Digital Commons Network^™

Quantitative Metabolomics And ¹³C-Enrichment Analysis Of The Effects Of Fat10 Overexpression On Serum And Hepatocytes, Emily C. Hunt

Dissertations

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease, is associated with obesity and type 2 diabetes, and as the prevalence of these conditions increases, the incidence of MASLD is expected to rise. However, the mechanisms that underlie the development of MASLD are complex and incompletely understood. Previous work from our group has indicated that the human leukocyte antigen-F adjacent transcript (Fat10) is overexpressed in the LEW.1WR1 rat model, which develops features of MASLD. The objective of this work was to quantify metabolites associated with MASLD in response to Fat10 overexpression. To achieve this end, we …

Landfalling Hurricanes : Impacts Of Urban Growth On Rainfall And Flooding And Advances In Ai-Based Forecasting, Ankur Kumar

Dissertations

Hurricanes remain among the most destructive natural hazards, producing widespread impacts through extreme rainfall, flooding, and damaging winds. Rapid urbanization in coastal regions further amplifies these risks by modifying land surface characteristics and increasing population, while accurately forecasting hurricane evolution remains a major challenge. This dissertation addresses these challenges through three interconnected research objectives focusing on urbanization-induced hurricane modification, hydrological response, and AI-based hurricane forecasting. The first objective investigates how incremental multi-decadal urban growth modifies hurricane rainfall distribution and rainband evolution during Hurricane Harvey (2017). Convection-permitting WRF simulations demonstrate that realistic urban growth alters boundary-layer structure, storm-relative inflow, convective organization, …

Thermodynamics Of Bubble-Through Liquid-Core Nuclear Thermal Rockets, Dakota John Santana

Dissertations

Liquid-Core Nuclear Thermal Rockets (LNTR) were originally investigated in the 1960s. Exploratory efforts have thus far been relegated to preliminary models that illustrate proof-of- concept or identify theoretical limits. Collectively they would report ranges for 𝐼𝑠𝑝 between 1000 −2000 𝑠 and thrust-to-weights between 0.5 −6. This work expands a model for the Bubbler class of LNTRs into an engineering model suitable for design exploration and system model integration. Bubblers use centrifugal force to trap molten fissile fuel while bubbling propellant radially inward to cool structural members and achieve temperatures >4500 𝐾. The Bubbler model detailed herein, dubbed Fornax, expands the …

Diffusion Of Excitons In Thin Films Of Quantum Dots, Dustin Roberts

Dissertations

Quantum dots are heavily used in modern devices, such as consumer television screens, lasers, medical sensors, solar cells, and quantum computing. Their tunability and photo-stability make them candidates for a variety of applications which formerly required either dyes or significant amounts of band structure engineering. Despite all of the current and active applications, there is a gap in the current literature with regards to how energy is transported through thin films of quantum dots, and what methods may be used to control transport direction and range. The goal of this dissertation is to help fill those gaps, towards the end …

Continuity And Development In The Eschatological Sabbath: Themes In Seventh-Day Adventist Thought (1842–2020), Joseph Nesbit

Dissertations

The Topic

This dissertation explores continuity and development in the eschatological understanding of the seventh-day Sabbath within selected Adventist theological writings from its Millerite origins to the contemporary scholarship of Jo Ann Davidson. The eschatological aspects of the Sabbath have played a central role in both pioneer and contemporary Adventist thought, particularly in its identification as the seal of God in Revelation and as a sign of covenant loyalty in the final crisis. While this understanding has displayed remarkable continuity in its essential themes, it has also undergone significant maturation in tone, scope, and theological emphasis. By tracing both enduring …

Cultivating An Evangelistic Culture At Mountain Chapel Methodist Church Through Preaching, Nicholas Channing Hughes

Dissertations

The purpose of this project was to examine the effectiveness of an intentional sermon series, Everyday Evangelism, in cultivating an evangelistic culture at Mountain Chapel Methodist Church, a Global Methodist congregation. The study used a program evaluation model and addressed the question, How does preaching cultivate an evangelistic culture in the local church, along with questions concerning growth in prayerfulness for the lost, gospel conversations, acts of compassion, invitations to Christian community, follow-up with seekers, and whether leaders exhibited greater change than the congregation as a whole. The project employed a pre- and post-series survey design using two participant groups, …

