Digital Commons Network^™

Regulators Of Mast Cell Activation, David Lyons

Dissertations

This research focuses on identifying novel mechanisms through which mast cells (MCs) can be activated, specifically focusing on the effects of transforming growth factor beta-1 (TGF-β1) on MC activation and cytokine release and how these pathways can contribute to disease. We found that MCs can be activated with TGF-β1 alone, inducing degranulation and cytokine release comparable to classical, immunoglobulin-E-mediated activation paradigms. This activated state resembles a described concept in immunology termed trained immunity – a process that allows innate immune cells to potentiate their future immune responses following priming with a stimulus. Hypothesizing that TGF-β1 is a novel stimulus of …

Oiko-Logic In Literature, Elias Joshua Taylor

Dissertations

My study utilizes ecocriticism, eco-Marxism, and posthumanism to discover how the sympathetic practices of both reading and ecology provide us with what I call an oiko-logic. Specifically, I read Jonathan Swift’s Gulliver’s Travels, Laurence Sterne’s Tristram Shandy, Herman Melville’s Moby-Dick, and John Williams’ Butcher’s Crossing. In Gulliver’s Travels we see Gulliver as an ecological threat in every journey, and Swift says that this is because we forget ourselves and deliberately choose to not attune—sometimes even choosing destruction. For Swift, we bungle things no matter which system we try, and we create degenerative devolution despite the fact that we can help. …

Let’S Take This Outside: Utilizing Outdoor Classrooms As A Response To The Coronavirus-19 Pandemic, Cortney Leigh Lamb

Dissertations

The worldwide school closures due to the Coronavirus (COVID)-19 pandemic that began in the spring of 2020 caused a disruption to educational systems (Bao et al., 2020; Engzell et al., 2021; Masonbrink & Hurley, 2020; Munir, 2021; United Nations International Children’s Emergency Fund, 2020). The pandemic created a dilemma in which school leaders around the world and in the United States had to make challenging decisions about how to open schools in the fall of 2020 and how to best educate students (Honein et al., 2021). The majority of school leaders choose to reopen schools in the fall of 2020 …

Inviting The Outside In: Nature's Contribution To Counselor Wellness, Naomi Medina

Dissertations

The positive influence of nature on client wellness and psychological health (BonhamCorcoran et al., 2022) is well reflected in the emergence of nature-based counseling interventions such as wilderness therapy, walk talk therapy, and horticulture therapy, among other counseling modalities that involve aspects of the natural world (Lewis et al., 2022). This suggests that the inclusion of nature within the counseling session could also contribute to the wellness of the counselor. The purpose of this research was to determine the extent to which presence of nature contributes to counselor wellness and which of the five senses may play a greater role …

Deficiency Of Adipose Aryl Hydrocarbon Receptor Protects Against Diet-Induced Metabolic Dysfunction Through Sexually Dimorphic Mechanisms, Nazmul Haque

Dissertations

Calorie imbalance due to high energy intake vs. expenditure is considered a major cause of obesity. Molecular mechanisms underlying diet-induced obesity remain unclear due to the complexity of disease progression. The impact of environmental factors contributing to obesity also remains poorly understood. Activation of the xenobiotic sensor, aryl hydrocarbon receptor (AhR), by obesogens may contribute to diet-induced obesity. AhR has the potential to influence lipid metabolism, insulin resistance, and the development of diabetes. Activation of AhR increases the risk of metabolic dysfunction by impairing adipose tissue function. Thus, the hypothesis was that conditional AhR depletion specifically from mature adipose tissue …

An Exploration Of The Pathway From Childhood Neglect To School Bullying Victimization, Natalie D. Johnson

Dissertations

The objective of the current study was to explore the association between two widely prevalent sources of trauma occurring early in life, child neglect and bullying victimization (BV), via adult recollections of maltreatment experiences. One hundred and twenty participants, recruited from a mid-sized university in the Rocky Mountain region of the United States, were ultimately included in the sample. Of the total sample, 30 participants (25%) endorsed a history of moderate to severe neglect in childhood and 62 participants (52%) endorsed experiencing at least one form of BV in school. Childhood maltreatment, including various forms of neglect and abuse, was …

