Digital Commons Network^™

The Role Of Glycogen Synthase Kinase 3 Β (Gsk-3Β) At The Cardiac Myofilament, Marisa Jean Stachowski

Dissertations

Altered kinase activity and localization is gaining appreciation as a mechanism contributing to cardiovascular disease. Previous work suggests that the kinase glycogen synthase kinase 3 β (GSK-3β) regulates contractile function of the myofilament, but this work was performed in vitro. The goal of this work was to investigate GSK-3β’s in vivo role in regulating myofilament function, the mechanisms involved, and the translational relevance in disease. GSK-3β’s myofilament localization was confirmed in wild type mouse and human tissue via western blot of myofilament enriched tissue and immunofluorescence. These experiments also revealed that GSK-3β phosphorylated at Y216 binds to the z-disc. We …

Healing Earth In A Time Of Crisis: Curriculum For Integral Ecology, Caleb Steindam

Dissertations

This intrinsic multiple case study examined secondary- and university-level educators’ experiences teaching with Healing Earth, a curriculum developed by the International Jesuit Ecology Project at Loyola University Chicago, which merges scientific, social, spiritual, and ethical analyses of pressing ecological issues. Based on the conceptual framework of integral ecology, Healing Earth is a response to Pope Francis’s (2015a) call for “a new way of thinking about human beings, life, society and our relationship with nature” (§215).

This study primarily consisted of in-depth interviews with educators who have used Healing Earth in a variety of secondary and post-secondary Catholic educational contexts. A …

Does Co-Speech Gesture Support Children’S Analogical Reasoning? An Investigation Into The Differential Effects Of Gesture On Learning, Amy Michelle Wilkinson

Dissertations

A well-established conceptualization of academic capitalism is rooted in the marriage of economic theory and critical social. Significantly, academic capitalism links economic dimensions with the political-ideological transformations of U.S. society associated with the fall of communism and the rise of neoliberalism. Academic capitalism is based on a recognition of the paradoxical nature of higher education and offers a lens through which to examine the ways in which institutions in the United States have come to prioritize learning for the labor market as a private good within the new global economy, while also becoming less beholden to the notion of learning …

Isaac Newton As A Prophetic Interpreter, Kenneth Jørgensen

Dissertations

Throughout his life, Sir Isaac Newton was deeply dedicated to the science of decoding biblical apocalyptic writings. To understand and appreciate Newton's prophetic scheme, it will be advantagous to have a certain grasp of what sources and ideas might have influenced him. No comprehensive study before this one has helped us see Newton from that perspective. A survey of the development of canonical apocalyptic hermeneutic and interpretation, beginning before the time of Christ and ending with Newton, shows that four distinct systems of hermeneutics had developed by that time. Historicism was the earliest and the preferred system among Protestants until …

Diversity, Equity, And Inclusion At Faith-Based Institutions: A Quantitative Study At Two Seventh-Day Adventist Institutions Of Higher Learning In North America, Erin Doggette

Dissertations

Problem

The need to address Diversity, Equity, and Inclusion at university campuses is critical. The campus climate impacts college students' overall collegial relationships and academic abilities. Since 1976, there has been an increase of 19.1% marginalized students enrolled in college. For these students, a sense of belonging is believed to aid in improved collegial relationships and better academic performance. According to the research, students who have positive perceptions of the campus climate tend to be more satisfied with their overall college experience and become more academically successful. Private, faith-based institutions must consider conducting campus climate surveys to assess potential diversity, …

Machine Learning Techniques For Network Analysis, Irfan Lateef

Dissertations

The network's size and the traffic on it are both increasing exponentially, making it difficult to look at its behavior holistically and address challenges by looking at link level behavior. It is possible that there are casual relationships between links of a network that are not directly connected and which may not be obvious to observe. The goal of this dissertation is to study and characterize the behavior of the entire network by using eigensubspace based techniques and apply them to network traffic engineering applications.