Transformational Leadership And Employees’ Organizational Citizenship Behavior: Examining The Role Of Perspective-Taking, Job Satisfaction, And Organizational Trust, Marie A. Smith

Dissertations

The study surveyed employees in the service and helping professions (for example retail, healthcare related, hospitality), to examine the impact of transformational leadership on employee organizational citizenship behavior (OCB). Specifically, it tested job satisfaction and organizational trust as possible mediators to the transformational leader to employee OCB relationship and evidence of perspective-taking as a possible moderator to either of these mediated relationships. The study employed PLS-SEM as the method of analysis and examined the influence of transformational leadership, and employee job satisfaction and trust, on employee OCB. The social exchange theory’s reciprocal nature and the leader-member exchange (LMX) theory, based …

Semi-Supervised Learning For Annotation And Representation Of Single-Cell Rna Sequencing And Spatial Transcriptomics Data, Haoran Liu

Dissertations

Semi-supervised learning has emerged as a powerful paradigm for analyzing single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) data, where full annotation is often costly or impractical. scRNA-seq technologies measure the expression of thousands of genes across tens of thousands of cells, whereas ST additionally captures the spatial coordinates of gene expression within intact tissue sections. Annotation is a key step in both scRNA-seq and ST analysis pipelines, aiming to identify cell types, spatial domains, and latent biological structures. However, most existing annotation approaches rely on separate clustering methods that are typically fully unsupervised and fail to leverage side information …

Computational Methods For Single-Cell And Multi-Omic Data Integration And Regulatory Network Inference, Jianlan Ren

Dissertations

Single-cell and multi-omic technologies have transformed the dissection of cellular heterogeneity and regulatory dynamics in health and disease. However, the high dimensionality, technical variability, and biological complexity of these datasets present significant challenges for integration, annotation, and interpretation. In this dissertation, a suite of computational approaches is introduced to address key problems in single-cell and multi-omic data analysis through model-based innovations and applied statistical frameworks.

First, a constrained deep learning framework for single-cell data integration, label transfer, and clustering is proposed. By incorporating biologically motivated constraints into the training process, robust performance is achieved across simulated and benchmark datasets spanning …

Material Degradation And Analysis Of N-Doped Graphene/Mof Nanocatalysts For Orr In Electrochemical Energy Systems, Niladri Talukder

Dissertations

The development of advanced electrochemical energy conversion and storage systems is crucial for achieving sustainable energy security. As alternatives to precious metal-based catalysts in electrochemical systems, especially for the oxygen reduction reaction (ORR), Nitrogen-doped Graphene with Metal-organic Frameworks (N-G/MOF) nanocatalysts have shown exceptional promise in recent years. This research advances the understanding of N-G/MOF nanocatalysts by systematically examining their structural features, degradation traits, correlated performance losses, and other aspects related to catalytic activities.

First, nitrogen-doped graphene (N-G) nanocatalysts were thoroughly investigated, resolving their physical properties, the influence of synthesis parameters, molecular-level material structures, and chemical and electronic structural details of …

Level Up Your Teaching: A Qualitative Analysis Of Teachers’ Perceptions On Gamification As A Tool For Learning, Bryant Wesley Lazenby

Dissertations

This qualitative study investigated K-12 teachers’ views about gamification as an instructional tool to increase student motivation, self-efficacy, and learning mastery. Kelly’s Curriculum Theory and Bandura’s Self-Efficacy Theory were used to investigate how gamified learning environments affect teacher practice and self-efficacy. Seventeen teachers participated in a researcher-designed Qualtrics survey that included both Likert-style and open-ended items. The researcher used descriptive statistics and thematic coding of responses, based on participants’ self-identified levels of gamification experience. The research produced three main findings, which showed that (1) Gamification motivates students through collaborative work, challenging tasks, and progress tracking systems, (2) Students build self-efficacy …

Understanding Medication Adherence Among American Indian/Alaska Native People With Type 2 Diabetes Within A Commercial Health System, Leandra Bitterfeld

Dissertations

American Indian/Alaska Native (AI/AN) adults experience higher rates of type 2 diabetes and worse glycemic control than non-Hispanic White Americans. Despite the importance of medication adherence for T2DM management, there is only one study in the last 15 years examining the relationship between medication adherence and A1C among AI/ANs. Furthermore, T2DM research among AI/ANs has largely been conducted within Indian Health Service and Tribal healthcare systems, though most AI/ANs live outside of reservations, meaning many use commercial health systems. The purpose of this dissertation is twofold. We sought to first understand the experience of AI/AN people accessing T2DM in a …

