Digital Commons Network^™

Like Teacher, Like Student: An Exploration Of Racial Matching On Black Student Identity Development In Secondary Education, Crystal Gloria Lennix

Dissertations

Research on racially matching teachers of color with students of color has demonstrated a plethora of benefits, whether it is in West-Indian teachers with West-Indian students (Warikoo, 2004), Mexicana educators with Mexicana students (Sosa-Provencio, 2019), or Black students with Black teachers (Brooms, 2017). Black teachers are warrior spirits, acknowledging education as a “racial, cultural, linguistic, and spiritual reclamation” for Black students (Sosa-Provencio, 2018). In this study, I sought to understand how the racial matching between Black teachers and Black students can impact Black students’ identity and achievement. Numerous studies say racial matching helps students, but only a few focus on …

Discerning The Role Of Microtubule Acetylation During Hiv-1 Infection, Drew Michael Lichon

Dissertations

The host-pathogen interactions underlying Human Immunodeficiency Virus type 1 (HIV-1) infection are complex and involve the exploitation of host cellular machinery. This thesis investigates the roles of dynein adaptors, microtubule acetylation, and TRIM69-mediated restriction in HIV-1 infection. Through a series of detailed experiments, we explore how HIV-1 utilizes multiple dynein adaptors, such as BICDR1 and Hook3, for intracellular transport, and reveal that these adaptors are critical for efficient viral trafficking. Conversely, the knockdown of Ninein surprisingly enhances HIV-1 infectivity, suggesting a nuanced regulatory role for this adaptor in viral transport. Further, this thesis challenges the prevailing paradigm that microtubule acetylation …

Support Needs Of Agrarian Women To Build Household Livelihood Resilience: A Case Study Of The Mekong River Delta, Tran Thi Ngoc Tran

Dissertations

Problem

Rural livelihood faces significant challenges due to the increasing frequency and severity of climate change impacts. However, the development of women’s livelihood resilience remains constrained by gender-blind policies, limited sex-disaggregated data, and a lack of integration of gender-specific needs and priorities in resilience-building interventions. This study aims to address these critical gaps. This study aims at exploring the perceived support needs of rural agrarian women in building household livelihood resilience to climate change. Specifically, it seeks to (1) understand how household livelihood resilience is perceived by rural agrarian women, and (2) identify the support they require to effectively adapt …

Computational Analysis And Characterization Of The Inducible 1-Cysteine Peroxiredoxin Promoter In The Malaria Parasite Plasmodium, Lara Ladney

Dissertations

Malaria afflicts over 200 million people annually, which results in over half a million deaths, primarily in sub-Saharan Africa. Malaria parasites are complex protozoan organisms that inhabit two hosts: humans, the site of asexual reproduction, and the Anopheles mosquito, where sexual reproduction occurs. To withstand the hostile extracellular environment of the Anopheles mosquito, the malaria parasite Plasmodium berghei employs antioxidant defense mechanisms. Previous work suggests upregulation of 1-Cysteine Peroxiredoxin (1-CPxn) when the mosquito uptakes a blood meal containing the parasite. The parasite must acclimate to the harsh environmental conditions of the mosquito midgut: find a way to counteract reactive oxygen …

Elucidating The Genetic Regulation Of Zebrafish Type Ii Collagen Alpha 1 B, Angelina Renee Carcione

Dissertations

Type II collagens (Col2) are essential proteins providing flexibility and structure to vertebrate animals. During development type II collagens play a vital role in the formation of many structures, such as the cartilage of the skeleton, the notochord, the retina and many other tissues. Conserved throughout vertebrates, cartilage is composed of two main cell types: chondrocytes, which make up the bulk of the structure, and perichondral cells, which form the epithelial layer that surrounds chondrocytes and is essential for bone growth and joint protection. While much is known about the expression and regulation of type II collagens in chondrocytes, specifically …

The Effect Of Inclusive Leadership By Pastoral Leaders On Catholic Parish Vitality, Matthew F. Manion

Dissertations

Catholic parish life in the United States has passed the point of decline where minor changes will enable it to grow again. Church leaders need a new missionary culture and outward-focused approaches to reach people today with the timeless truths of the faith. The old mindset of putting all the responsibility on the shoulders of the clergy to solve problems no longer works. Since heterogeneous groups make better decisions than homogeneous groups in complex, adaptive situations, this study explores the hypothesis that inclusive leadership by Catholic parish leaders leads to more innovation and better solutions to the challenges of church …

