcher utilized a group of highly educated Hmong female administrators in the Central Valley, California area. This group of individuals shared their experiences of supports …

Quantifying Non-Muscle Myosin 2 Filament Dynamics, Melissa Ann Quintanilla

Dissertations

Non-muscle myosin 2 is a motor protein that, when assembled into filaments, works on the actin cytoskeleton to produce contractile forces within cells. This type of myosin dynamically assembles within cells to exert forces necessary for a wide variety of functions including cell division, migration, and multicellular movement. The ability to dynamically assemble contractile networks, and the ability to control the assembly and placement of these myosin filaments in both space and time, is therefore required throughout cell physiology. We used a suite of dynamic, quantitative imaging approaches to identify deterministic factors that drive myosin filament appearance and amplification as …

Establishing A Novel Lipid-Polyamine Metabolic Connection To Virus Replication, Yazmin Edith Cruz Pulido

Dissertations

Polyamines are small positively charged alkylamines found in all living cells. These ubiquitous molecules have been found to play a variety of roles ranging from stabilizing nucleic acids (DNA and RNA) to cellular proliferation. Studies have also identified roles for polyamines in viral packaging and viral enzyme function. However, the role of polyamines on cellular components and their effect on viral replication is less known. In our efforts to identify the lipid-polyamine metabolic connection to virus replication we utilized a human hepatocyte cell line in which polyamines were depleted via pharmacological or genetic approaches and studied the effects on lipid …

Revitalizing The Middle-Skill Talent Pipeline: Exploring The Decision To Enroll In A Postsecondary Career And Technical Education Program, Felicia Hall

Dissertations

A workforce shortage exists within occupations requiring educational training beyond high school but less than a 4-year degree, known as middle-skill occupations. Career and Technical Education (CTE) programs offered at community colleges throughout the United States equip graduates at the middle-skill level. Although affordable CTE programs are readily available, little is currently known about what makes students consider and ultimately enroll in postsecondary CTE programs. This qualitative phenomenological study investigated the decision to enroll in a postsecondary CTE program as experienced by current students at a North Alabama community college to identify enablers and barriers faced during the decision to …

Timeseries Forecasting Of U.S. Housing Price Index Using Machine Learning And Deep Learning Models, Krishna Chaitanya Nunna

Dissertations

Time series forecasting is a promising technique for various applications which predicts future values or patterns by taking historical data as base. Forecasting future trends is very beneficial for different industries to make valuable decisions and strategies. One such industry is housing market; it has biggest influence on U.S. economy. Housing price index (HPI) is a one of the crucial economic indices published by various government funded and private agency to benefit several industries and individuals for better analysis of future trends of housing market.

Several factors influence the HPI, economical, geographical, and demographic features. Development of traditional time series …

Teachers' And Administrators' Opinions Of Lgbtq Students And Inclusive Education, Katie Vining

Dissertations

The goal of this study was to explore opinions of teachers and administrators in the South, when dealing with inclusive education within their school. Additionally, the goal was to examine the reported effect of teachers and administrators’ opinions of providing LGBTQ students with inclusive education on the school climate and risk factors of students. The study explored what practices and strategies have been implemented to provide an inclusive education for LGBTQ students.

The results of this study confirmed that bullying of LGBTQ students exists in schools in Alabama, Louisiana, and Mississippi, and a lack of specific policy to address the …

Structural Features Of Hiv-1 Integrase In The Late Stage Of Viral Replication, Tolga Catmakas

Dissertations

HIV-1 integrase (IN) is an essential enzyme for the viral life cycle as it integrates viral genomic material into the host cell genome. In addition to its’ essential catalytic function, IN has another important non-catalytic role where it binds the viral RNA to facilitate successful particle maturation during the viral life cycle. A significant number of IN mutants, addressed as class II IN mutants, show various defects, affecting different steps of the viral life cycle. Class II IN mutants exhibit aberrant morphology where viral ribonucleoprotein particles are mislocalized outside of the capsid core. This phenomenon can be observed in the …

An Examination Of Influential Factors Of Academic Dishonesty And Ethical Decision-Making Among Community College Nursing Students, Roshelle L. Lemon-Howard

Dissertations

Academic dishonesty remains a pervasive, multi-discipline dilemma which has been reported as having the propensity of resulting in longstanding consequences beyond academic settings. Previous research has suggested that students who participate in dishonest behaviors while attending institutions of higher education have greater tendencies to engage in dishonest and unethical behaviors within professional settings. Notably, schools of nursing are not exempt from academic dishonesty and the ramifications that have been associated with such misconduct. Although academic dishonesty has been examined from various perspectives, and in numerous contexts, current studies that compare relationships between peer and faculty influences on academic dishonesty and …