Polycystin-2 Is Cardioprotective Against Myocardial Infarction By Regulating The Calcium-Mediated Er-Stress Response, Virdjinija Vuchkovska

Dissertations

Patients with autosomal polycystic kidney disease (ADPKD) have an increased risk and worse outcomes after acute myocardial infarction, but the mechanism for this is unknown. Polycystin 2 (PC2), one of the two main proteins mutated in ADPKD, is a calcium permeant channel that localizes to the ER/SR. In non-cardiac cells, PC2 regulates the unfolded protein response (UPR) pathway under ER stress. However, whether PC2 is cardioprotective against ER stress is unknown. We found that PC2 expression increased in cardiomyocytes from human ischemic hearts and infarcted murine hearts. Cardiomyocyte-specific PC2 KO (PC2 KO) mice had worsened cardiac function after myocardial infarction …

Using Light To Dissect Mechanisms Of Septin Recruitment, Shreya Chandrasekar

Dissertations

Cells interpret biochemical and mechanical signals through dynamic regulation of the cytoskeleton and adhesion complexes, enabling key processes such as shape adaptation, force generation and migration. As these signals vary in both time and space, they can be challenging to resolve using traditional bulk assays. To overcome this limitation, we employ light-based optogenetic tools to reversibly modulate biochemical signals and mechanical equilibrium within cells. Specifically, we use the iLID optogenetic approach to locally activate signaling and manipulate contractility within the cytoskeleton for the purpose of investigating the role of RhoA and contractility on septin organization and adhesion protein localization. We …

Title I School Principals And Academic Coaches’ Perceptions Of School Strategic Planning, Implementation, And Monitoring On Plan Outcomes: A Case Study, Elizabeth A. Mize

Dissertations

This qualitative case study involved a sample of Title I elementary schools, their principal, academic coach, and district Title I supervisor, who are involved in the school strategic planning process. The study aimed to explore the strategies and processes Title I schools use to develop, implement, and monitor their school strategic plans to grow student achievement. Data collection methods included a demographic questionnaire, a document analysis of each school’s strategic plan and mid-year monitoring plan, and one-on-one semi-structured interviews. The findings highlighted the importance of well-developed plans that incorporate implementation processes and strong monitoring used to adjust, if needed, the …

Educators’ Perspectives, Practices, And Implications Of Ai In Education For A Title I Middle School, Melanie N. Garland

Dissertations

This study examines educators’ perspectives, instructional practices, and the perceived implications of artificial intelligence (AI) integration within a Title I school context. As AI technologies become more embedded in educational settings, it is essential to understand how teachers in under resourced environments engage with these tools. The research explores how educators perceive the benefits and challenges of AI, the extent of its integration into their pedagogy, and the broader implications for access, particularly for subgroups such as students with disabilities (SWD) and English language learners (ELLs), as well as student engagement and instructional effectiveness. A qualitative case study methodology was …

Privacy Preserving-Based Artificial Intelligence For Precision Agriculture, Partha P. Sengupta

Dissertations

The research work finds a solution to precision agriculture of cotton cultivation using artificial intelligence (AI) models. Two sets of model performance based on the application are selected namely a low resource and a high resource setting. This is because using drone surveys to capture images identifying the classes of stressed and unstressed cotton plantation requires limited model architecture and CPU based computation. Thus, traditional AI models were selected for low resource settings. Again, for high computation intensive models like transfer learning-convolution neural network (CNN) based architectures were grouped into high resource settings. There was another issue of class imbalance …

Understanding Crystallization Behaviors Of Polyethylene-Derived Vitrimers, Sara Valdez

Dissertations

Polyolefins (POs), particularly polyethylene (PE) and polypropylene (PP), are among the most widely utilized polymers globally, valued for their low production costs and favorable mechanical properties stemming from their semicrystalline microstructure. However, their extensive use and improper disposal have raised serious environmental and human health concerns. In response, PO-derived covalent adaptable networks (CANs) have emerged, integrating dynamic chemistries to enable recyclability and sustainable end-of-life strategies. While existing literature has largely focused on novel CAN systems, structure–property relationships, and network rearrangement in relation to thermal transitions (e.g., topological freezing temperature), the influence of network formation on crystallinity and crystallization kinetics remains …