Moving Forward By Looking Back: How Family Firms Create Competitive Advantage By Embracing Their History, Adam Goldman

Dissertations

Family businesses are the engine that drives the United States economy. While extensive implications have been made in the literature about the advantages or disadvantages of family-owned businesses compared to non-family-owned businesses, the focus of this study was to show how small to medium-sized family-owned firms (FF SMEs) based in the United States can use their unique history to create a competitive advantage. Drawing on imprint theory and the resource-based view (RBV), this history-informed study helped identify the impact that founder imprints, business traditions, and storytelling have on the business performance of FF SMEs. Using quantitative methods, the findings of …

Topological Data Analysis Of Weight Spaces In Convolutional Neural Networks, Adam Wagenknecht

Dissertations

Convolutional Neural Networks (CNNs) have become one of the most commonly used tools for performing image classification. Unfortunately, as with most machine learning algorithms, CNNs suffer from a lack of interpretability. CNNs are trained by using a training data set and a loss function to tune a set of parameters known as the layer weights. This tuning process is based on the classical method of gradient descent, but it relies on a strong stochastic component, which makes the weight behavior during training difficult to understand. However, since CNNs are governed largely by the weights that make up each of the …

K-12 Teachers’ Retention Of Arts Integrated Professional Development, Roxane Mcwilliams

Dissertations

Arts integration is an interdisciplinary teaching model in which the arts become a conduit for the contextualization and understanding of non-arts content. Research has shown this approach increases academic engagement and content retention (Rinne et al., 2011). The use of arts integration also provides gains for teachers. Teachers perceive their practice more innovative and better able to reach the needs of diverse learners (Bellisario & Donovan, 2012). For the benefits of arts integrated learning to be achieved, teachers must acquire the knowledge and techniques of this teaching model. This requires knowledge in both arts content as well as the pedagogical …

Pathogen Risk Assessment On Arabian Felines In The United Arab Emirates, Laia Montserrat Stefano

Dissertations

The Arabian Peninsula has been known to harbour five species of felines, namely leopards (Panthera pardus), cheetahs (Acinonyx jubatus), caracals (Caracal caracal), sand cats (Felis margarita), and wildcats (Felis silvestris). Currently, their situation in the wild is critical in the region and ex situ breeding efforts are the greatest hope to restore their populations. However, these efforts need to go hand-in-hand with focus on their health, since pathogens are known to be a serious threat to animals under managed care. Globally, the potential pathogens of these five species include viruses, …

Characterization And Genomic Analysis Of Two Escherichia Coli O157:H7 Bacteriophages Isolated From Pigeons, Mohamad I. Alolama

Dissertations

Enterohemorrhagic Escherichia coli, also known as EHEC, is a subset of Shiga toxin-producing E. coli (STEC), and it has recently been identified as one of the principal foodborne pathogens. E. coli O157:H7 is the most important serotype of STEC for its role in causing foodborne illnesses. E. coli O157:H7 could cause various gastroenteritis symptoms such as diarrhea, hemolytic uremic syndrome, hemorrhagic colitis, and thrombotic thrombocytopenic purpura and may cause death. Elimination of E. coli O157:H7 during food processing and storage is a possible solution. Bacteriophages have a significant impact on bacterial populations in nature due to their ability to …

Impact Of Teaching Mathematics With Four Teaching Strategies On Fifth Grade Students’ Learning Of Fractions Addition And Subtraction, Nabil Riziq Al Farra

Dissertations

There are different tools, resources, and materials that mathematics teachers may use to enhance the teaching and learning processes under many types of teaching strategies such as technology (e.g., videos and virtual manipulatives), real objects (e.g., concrete manipulatives), and other teaching strategies are traditional (e.g., lectures). Some of the most important things that a teacher has to consider is the students’ learning needs and how to reach to their minds by different teaching strategies with a variety of resources and assess which are more effective in students’ learning anddevelopment in mathematics.