Coach-Athlete Conflict And Well-Being Outcomes For Division I Athletes, Alisha M. Hilliard

Dissertations

The purpose of the research was: to qualitatively explore and further understand NCAA Division I (DI) athletes’ experiences with coach conflict and the impact of that conflict on well-being. To serve the purpose of this research, the primary researcher used a purposive sample of DI student-athletes by contacting them directly or sharing the study with faculty, graduate students, and athletic department personnel who work with student-athletes. An interpretive phenomenological approach was utilized while engaging in qualitative inquiry to pursue richer answers to the research question, because these approaches “seek to explore, describe, and analyze the meaning of individual lived experience” …

Biophysical Factors Affecting Habitat Suitability For Crassostrea Virginica, Jason D. Tilley

Dissertations

Oyster reefs provide a variety of important ecosystem services. However, the mortality rate of eastern oyster, Crassostrea virginica, the dominant species that produces oyster reefs in the northern Gulf of Mexico, is increasing at an alarming rate due to a variety of abiotic and biological factors. I examined how biophysical factors, including the less-studied fatty acid profiles of the suspended particulate matter on which oysters feed, influenced morphometric condition of C. virginica.

I sampled suspended particulate matter (SPM) and oysters in-situ in the western Mississippi Sound, which historically supported the majority of oyster production in Mississippi waters. Sampling …

Engagement In Mental Health Research: The Role Of Mental Health Awareness And Perceived Intervention Stigma In Clinical Research Engagement Among African American Faith Communities, Camelia Harb

Dissertations

The dearth of participation in clinical research by marginalized racial and ethnic groups is a commonly cited limitation of research studies. To better understand research engagement among marginalized groups, this study proposed a mixed methods design examining the roles of mental health awareness and perceived intervention stigma on the capacity to engage in clinical research among a sample of African American faith community members. The primary aims were to: 1) examine the associations between and predictive roles of mental health awareness and perceived intervention stigma on clinical research engagement; 2) evaluate the moderating role of perceived intervention stigma; and 3) …

Adaptive Leadership During Times Of Great Change And Opportunity, Danielle Daubin

Dissertations

Purpose: The purpose of this exploratory phenomenological study was to identify and describe the strategies used by middle school principals to build an adaptive capacity based on the five key characteristics of adaptive leadership identified by Heifetz et al. (2009).

Methodology: Three counties in northern California were selected to conduct a phenomenological study on middle school principals. Of this population, purposeful sampling was applied to identify participants who met specific criteria. Ten participants were selected: four from Contra Costa County, three from San Joaquin County, and three from Stanislaus County. The researcher conducted one-on-one interviews to gather data, which was …

Never-Ending Parenting: Challenges Experienced By Caregivers Of Adults With Severe Autism, Andrea Palerino

Dissertations

Despite the large number of children with autism spectrum disorder (ASD) who are annually aging out of the school-based systems in the United States, much of the academic literature has been focused on the concerns and challenges of preschool or school-aged children with ASD. As a result, there lacks a clear understanding of how primary caregivers of adult children with severe autism spectrum disorder (SASD) utilize various forms of capital to navigate care.

This study proposed to fill that gap by employing Bourdieu's notions of capital as a theoretical framework for the interview protocol to address accessing community services, securing …

Power-Up With Emotional Intelligence: Exploring Flight Attendant Leadership And Crew Resource Management In A Dynamic Post-Pandemic Travel Environment, Carlin Laviolet Clarke

Dissertations

In the post-pandemic travel environment, disruptive passengers fail to accept flight attendants’ leadership and cause unruly incidents that compromise flight safety, damage airlines, and present behavioral challenges that can lead to physical harm (Al-Arshani, 2021; Albert, 2016; Araiza, 2022; Albert, 2016; FAA, 2021; Inspire Academy, n.d.-a.; International Air Transport Association [IATA], n.d.-b; James, 2022; Pederson et al., 2021; Ramona & Anbro, 2017; Timmis et al., 2018; TSA, 2021; Wong & Neustaedter, 2017). Flight attendants rely on Crew Resource Management (CRM) skills to manage inflight incidents; however, CRM promotes team effectiveness and flight attendants are often dispersed throughout the cabin and …