Exploring Faculty Perspectives Of Roadblocks To Accommodating Students With Disabilities In Community Colleges, Shalither S. Cushenberry

Dissertations

This qualitative study explores faculty perspectives on student accommodation in the community college setting. The one-on-one, semi-structured, in-depth interviews with faculty and perspectives of accommodation experts will result in outcomes that better prepare faculty, as a workforce, to support students with accommodations. The study utilized the social cognitive career theory (SCCT) to understand how increasing faculty awareness and engagement through professional development can enhance their ability to provide services to students with accommodation requests. The study underscores the critical importance of understanding the rationale for students with granted accommodations and faculty members supporting their academic success. The findings revealed gaps …

Narrative Economics Of Sports Gambling Legalization: A Case Study Of The United States, Tyler John Hajek

Dissertations

Following the end of the Professional and Amateur Sports Protection Act in 2018, legalized sports betting has become prevalent in the United States (U.S.). Most states legalized the activities due to consumer interest and financial potential for tax revenue generation. The purpose of this study was to explore how legalized sports betting influenced tax revenues in the initial years of expanded adoption in the U.S. To address this purpose, the research questions were structured to uncover if states collectively benefited from the introduction of legalized sports betting, what states have financially benefitted from the implementation of legalized sports betting, and …

The Interpretation And Historical Performance Practices Of Black Choral Music: The Spiritual And Gospel Music, A Comparative Study, Travis Terrence Kornegay

Dissertations

African American spirituals and gospel music are two foundational folk traditions that have profoundly shaped the American musical landscape and continue to influence cultural identity and sacred expression. Emerging from the resilience and faith of enslaved African Americans, spirituals often carried coded messages of liberation. Meanwhile, gospel music developed in the early twentieth-century urban Black church, blending elements of spirituals, blues, and jazz to communicate collective and personal religious experiences. Although linked by shared cultural lineage, the genres diverge in their historical development, linguistic expression, and performance practices, necessitating comparative scholarly inquiry. This dissertation investigates the similarities and key differences …

Public Perceptions Of Sexual And Dating Violence: How Attitudes On Sexual Education, Pornography, And Masculinity Relate To Rape Myth Acceptance, Bailey Lane Saldana

Dissertations

Rape myths are false beliefs that explain sexual violence, and uphold current beliefs on sexual violence (Payne, Lonsway, & Fitzgerald, 1999). These myths can be learned and reinforced through a variety of sources, including formal school-based sexual education programs, pornography consumption, and peers. Through two studies, sexual education and rape myth were examined. In the first study, an exploratory content analysis of state sexual education guidelines was completed to better understand what information and guidance is provided by states to those providing sexual education. In the second study, a sample of 420 U.S. adults completed a factorial survey experiment wherein …

University Athletic Subsidies Connections To Various Campus-Wide Outcomes, Daniel Vainner

Dissertations

This study examines the relationship between university athletic subsidies and outcomes for the broader undergraduate student population. The athletic subsidy, referred to as an athletic tax, is defined as institutional and student fees used to support athletics. Although athletics are often viewed as enhancing institutional prestige and recruitment, most universities depend heavily on subsidies to sustain their programs. In 2019, National Collegiate Athletic Association (NCAA) institutions spent over $18.8 billion on athletics, with $8.3 billion, or 44 percent, coming from institutional and student sources rather than athletic revenue (NCAA, 2019a). This research explores whether such subsidization predicts measurable differences in …

Do Need For Cognition And Need For Affect Moderate The Relationship Between Lecture Style, Learning Strategies, And Retention?, Mary Chapman

Dissertations

Boredom is detrimental to academic achievement. Using shallow learning strategies such as rote memorization is similarly unfavorable for success in academic settings compared to using deep learning strategies such as generating examples. Such is the consensus among scholars, but research conducted in both constructs reveals inconsistencies. The purpose of this study was to experimentally manipulate boredom and learning strategies to determine how boredom and learning strategies impact achievement, as well as to investigate whether certain individual differences, need for cognition and need for affect, change the relationships between boredom, learning strategies, and retention. In an online study, I recruited 131 …

Pilot Study Of The Barriers To Exercise Adherence And Motivation (Beam) Questionnaire For Adults With Osteoarthritis, Haley Ciara Hughes