The purpose of this study is to investigate the …

Approximate Computing Based Processing Of Mea Signals On Fpga, Mohammad Emad Hassan

Dissertations

The Microelectrode Array (MEA) is a collection of parallel electrodes that may measure the extracellular potential of nearby neurons. It is a crucial tool in neuroscience for researching the structure, operation, and behavior of neural networks. Using sophisticated signal processing techniques and architectural templates, the task of processing and evaluating the data streams obtained from MEAs is a computationally demanding one that needs time and parallel processing.
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/="/">This thesis proposes enhancing the capability of MEA signal processing systems by using approximate computing-based algorithms. These algorithms can be implemented in systems that process parallel MEA channels using the Field …

Exploring The Use Of Cultural Values In The Evaluation Of Programs With Native American Tribes, Karen Lynn Alexander

Dissertations

This dissertation is a qualitative study that explores the importance of including cultural values in evaluation and whether this would lead to an increase in utilization of evaluation results. It was first wondered whether Native American values are included when evaluations are completed for Indigenous Tribes. A review of evaluations revealed that evaluations in the published literature are including general Native American values, although a document review alone was found to be insufficient as a method to capture the nuances related to value expression. It is suggested that more research is needed in the area of metaevaluation to include culturally …

Research Training And Certification Protocol For Medical Students, Michelle Arisleida Padley

Dissertations

Early and frequent exposure to research is imperative to initiating and sustaining long term for medical student research interest. The attitude and approach of physician mentors has been demonstrated to have a substantial effect on student perceptions of research involvement. The purpose of this study is to determine best practices for assessing student perceptions for a research certification program. An additional long-term objective is to utilize these findings to help maintain interest in research throughout their medical careers. Research is an essential aspect of the prestige of medical schools, and the benefits of academic research institutions have numerous facets, including …

Disease Risk Of Reintroducing Primates Confiscated From The Illegal Wildlife Trade, Ana Patricia Mendoza Becerra

Dissertations

Zoonotic infections are easily shared between human and other primates, and thus primate trafficking poses a high risk of introducing zoonotic pathogens into urban environments as well as spreading human-associated diseases into natural environments when infected primates are released. The magnitude of these risks has not been thoroughly studied in the context of primate trafficking and rehabilitation of Neotropical primates. In this dissertation, I address some knowledge gaps in disease risk analysis of reintroducing trafficked primates. In chapter 1, I describe the dynamics, diversity, and composition of live wildlife trafficking in urban markets in Peru. I found these markets are …

Workplace Violence Prevention Training: A Cross-Sectional Study Of Home Healthcare Workers, Tamara F. Small

Dissertations

HHCWs are at increased risk for WPV due to working alone in unsupervised, unpredictable, and potentially dangerous work environments. Similar to healthcare workers employed in institutionalized settings, HHCWs primarily experience Type II, verbal abuse from patients. Little is known about how HHCWs promote personal safety while at work. Guided by Haddon's Matrix, the purpose of this manuscript option dissertation was to estimate WPV exposures and identify interventions and resources used by HHCWs to promote personal safety and mitigate and prevent WPV. For this manuscript option dissertation, there are three distinct projects, all related to HHCWs and exposure to WPV.

A Comparison Of Perceptions Of Incivility Among Nursing Students And Faculty In Pre-Licensure Nursing Programs, Karen Aul

Dissertations

This study used a mixed method approach to examine the frequency and types of perceived and experienced uncivil behaviors among nursing students and faculty. The Incivility in Nursing (INE) Survey that was developed by Clark in 2004 was administered to a convenience sample of nursing students and faculty from four nursing programs. The sample included 159 senior pre-licensure nursing students and 14 faculty members within diploma, associate, and baccalaureate nursing education programs. Stress was mentioned in all program types as a contributing factor to student and faculty incivility. The analysis of the quantitative data found variability between nursing program types …

Understanding The Ethical Decision-Making Processes Of Equine-Assisted Psychotherapy Practitioners, Lisa Krystosek