A new method that uses the joint time-frequency interpretation of eigensubspace representation for network statistics …

Ecological Restoration Parks In Xi’An, China: An Evolving Type, Han Yan

Dissertations

This dissertation examines four urban ecological restoration projects used as public spaces in the city of Xi'an, China. The overall goal is to understand the social and ecological implications of the site features at both design and planning scale and define what is ecological restoration in China's urban context. The result of the research shows that the top-down planning initiatives approach for establishing ecological restoration sites in urban areas that meet the need for more public open space in addition to restoring healthy urban ecological systems is very different from the definition of what is traditionally understood as "ecological restoration". …

The Role Of Microorganisms In Rare Earth Elements Bioaccumulation, Maedeh Soleimanifar

Dissertations

Rare earth elements (REE) are valuable raw materials in our modern life. Extensive REE application from electronic devices to medical instruments and wind turbines, and non-uniform distribution of these resources around the world, make them strategically and economically important for countries. Current REE physical and chemical mining and recycling methods could have negative environmental consequences, and biologically-mediated techniques could be applied to overcome this issue.

In this research, the first objective is to investigate the bioextraction of cerium oxide and neodymium oxide nanoparticles (REE-NP) by a pure culture Methylobacterium extorquens AM1 (ATCC®14718™). Results show that adding up to 1,000 ppm …

Fluorescence Probes For Bioimaging: Synthesis, Photophysical Properties And Applications, Mehrun Nahar Uddin

Dissertations

Fluorescent probes are a vital tool in the study of cell imaging. There are many types of fluorescent probes ranging from inorganic and organic nanoparticles to organic molecules. When used judiciously, they can help provide essential information on cellular structure and function. The introduction of two-photon microscopy has expanded the need for new probes, in particular near-infrared (NIR) absorbing and emitting fluorescent probes. The photochemical and photophysical properties of NIR probes play a crucial role in their effectiveness in cell imaging by both conventional and two-photon excitation (2PE) microscopy. In this research, the synthesis, photophysical properties, and two-photon absorption (2PA) …

Bodipy Based Photodynamic Therapy And Potassium Probes, Xiangshan Liu

Dissertations

Boron dipyrromethene (BODIPY) has become more and more popular in photophysical and biological applications. BODIPY based fluorescence compounds have numerous advantage properties including low toxicity, high absorption extinction coefficients, high fluorescence quantum yields, sharp fluorescence emissions, and resistance to photobleaching. All the good properties lead to the wide applications of BODIPY based compounds. In this research, two different kinds of BODIPY are synthesized. Firstly, BDBrC containing carbazole and BODIPY core is synthesized. Cellular uptake research shows BDBrC can target on lysosome and singlet oxygen generation research result indicates that BDBrC can be used in photodynamic therapy. BDBrC also shows pH-sensitive …

Synthesis And Characterization Of Glycosaminoglycan Mimetic Variants For Cartilage Tissue Engineering Applications, Richard David Vincent Jr.

Dissertations

No abstract provided.

Simulated Presence Use For Quality Of Life Maintenance And Reduction Of Symptoms Of Distress In Persons Living With Dementia In Long-Term Care, Erin E. Bush

Dissertations

Nursing home residents with dementia often have an array of neuropsychiatric symptoms, including dementia-related agitation. It is theorized that many of these agitation symptoms occur due to unmet psychosocial needs that could be met by the presence of a caring nursing staff member, family member, or friend.

The purpose of this study was to determine whether live simulated presence improves dementia-related agitation when offered, identify barriers and facilitators to simulated presence between caregivers and residents of long-term care during the COVID-19 pandemic, and to determine if live simulated presence by a caregiver delivered one-on-one improved quality of life in long-term …

What Does Masculinity Have To Do With It? The Roles Of Fathers In The Socialization Of Children’S Emotions And Emotion Regulation, Kathryn Cherry

Dissertations

Emotion regulation skills are important in a variety of domains throughout the lifespan, including psychological, social, academic, and occupational functioning. Research on children’s emotion regulation skill development often examines the family, exploring caregiver approaches to emotion socialization. However, this research has predominantly been conducted with mothers. Fathering is of particular interest to children’s emotional development for a variety of reasons, including the role of traditional Western masculine norms in gendered differences in emotion expression and regulation techniques. Fathers’ conformity with masculine norms and difficulty with emotion regulation have potential to impact their emotion socialization practices, and therefore relate to their …