Dissertations

Osteoarthritis (OA) is a chronic condition affecting over 33 million adults in the United States (Center for Disease Control and Prevention [CDC], 2024). While exercise is one of the leading, non-pharmacological treatments for OA (Zhang et al., 2008), patients often struggle to meet physical activity guidelines, increasing their risk of lifelong disability, falls, and dependence (Wallis et al., 2013). Researchers in physiotherapy have struggled to identify effective, individualized treatments to improve exercise adherence for patients with OA that maintain long-term effects (Ezzat et al., 2015); an area behavior analysts could offer insight and guidance. Behavior analysts have developed indirect functional …

Factors Shaping Data-Based Decision-Making: The Role Of Self-Efficacy, Anxiety, And School Culture In Mississippi’S State Tested Subjects, Cymone E. Bradford

Dissertations

This quantitative study examined the factors influencing Mississippi state-tested teachers’ engagement in data-based decision-making (DBDM). The purpose of the study was to explore how self-efficacy, anxiety, and school culture shape teachers’ experiences using data to guide instruction. A researcher-developed instrument measuring four constructs self-efficacy in data interpretation, anxiety related to DBDM, self-efficacy and engagement in DBDM, and school culture and DBDM was administered to Mississippi teachers of state-tested subjects. Descriptive statistics, a one-way ANOVA, correlation analysis, and multiple regression were used to analyze the data.

Results revealed significant differences in demographic characteristics of age and frequency of data use when …

Finding Utopia: An Examination Of Pedagogical Approaches To Teaching Utopianism In U.S. College Classrooms, Brittany Page Brake

Dissertations

This dissertation investigates how, and if, utopianism is being taught in college classrooms across the United States. Long considered impractical, overly idealistic, and/or politically dangerous, utopianism has been largely marginalized in political science and American culture. However, this project finds that there are instructors teaching utopianism and they are using the concept to challenge students to think differently about governance, justice, and institutional design. Drawing from political theory literature, course syllabi submitted by faculty from different U.S. universities, interviews with instructors, and personal case studies of my own courses at Central State University and Manchester University, I explore how utopian …

Three Funny Things: A Multicultural Validation, Jon Hook

Dissertations

This dissertation evaluated the efficacy of Three Funny Things, a humor-based positive psychology intervention (PPI) designed to enhance subjective well-being (SWB) and reduce depressive symptoms. Subjective well-being was operationalized through self-reported happiness, measured by the Authentic Happiness Inventory (AHI), and depressive symptomatology, measured by the Center for Epidemiologic Studies Depression Scale (CES-D). A repeated-measures design was employed across three time points: baseline (Time 1), post-intervention (Time 2), and one-month follow-up (Time 3). Participants (N = 126) represented a racially diverse community sample, including individuals identifying as White (61%), Black or African American (18%), Hispanic or Latino/a (11%), Asian (6%), and …

Development Of The Hydrogeology Concept Inventory And Exploration Of Its Embedded Spatial Thinking Components, Oluwarotimi Akindele Popoola

Dissertations

Hydrogeology is a sub-discipline of geoscience that deals with the occurrence and movement of water and possible contaminants within the subsurface. Understanding basic principles of hydrogeology is important for applying practical solutions to hydrogeology problems. Hydrogeology is a visuospatial discipline in which spatial thinking skills play a significant role. To assess the hydrogeology knowledge of students, a valid and reliable assessment instrument with spatial components is required.

This research was conducted as a series of quantitative studies with three goals: (1) to develop the Hydrogeology Concept Inventory (HCI), a valid and reliable measure of upper-level undergraduate students’ hydrogeology knowledge, (2) …

Language Learner Literature: A Mixed Methods Study, Esmeralda Mora

Dissertations

This dissertation, Language Learner Literature: A Mixed Methods Study, by Esmeralda Mora, Ed.D., of National Louis University, specializing in Curriculum, Advocacy, and Policy, investigated the impact of shifting a Midwest high school world language department from a traditional, grammar-focused model to a proficiency-based approach centered on Language Learner Literature (LLL). Employing a Modified Explanatory Sequential Mixed Methods Design, the study first analyzed longitudinal AAPPL proficiency scores from 1,134 high school students (2020–2025) using T-tests and Multiple Linear Regressions to establish measurable outcomes (the "what"). This quantitative phase demonstrated significant and consistent gains in expressive skills (Writing and Speaking) post-LLL implementation, …