Dissertations

Equine-assisted psychotherapy is a unique field in which interdisciplinary teams of practitioners provide mental health services to clients. These teams are comprised of at least two practitioners, one licensed mental health specialist and one certified equine specialist. While ethics and ethical decision-making are significant issues in the mental health industry, there exists a significant gap in the literature pertaining to the ethical decision-making processes of interdisciplinary teams of equine-assisted psychotherapy practitioners. This dissertation aimed to address the gap through the development of an understanding of how teams of equine-assisted psychotherapy practitioners engage in ethical decision making. Further, the researcher sought …

Characterization Of Tick And Host-Associated Factors Linked To Induction Of Alpha-Gal Syndrome., Surendra Raj Sharma, Surendra Raj Sharma

Dissertations

Alpha-Gal Syndrome (AGS) is a delayed allergic reaction caused by specific IgE antibodies to the oligosaccharide galactose-α-1,3-galactose (α-gal) present in red meat. AGS is a growing concern globally, with over 34,000 confirmed cases in the United States alone. Studies have linked AGS to tick bites, which sensitizes hosts against α-gal antigens and elevates α-gal specific IgE. This dissertation investigates the role of tick and host-associated factors in AGS development. Microbiome analysis of Am. americanum ticks revealed a comprehensive core microbiome profile and showed that new Fransiella-like endosymbionts dominate and outcompete conventional tick Coxiella endosymbionts. Ticks subjected to tetracycline treatment showed …

Improving Interventions On Cardiovascular Disease And Diet: A Policy Incentive Analysis, Sandra Hurst

Dissertations

Introduction: Various cardiovascular diseases (CVD) can be catastrophic and can lead to irreversible outcomes. There are limited, improved regulations on awareness of primordial and primary preventions that may decrease CVD progression and mortality. Before policies and recommendations can be set, policymakers should understand CVD and the importance of maintaining a healthy diet to decrease the risk of CVDs and improve patient adherence. Therefore, this project aims to analyze federal healthy food incentive policies to promote healthy diet behaviors that reduce CVD risk.

Method: The method used was existing data for a comparative policy analysis that included a policy proposal process: …

Simulation Usage As A Partial Replacement Of Traditional Clinical: A Study Of Administrator And Faculty Perceptions In Practical Nursing Programs In Pennsylvania, Cynthia A. Cornelius

Dissertations

There has been a significant amount of research regarding simulation use in nursing education; however, there is limited research available regarding the replacement of traditional clinical with simulated clinical. This research included a mixed-method design formulated to determine Pennsylvania Practical Nursing Programs' current simulation usage and Pennsylvania Practical Nursing Directors', Assistant Administrators', and Faculty Members' perceptions regarding replacing a portion of traditional clinical with simulated clinical. An 18-item electronic questionnaire was delivered to 309 potential respondents via the Qualtrics electronic survey distribution system, with 191 responding.

Probing Amyloid-Beta Protein Structure And Dynamics With A Selective Antibody, Shikha Grover

Dissertations

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. The AD brain is characterized by significant neuronal loss and accumulation of insoluble fibrillar amyloid-β protein (Aβ) plaques and tau protein neurofibrillary tangles in the brain. However, over the last decade, many studies have shown that the neurodegenerative effect of Aβ may in fact be caused by various soluble oligomeric forms as opposed to the insoluble fibrils. Furthermore, the data suggest that a pre-fibrillar aggregated form, termed protofibrils, mediates direct neurotoxicity, and triggers a robust neuroinflammatory response.

Antibodies targeting the various conformation of Aβ are important therapeutic agents to prevent the progression …

Lived Experiences And Insight On Development Of Emotional Intelligence In Professional Nursing Practice, Jennifer L. Jessen

Dissertations

The purpose of this qualitative, experiential narrative study was to examine how emotional intelligence is applied in clinical nursing practice and how a nurse develops those skills in professional practice using a qualitative, experiential narrative design. The selected research participant was asked to verify her emotional quotient (EQ) score with the MSCEIT emotional intelligence test and participate in repeated interviews detailing the major events, patients, coworkers, mentors, and support systems in her life from her first experiences in healthcare to the present. Evidence of emotional intelligence (EI) was identified in her stories and applied to the Salovey and Mayer model …

Strategies For The Improvement Of Healthcare Through Simulation, Roger C. Lankheet

Dissertations

Medical errors continue to plague the healthcare industry. The annual rates of morbidity are approximately 2.69 million (AHRQ, 2019), while mortality rates exceed 400,000 per annum (Makary & Daniel, 2016). There may be no panacea to combat these egregious rates. However, simulation of patient care events may better prepare healthcare professionals to prevent medical errors as it has been proven to be an effective learning strategy (Kirkham, 2018), enhancing skills while gaining experiential knowledge, without risk to actual patients.