Performer’S Guide To Three Miniatures For Tuba And Piano By Anthony Plog, Steven Dixon

Dissertations

This dissertation will discuss the history, musical and technical challenges, and preparation techniques for Anthony Plog’s Three Miniatures for tuba and piano. The document will begin with biographical information about both the composer and the tubist who premiered the piece, Daniel Perantoni, and historical information about the composition of the work. A thorough discussion of each movement will follow, including a short description of the form of each movement, challenges that the tubist will encounter, and techniques to overcome these challenges, including suggestions for supplemental material to improve technique. The appendices will include interviews with Plog and Perantoni.

Three …

Granulins In Norm And Neurodegenerative Pathologies, Anukool Bhopatkar

Dissertations

Granulins (GRNs) are small, cysteine-rich modules produced from the proteolytic cleavage of the precursor protein called progranulin (PGRN). GRNs are present in the form of seven tandem repeats within the precursor and are known to be produced in the extracellular and in lysosomal environments. In physiology, PGRN and GRNs plays pleiotropic roles such as neuronal growth and differentiation, immunomodulation, wound healing. Recent studies have implicated pathological role for PGRN in Alzheimer disease (AD) and frontotemporal dementia (FTD) but specific mechanism(s) remains unclear. However, potential interactions between GRNs and Ab42 and TDP-43 seem like a plausible underlying mechanism. Studies presented here …

Sustainable Development Among Four–Year Higher Education Institutions In The United States: A Geographic And Anthropological Perspective, Kori Nadine Armstrong

Dissertations

This dissertation investigates the factors that contribute to the cultural characteristics of sustainability among higher education institutions (HEIs) in the United States to shed light on how they represent themselves as sustainable. It documents four-year HEIs in the United States that self-identify as sustainable; evaluates how these institutions portray themselves to society as sustainable; and documents who is leading sustainability on U.S. college campuses. This dissertation fills an important gap in the literature on sustainable development in higher education that Holm and others (2016) have identified. Although education for sustainable development (ESD) has been recognized as an important topic, and …

The Significance Of Continuing Education On The Intention Of Advanced Practice Registered Nurses To Report Child Maltreatment, Adaorah N. U. Azotam

Dissertations

The Centers for Disease Control have recognized child maltreatment as a national epidemic that calls for healthcare providers to focus on early identification and prevention of violence against children. Even though society has this expectation for healthcare professionals, research has shown that there is still a pervasive phenomenon of underreporting this societal ill. Current nursing research identifies education as a significant factor in determining the decision to report child maltreatment in the mandatory reporter role. Based on this conclusion, the Theory of Planned Behavior (TPB) served as the research framework to understand the pertinent facilitating components of intended reporting behaviors …

Effects Of Creatine Supplementation Protocols And Doxorubicin On Cardiac And Skeletal Muscle Phosphocreatine System, Salaheddin M. A. Sharif

Dissertations

Doxorubicin (Dox) is a highly effective anticancer drug used to treat several cancer types; however, its use is limited due to its cytotoxicity (cardiotoxicity and myotoxicity). Doxorubicin-induced cardiotoxicity might occur within days and lead to congestive heart failure. Doxorubicin-induced myotoxicity involves fatigue, cachexia, and skeletal muscle dysfunction. Although the exact mechanisms causing Dox-induced cytotoxicity are not entirely understood, an alteration in the phosphocreatine system seems to be a central mechanism where studies showed Dox decreased phosphocreatine (PCr), creatine (Cr), impaired creatine kinase (CK) enzyme function, and decreased creatine transporter (CrT) expression in cultured cardiomyocytes. Ultimately, Dox-induced cytotoxicity might compromise quality …

The Role Of Berberine, A Clinically Relevant Plant Derived Alkaloid, In T Cell-Mediated Immunosuppression, Alexandra Adorno Vita

