Digital Commons Network^™

The Effect Of Exercise On Cardiac Function And Doxorubicin Accumulation In Left Ventricular Tissue Of Rats, Brock Thomas Jensen

Dissertations

Doxorubicin (DOX) is an anthracycline antibiotic that has cytotoxic actions. The therapeutic use of DOX to treat a wide array of cancers is limited by a dose-dependent cardiotoxicity. Although DOX is known to have several adverse side-effects, acute and chronic cardiotoxicity have received the most attention as both may eventually lead to heart failure. While exercise has been shown to protect against DOX cardiotoxicity, a clear and consistent mechanism to explain its cardioprotective effects is lacking. High performance liquid chromatography (HPLC) is a valuable instrument that can be used to evaluate cardiac DOX accumulation. We hypothesized that a reduction in …

Power Dynamics And Questioning In Elementary Science Lessons, Lori Ann Reinsvold

Dissertations

Discourse interactions between a teacher and students in an inquiry-based fourth-grade science classroom were analyzed to investigate how power dynamics and questioning strategies within elementary science lessons help support students in building their science understanding. Five inquiry-based classroom sessions were observed; verbal interactions were audio- and video-recorded. Research data consisted of observation transcripts, teacher interviews, student work, and instructional materials. Analyses were conducted on the frequencies of utterances, participation roles, power categories, and questioning categories. Results revealed that when students used more frequent power, (a) no significant differences were noted between frequencies of teacher and student talk, (b) the teacher …

The Role Of Amyloid-Beta Assembly State In Monocyte Maturation And Smooth Muscle Cell Degeneration, Nikkilina Renee Crouse

Dissertations

Alzheimer's Disease (AD) is a progressive, neurodegenerative disorder which is ranked as a leading cause of death among Americans. AD is characterized by the presence of intracellular neurofibrillary tangles and extracellular plaques made of amyloid ß (Aß). Together these pathologies lead to severe memory impairment in patients, but research has implicated the presence of the Aß deposits as likely causes for AD progression. Aß is produced through the proteolytic cleavage of the integral membrane amyloid precursor protein, which occurs through the action of beta- and gamma-secretases and produces 39-43 amino acid Aß peptides. In AD, the Aß plaques are comprised …

Using Feed-Forward Networks To Infer The Activity Of Feedback Neuronal Networks, Xinxian Huang

Dissertations

The nervous system is one of the most important organ systems in a multicellular body. Animals, including human beings perceive, learn, think and deliver motion instructions through their nervous system. The basic structural units of the nervous system are individual neurons which constitute different neuronal networks with distinct functions. In each network, constituent neurons are coupled with different connection patterns, for example, some neurons send feed-forward information to the coupling neurons while others are mutually coupled. Because it is often difficult to analyze large interconnected feedback neuronal networks, it is important to derive techniques to reduce the complexity of the …

Anti-Solvent Precipitation And Subsequent Film Formation Of Hydrophobic Drugs For Drug Delivery, Xiangxin Meng

Dissertations

It is estimated that about forty percent of the drug molecules being developed by the pharmaceutical industry are hydrophobic in nature, leading to poor water solubility and bioavailability in the gastrointestinal tract. Dissolution is a limiting factor in their in vivo performance, and increasing their dissolution rate is a major challenge. It has been proven that the dissolution rate is directly proportional to the specific surface area, which can be effectively increased by reducing the particle size. Therefore, considerable efforts have gone into developing reliable and efficient methods for the manufacture of fine particles. Particle size reduction technologies such as …

High-Order Adaptive Methods For Computing Invariant Manifolds Of Maps, Jacek K. Wrobel

Dissertations

The author presents efficient and accurate numerical methods for computing invariant manifolds of maps which arise in the study of dynamical systems. In order to decrease the number of points needed to compute a given curve/surface, he proposes using higher-order interpolation/approximation techniques from geometric modeling. He uses B´ezier curves/triangles, fundamental objects in curve/surface design, to create adaptive methods. The methods are based on tolerance conditions derived from properties of B´ezier curves/triangles. The author develops and tests the methods for an ordinary parametric curve; then he adapts these methods to invariant manifolds of planar maps. Next, he develops and tests the …

Transcriptional Regulation Of Nitrogenase And Identification Of A Fructose Transport System In Anabaena Variabilis, Justin Lynn Ungerer