The Impact Of Professionalism Education And Formative Feedback In Doctor Of Physical Therapy Students Utilizing The Abbreviated Cpi Feedback Form In The On-Campus Clinic Environment, William L. Scott

Dissertations

Problem

The American Physical Therapy Association (APTA) developed the Clinical Performance Instrument (CPI) to assess the professional behaviors required for a Doctor of Physical Therapy (DPT) student to be considered "entry level" in their clinical training. Feedback from our clinical partners has indicated that, historically, students from the Andrews University DPT program have scored lower than students from other programs in several areas of the CPI during their clinical experiences. According to subjective reports from our clinical partners, these areas included safety, professional behavior, accountability, communication, and critical thinking. These five areas have been the focus of our efforts in …

Mansiones: A New Look At Mansio Archaeology In Light Of San Miceli And Household Archaeology, Christopher Randall Chadwick

Dissertations

Problem

The identification of mansiones in the archaeological record has proven difficult, if not impossible. One factor contributing to the problem has been focusing on typological and descriptive studies in order to identify the functional characteristics of mansiones. Another has been the lack of any explicit method and theory for interpreting the functional characteristics of the archaeological data related to mansiones. Both of these factors have been observed in the recent excavations at San Miceli.

Method

Due to the functional nature of mansiones, there is a need to reevaluate current paradigms for interpreting the archaeological data related to mansiones. One …

Characterizing Niche Specialization In Staphylococcus Epidermidis, Sandra Jablonsk

Dissertations

This thesis investigates the microbial diversity of Staphylococcus epidermidis (S. epidermidis) across various anatomical sites in the human body. While traditionally viewed as a benign skin microbe, S. epidermidis also inhabits the urinary, gastrointestinal, and respiratory tracts, raising questions about its genetic variation and adaptability in different environments. The research aims to compare strains of S. epidermidis isolated from the oral cavity, nostrils, urinary tract, and skin of healthy individuals to determine if they share a common ancestor or if they evolved independently in response to specific environmental factors. The study comprises three main aims. Aim 1 focuses on assessing …

Insights On The Cranial Anatomy And Osteohistology Of Cyonosaurus, Alexander Acker

Dissertations

This study investigates the cranial anatomy and life history of the small-bodied gorgonopsian Cyonosaurus. Previous research on gorgonopsians has disproportionately focused on larger members of the clade, leaving smaller forms relatively understudied. This gap has led to several unresolved questions, the most pressing of which concerns gorgonopsian ontogeny. Specifically, it remains unclear whether small-bodied gorgonopsians represent genuinely diminutive adult individuals or juveniles of larger species. The specimen NHCC LB1087 presents an ideal opportunity to address this issue and gain new insights into the biology of small-bodied gorgonopsians. The first chapter focuses on cranial anatomy. Due to the specimen’s preservation, many …

Novel Ai/Ml-Based Frameworks For Protein Conformation Selection In Drug Discovery Applications, Shivangi Gupta

Dissertations

Drug development is a lengthy, expensive process with a high failure rate. The urgency brought on by the COVID-19 pandemic has accelerated the integration of artificial intelligence (AI) and machine learning (ML) to enhance drug discovery by increasing target specificity, reducing toxicity, and optimizing formulation strategies. Building on this momentum, this dissertation introduces novel AI/ML-driven frameworks for protein conformation selection and classification, addressing critical challenges in modern drug discovery. However, designing such a novel AI/ML data-driven framework is a difficult task because most real-world biomedical datasets suffer from class imbalance issues, which can significantly skew AI/ML model training, resulting in …

The Ethical Theory Of Enrique Dussel: An Investigation Of Violence And Coercion In His Three Foundational Principles, Eric Antonio Del Valle Cruz

Dissertations

Problem

Enrique Dussel's ethics proposes addressing global inequality through legitimate coercion as a means of liberating the poor, contrasting it with the violence of the current system. However, the inclusion of life-threatening acts, such as armed revolution, as coercion raises practical challenges for the Christian community, including ethical-political dialogue, inclusion of opposing parties, and potential dehumanization, which need further exploration in light of Dussel’s use of Scripture in support of his proposals.