The purpose of this qualitative study was to gain a better understanding of factors that impede or foster the frequent utilization …

K-12 Principals And Special Education: A Study Of Mississippi Principals’ Knowledge Of Special Education Policies And Procedures, Jodi Cameron-Polk

Dissertations

This study sought to assess the knowledge of Mississippi K-12 public school principals and assistant principals in special education law, policies, and procedures concerning the six principles (i.e., zero reject, non-discriminatory evaluation, least restrictive environment, free appropriate public education, due process, and parent participation) of the Individuals with Disabilities Education Improvement Act of 2004. This study also sought to establish by which method (i.e., university coursework, administrative trainings, on-the-job experiences, self-taught research, or did not learn this) they acquired their knowledge of special education law, policies, and procedures. The researcher adapted Jesteadt’s survey tool to ascertain participants’ special education teaching …

The Body Of Christ And The Law: A Comparative Study Of Romans 7:4 And Galatians 2:19, Dominic Bornand

Dissertations

In Romans and Galatians, Paul refers to a spiritual death to sin (Rom 6:2) and to the law (Rom 7:4; Gal 2:19). As the means of the believer's death to the law, Paul mentions the "body of Christ" in Rom 7:4 and the "law" in Gal 2:19. These verses seem to suggest some sort of relationship between the body of Christ and the law, as well as between the law and sin. The purpose of this study is to determine the type of relationship between the body of Christ and the law, as well as between law and sin. The …

Religiosity, Family Sexual Communication & Gender As Predictors Of Attitudes Toward Oral Sex Among College/University Students In The United States, Antoinette Napier

Dissertations

Purpose

The purpose of this study was to investigate whether religiosity, family sexual communication and gender were predictors of attitudes toward oral sex among college/university students in the United States.

Method

Participants completed several surveys, which measured participants' personal religiosity, family sexual communication, and attitudes toward oral sex. A path analysis model was used to analyze the relationship between the proposed variables.

Results

The path analysis hypothesized model resulted in a poor fit for the data. The model was respecified by removing three items which showed weak beta weights. The respecified model produced a good fit for the data. The …

Hyperinsulinemic Lew.1wr1 Rats Develop Insulin Resistance And Nonalcoholic Steatohepatitis, Madushika M. Wimalarathne

Dissertations

The pathophysiological causes of nonalcoholic steatohepatitis (NASH) development are not fully understood but are often associated with hyperinsulinemia, insulin resistance and ectopic lipid accumulation. A subpopulation of type 1 diabetes patients develops the pathophysiological parameters to be termed “double diabetes,” which is associated with NASH. The objective of this work was to identify metabolic features of double diabetes and assess if LEW.1WR1 rats develop NASH. I assessed pathophysiologically relevant protein changes using proteomics and western blotting. I found that 17-week-old LEW.1WR1 rats showed protein changes related to non-alcoholic fatty liver disease, a precursor to NASH. We tested a second population …

Childhood Trauma And The Faith Maturity Of Seventh-Day Adventist Pastors And Seminarians, Pete A. Palmer

Dissertations

Problem

Unfortunately, Childhood Trauma is a fact of life. For instance, children lose parents/guardians through death or divorce. Children grow up in impoverished situations. Children have parents who suffer from mental illness and/or commit suicide. In addition, more unfortunately, some children are mistreated, neglected, and/or abused. The long-lasting impact of Childhood Trauma includes increased morbidity and mortality, and decreased opportunities for prosperity. This research sought to establish a statistical relationship between Childhood Trauma and Faith Maturity. Childhood Trauma has been demonstrated to affect attachment processes in children and, since religion is an attachment process and God is an attachment figure, …