Dissertations

Little is known about the regulation of nitrogenase genes in cyanobacteria. Transcription of the nifH1 and vnfH genes, encoding dinitrogenase reductases for the heterocyst-specific Mo-nitrogenase and the alternative V-nitrogenase, respectively, was studied using a lacZ reporter. Two promoters were found to be responsible for expression of nifHDK; a weak promoter within nifU1 and a strong promoter upstream of nifB (the nifB1 promoter). The region immediately upstream of vnfH did not drive expression of lacZ, however the region that included the promoter for the upstream gene, ava4055 did. Characterization of the previously reported nifH1 and vnfH transcriptional start sites by 5' …

Race And Justice In Mississippi's Central Piney Woods, 1940-2010, Patricia Michelle Buzard-Boyett

Dissertations

“Race and Justice in Mississippi’s Central Piney Woods, 1940-2010,” examines the black freedom struggle in Jones and Forrest counties. The writer concludes that more than any other region of Mississippi, the Central Piney Woods became the pivotal theater in the war for racial justice because the intensity of its racial oppression combined with its unparalleled suffrage campaign, and watershed street protests forced a federal alliance, instigated landmark court rulings, and generated black political victories that lay the foundations for a more equitable racial order. To obtain a broader perspective on the forces that transformed racial justice over time, this community …

Bitter-Sweet Home: The Pastoral Ideal In African-American Literature, From Douglass To Wright, Robyn Merideth Preston-Mcgee

Dissertations

Discussions of the pastoral mode in American literary history frequently omit the complicated relationship between African Americans and the natural world, particularly as it relates to the South. The pastoral, as a sensibility, has long been an important part of the southern identity, for the mythos of the South long depended upon its association with a new “Garden of the World” image, a paradise dependent upon slave labor and a racial hierarchy to sustain it. For African Americans, the rural South has been both a home and a place of violence and oppression, particularly during the period of slavery through …

"Reading" The Apprentice: Commerce, Culture, And The Manufacturing Of Reality, Sharon Simpson Terrell

Dissertations

This study examines the six original seasons of the reality television series The Apprentice as a postmodern, cultural artifact. Grounded in Burke’s (1967) “literature as equipment for living,” and Brummett’s (1984) consideration that televised content constitutes literature, the theory of “televised discourse as equipment for living” provided the guide to examine the series. Hall’s (1980) “reading against the grain” oppositional reading technique was utilized to interrogate both the manifest and latent content. The content of the series may indeed provide the audience with a guide to ideological beliefs of both commerce and culture, thereby creating a manufactured reality for its …

The Integral Role Of Organizational Characteristics And Their Impact On Lean Implementation Success, John J. Cooper

Dissertations

ABSTRACT The increasingly competitive nature of the manufacturing industry has forced manufacturers to examine alternatives to traditional management philosophies. Although lean's success had been proven it was not uncommon for companies that opt to implement lean concepts to meet with mixed results and sometimes even outright failure. The purpose of the study was to investigate the relationship between organizational characteristics and issues associated with lean implementation. The study identified the following organizational characteristics (a) organizational leadership, (b) organizational culture, and (c) organizational change and examined the role each played in lean implementation efforts. The study also looked at sixteen individual …

Frameworks For Estimating Virtual Water Flows Among U.S. States, Stanley T. Mubako

Dissertations

The United States is the world's top virtual water exporting nation, but not much is known about the country's internal virtual water flow patterns and the volumes involved. Previous studies have suggested that the import of virtual water, defined as the volume of water required to produce a commodity or service, can relieve pressure on a region's water resources. This study seeks to quantify virtual water flows among U.S. states using the water footprint and input-output analytical methods, and to compare the quantitative results to actual water use volumes in agriculture. The results showed an overall pattern where virtual water …

How To Remain Childlike, Billy Ray Middleton

Dissertations

How to Remain Childlike examines themes of place and identity, focusing on how regionalism impacts the individual’s perception of self. The stories herein, set in the post-millennial South, focus on characters with a worldly recognition of prevailing misconceptions that cast Southerners as unsophisticated and anti-intellectual. Though these characters recognize the beauty of the South, they possess ambivalence toward the region, a desire to be less insular and more cosmopolitan. This ambivalence, a love for the South coupled with a longing to escape it, highlights the importance of place in the process of self-definition.

Moon Landing, Jennifer Ann Marquardt

Dissertations

The following short stories began and were finished—at least as finished as they appear here—during my time at the Center for Writers.

The Oddity As Commodity: Television And The Modern Day Freak Show, Robin Marie Cecala

Dissertations

A new genre of documentary and reality program has appeared on cable television in recent years. Suddenly, little people, conjoined twins, the morbidly obese, Treeman and Mermaid Girl are the new stars of cable. This latest genre features people with medical conditions once exhibited in the turn of the century freak shows.