Purpose

This dissertation aims to assess Dussel's philosophical principles and their connection to coercion and violence, ultimately establishing a framework for a conservative Christian proposal that combines the …

Analyzing The Population Structure Of The Rhizobia Associated With Astragalus Lentiginosus, Joshua Adam Melnick

Dissertations

Legumes are an incredibly diverse and agriculturally important family of plants. They have a special relationship with symbiotic bacteria known as rhizobia which fix nitrogen into ammonia within nodules on their roots. Astragalus is the largest plant genus on Earth, and the species Astragalus lentiginosus is extraordinarily diverse, consisting of approximately 40 varieties. However, the rhizobia of A. lentiginosus have never been studied. In this study, root nodules were extracted from 17 varieties of A. lentiginosus to obtain rhizobial strains and metagenomes. A. lentiginosus primarily associates with rhizobia from the genera Mesorhizobium and Allomesorhizobium. There was little evidence of horizontal …

The Impact Of Lactobacillus Supplementation On Gut Microbiome Composition And Phage Induction In Mice, Kimia Boreiri

Dissertations

The mammalian gastrointestinal (GI) tract harbors a dense and dynamic community of microbes known as the gut microbiota, which plays vital roles in digestion, immunity, and overall health. Among these, probiotic bacteria such as Lactobacillus strains have garnered attention for their ability to influence microbial community structure and host physiology. This study investigated the effects of five Lactobacillus strains, Lactobacillus casei R1A482, Lactobacillus casei O3, Lactobacillus rhamnosus GG, Lactobacillus gasseri ATCC 33323, and Lactobacillus paragasseri UMB1065, on the gut microbiome of Swiss Webster mice over a six-week feeding period. To reduce stress, mice were fed Lactobacillus strains using gelatin pellets …

Role Of Coronavirus Envelope Protein On Infectivity, Garrett E. Zaagman

Dissertations

Coronaviruses infect a wide range of hosts and have caused recent human pandemics. While much has been learned, gaps remain in understanding viral assembly and egress, particularly the role of the envelope (E) protein in specific infectivity. To study this, recombinant MHV viruses were created with E gene deletions and HiBiT-tagged spike (S) proteins to monitor virion release. In mouse cells, MHV∆E S-HiBiT secreted less spike and fewer infectious particles, indicating reduced specific infectivity. Comparisons between human HeLa-CEACAM and mouse DBT cells showed species-specific support for virus production. TMED10, a host membrane protein, was tested as a potential E-interacting partner …

Anti-Inflamatory Mechansim Of Bacillus Subtilis Derirved Exopolysaccharide, Adrian Taylor Ibarra

Dissertations

Exopolysaccharides (EPS) secreted by the commensal bacterium Bacillus subtilis exhibit potent anti-inflammatory properties, yet the underlying molecular mechanisms remain incompletely understood. We hypothesized that EPS reprograms antigen-presenting cells toward a tolerogenic state by modulating TLR4–MyD88 signaling. To test this, we began using a chemically defined, high-yield EPS production and purification protocol that largely eliminates protein and DNA contaminants, thus improving functional reproducibility across experiments using this new method. In vitro, EPS engaged TLR4 on murine dendritic cells (DC2.4) without inducing classical NF-κB activation, seen by LPS stimulation. Rather, EPS treatment upregulated inhibitory molecules, PD-L1 and PD-L2 while leaving activation markers, …

Developing Chemically Defined Serum-Free Medium For Leukemic Blast And Stem Cell Expansion, Carmen Eva Finley

Dissertations

The relapse and chemotherapy resistance are the major challenges of acute myeloid leukemia (AML) treatment, driven by a rare population of leukemia stem cells (LSCs). LSCs are unique types of cells which evade standard chemotherapies and can regenerate AML post-treatment. Targeting LSC therapy remains limited, in part due to the lack of reliable in vitro AML culture systems to grow LSCs for drug discovery. This study aimed to engineer a chemically defined, serum-free 2D in vitro culture condition that supports either the expansion of leukemic blasts (LBs) or primary human LSCs by optimizing current protocols for hematopoietic stem cells (HSCs) …

“What’S Happening In The Gulf Of Maine?”: Middle School Students’ Engagement In Climate Science Through Data Visual Representation And Reflections, Grace Ocular