Dissertations

The primary focus of this research was to determine the effect of berberine (BBR), a clinically relevant plant-derived alkaloid, on follicular T helper (Tfh) cell activation and differentiation, with implications for the generation of T cell-dependent humoral responses. This research revealed a novel function of BBR as a suppressor of Tfh cell proliferation in secondary lymphoid organs of BBR-treated mice that underwent immunization for arthritis induction in a collagen-induced arthritis (CIA) mouse model. Tfh cells provide signaling to B cells that is crucial for the generation of T cell-dependent humoral responses, such as affinity maturation, isotype class switching, and the …

Biochemical Ecology Of The Western Rattlesnakes: Venom Variation And Toxin Profiling Of The Crotalus Viridis/Oreganus/Scutulatus Complex, Cara Smith

Dissertations

Biochemical ecology examines the complex and dynamic relationships between organisms and their environment from a molecular perspective. This requires a holistic integration of ecology, evolution, and natural history with the fine-scale resolution of molecular biology and functional biochemistry. Venomous snakes have evolved a wide variety of extreme behavioral, physiological, and biochemical adaptations for prey capture, making them an ideal model for the study of predator trait evolution and protein adaptation. However, venoms must be understood from an ecological perspective in order to comprehend the evolutionary forces that shape the diversity of toxin families present in venoms. This holistic picture has …

Mental Health Treatment In Juvenile Correctional Facilities: Utilizing Assessment To Inform Treatment, Sarah Riccio

Dissertations

Youth in juvenile correctional facilities face a wide range of mental health difficulties. Over the years, the juvenile justice system has prioritized the need for providing appropriate and effective treatment services to youth throughout their detainment. Despite these ongoing efforts, treatment practices in juvenile correctional facilities continue to fall short. This study will first focus on assessment practices within these facilities and the impact current practices have on diagnosis and subsequent treatment. Emphasis will be placed on the importance of comprehensive evaluations for informing diagnosis and determining the individual treatment needs of detained youth. An integrated approach to assessment will …

An Intergenerational Photo Exploration Of Self Care Actions In Self-Identifying Strong Black Women, Vanessa Patrice Goodar

Dissertations

The current study sought to expand upon the Giscombé Superwoman Schema (2010) specifically exploring the role of vulnerability resistance and help obligation as potential barriers to changing comprehensive self-care health commitments in self-identifying Strong Black Women (SBW). The Superwoman Schema characteristics of vulnerability resistance and help obligation along with socio-economic factors of income, religious affiliation and marital status were assessed in the project using a visual-ethnography approach to Photo Voice methods and five intergenerational focus groups of SBW's born between 1946 and 2002. The collective self-care knowledge of these eighteen participants was analyzed using a participatory action research discussion framework …

The Relationship Between Trauma, Attachment, Self-Compassion, And Emotion Regulation: A Structural Equation Model, Susanna Jane Turner

Dissertations

Previous research has examined the relationship between trauma, attachment, selfcompassion, and emotion regulation, but never with an incarcerated population. Given the link between emotion regulation and illegal behaviors, it may be helpful to more fully understand this relationship in order to lay the groundwork for future intervention research. I gathered data from 378 participants. I then examined the relationships between these constructs on data from 204 participants, the number that remained after cleaning the data, by way of a structural equation model. Findings suggest that greater experiences of trauma may lead to insecure attachment styles, impacting individuals’ ability to trust …

Exploring Teacher And Student Experiences In A Nature-Based Mathematical Environment, Brian Holt Tucker

Dissertations

This research study explored the experiences of this teacher-researcher and eight student-participants in a Montessori-inspired, nature-based mathematical environment. I utilized an action research study framework with a critical event narrative analysis to describe mine and my student-participants’ experiences throughout this study, using Uhrmacher et al.’s (2017) instructional arc as a guide. I restoried each participants’ lived and told stories as the curriculum seamlessly moved through the arc: intended to operational to received curriculum. The restoried narratives revolved around the identified critical events each participant experienced throughout the mathematical learning experience. The multiple restoried narratives required data collection that included observations, …