The goal of this dissertation is to argue that documentary programming on cable is becoming a modern version of the P.T. Barnum-style freak shows. The analysis uses both qualitative and quantitative methods to examine representations of race, culture and disability. The dissertation also discusses the history of the …

Mother-Son Connectedness, Substance Use, And Young Men's Criminal Justice System Involvement, Kim L. Moreno Phd

Dissertations

The relationship between a mother and her son and its influence on health and risk behaviors as a boy becomes a man has had little exploration. The purpose of this study was to examine the relationships between mother-son connectedness, substance use, serious delinquency, violent delinquency, and criminal justice system involvement in young men. This study uses data from The National Longitudinal Study of Adolescent Health (ADD Health), a school-based study of students in grades 7–12 in the United States. Multiple regression, ANOVA, and logistic regression were used to analyze independent and dependent variables. Results show a perception of connectedness, which …

Microarray Data Mining And Gene Regulatory Network Analysis, Ying Li

Dissertations

The novel molecular biological technology, microarray, makes it feasible to obtain quantitative measurements of expression of thousands of genes present in a biological sample simultaneously. Genome-wide expression data generated from this technology are promising to uncover the implicit, previously unknown biological knowledge. In this study, several problems about microarray data mining techniques were investigated, including feature(gene) selection, classifier genes identification, generation of reference genetic interaction network for non-model organisms and gene regulatory network reconstruction using time-series gene expression data. The limitations of most of the existing computational models employed to infer gene regulatory network lie in that they either suffer …

Examining Dietary Acculturation In Hispanic Males Residing In South Mississippi, Diana Katherine Cuy Castellanos

Dissertations

This study explored dietary behavior in terms of dietary intake, dietary intake change and dietary contributing factors in a sample of Hispanic males residing in southern Mississippi that are at various stages of the acculturation process. Grounded theory and the bidimensional acculturation model were incorporated to identify the dietary factors and assess acculturation in each participant. Qualitative and quantitative measures were used in data collection. Qualitative measurements included Semistructured interviews, a focus group, and photovoice with group interviews. The ARSMA-II, Marginality Scale, Fruit/Vegetable and Fat Food Screeners, a psychosocial dietary questionnaire, and the New Vital Signs Food Label for Health …

The Role Of Attachment And Language In Analogical Reasoning, Tamra Elizabeth Beckman

Dissertations

The present study examined the relationships between attachment and analogical reasoning within two domains: social reasoning and physical reasoning. Verbal reasoning was assessed as a possible mediator of these relationships. This study was conducted with 67 typically-developed children between the ages of nine to 11 years of age who were recruited from The University of Southern Mississippi's student population and from schools in Hattiesburg, MS and Ocean Springs, MS. Attachment security was assessed using the Kerns Security Scale (Kerns, Klepac, & Cole, 1996), and verbal reasoning was assessed with the Weschler Intelligence Scale for Children-3rd edition (Weschler, 1991). Analogical reasoning …

Assessing The Validity Of The Communalism Scale Using Cultural Groups, Lashawn Thompson

Dissertations

Communalism has become a very important variable for research investigation recently because the field of cultural psychology has been searching for new models to foster a clear understanding of culture or for ways to improve current models. This study investigated the validity of using The Communalism Scale to assess the communal (group focus rather than individual focus) aspect of culture in specific ethnic groups. Until now, the scale was used only with African Americans; however, the current study assessed the validity of the scale with several cultural groups. Results from previous studies have demonstrated clear internal consistency for The Communalism …

Intergroup Forgiveness In The Middle East: Cognitive And Affective Antecedents To Intergroup Forgiveness And The Relationship Between Intergroup Forgiveness And Psychological Well-Being Among Israeli Jews, Alon Rice

Dissertations

In the past three decades, there has been a burgeoning interest in the scientific study of interpersonal forgiveness. However, only a few studies have elucidated cognitive and affective variables related to intergroup forgiveness. Moreover, no study has examined the degree to which intergroup forgiveness may contribute to one’s psychological well-being, nor has any study thoroughly examined intergroup forgiveness in Israel. Current study results have shown a significant relationship between quality of intergroup contact between Israeli Jews and Israeli Arabs/Palestinians, and Israeli Jews’ forgiveness attitudes toward Palestinians, a relationship mediated by Israeli Jews’ trust, attitudes, and empathy toward Palestinians, as well …

A Comparison Of Social Stories With And Without A Reinforcement Component, Erin Cuneo Perry