Dissertations

This study examined how middle school students engaged with science concepts while working with data visualizations during a field trip learning experience. Fifty-one teams of 2–4 students from 35 schools participating in the LabVenture program were video- and audio-recorded. Students completed two activities: one using a frequency table of marine species illustrating threats to Maine’s lobster population, and another using maps depicting changes in Gulf of Maine sea surface temperature. After each activity, students annotated the visualization, discussed their claims, and recorded short reflections. Transcripts were coded for science-related talk, and annotations and gestures were also analyzed. Findings indicate that …

The Bacterial Sensing Nuclear-Oligomerization Domain 2 Receptor In The Brain: Location And Potential Function, Julia Smyth

Dissertations

Nucleotide-binding oligomerization domain-2 (NOD2) is a cytosolic receptor, activated by bacterial peptides that initiates innate immune responses through nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and Caspase-1 pathways. While the role of NOD2 in inflammation outside the central nervous system (CNS) is well-established, especially in the gastrointestinal system, its expression and function in the brain remain poorly defined. Previous genetic studies suggest a link between NOD2 and neurological and psychiatric conditions, including stroke, Parkinson’s disease, and schizophrenia. However, information regarding NOD2 expression, localization, and function in the CNS is limited. In this work, we investigated NOD2 expression, localization, and regulation …

Effects Of Nitrogen, Phosphorus And The Fungicide Azoxystrobin Additions On Larval And Post-Metamorphic Fitness Of American Toads (Anaxyrus Americanus), Michael Vosburgh

Dissertations

Since European settlement, vast areas of U.S. land have been modified by humans. In the Midwest, an estimated 99% of native grasslands have been replaced by agriculture and urban development. Such alternations have replaced native habitat, redefined hydrology and introduced a wide array of chemicals into aquatic ecosystems. Modern agricultural practices utilize fertilizers and pesticides to maximize crop production. These chemicals frequently runoff into surrounding waters, potentially effecting aquatic organisms. One group of organism thought to be susceptible to agricultural contaminants are amphibians. Amphibians are vulnerable to pollution due, in part, to their permeable skin and biphasic life history. Global …

The Forced Sterilization Of Quechua-Speaking Women In Peru: The Role Of Epistemic Injustice In The Perpetration Of Genocide, Geraldine Diaz

Dissertations

The forced sterilization of Quechua-speaking women in Peru from 1996 to 2000 represents a case of genocide in which the state as an epistemic agent has a fundamental role. Although the systematic sterilization was carried out under the guise of a family planning program, the targeting of these women provides strong circumstantial evidence of genocidal intent. According to the testimonies of these women, medical staff, acting on behalf of the government, performed tubal ligation procedures through coercion, threats, lies, bribery, manipulation, and other tactics where the state intentionally withheld information, misinformed women, and failed to obtain proper consent. This research …

Response Of Benthic Macroinvertebrate Community Structure And Aquatic Insect Secondary Production To Coarse Woody Debris Addition In Peri-Urban To Urban Golf Course Ponds, Ryan Johnson

Dissertations

Golf courses represent 29% and 26% of all greenspace areas in the U.S. urban regions and the Chicago metropolitan region, respectively; however, they are often overlooked among urban greenspaces as a tool to mitigate the impacts of increased urbanization on ecological communities. The primary aim of this research was to assess whether manipulating golf course pond habitats by adding coarse woody debris (CWD) would enhance aquatic invertebrate community structure and secondary production, with the potential to increase local biodiversity. One pond in each of six golf courses was selected for this study and sampled in summer 2020 before wood addition …

What About The Children? An Exploration Of Family Counselors' Play Therapy Training And Preparedness To Integrate Children Into Family Counseling, Patricia J. Walker Monical

Dissertations

Children are an important part of families, yet family counselor education programs often do not incorporate training for including children in family counseling. At some point in their careers, family counselors and therapists will encounter clients who have children 3–12 years old. The problem is that since these professionals often receive little to no training in play therapy and thus do not typically include young children in family therapy, these younger family members are often overlooked. Research has confirmed that, due to a lack of sufficient training and supervision in play therapy, many family therapists report feeling unprepared to work …

Game-Based Learning With Augmented Reality, Kantida Nanon

Dissertations

Augmented Reality (AR) technology provides an effective and controllable learning environment, especially for complicated, potentially dangerous, or critical content. Effective implementation of interaction and platforms for educational tools can maximize learner engagement and optimize the learning experience. This dissertation explores the potential of AR technology to enhance learning experiences across multiple platforms and subject areas, particularly within chemistry and mathematics. The dissertation is grounded in the field of Human-Computer Interaction (HCI) and explores the potential of AR to increase learner engagement, improve learning outcomes, and transform traditional pedagogical practices.