Becoming Ourselves: A Photo-Narrative Inquiry Into Mindfulness In The Teaching Lives Of Urban Educators, John Brian Miller

Dissertations

This dissertation explored how mindfulness shapes the way educators find meaning and coherence to their narrative selves amid the complex interlocking contexts in urban schools. Drawing on the theoretical lens of a narrative concept of self found in MacIntyre and others, I used a photo-narrative inquiry, observations, and interviews to collect data from the five participants in this study. I then constructed narrative vignettes that highlighted themes internal to each participant’s way of storying their teaching lives in urban schools through the lens of mindfulness. Analysis of participant stories leads to the conclusion that mindfulness is a grounding for self …

Teachers “Write” Video--A Case Study On The Processes And Participants Of A Video Composition Professional Development Program: A Utah Context, Nathan Smith Jones

Dissertations

In a media dominated world, where video composition (an integral media literacy pedagogy) has remained extremely limited in university teacher prep programs in states like Utah, this qualitative descriptive case study investigated the whys and hows of the processes, purposes, and marketing of an in-service Pedagogical Video Composition (PVC) teacher professional development program and the media literacy practices of the teachers it impacted. Participants were four staff members of Utah’s SHIFT Professional Development program, and four of its teacher participants The study’s data collection included artifacts, an observation, and (primarily) interviews during the first full school year of COVID-19 (Fall, …

Lxr Acts As A Differentiator In The Regulation Of Fas And G6pdh Gene Expression Under Insulin Resistant Conditions, Jaafar Hachem

Dissertations

Diabetes is a chronic disease that effects 10 percent of the world’s population and causes more than 1.5 million deaths a year and billions of dollars in associated health care cost. It can lead to very serious complications such as renal failure, liver cirrhosis, heart attack, and vision loss. The most common type of diabetes is type 2 diabetes. Type 2 diabetes arises when blood glucose levels remain chronically high due to insulin resistance. The reason for this elevation is due to the failure of insulin to allow tissues to uptake glucose causing problems in subsequent metabolic pathways. Over the …

The Effects Of Cost, Level Of Safety, And Severity Of Injury On Manager Decisions To Implement A Safety Solution, Jonathan M. Hochmuth

Dissertations

Workplace injuries continue to be a source of substantial human and financial costs each year. Behavioral safety processes have been effective in reducing workplace injuries by increasing safety-related behaviors. In recent years, the focus in behavioral safety has shifted towards the role of managers in establishing and maintaining safe behaviors and conditions in the workplace. Understanding how managers make decisions to allocate resources is critical to improving safety. The field of behavioral economics has developed methods for studying decision-making. While there have been calls to apply these methods to occupational safety, there are only two empirical studies which have done …

Experiences Of African American Students In Pre-Licensure Schools Of Nursing: A Qualitative Descriptive Study, Barbara Jean White

Dissertations

Despite more than 40 years of research and governmental support, African Americans continue to be underrepresented in the nursing profession compared to the population it serves. Though some progress has been made over the past 20 years, the American Nurses Association (ANA), American Association of Colleges of Nursing (AACN), National Black Nurses Association (NBNA) and Institute of Medicine (IOM) continue to identify increasing diversity as a disciplinary priority. Further understanding of the experiences of African American nursing students is needed to inform decisions about recruitment, retention and successful matriculation of these students. This qualitative descriptive study focused on understanding the …

The Response Of A Rural Missouri Middle School To The Covid-19 Pandemic: A Case Study Of Instruction, Communication, And Access To Technology, Christian Scott Meier

Dissertations

The doors of a rural Missouri middle school were closed in mid-March for what turned out to be the remainder of the 2019‒2020 school year (Schremp Hahn, 2020). Many schools were unprepared for the swift nature with which the shutdowns occurred (Bernhard, 2020a). The purpose of this case study was to examine the opinions and perceptions of parents, teachers, and the principal at a Missouri middle school regarding the school’s response to the COVID-19 closure to determine the best possible strategies for mitigating learning loss during future extended closures. The summer slide was the lens through which the study was …