Dissertations

The purpose of the current study was to compare the effectiveness of Social Stories ^TM (Gray, 2004) used in isolation and when combined with a reinforcement component to increase appropriate behaviors and decrease inappropriate behaviors. Treatment effects for socially inappropriate behaviors and appropriate replacement behaviors were tracked. The setting of the current study was in a school district. The diagnoses of two of the participants included Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS), and the other two participants were diagnosed with Autistic Disorder. All participants read a social story to their teacher prior to the time at which the target …

A Methodology To Develop A Communication Protocol For Visualizing Simulations In A Collaborative Virtual Reality Environment, Lacey Suzanne Duckworth

Dissertations

In the technology field, simulations and collaborative virtual reality environments (CVREs) are not generally combined because it is complicated to develop large scale simulations within CVREs. The complexity of combining these two technologies in order to form a better form of visualization stems from the lack of a methodology to help derive these scalable simulations. Simulations require very complex calculations that the CVRE cannot perform as it is overloaded in calculations for the maintenance and stability of the environment itself. Since the simulation cannot be held within the CVRE, the solution is to move the simulation external to the CVRE …

The Structure Of Equine Personality, Rachel Etta Kristiansen

Dissertations

The current study was designed to investigate the structure of equine personality. Two personality questionnaires were replicated from previous studies and implemented simultaneously to test the theory that different questionnaires may extract different personality structures. Breed and sex differences were also hypothesized to be significantly different for some personality dimensions. A total of 827 horses were rated on a 90-item personality questionnaire. Participants were recruited online via email and completed the survey at their own convenience. An additional 121 respondents rated a horse that had already been rated; these results were used to calculate inter-rater reliability.

After data collection was …

An Exploratory Investigation On The Effects Of An Electronic Recording System For Repeated Reading, Seajae Calvin Hartness

Dissertations

Repeated Reading is a common reading intervention that has been used to help students read fluently since 1979. There are many variations of Repeated Reading that have been investigated and found to be effective. However, there is a relative research deficit on the effectiveness of software programs for administering Repeated Reading. This exploratory research project examined the effectiveness of Repeated Reading with an electronic recording system. The performance of the electronic Repeated Reading group was compared to the performance of participants who received traditionally administered Early Intervention Program services. The results suggest that electronically scored Repeated Reading is as effective …

Attitudes Toward Multimedia (Karaoke) And Popular Culture When Learning English As A Foreign Language In Taiwan, Chen-Yin Lee

Dissertations

No abstract provided.

Self-Efficacy And Retention Among Ethnically Diverse Nursing Students, Jacqueline Carol Lewis

Dissertations

No abstract provided.

Whither Criminology?: On The State Of Criminology's Paradigm, Brendan David Dooley

Dissertations

What is the condition of criminology’s paradigm? The reply to this question has implications bearing on the profession’s bona fides as a science as well as its sustainability as an independent academic enterprise. The work attempts to capture the elusive term through the use of five themes: theoretical consensus, methodological consensus, boundaries, the departure from sociology, and the current and future status of the field. In approaching this question the work presents an analysis of both qualitative and quantitative data. Semi-structured interviews were conducted with seventeen renowned criminologists. The centerpiece of the latter data set was assembled and analyzed in …

The Leadership Practice Of Museum Educators, Tina R. Nolan

Dissertations

This grounded theory study is an examination of the culture, context, conditions and competencies of a set of six museum educators from a large city in the United States. Participants were education department leaders from a variety of museum types, including: A science museum, an ethnic arts museum, a settlement house museum, a children‘s museum, an aquarium, and a zoo. An analysis of data points to an emerging framework that codifies particular leadership settings and domains of practice for leaders of museum educators. An array of data collections were employed in the study, including: Semi-structured interviews, unstructured observations, written reflections …

Invariance In The Factor Structure Of Translated Instruments: Multiple Group Confirmatory Factor Analysis And Mimic Models, Fatma Ayyad

Dissertations

When factorial invariance is established across translated forms of an instrument, the meaning of the construct crosses language/cultures. If factorial invariance is not established, score discrepancies may represent true language group differences or faulty translation. This study seeks to disentangle this by determining whether cultural/linguistic variance can be decomposed separately from construct variance intended in the measuring instrument.

Translated forms of the God Mediated Control factor of the Belief in Personal Control Scale (BPCS) (Berrenberg, 1987) was analyzed across multiple samples for measurement and structural invariance among American native English speakers, Arab native Arabic speakers, and Arab bilingual Arabic/English speakers. …