The dissertation is divided into two parts. The first part examines …

Crowd-Sourced Learning For Computer Graphics Applications, Yunhao Zhang

Dissertations

Computer Graphics (CG) revolves around virtual content creation using computational methods, spanning applications from games to visual effects. Typically, the creation of CG content is led by expert practitioners who guide computational algorithms towards satisfactory results. Thus, creating CG content often requires manual iterations encompassing algorithm design, parameter tuning, and aesthetic feedback. This work investigates how to leverage crowd-sourcing to streamline such creation processes, focusing on animation and simulation. In animation, a novel crowd-sourcing framework is proposed for combat animation, enabling users to analyze motion similarities, and retrieve matching motions using novel crowd-sourced motion features. Such features enable quantifying previously …

Beyond Average Effects In Education Research Syntheses: Explaining Heterogeneity Of Concept Mapping Research In Science Education Through Meta-Regression Modeling, Aaron Wenger

Dissertations

Contemporary education research seeks causal inferences in order to guide policy and practice. Often well-controlled quasi-experimental and experimental designs are used as they are very useful for supporting and contextualizing causal inferences. Nevertheless, individual studies, even high-quality, resource-intensive randomized controlled trials, are not able to establish generalized claims. Because primary studies vary over dozens of variables (e.g., grade, subject, duration) simply conducting additional primary studies cannot change this. Furthermore, the informal assessments of primary studies common in literature reviews are unable to resolve certain challenges (e.g., publication bias) that are described in the emerging field of meta-research. These challenges require …

A Latent Profile Analysis Of High-Risk Children's Problematic Sexual Behavior, Claudia Campbell

Dissertations

As research and intervention regarding children’s problematic sexual behavior (PSB) have broadly defined PSB, including all forms of developmentally atypical sexual behavior and all potential etiological factors, limited work to date has identified subtypes or unique patterns of PSB. The aim of the current study was to examine the presence of unique patterns of PSB and etiological factors among high-risk children utilizing latent profile analysis (LPA) based on children’s self-focused PSB, interpersonal PSB (IPSB), maltreatment factors, co-occurring symptoms, adaptive functioning, and family functioning. The present study included 689 8-year-old children (50.1% male, 50.2% Black) with potential PSB and their caregivers …

Circadian Body Temperature And Activation Rhythms And The Well-Being Of Independent Older Women, Diana J. Mason

Dissertations

This study examined changes in the circadian parameters of body temperature and activation and their relationship to the well-being of the older woman.

Going With The Flow: How Direct And Indirect Alterations To Streamflow Influence Headwater Fish Communities In The Southeast, Langston Haden

Dissertations

Streamflow has been deemed the “master variable” regulating riverine communities as it can influence the chemical, physical, and biological components of river systems. Anthropogenic changes have and will continue to alter streamflow through direct (e.g. road culverts) and indirect (e.g. climate change) processes. Understanding how these alterations impact riverine communities is essential for maintaining and restoring ecosystem properties like biodiversity. Our objective is to integrate ecological theory and conservation approaches to understand how direct and indirect alterations to streamflow influence freshwater fish communities within the biodiverse headwater streams of the southeastern U.S. In a test of a standardized barrier protocol …

Impact Of Safety Training On Employee's Perceptions Of Organizational Safety Culture, Brooke Reid-Graves

Dissertations

Workplace safety and well-being are vital for all workers, regardless of their profession (Young et al., 2022). Studies show that providing employees with training focused on recognizing hazards and implementing safety practices is essential for reducing occupational risks (Namian et al., 2020; Rose & Rae, 2017). Research underscores the importance of fostering a positive organizational safety culture for risk reduction (Berry et al., 2020; Downey, 2019). Understanding the impact of safety training on shaping an organization’s safety culture is key to promoting safe working environments (Mahjoub, 2013).

This study utilized the perspectives of high school staff regarding safety training and …